SIRT1

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The anti-aging effects of SIRT1 activation include:

– Protection against oxidative stress

– Regulation of age-related diseases

– Increased stress resistance

– Potential lifespan elongation

– Involvement in the metabolic response to calorie restriction

– Extension of lifespan in various organisms

– Resistance to oxidative stress and cardiovascular health

– Cellular protection and regulation of gene expression

– Support for vascular and metabolic health

– Impact on age-related diseases and longevity

– Correlation with age, cholesterol levels, and eNOS expression

– Potential compensatory mechanism against oxidative stress

– Induction of antioxidants and contribution to longevity through gene-environment interactions.


SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuinhomolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity).[8]
Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.[6] Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity.[9]Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15] In mammals, SIRT1 has been shown to deacetylate and thereby deactivate the p53 protein.[16] SIRT1 also stimulates autophagy by preventing acetylation of proteins (via deacetylation) required for autophagy as demonstrated in cultured cells and embryonic and neonatal tissues. This function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction.[17] Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15] Human aging is characterized by a chronic, low-grade inflammation level[18] and NF-κB is the main transcriptional regulator of genes related to inflammation.[19] SIRT1 inhibits NF-κB-regulated gene expression by deacetylating the RelA/p65 subunit of NF-κB at lysine 310.[20][21] Increased expression of SIRT1 protein extended both the mean and maximal lifespan of mice.[53] In these mice health was also improved as well as bone and muscle mass. Another SIRT1 activator (SRT1720) also extended lifespan and improved the health of mice.[54]

A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human

Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.

LONGEVITY FORMULA: ✅AMPK ✅Autophagy ✅SIRT1 ✅Insulin Sensitivity XmTOR XOxidative Stress XInflammation

  • ✅=Activate, INCREASE, ENHANCE
  • X=Turn Down, Neutralize, Inhibit

  This is EXACTLY what the blends and fasting achieves.  1000 Scientific Studies

        1. A novel pathway regulates memory and plasticity via SIRT1 and miR-134
        2. Metabolic adaptations through the PGC‐1α and SIRT1 pathways
        3. Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice
        4. SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice
        5. How does SIRT1 affect metabolism, senescence and cancer?
        6. SIRT1 and energy metabolism
        7. Regulation of SIRT1 in cellular functions: Role of polyphenols
        8. SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
        9. Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
        10. SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
        11. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
        12. Mammalian SIRT1 Represses Forkhead Transcription Factors
        13. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
        14. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
        15. miR-34a repression of SIRT1 regulates apoptosis
        16. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
        17. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
        18. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
        19. Mechanism of Human SIRT1 Activation by Resveratrol
        20. Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
        21. Calorie restriction, SIRT1 and metabolism: understanding longevity
        22. Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
        23. SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
        24. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
        25. Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
        26. Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
        27. Sirt1 protects against high-fat diet-induced metabolic damage
        28. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
        29. Increase in Activity During Calorie Restriction Requires Sirt1
        30. DBC1 is a negative regulator of SIRT1
        31. SIRT1 transgenic mice show phenotypes resembling calorie restriction
        32. Tissue-specific regulation of SIRT1 by calorie restriction
        33. SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
        34. The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
        35. Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
        36. SIRT1 and other sirtuins in metabolism
        37. Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1
        38. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
        39. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
        40. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
        41. SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
        42. AMPK and SIRT1: a long-standing partnership?
        43. SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
        44. Caloric restriction, SIRT1 and longevity
        45. Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression
        46. Negative regulation of the deacetylase SIRT1 by DBC1
        47. SIRT1 controls endothelial angiogenic functions during vascular growth
        48. SIRT1 and insulin resistance
        49. Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
        50. SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B
        51. The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
        52. Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin
        53. SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase
        54. MiR-34, SIRT1, and p53: The feedback loop
        55. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
        56. PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
        57. Phosphorylation Regulates SIRT1 Function
        58. Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
        59. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
        60. Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
        61. SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling
        62. Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
        63. SIRT1 Regulates HIV Transcription via Tat Deacetylation
        64. SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer
        65. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
        66. Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
        67. Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
        68. Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
        69. Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
        70. SIRT1 and endocrine signaling
        71. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
        72. SirT1 Regulates Adipose Tissue Inflammation
        73. The interaction between FOXO and SIRT1: tipping the balance towards survival
        74. Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
        75. SIRT1: recent lessons from mouse models
        76. SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
        77. Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
        78. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
        79. Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
        80. SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
        81. SIRT1 promotes DNA repair activity and deacetylation of Ku70
        82. SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
        83. Sirt1 contributes critically to the redox-dependent fate of neural progenitors
        84. Sirt1 modulates premature senescence-like phenotype in human endothelial cells
        85. STAT3 inhibition of gluconeogenesis is downregulated by SirT1
        86. RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
        87. Shear stress, SIRT1, and vascular homeostasis
        88. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis
        89. The ups and downs of SIRT1
        90. Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
        91. The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer
        92. Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
        93. SIRT1 in Neurodevelopment and Brain Senescence
        94. SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes
        95. Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets
        96. Function of the SIRT1 protein deacetylase in cancer
        97. SIRT1 and SIRT2: emerging targets in neurodegeneration
        98. Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation
        99. SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
        100. JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
        101. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1
        102. Protective roles of SIRT1 in atherosclerosis
        103. SIRT1: Regulation of longevity via autophagy
        104. Cancer-Specific Functions of SIRT1 Enable Human Epithelial Cancer Cell Growth and Survival
        105. Cytoplasm‐localized SIRT1 enhances apoptosis
        106. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
        107. Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
        108. Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
        109. Hormonal Control of Androgen Receptor Function through SIRT1
        110. SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1 POSSIBLE ROLE IN AMP-ACTIVATED PROTEIN KINASE ACTIVATION
        111. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
        112. SIRT1 Regulates the Function of the Nijmegen Breakage Syndrome Protein
        113. SIRT1 and p53, effect on cancer, senescence and beyond
        114. SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
        115. Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
        116. Small molecule SIRT1 activators for the treatment of aging and age-related diseases
        117. SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein α Transcriptional Complex
        118. Exercise Training Promotes SIRT1 Activity in Aged Rats
        119. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
        120. Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats
        121. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
        122. SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
        123. SIRT1 regulation of apoptosis of human chondrocytes
        124. Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice
        125. SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
        126. Progressive loss of SIRT1 with cell cycle withdrawal
        127. MicroRNA regulation of SIRT1
        128. SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease
        129. Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα
        130. Biochemical effects of SIRT1 activators
        131. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
        132. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
        133. Mammalian Sirt1: insights on its biological functions
        134. Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage
        135. Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1
        136. Sirt1 activation protects the mouse renal medulla from oxidative injury
        137. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
        138. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
        139. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
        140. Deacetylation of cortactin by SIRT1 promotes cell migration
        141. SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
        142. Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands
        143. Metabolic benefits from Sirt1 and Sirt1 activators
        144. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
        145. SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
        146. Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
        147. Negative regulation of inflammation by SIRT1
        148. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
        149. Protective Role of SIRT1 in Diabetic Vascular Dysfunction
        150. SIRT1 and neuronal diseases
        151. A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
        152. SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
        153. JNK2-dependent regulation of SIRT1 protein stability
        154. SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization
        155. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
        156. Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications
        157. Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress
        158. Emerging roles of SIRT1 in vascular endothelial homeostasis
        159. PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
        160. Activation of Sirt1 Decreases Adipocyte Formation During Osteoblast Differentiation of Mesenchymal Stem Cells
        161. Redox regulation of SIRT1 in inflammation and cellular senescence
        162. SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
        163. SIRT1 contributes to telomere maintenance and augments global homologous recombination
        164. Metformin suppresses hepatic gluconeogenesis through inductionof SIRT1 and GCN5
        165. Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
        166. Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib
        167. Sirt1: a metabolic master switch that modulates lifespan
        168. Dietary activators of Sirt1
        169. SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
        170. Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress
        171. sirt1-null mice develop an autoimmune-like condition
        172. SIRT1: Tumor promoter or tumor suppressor?
        173. SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1
        174. FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression
        175. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
        176. SIRT1 Activation Confers Neuroprotection in Experimental Optic Neuritis
        177. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
        178. Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
        179. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
        180. Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma
        181. Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
        182. SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
        183. Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
        184. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
        185. Sirtuin 1 (SIRT1): The Misunderstood HDAC
        186. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
        187. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
        188. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
        189. Janus-faced role of SIRT1 in tumorigenesis
        190. SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
        191. High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction
        192. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
        193. DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
        194. SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation
        195. Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
        196. A Review of Sirt1 and Sirt1 Modulators in Cardiovascular and Metabolic Diseases
        197. SIRT1-mediated acute cardioprotection
        198. Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
        199. SIRT1: roles in aging and cancer
        200. The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet
        201. Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
        202. SIRT1 Is a Circadian Deacetylase for Core Clock Components
        203. Regulation of SIRT1 protein levels by nutrient availability
        204. SIRT1 deacetylates APE1 and regulates cellular base excision repair
        205. MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1
        206. Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation
        207. Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters
        208. Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
        209. Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts
        210. Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure
        211. Sirt1 and the Mitochondria
        212. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
        213. High glucose downregulates endothelial progenitor cell number via SIRT1
        214. Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway
        215. NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance
        216. SIRT1, metabolism and cancer
        217. FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States
        218. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
        219. SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1
        220. Resveratrol inhibits insulin responses in a SirT1-independent pathway
        221. SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
        222. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
        223. SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
        224. SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer
        225. SIRT1 Promotes Differentiation of Normal Human Keratinocytes
        226. Sirt1 activation by resveratrol is substrate sequence-selective
        227. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
        228. A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
        229. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
        230. miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells
        231. SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance
        232. Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
        233. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
        234. Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction
        235. The Roles of SIRT1 in Cancer
        236. The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
        237. Sirt1 increases skeletal muscle precursor cell proliferation
        238. Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
        239. NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease
        240. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
        241. SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages
        242. MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1
        243. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
        244. SIRT1 stimulation by polyphenols is affected by their stability and metabolism
        245. Control of Multidrug Resistance Gene mdr1 and Cancer Resistance to Chemotherapy by the Longevity Gene sirt1
        246. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
        247. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
        248. Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
        249. Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells
        250. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
        251. MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
        252. The Direct Involvement of SirT1 in Insulin-induced Insulin Receptor Substrate-2 Tyrosine Phosphorylation
        253. Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma
        254. Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase
        255. SIRT1 Activation by Small Molecules KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
        256. The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+
        257. MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
        258. Cellular Regulation of SIRT1
        259. SIRT1: Regulator of p53 Deacetylation
        260. SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts
        261. SIRT1 Shows No Substrate Specificity in Vitro
        262. A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
        263. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
        264. The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
        265. SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
        266. SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions
        267. MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
        268. SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
        269. AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
        270. Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
        271. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
        272. SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells
        273. Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function
        274. The ways and means that fine tune Sirt1 activity
        275. SIRT1 and insulin resistance
        276. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
        277. Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity
        278. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
        279. SIRT1 Regulates Autoacetylation and Histone Acetyltransferase Activity of TIP60
        280. The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
        281. Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes
        282. Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection
        283. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
        284. SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents
        285. Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage
        286. Inhibition of transcriptional activity of c-JUN by SIRT1
        287. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
        288. Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS
        289. Role of SIRT1 in homologous recombination
        290. Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
        291. Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
        292. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
        293. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
        294. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
        295. Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation
        296. Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
        297. SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma
        298. Structural and Functional Analysis of Human SIRT1
        299. SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
        300. Induction of apoptosis by inhibition of sirtuin SIRT1 expression
        301. SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity
        302. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
        303. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
        304. Resveratrol and novel potent activators of Sirt1: effects on aging and age-related diseases
        305. SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis
        306. SIRT1 longevity factor suppresses NF‐κB ‐driven immune responses: regulation of aging via NF‐κB acetylation?
        307. Sirt1 protects the heart from aging and stress
        308. Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function
        309. miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
        310. Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons
        311. SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
        312. Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
        313. SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress
        314. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
        315. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
        316. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
        317. Targeting cardiovascular disease with novel SIRT1 pathways
        318. Peptide Switch Is Essential for Sirt1 Deacetylase Activity
        319. The anti-aging, metabolism potential of SIRT1.
        320. SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
        321. A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
        322. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
        323. Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation
        324. Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways
        325. Controlling SIRT1 expression by microRNAs in health and metabolic disease
        326. Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
        327. Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors
        328. Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
        329. High-intensity interval training increases SIRT1 activity in human skeletal muscle
        330. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
        331. Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway
        332. Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
        333. The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance
        334. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
        335. SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
        336. SIRT1: new avenues of discovery for disorders of oxidative
        337. Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
        338. Neurogenesis directed by Sirt1
        339. Sirt1 Involvement in rd10 Mouse Retinal Degeneration
        340. SIRT1 metabolic actions: Integrating recent advances from mouse models
        341. SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis
        342. Expression and role of SIRT1 in hepatocellular carcinoma
        343. SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
        344. Regulation of SIRT1 activity by genotoxic stress
        345. Sirt1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets
        346. SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
        347. Association of SIRT1 gene variation with visceral obesity
        348. Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
        349. SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
        350. Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
        351. Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
        352. TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1
        353. SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice
        354. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
        355. Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
        356. Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF‐β/Smad3 Pathway
        357. Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase
        358. MicroRNA‐146b promotes adipogenesis by suppressing the SIRT1‐FOXO1 cascade
        359. The role of SIRT1 in ocular aging
        360. Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1
        361. Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
        362. Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer
        363. USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development
        364. Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
        365. Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein
        366. Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation
        367. MST1 Promotes Apoptosis through Regulating Sirt1-dependent p53 Deacetylation
        368. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression
        369. SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
        370. SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
        371. SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
        372. MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1
        373. The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
        374. Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD
        375. SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
        376. Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria
        377. Distinct HIC1-SIRT1-p53 Loop Deregulation in Lung Squamous Carcinoma and Adenocarcinoma Patients
        378. H2O2 Accelerates Cellular Senescence by Accumulation of Acetylated p53 via Decrease in the Function of SIRT1 by NAD+ Depletion
        379. Nicotinamide-induced Mitophagy EVENT MEDIATED BY HIGH NAD+/NADH RATIO AND SIRT1 PROTEIN ACTIVATION
        380. Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
        381. Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets
        382. SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis
        383. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
        384. Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway
        385. Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation
        386. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
        387. Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
        388. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
        389. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
        390. SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology
        391. Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1–FOXO1 signaling pathway
        392. MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
        393. SirT1 fails to affect p53‐mediated biological functions
        394. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
        395. SIRT1 deacetylates RORγt and enhances Th17 cell generation
        396. Nutrient-dependent regulation of PGC-1α’s acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
        397. The controversial links among calorie restriction, SIRT1, and resveratrol
        398. SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor α in Breast Cancer
        399. Sirt1 Mediates Hyperbaric Oxygen Preconditioning-Induced Ischemic Tolerance in Rat Brain
        400. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
        401. mIGF‐1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart
        402. SIRT1 stabilizes PML promoting its sumoylation
        403. PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
        404. Agrp Neurons Mediate Sirt1‘s Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity
        405. SIRT1, STEM CELLS, AGING, AND STEM CELL AGING
        406. Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
        407. Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
        408. Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice
        409. Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
        410. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke
        411. Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
        412. SIRT1 is required for long-term growth of human mesenchymal stem cells
        413. Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
        414. Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes
        415. Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
        416. Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
        417. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
        418. The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
        419. ΔNp63&alpha Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse
        420. Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women
        421. Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
        422. Activation of Sirt1 Decreases Adipocyte Formation during Osteoblast Differentiation of Mesenchymal Stem Cells
        423. Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
        424. Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
        425. Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
        426. Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2†
        427. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
        428. Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1
        429. SIRT1 Is a Novel Regulator of Key Pathways of Human Labor
        430. Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
        431. SIRT1 in cardiovascular aging
        432. SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex
        433. SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
        434. SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
        435. SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
        436. Resveratrol Inhibits β-Amyloid-Induced Neuronal Apoptosis through Regulation of SIRT1-ROCK1 Signaling Pathway
        437. The physiological roles of Sirt1 in skeletal muscle
        438. Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
        439. Balance between SIRT1 and DBC1 expression is lost in breast cancer
        440. SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
        441. CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage
        442. Human SIRT1: A potential biomarker for tumorigenesis?
        443. Regulation of SIRT1 by MicroRNAs
        444. SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism
        445. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
        446. Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism
        447. A Functional Link Between SIRT1 Deacetylase and NBS1 in DNA Damage Response
        448. PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway
        449. Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression
        450. C/EBPα regulates SIRT1 expression during adipogenesis
        451. Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network
        452. Comparative and pharmacophore model for deacetylase SIRT1
        453. Stimulation of Sirt1-Regulated FoxO Protein Function by the Ligand-Bound Vitamin D Receptor
        454. SIRT1 gene is associated with major depressive disorder in the Japanese population
        455. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
        456. The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
        457. SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
        458. Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
        459. Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver
        460. Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
        461. SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
        462. SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
        463. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
        464. Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
        465. Sirt1: Def-eating senescence?
        466. Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise
        467. A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis
        468. Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
        469. Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation
        470. Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection
        471. A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
        472. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
        473. Distribution Analysis of Deacetylase SIRT1 in Rodent and Human Nervous Systems
        474. Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
        475. SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity
        476. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
        477. Roles of FoxO1 and Sirt1 in the central regulation of food intake
        478. Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1
        479. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
        480. Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
        481. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging
        482. SIRT1 in the brain—connections with aging-associated disorders and lifespan
        483. Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
        484. Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide
        485. Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
        486. SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
        487. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
        488. Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity
        489. Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation
        490. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
        491. BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
        492. Brain Activation of SIRT1: Role in Neuropathology
        493. SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
        494. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
        495. Silibinin Protects Against Isoproterenol-Induced Rat Cardiac Myocyte Injury Through Mitochondrial Pathway After Up-regulation of SIRT1
        496. Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity
        497. SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β
        498. Function of SIRT1 in physiology
        499. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
        500. SIRT1 Regulates Dendritic Development in Hippocampal Neurons
        501. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
        502. SIRT1 Is Involved in Glucocorticoid-mediated Control of Uncoupling Protein-3 Gene Transcription
        503. SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging
        504. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
        505. Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
        506. LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells
        507. Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
        508. Identification of a Domain within Peroxisome Proliferator-Activated Receptor γ Regulating Expression of a Group of Genes Containing Fibroblast Growth Factor 21 That Are Selectively Repressed by SIRT1 in Adipocytes
        509. Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism
        510. Resveratrol Upregulated SIRT1, FOXO1, and Adiponectin and Downregulated PPARγ1–3 mRNA Expression in Human Visceral Adipocytes
        511. Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
        512. Sirt1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor
        513. Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons
        514. Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
        515. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
        516. Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type‐2 diabetes
        517. Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
        518. Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
        519. SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD
        520. SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
        521. Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex
        522. Age-associated decrease of SIRT1 expression in rat hippocampus: Prevention by late onset caloric restriction
        523. SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth
        524. SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
        525. Tumor necrosis factor α–mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
        526. Sirt1 Promotes Axonogenesis by Deacetylation of Akt and Inactivation of GSK3
        527. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
        528. Towards elucidating the role of SirT1 in osteoarthritis.
        529. Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis
        530. Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis
        531. Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways
        532. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti‐aging and metabolic effects of sirtuins
        533. SirT1 in muscle physiology and disease: lessons from mouse models
        534. Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells
        535. Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance
        536. Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway
        537. Resveratrol‐mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
        538. The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO
        539. Deacetylation by SIRT1 Reprograms Inflammation and Cancer
        540. Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar
        541. SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice
        542. Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases
        543. Metabolic actions of hypothalamic SIRT1
        544. SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
        545. SIRT1 and NAD as regulators of ageing
        546. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
        547. The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology
        548. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network
        549. Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
        550. SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases
        551. SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability
        552. SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells
        553. SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol
        554. Protection by EGb 761 against β-amyloid-induced neurotoxicity: Involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
        555. Impact of Sirt1 on mammalian aging
        556. The role of SirT1 in muscle mitochondrial turnover
        557. SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis
        558. AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation
        559. P53 and Sirt1: Routes of metabolism and genome stability
        560. SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines
        561. Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells
        562. SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging
        563. Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions
        564. Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
        565. Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
        566. SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60
        567. The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock
        568. Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation
        569. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin‐like growth factor receptor pathway
        570. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
        571. SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation
        572. SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory
        573. mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction
        574. Downregulation of Sirt1 as aging change in advanced heart failure
        575. SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas
        576. Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner
        577. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
        578. Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: Involvement of SIRT1 and TGF-β1 pathway
        579. The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
        580. SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
        581. SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
        582. Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
        583. Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
        584. Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1
        585. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
        586. Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity
        587. Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy
        588. Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
        589. The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
        590. Emerging Roles of SIRT1 in Cancer Drug Resistance
        591. Multifaceted Modulation of SIRT1 in Cancer and Inflammation
        592. Relationship between mitochondrial DNA Copy Number and SIRT1 Expression in Porcine Oocytes
        593. Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation
        594. SIRT1 Contains N- and C-terminal Regions That Potentiate Deacetylase Activity
        595. Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT‐mediated NAD biosynthesis
        596. SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
        597. Sirt1 restrains lung inflammasome activation in a murine model of sepsis
        598. SIRT1 – An Anti-Inflammatory Pathway at the Crossroads Between Metabolic Disease and Atherosclerosis
        599. Silencing Insulin Resistance through SIRT1
        600. Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
        601. Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
        602. The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis
        603. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
        604. Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
        605. Sirt1-deficient mice exhibit an altered cartilage phenotype
        606. miR-543 promotes gastric cancer cell proliferation by targeting SIRT1
        607. The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
        608. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
        609. α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
        610. Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1
        611. SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
        612. Translating cell survival and cell longevity into treatment strategies with SIRT1
        613. Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart
        614. Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress
        615. Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
        616. SIRT1: A novel target to prevent atherosclerosis
        617. Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
        618. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
        619. ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
        620. SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
        621. Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
        622. SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
        623. SIRT1 — a metabolic sensor that controls blood vessel growth
        624. Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo
        625. ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism
        626. SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy
        627. Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
        628. SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
        629. Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells
        630. Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
        631. Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor‐induced neurite outgrowth in PC12 cells
        632. Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
        633. Amurensin G, a Potent Natural SIRT1 Inhibitor, Rescues Doxorubicin Responsiveness via Down-Regulation of Multidrug Resistance 1
        634. Vitamin D Protects Human Endothelial Cells from H2O2 Oxidant Injury Through the Mek/Erk-Sirt1 Axis Activation
        635. Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition
        636. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
        637. SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
        638. The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
        639. Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
        640. Sirt1 in cerebral ischemia
        641. SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
        642. FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression
        643. A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration
        644. Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4+ T Cells
        645. Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy
        646. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
        647. Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
        648. Physiological and Pathophysiological Functions of SIRT1
        649. Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats
        650. Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
        651. Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1
        652. SIRT1: Role in cardiovascular biology
        653. SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
        654. SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
        655. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
        656. Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
        657. Resveratrol activates SIRT1 in a Lamin A-dependent manner
        658. Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
        659. Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
        660. Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK
        661. A Potential Treatment of Non-Alcoholic Fatty Liver Disease with SIRT1 Activators
        662. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
        663. Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
        664. Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure
        665. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
        666. Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action
        667. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition
        668. SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
        669. Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity
        670. SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells
        671. The role of SIRT1 in tumorigenesis
        672. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
        673. Chronic pancreatitis and pancreatic cancer demonstrate active epithelial–mesenchymal transition profile, regulated by miR-217-SIRT1 pathway
        674. Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein
        675. Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance
        676. The role of SIRT1 in diabetic kidney disease
        677. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
        678. Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70
        679. SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation
        680. Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells
        681. Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation
        682. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
        683. SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
        684. SIRT1 in metabolic syndrome: Where to target matters
        685. SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
        686. Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
        687. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
        688. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
        689. BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
        690. SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
        691. Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer
        692. Sirt1 Deletion Leads to Enhanced Inflammation and Aggravates Endotoxin-Induced Acute Kidney Injury
        693. Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression
        694. Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
        695. Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase
        696. SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase
        697. p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms
        698. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
        699. SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis
        700. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
        701. SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
        702. SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways
        703. Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors
        704. Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
        705. SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
        706. Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
        707. Interference between PARPs and SIRT1: a novel approach to healthy ageing?
        708. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
        709. MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
        710. Fructose induces gluconeogenesis and lipogenesis through aSIRT1-dependent mechanism
        711. NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
        712. SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells
        713. Identification, stability and expression of Sirt1 antisense long non-coding RNA
        714. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
        715. A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers
        716. SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism
        717. miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in human fibrosarcoma cells
        718. SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α–Dependent Glycolysis
        719. Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis
        720. SIRT1 associates with eIF2-alpha and regulates the cellular stress response
        721. Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
        722. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells
        723. Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
        724. Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
        725. Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
        726. The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition
        727. The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
        728. Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
        729. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
        730. Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes
        731. The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling
        732. FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide
        733. SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens
        734. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
        735. MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
        736. SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice
        737. SIRT1 and Caloric Restriction: An Insight Into Possible Trade-Offs Between Robustness and Frailty
        738. Induction of Sirt1 by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response
        739. Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice
        740. Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
        741. SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
        742. Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
        743. PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders
        744. Cross-talk between SIRT1 and p66Shc in vascular diseases
        745. Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
        746. Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
        747. Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1
        748. SirT1 brings stemness closer to cancer and aging
        749. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
        750. Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1
        751. SirT1 brings stemness closer to cancer and aging
        752. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
        753. SIRT1 enhances matrix metalloproteinase‐2 expression and tumor cell invasion in prostate cancer cells
        754. High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
        755. Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors
        756. Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells
        757. Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
        758. Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1
        759. Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
        760. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
        761. Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits
        762. PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells
        763. Critical Reviews™ in Eukaryotic Gene Expression
        764. Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells
        765. NO Targets SIRT1
        766. SIRT1 Directly Regulates SOX2 to Maintain Self‐Renewal and Multipotency in Bone Marrow‐Derived Mesenchymal Stem Cells
        767. Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
        768. Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
        769. SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons
        770. SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression
        771. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
        772. SIRT1 modulation of adipogenesis and adipose function
        773. Changes in SIRT1 Expression and Its Downstream Pathways in Age-Related Cataract in Humans
        774. The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation
        775. The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response
        776. Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling
        777. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway
        778. Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
        779. Resveratrol is neuroprotective because it is not a direct activator of Sirt1—A hypothesis
        780. SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
        781. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells
        782. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model
        783. Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes
        784. Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
        785. Tat-SIRT1 Tango
        786. Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
        787. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65
        788. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway
        789. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells
        790. Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
        791. Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
        792. Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin
        793. SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene
        794. Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
        795. Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues
        796. SIRT1 and insulin resistance
        797. The ups and downs of SIRT1
        798. SIRT1: recent lessons from mouse models
        799. Phosphorylation of HuR by Chk2 regulates SIRT1 expression
        800. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
        801. Phosphorylation regulates SIRT1 function
        802. Protective roles of SIRT1 in atherosclerosis
        803. Mammalian SIRT1: insights on its biological functions
        804. SIRT1 regulates aging and resistance to oxidative stress in the heart
        805. Mechanism of human SIRT1 activation by resveratrol
        806. JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
        807. Regulation of SIRT1 in cellular functions: role of polyphenols
        808. Metabolic benefits from SIRT1 and SIRT1 activators
        809. A review of SIRT1 and SIRT1 modulators in cardiovascular and metabolic diseases
        810. SIRT1 is significantly elevated in mouse and human prostate cancer
        811. AMPK and SIRT1: a long-standing partnership?
        812. How does SIRT1 affect metabolism, senescence and cancer?
        813. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
        814. SIRT1 and endocrine signaling
        815. DBC1 is a negative regulator of SIRT1
        816. SIRT1 and neuronal diseases
        817. SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦
        818. Tissue-specific regulation of SIRT1 by calorie restriction
        819. Shear stress, SIRT1, and vascular homeostasis
        820. JNK2-dependent regulation of SIRT1 protein stability
        821. SIRT1 regulates adipose tissue inflammation
        822. The critical role of the class III histone deacetylase SIRT1 in cancer
        823. SIRT1 controls endothelial angiogenic functions during vascular growth
        824. Function of the SIRT1 protein deacetylase in cancer
        825. SIRT1: roles in aging and cancer
        826. Cellular regulation of SIRT1
        827. A role for the NAD-dependent deacetylase SIRT1 in the regulation of autophagy
        828. Increase in activity during calorie restriction requires SIRT1
        829. Regulation of SIRT1 protein levels by nutrient availability
        830. A novel pathway regulates memory and plasticity via SIRT1 and miR-134
        831. SIRT1 is essential for normal cognitive function and synaptic plasticity
        832. Biochemical effects of SIRT1 activators
        833. Progressive loss of SIRT1 with cell cycle withdrawal
        834. Emerging roles of SIRT1 in vascular endothelial homeostasis
        835. SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
        836. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
        837. SIRT1, is it a tumor promoter or tumor suppressor?
        838. Metabolic adaptations through the PGC-1α and SIRT1 pathways
        839. Resveratrol is not a direct activator of SIRT1 enzyme activity
        840. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
        841. SIRT1 and p53, effect on cancer, senescence and beyond
        842. SIRT1 protects against high-fat diet-induced metabolic damage
        843. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
        844. Cytoplasm‐localized SIRT1 enhances apoptosis
        845. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
        846. SIRT1 regulation of apoptosis of human chondrocytes
        847. Caloric restriction, SIRT1 and longevity
        848. Protective role of SIRT1 in diabetic vascular dysfunction
        849. Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
        850. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
        851. SIRT1 is a novel regulator of key pathways of human labor
        852. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
        853. Expression and role of SIRT1 in hepatocellular carcinoma
        854. Brain SIRT1: anatomical distribution and regulation by energy availability
        855. Calorie restriction, SIRT1 and metabolism: understanding longevity
        856. Mammalian SIRT1 represses forkhead transcription factors
        857. Hormonal control of androgen receptor function through SIRT1
        858. SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
        859. SIRT1 transgenic mice show phenotypes resembling calorie restriction
        860. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
        861. SIRT1 shows no substrate specificity in vitro
        862. SIRT1 regulates energy metabolism and response to caloric restriction in mice
        863. SIRT1 modulation as a novel approach to the treatment of diseases of aging
        864. SIRT1 is an inhibitor of proliferation and tumor formation in colon cancer
        865. SIRT1 gain of function increases energy efficiency and prevents diabetes in mice
        866. Dietary activators of SIRT1
        867. miR-34a repression of SIRT1 regulates apoptosis
        868. SIRT1-null mice develop an autoimmune-like condition
        869. SIRT1: regulation of longevity via autophagy
        870. SIRT1 negatively regulates the mammalian target of rapamycin
        871. The interaction between FOXO and SIRT1: tipping the balance towards survival
        872. STAT3 inhibition of gluconeogenesis is downregulated by SIRT1
        873. SIRT1 stimulation by polyphenols is affected by their stability and metabolism
        874. Negative regulation of the deacetylase SIRT1 by DBC1
        875. SIRT1 improves healthy ageing and protects from metabolic syndrome-associated cancer
        876. SIRT1 modulates premature senescence-like phenotype in human endothelial cells
        877. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
        878. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
        879. Exercise training promotes SIRT1 activity in aged rats
        880. SIRT1 regulates the function of the Nijmegen breakage syndrome protein
        881. Interactions between E2F1 and SIRT1 regulate apoptotic response to DNA damage
        882. A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
        883. The physiological roles of SIRT1 in skeletal muscle
        884. SIRT1 acts as a modulator of neointima formation following vascular injury in mice
        885. FoxO1 mediates an autofeedback loop regulating SIRT1 expression
        886. SIRT1 deacetylates and positively regulates the nuclear receptor LXR
        887. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
        888. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
        889. Stabilization of Suv39H1 by SIRT1 is part of oxidative stress response and ensures genome protection
        890. SIRT1-mediated acute cardioprotection
        891. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
        892. SIRT1 regulates circadian clock gene expression through PER2 deacetylation
        893. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
        894. Role of SIRT1 in homologous recombination
        895. SIRT1 promotes differentiation of normal human keratinocytes
        896. SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
        897. Inhibition of transcriptional activity of c-JUN by SIRT1
        898. Age‐associated loss of SIRT1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific SIRT1‐overexpressing (BESTO) mice
        899. Hypothalamic SIRT1 regulates food intake in a rodent model system
        900. Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
        901. SIRT1 genetic variation is related to BMI and risk of obesity
        902. Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
        903. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
        904. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
        905. SIRT1: a metabolic master switch that modulates lifespan
        906. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
        907. SIRT1 contributes critically to the redox-dependent fate of neural progenitors
        908. A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
        909. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
        910. Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
        911. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
        912. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
        913. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9
        914. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
        915. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
        916. Controlling SIRT1 expression by microRNAs in health and metabolic disease
        917. Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
        918. The anti-aging, metabolism potential of SIRT1.
        919. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
        920. Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
        921. SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
        922. SIRT1 activation protects the mouse renal medulla from oxidative injury
        923. SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR♦
        924. SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
        925. Function of SIRT1 in physiology
        926. SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
        927. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
        928. SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
        929. SIRT1 increases skeletal muscle precursor cell proliferation
        930. SIRT1 promotes DNA repair activity and deacetylation of Ku70
        931. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
        932. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
        933. SIRT1 regulates HIV transcription via Tat deacetylation
        934. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
        935. SIRT1 protects the heart from aging and stress
        936. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
        937. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
        938. SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
        939. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
        940. Human SIRT1 interacts with histone H1 and promotes formation of facultative heterochromatin
        941. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
        942. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
        943. Age related changes in NAD+ metabolism oxidative stress and SIRT1 activity in wistar rats
        944. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
        945. SIRT1 deficiency attenuates spermatogenesis and germ cell function
        946. SIRT1 in muscle physiology and disease: lessons from mouse models
        947. SIRT1 involvement in rd10 mouse retinal degeneration
        948. High-intensity interval training increases SIRT1 activity in human skeletal muscle
        949. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
        950. Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma
        951. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
        952. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma
        953. Association of SIRT1 gene variation with visceral obesity
        954. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
        955. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
        956. SIRT1 regulates UV-induced DNA repair through deacetylating XPA
        957. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
        958. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
        959. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
        960. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
        961. The role of SIRT1 in tumorigenesis
        962. Low SIRT1 expression, which is upregulated by fasting, in human adipose tissue from obese women
        963. SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/-mice
        964. The type III histone deacetylase SIRT1 is essential for maintenance of T cell tolerance in mice
        965. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
        966. Deacetylation of cortactin by SIRT1 promotes cell migration
        967. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
        968. SIRT1 gene is associated with major depressive disorder in the Japanese population
        969. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
        970. SIRT1 contributes to telomere maintenance and augments global homologous recombination
        971. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
        972. SIRT1 deacetylates APE1 and regulates cellular base excision repair
        973. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
        974. SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
        975. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα
        976. SIRT1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
        977. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
        978. SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma
        979. SIRT1: tumor promoter or tumor suppressor?
        980. SIRT1 activation confers neuroprotection in experimental optic neuritis
        981. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
        982. Resveratrol regulates human adipocyte number and function in a SIRT1-dependent manner
        983. SIRT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
        984. Activation of SIRT1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
        985. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1
        986. Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
        987. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
        988. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
        989. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
        990. Peptide switch is essential for SIRT1 deacetylase activity
        991. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
        992. Activation of SIRT1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts
        993. SIRT1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
        994. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
        995. The direct involvement of SIRT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
        996. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
        997. Physiological and pathophysiological functions of SIRT1
        998. Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
        999. SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1, 2 and HMGCS1, 2
        1000. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
        1001. Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
        1002. Roles of SIRT1 in the acute and restorative phases following induction of inflammation
        1003. SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model
        1004. Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance
        1005. SIRT1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
        1006. Modulation of SIRT1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
        1007. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
        1008. The NAD World: a new systemic regulatory network for metabolism and aging—SIRT1, systemic NAD biosynthesis, and their importance
        1009. Balance between SIRT1 and DBC1 expression is lost in breast cancer
        1010. Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters
        1011. Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
        1012. Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson’s disease
        1013. Human SIRT1: a potential biomarker for tumorigenesis?
        1014. RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
        1015. SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
        1016. Overexpression of SIRT1 protects pancreatic β-cells against cytokine toxicity by suppressing the nuclear factor-κB signaling pathway
        1017. SIRT1 is a circadian deacetylase for core clock components
        1018. SIRT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
        1019. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance
        1020. SIRT1-dependent regulation of chromatin and transcription: linking NAD+ metabolism and signaling to the control of cellular functions
        1021. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1: possible role in AMP-activated protein kinase activation
        1022. Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems
        1023. SIRT1 fails to affect p53‐mediated biological functions
        1024. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
        1025. High glucose downregulates endothelial progenitor cell number via SIRT1
        1026. Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
        1027. SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiology
        1028. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells
        1029. Neurogenesis directed by SIRT1
        1030. Lysine deacetylation in ischaemic preconditioning: the role of SIRT1
        1031. miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
        1032. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
        1033. Regulation of cartilage-specific gene expression in human chondrocytes by SIRT1 and nicotinamide phosphoribosyltransferase
        1034. Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
        1035. Kidney-specific overexpression of SIRT1 protects against acute kidney injury by retaining peroxisome function
        1036. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
        1037. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
        1038. Resveratrol protects human endothelium from H2O2-induced oxidative stress and senescence via SIRT1 activation
        1039. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
        1040. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
        1041. Roles of FoxO1 and SIRT1 in the central regulation of food intake
        1042. SIRT1 is a redox‐sensitive deacetylase that is post‐translationally modified by oxidants and carbonyl stress
        1043. Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
        1044. SIRT1 deacetylates c-Myc and promotes c-Myc/Max association
        1045. Calorie restriction enhances cell adaptation to hypoxia through SIRT1-dependent mitochondrial autophagy in mouse aged kidney
        1046. Translating cell survival and cell longevity into treatment strategies with SIRT1
        1047. Deacetylation of FoxO by SIRT1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
        1048. Macrophage α1 AMP-activated protein kinase (α1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
        1049. The controversial links among calorie restriction, SIRT1, and resveratrol
        1050. Resveratrol inhibits insulin responses in a SIRT1-independent pathway
        1051. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein α transcriptional complex
        1052. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1
        1053. The role of SIRT1: at the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology
        1054. Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation
        1055. Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
        1056. SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
        1057. SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer
        1058. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
        1059. Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
        1060. Role of sirtuin histone deacetylase SIRT1 in prostate cancer: a target for prostate cancer management via its inhibition?
        1061. Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection
        1062. ΔNp63&alpha overexpression induces downregulation of SIRT1 and an accelerated aging phenotype in the mouse
        1063. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
        1064. Impact of SIRT1 on mammalian aging
        1065. Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
        1066. SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
        1067. Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
        1068. A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
        1069. Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
        1070. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+
        1071. SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis
        1072. PPARα-SIRT1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway
        1073. #VALUE!
        1074. Hepatic SIRT1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
        1075. Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity
        1076. SIRT1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
        1077. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the SIRT1 pathway
        1078. SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
        1079. SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
        1080. SIRT1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
        1081. Melatonin, a novel SIRT1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
        1082. The SIRT1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
        1083. SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60
        1084. SIRT1 hyperexpression in SHR heart related to left ventricular hypertrophy
        1085. Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: implication in pathogenesis of COPD
        1086. Relationship between SIRT1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
        1087. Regulation of MEF2 by histone deacetylase 4-and SIRT1 deacetylase-mediated lysine modifications
        1088. SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
        1089. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
        1090. Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1
        1091. Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin
        1092. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
        1093. Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
        1094. SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
        1095. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
        1096. SIRT1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
        1097. PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
        1098. SIRT1 regulates oxidant-and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol
        1099. SIRT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
        1100. Cilostazol inhibits oxidative stress–induced premature senescence via upregulation of SIRT1 in human endothelial cells
        1101. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance
        1102. SIRT1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets
        1103. SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts
        1104. SIRT1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor
        1105. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
        1106. Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
        1107. SIRT1 longevity factor suppresses NF‐κB‐driven immune responses: regulation of aging via NF‐κB acetylation?
        1108. Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway
        1109. SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol
        1110. SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
        1111. Interference between PARPs and SIRT1: a novel approach to healthy ageing?
        1112. Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
        1113. Agrp neurons mediate SIRT1‘s action on the melanocortin system and energy balance: roles for SIRT1 in neuronal firing and synaptic plasticity
        1114. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
        1115. Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
        1116. Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene SIRT1
        1117. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
        1118. Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
        1119. CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
        1120. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
        1121. Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
        1122. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
        1123. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
        1124. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α expression in experimental stroke
        1125. Metabolic regulation of SIRT1 transcription via a HIC1: CtBP corepressor complex
        1126. Tumor necrosis factor α–mediated cleavage and inactivation of SIRT1 in human osteoarthritic chondrocytes
        1127. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SIRT1 expression
        1128. Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
        1129. Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
        1130. SIRT1: a novel target to prevent atherosclerosis
        1131. SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
        1132. Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
        1133. Do we age on SIRT1 expression?
        1134. SIRT1—a metabolic sensor that controls blood vessel growth
        1135. Proatherogenic abnormalities of lipid metabolism in SIRT1 transgenic mice are mediated through Creb deacetylation
        1136. Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
        1137. SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
        1138. SIRT1, stem cells, aging, and stem cell aging
        1139. Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
        1140. SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
        1141. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
        1142. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation
        1143. Role of p53 in the anti-proliferative effects of SIRT1 inhibition in prostate cancer cells
        1144. C/EBPα regulates SIRT1 expression during adipogenesis
        1145. The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
        1146. Activation of SIRT1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
        1147. SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
        1148. A role for SIRT1 in the hypoxic response
        1149. Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
        1150. SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts
        1151. Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
        1152. Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells
        1153. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
        1154. Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients
        1155. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
        1156. Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1
        1157. SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin‐like growth factor receptor …
        1158. Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis
        1159. Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway
        1160. SIRT1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells
        1161. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
        1162. H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion
        1163. SIRT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
        1164. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
        1165. Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type‐2 diabetes
        1166. Nutrient-dependent regulation of PGC-1α’s acetylation state and metabolic function through the enzymatic activities of SIRT1/GCN5
        1167. SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
        1168. Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase
        1169. SIRT1 associates with eIF2-alpha and regulates the cellular stress response
        1170. SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis
        1171. SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
        1172. Comparative and pharmacophore model for deacetylase SIRT1
        1173. Mediobasal hypothalamic SIRT1 is essential for resveratrol’s effects on insulin action in rats
        1174. SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription
        1175. Induction of hypothalamic SIRT1 leads to cessation of feeding via agouti-related peptide
        1176. SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
        1177. Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans
        1178. SIRT1 stabilizes PML promoting its sumoylation
        1179. Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells
        1180. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates SIRT1-dependent transcriptional activity
        1181. Effect of estrogens on bone marrow adipogenesis and SIRT1 in aging C57BL/6J mice
        1182. Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
        1183. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti‐aging and metabolic effects of sirtuins
        1184. SIRT1 variants are associated with aging in a healthy Han Chinese population
        1185. Stimulation of SIRT1-regulated FoxO protein function by the ligand-bound vitamin D receptor
        1186. The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
        1187. The time of metabolism: NAD+, SIRT1, and the circadian clock
        1188. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in skeletal muscle through the PGC-1α …
        1189. The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
        1190. Silencing insulin resistance through SIRT1
        1191. Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS …
        1192. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
        1193. Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells
        1194. SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA
        1195. SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy
        1196. Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via SIRT1–FOXO1 signaling pathway
        1197. Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress
        1198. SIRT1 brings stemness closer to cancer and aging
        1199. Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition
        1200. The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling
        1201. Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E β-cells and human islets through a SIRT1-dependent mechanism
        1202. … Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically …
        1203. SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
        1204. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1-and HEY2-mediated transcriptional repression
        1205. Early apoptotic vascular signaling is determined by SIRT1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation
        1206. Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
        1207. Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al 2 O 3 ) …
        1208. SIRT1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol
        1209. MST1 promotes apoptosis through regulating SIRT1-dependent p53 deacetylation
        1210. Role of SIRT1 in heat stress-and lipopolysaccharide-induced immune and defense gene expression in human dental pulp cells
        1211. Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway
        1212. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
        1213. Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors
        1214. SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons
        1215. FoxO1 and SIRT1 regulate β-cell responses to nitric oxide
        1216. Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network
        1217. Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1
        1218. Resveratrol is neuroprotective because it is not a direct activator of SIRT1—A hypothesis
        1219. Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1–3 mRNA expression in human visceral adipocytes
        1220. Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of SIRT1 in diabetic Wistar …
        1221. Disruption of a SIRT1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation
        1222. Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
        1223. #VALUE!
        1224. p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic …
        1225. Inhibition of SIRT1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
        1226. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
        1227. SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells
        1228. Downregulation of SIRT1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells
        1229. SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians
        1230. SIRT1 modulates high‐mobility group box 1‐induced osteoclastogenic cytokines in human periodontal ligament cells
        1231. Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats
        1232. SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome
        1233. A functional link between SIRT1 deacetylase and NBS1 in DNA damage response
        1234. SIRT1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
        1235. Could SIRT1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
        1236. SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty
        1237. Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells
        1238. Induction of SIRT1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response
        1239. SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
        1240. Distribution of the longevity gene product, SIRT1, in developing mouse organs
        1241. A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression
        1242. Roles of SIRT1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis
        1243. Activating SIRT1: a new strategy to prevent atherosclerosis?
        1244. Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional …
        1245. Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via SIRT1 expression
        1246. SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase
        1247. SIRT1—a sensor for monitoring self-renewal and aging process in retinal stem cells
        1248. Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
        1249. Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2α)
        1250. Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic …
        1251. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) …
        1252. Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically‐obese db/db …
        1253. SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
        1254. SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study
        1255. Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
        1256. FoxO-dependent and-independent mechanisms mediate SIRT1 effects on IGFBP-1 gene expression
        1257. A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells
        1258. Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase
        1259. Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1
        1260. Genetic study between SIRT1, PPARD, PGC-1 α genes and Alzheimer’s disease
        1261. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age‐related neoplasms
        1262. SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestion
        1263. Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival …
        1264. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
        1265. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by SIRT1 and FoxO1
        1266. Proteomic analyses of SIRT1-mediated cisplatin resistance in OSCC cell line
        1267. AROuSing SIRT1: identification of a novel endogenous SIRT1 activator
        1268. SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
        1269. Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation
        1270. Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates β-catenin signaling and NFκB-specific transcription activity leading to MDR1 and Bcl-xL gene …
        1271. Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function
        1272. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1‐independent sensitization to TRAIL‐induced apoptosis
        1273. SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications
        1274. Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin-and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile
        1275. SIRT1 links CIITA deacetylation to MHC II activation
        1276. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2
        1277. Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells
        1278. Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function
        1279. Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2
        1280. SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
        1281. SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kγ activity through deacetylation of specific lysine residues in mammals
        1282. SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention–the TULIP Study
        1283. The type III histone deacetylase SIRT1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation
        1284. Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
        1285. Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1
        1286. Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of SIRT1 and Ku70
        1287. NO targets SIRT1: a novel signaling network in endothelial senescence
        1288. Low-frequency electroacupuncture improves insulin sensitivity in obese diabetic mice through activation of SIRT1/PGC-1 in skeletal muscle
        1289. SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree
        1290. Delivery of Oct4 and SIRT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium
        1291. SIRT1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
        1292. Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis
        1293. PARP-2 regulates SIRT1 expression and whole-body energy expenditure
        1294. Involvement of the p65/RelA subunit of NF-κB in TNF-α-induced SIRT1 expression in vascular smooth muscle cells
        1295. Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells
        1296. BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
        1297. Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells
        1298. SIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity
        1299. SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction
        1300. Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice
        1301. Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue …
        1302. Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic …
        1303. SIRT1: a guardian at the gates of adipose tissue inflammation
        1304. Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor γ transactivation
        1305. Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells
        1306. Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
        1307. The role of SIRT1 in renal rejuvenation and resistance to stress
        1308. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
        1309. Tat-SIRT1 tango
        1310. Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
        1311. Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells
        1312. Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
        1313. Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
        1314. Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
        1315. A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide
        1316. Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts
        1317. Serum withdrawal up‐regulates human SIRT1 gene expression in a p53‐dependent manner
        1318. Hexosamines stimulate apoptosis by altering SIRT1 action and levels in rodent pancreatic β-cells.
        1319. Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML
        1320. Nicotinamide phosphoribosyltransferase is essential for interleukin-1β-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal …
        1321. Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes
        1322. Limited role of SIRT1 in cancer protection by dietary restriction
        1323. Zyxin is a novel interacting partner for SIRT1
        1324. Influence of aging and hemorrhage injury on SIRT1 expression: possible role of myc-SIRT1 regulation in mitochondrial function
        1325. From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian SIRT1 and systemic NAD biosynthesis
        1326. Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the α-myosin heavy chain expression
        1327. Is SIRT1 a miracle bullet for longevity?
        1328. Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2
        1329. … receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1
        1330. Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice
        1331. Does hypothalamic SIRT1 regulate aging?
        1332. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
        1333. Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin’s protection against UV-induced A375-S2 cell apoptosis
        1334. WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis
        1335. Metabolic signals regulate SIRT1 expression
        1336. Old drug acquires new target: metformin and SIRT1
        1337. Resveratrol induces SIRT1-and energy–stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment
        1338. MiR-34, SIRT1, and p53: the feedback loop
        1339. Food restriction improves glucose and lipid metabolism through SIRT1 expression: a study using a new rat model with obesity and severe hypertension
        1340. Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats?
        1341. Calorie restriction and obesity under the regulation of SIRT1
        1342. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SIRT1 activity
        1343. Resveratrol (trans‐3, 5, 4′‐trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF‐κB
        1344. SIRT1 performs a balancing act on the tight-rope toward longevity
        1345. p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
        1346. SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells
        1347. Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca 2+ and AMPK/SIRT1
        1348. SIRT1 protein levels in cancer: Tuning SIRT1 to the needs of a cancer cell
        1349. Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation
        1350. Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1
        1351. Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
        1352. CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes
        1353. Regulatory role of SIRT1 on the gene expression of fatty acid‐binding protein 3 in cultured porcine adipocytes
        1354. Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats
        1355. Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1
        1356. Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
        1357. MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating SIRT1
        1358. Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1
        1359. Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors
        1360. Is systemic activation of SIRT1 beneficial for ageing-associated metabolic disorders?
        1361. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SIRT1
        1362. Poly (ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
        1363. Red wine decreases asymmetric dimethylarginine via SIRT1 induction in human endothelial cells
        1364. Anticancer Effects of 15d-Prostaglandin-J2 in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC
        1365. Pharmacophore mapping and virtual screening for SIRT1 activators
        1366. Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
        1367. Sirtuin 1 (SIRT1) the misunderstood HDAC
        1368. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
        1369. Substrate specificity of SIRT1-catalyzed lysine Nε-deacetylation reaction probed with the side chain modified Nε-acetyl-lysine analogs
        1370. Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats
        1371. Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers
        1372. … peroxisome proliferator-activated receptor γ regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in …
        1373. MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SIRT1
        1374. Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and SIRT1
        1375. A nutrient‐sensitive interaction between SIRT1 and HNF‐1α regulates Crp expression
        1376. High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression
        1377. Dual targeting of the antagonistic pathways mediated by SIRT1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions
        1378. Cisplatin induces SIRT1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
        1379. Determinants of serum-induced SIRT1 expression in older men: the CHAMP study
        1380. Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death
        1381. Anti-aging protein SIRT1: A role in cervical cancer?
        1382. SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview
        1383. Dysregulation of Myeloid‐specific Transcription Factors in Congenital Neutropenia: Rescue by NAMPT/NAD+/SIRT1
        1384. SIRT1 inhibitory diterpenoids from the Vietnamese medicinal plant Croton tonkinensis
        1385. Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear SIRT1
        1386. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
        1387. Comparative deacetylase activity of wild type and mutants of SIRT1
        1388. Discovery of oxazolo [4, 5-b] pyridines and related heterocyclic analogs as novel SIRT1 activators
        1389. SIRT1, notch and stem cell” age asymmetry”
        1390. Glucagon-like peptide 1 inhibits the sirtuin deacetylase SIRT1 to stimulate pancreatic β-cell mass expansion
        1391. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
        1392. Protection by EGb 761 against β-amyloid-induced neurotoxicity: involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
        1393. Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD+-dependent SIRT1 activity
        1394. Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
        1395. Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors
        1396. Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology
        1397. A novel role of SIRT1 in sildenafil induced cardioprotection in mice
        1398. p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells
        1399. Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase
        1400. Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats
        1401. Silencing metabolic disorders by novel SIRT1 activators
        1402. WldS Reduces Paraquat-Induced Cytotoxicity via SIRT1 in Non-Neuronal Cells by Attenuating the Depletion of NAD
        1403. Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells
        1404. High fat diet increases and the polyphenol, S17834, decreases acetylation of the SIRT1-dependent lysine-382 on p53 and apoptotic signaling in …
        1405. Effects of resveratrol on pig primary preadipocytes proliferation, differentiation and transcription expression of SIRT1 gene
        1406. SIRT1 promotes DNA damage repair and cellular survival
        1407. Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
        1408. Negative regulation of stress‐induced matrix metalloproteinase‐9 by SIRT1 in skin tissue
        1409. Leptin gene transfer regulates fibromuscular development and lipid deposition in muscles via SIRT1, FOXO3a and PGC-1α in mice in vivo
        1410. A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of SIRT1 in the metabolic regulation of caspase-2
        1411. Functional interplay between Parp-1 and SIRT1 in genome integrity and chromatin-based processes
        1412. Correction: Corrigendum: SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
        1413. Intra-arterial targeted islet-specific expression of SIRT1 protects β cells from streptozotocin-induced apoptosis in mice
        1414. Poly (ADP‐ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes
        1415. SIRT1 as a key regulator orchestrating the response to caloric restriction
        1416. Isolation of megastigmane sesquiterpenes from the silkworm (Bombyx mori L.) droppings and their promotion activity on HO-1 and SIRT1
        1417. SIRT1 Activation Mediates Sildenafil-Induced Cardioprotection Against Ischemia/Reperfusion Injury in Mice
        1418. Effects of baicalin against oxidative stress injury of SH-SY5Y cells by up-regulating SIRT1
        1419. … acid B protects beta-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2–HO-1 and SIRT1
        1420. SIRT1 as a new therapeutic target in metabolic and age-related diseases
        1421. EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1
        1422. Real-time fluorescence imaging of SIRT1 cytosolic translocation under the treatment of growth factor deprivation
        1423. SIRT1, p53 and mitotic chromosomes
        1424. High-affinity Na+-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1
        1425. #VALUE!
        1426. Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification …
        1427. Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD+ level, SIRT1 activity and replicative lifespan of human Hs68 cells
        1428. No significant association between SIRT1 gene and methamphetamine‐induced psychosis in the Japanese population
        1429. Myocardial SIRT1 expression following endurance and resistance exercise training in young and old rats
        1430. SIRT1 and neurodegenerative diseases
        1431. Targeting SIRT1-a multitasker
        1432. Genetic and expression analysis of the SIRT1 gene in gastric cancers
        1433. Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in …
        1434. Resveratrol (trans-3, 5, 4′-trihydroxystilbene) induces SIRT1 and down-regulates NF-κB activation to abrogate DSS-induced colitis
        1435. Identification of single nucleotide polymorphisms of SCD and SIRT1 and evaluation of their genetic diversities in chickens
        1436. Not miR-ly aging: SIRT1 boosts memory via a microRNA-dependent mechanism
        1437. Inhibition of SIRT1 increases EZH2 protein level and enhances the repression of EZH2 on target gene expression
        1438. Effect of SIRT1 gene on cardiac function and life
        1439. SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing PTP1B and activating the IGF receptor pathway
        1440. Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells
        1441. Nicotinamide, a Recognized Inhibitor of SIRT1, Promotes Expansion in Ex Vivo Cultures of Short and Long-Term Repopulating Cells.
        1442. SIRT1 inhibits IL-1β mRNA transcription in lipopolysaccharide tolerant THP-1 cells
        1443. Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1
        1444. SIRT1 increases satellite cell cycle progression
        1445. 3D-QSAR of SIRT1 activators targeting against diet-induced metabolic syndrome
        1446. Research progression of deacetylase (SIRT1)
        1447. Disruption of Igfbp1 fails to rescue the phenotype of SIRT1−/− mice
        1448. iNOS inactivates SIRT1, a key regulator of stress resistance and metabolism, by S-Nitrosylation
        1449. Abstract SY11-03: SIRT1 transgenic and cancer models
        1450. Effects of resveratrol on SIRT1 expression, eNOS activity and NO secretion of hyperlipid cultured HUVEC
        1451. SIRT1: a novel adipocyte and myocyte regulatory factor
        1452. Toward productive aging: SIRT1, systemic NAD biosynthesis, and the NAD world
        1453. Expression of SIRT1 in primary human uveal melanoma
        1454. Involvement of SIRT1 in mouse myocardial hypertrophy induced by isorenin [J]
        1455. Modeling miRNA regulation in signaling networks: miR-34a regulation of the p53/SIRT1 module
        1456. SIRT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
        1457. The antioxidative role of SIRT1/PGC-1α pathway in Parkinson disease
        1458. SIRT1 activators promote p65 deacetylation and suppress TNFa stimulated NF‐kB activation
        1459. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SIRT1-independent pathway in LβT2 gonadotrope cells
        1460. Overexpression of SIRT1, a Longevity Gene-Encoded Protein, and Induction of Apoptosis by Its Inhibition In Adult T-Cell Leukemia Cells
        1461. #VALUE!
        1462. SIRT1 expression in adult acute leukemia and its clinical significance [J]
        1463. Overexpression of the Sirtuin SIRT1 Increases Insulin Sensitivity in Aging Mice.
        1464. Development of Fluorescent Quantitative PCR Assay for Porcine SIRT1 Gene
        1465. Nox4 regulates cellular survival by modulating FoxO3a activity and SIRT1 expression
        1466. Neuroprotective mechanisms of SIRT1
        1467. Mechanism of SIRT1 acting on tumor formation
        1468. SIRT1, a Stress-responsive Deacetylase is Required for Development of Compensatory Cardiac Hypertrophy
        1469. The race to control aging and diseases: Sir2/SIRT1 against Ras, TOR and Akt/S6K
        1470. SIRT1 overexpression modifies cardiac energy metabolism
        1471. SIRT1 activator SRT1720 suppresses inflammatory reaction in OVA-induced asthma model mouse
        1472. SIRT1 is not required for exercise‐induced mitochondrial biogenesis, but maintains basal organelle content and function
        1473. Both the Activity and Stability of the Transcriptional Repressor PLZF Are Modified by the Class III Histone Deacetylase SIRT1.
        1474. Long-Term Calorie Restriction increases SIRT1 expression and Inhibits Vascular Senescence in Mice
        1475. Reduced SIRT1 leads to increased Th2 cytokine expression via hyper-acetylation of GATA3
        1476. SIRT1 and adult stem cell senescence
        1477. Mechanism of regulating deacetylase SIRT1 expression and activity.
        1478. SIRT1 Deficiency Suppresses the Maintenance of Hematopoietic Stem Cell Pool.
        1479. SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.
        1480. The Longevity Factor SIRT1 Protects Heart from Ischemia/Reperfusion Stress
        1481. SIRT1 and Ku70 expression in acute leukemia and its clinical significance
        1482. SIRT1 regulates human vascular smooth muscle cell Lifespan
        1483. Upregulation of SIRT1 protects lens epithelial cells in oxidative conditions and cataract formation in humans
        1484. Role of SIRT1 in Proliferation and Self-Renewal of Mouse Embryonic Stem Cells.
        1485. SIRT1 controls endothelial angiogenic functions during vascular growth and maturation
        1486. SIRT1 diminishes atherogenesis by suppressing NF-kB signaling-mediated pro-inflammatory events
        1487. Role of SIRT1 histone deacetylase in melanoma: A target for melanoma management via its inhibition
        1488. Abstract# 4441: c-Myc/SIRT1 feedback loop: A novel regulation of c-Myc induced cellular transformation
        1489. SIRT1 overexpression in pancreatic adenocarcinomas correlates with shortened patient survival and small molecule inhibition as well as target knockdown of SIRT1 …
        1490. Caloric restriction and SIRT1 modulate APP metabolism in vitro and in vivo
        1491. Nuclear shuttling of SIRT1 is associated with caloric restriction-induced cardioprotection
        1492. In silico evidence supports a role for DNA methylation in SIRT1-mediated effects of dietary restriction
        1493. Regulation of translation and transcription by SIRT1: Potential novel mechanisms for regulating stress response and aging
        1494. Treatment with the SIRT1 activator SRT1720 reduces large elastic artery stiffness, superoxide production and inflammation in old mice
        1495. SIRT1 Activators Attenuate Retinal Ganglion Cell Loss During Acute Optic Neuritis
        1496. BDNF-deficiency downregulates SIRT1 and upregulates SIRT2 expression in aging mouse retina
        1497. Chronic treatment with SIRT1 activator SRT1720 ameliorates age-associated vascular endothelial dysfunction in B6D2F1 mice
        1498. SIRT1 inhibition induces apoptosis in human CML progenitors by enhancing p53 acetylation and activation
        1499. A novel SIRT1 activator SIRT1720 triggers in vitro and in vivo cytotoxicity in multiple myeloma via ATM-dependent mechanism
        1500. SIRT1-Mediated Deacetylation Promotes Akt Membrane Localization and Activation During Development of Cardiac Hypertrophy.
        1501. The Role of SIRT1 in Reproduction.
        1502. SIRT1 Regulates PTEN/Akt/FOXO1 Pathway to Trigger ROS-Induced Apoptosis In Mouse Embryonic Stem Cells.
        1503. Pharmacological inhibition of the stress-related deacetylase SIRT1 enhances eradication of cml stem cells
        1504. SIRT1 modulates foxo-dependent transcription and prevents smooth muscle cell apoptosis in response to oxidative stress
        1505. SIRT1 and Heart Disease [J]
        1506. SIRT1 takes down tumors
        1507. Study on the clinicopathologic significance and expression of SIRT1
        1508. Brain space for SIRT1
        1509. SIRT1 and Tumorigenesis
        1510. Resveratrol, an Activator of Protein Deacetylase SIRT1, Suppresses Oxidative Stress-Induced Cell Death by Upregulating MnSOD Expression through Transactivation …
        1511. SIRT1 keeps escapees quiet
        1512. SIRT1 in transcription regulation
        1513. Significance of SIRT1 expression in breast cancer
        1514. The SIRT1 Activator Resveratrol Suppresses Cardiomyocyte Hypertrophy by Promoting Histone H3 Lys9 Deacetylation and Tri-methylation
        1515. Response to Gomez-Cabrera et al: update on SIRT1 signaling
        1516. SIRT1 and cell migration
        1517. Abstract# 5092: Inhibition of SIRT1 by sirtinol causes p53-independent activation of FoxO1 in human prostate cancer cells.
        1518. Inhibition of FoxO1-SIRT1 Signaling by Sustained Acetylation of PGC-1 Alpha Promotes Angiotensin II-Induced Vascular Senescence
        1519. Expression and significance of SIRT1 in breast cancer with diabetes meilitus
        1520. SIRT1 and neoplasms
        1521. Abstract# 4126: SIRT1 is required for normal prostate gland development and androgen signaling in vivo
        1522. Evidence for a Common Mechanism of SIRT1 Regulation by
        1523. The skinny on SIRT1 regulation
        1524. SIRT1 and neoplasms.
        1525. The regulatory effect of SIRT1 on CⅡTA under hypoxia
        1526. 152. Involvement of Trp53 in SIRT1 function during embryo development
        1527. Identification of DNA Targets for SIRT1 in Human Cells
        1528. Authentic SIRT1 activators? No, for Sirtin
        1529. SIRT1 Gene Eukaryotic Eexpression of SD Rat
        1530. SIRT1 Fluorometric Drug Discovery Kit
        1531. Protective Roles of SIRT1 in Vascular Diseases
        1532. SIRT1 Phosphorylation and Cell Proliferation
        1533. Effect of SIRT1 on insulin secretion in MIN6 cell line and its mechanism
        1534. SIRT1 Rabbit Polyclonal Antibody
        1535. The Correlation of SIRT1 and Skin Senescence
        1536. A potential tumor suppressive role of SIRT1 in Cancer
        1537. Nuclear SIRT1 activity regulates oxidative capacity
        1538. SIRT1 Regulates Notch4 Signaling In Endothelial Cells
        1539. SIRT1 promotes DNA repair activity in response to radiation
        1540. The Regulation of SIRT1 in Endocrine and Metabolism
        1541. Effects of dairy consumption on SIRT1 and metabolic risk in humans
        1542. Inhibition of SIRT1 Catalytic Activity
        1543. SIRT1 promotes differentiation of normal human keratinocytes
        1544. SIRT1, metabolism and calorie restriction
        1545. The role of SIRT1 in restricted energy intake
        1546. Expression and significance of SIRT1 in breast cancer with diabetes mellitus
        1547. #VALUE!
        1548. Expression of SIRT1 in Retinoblastoma: A Potential Therapeutic Target
        1549. Cancer Connection: Tumor-fighter throttles life-extending protein SIRT1
        1550. Identification of a novel SIRT1/FEN1 interaction and their regulation by karyopherins
        1551. SIRT1 DIMINISHES ATHEROGENESIS BY SUPPRESSING NF-‐ΚB SIGNALING-‐MEDIATED PRO-‐INFLAMMATORY EVENTS
        1552. The SIRT1 mRNA expression in human intervertebral disc
        1553. SIRT1 Involvement in Mouse and Human Retinal Development and Function
        1554. miR-200a targets SIRT1 for malignant transformation
        1555. The Role of SIRT1 in Resveratrol Toxicity
        1556. Role of SIRT1 in Smooth Muscle Cell Function and Vascular Remodeling
        1557. SIRT1 enhances drug resistance of CML K562 cells
        1558. On the role of TLR2 and SIRT1 in the development of diabetes mellitus
        1559. Effect of SIRT1 on the Transcription of HIV-1 Induced by Tat
        1560. Abstract B46: Essential roles of SIRT1 for BCR‐ABL transformation and genetic mutations
        1561. Effects of CR on H_2O_2-Induced Stress Injury and Expression of SIRT1 in PC12 Cells
        1562. The SIRT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells
        1563. SIRT1 Gene Silencing: A Potential Therapeutic Strategy for Pancreatic Cancer
        1564. Molecular mechanisms of a disease susceptibility variant of SIRT1: Genotoxic stress‐induced, CTCF‐dependent activation of SIRT1 gene expression
        1565. Deficiency Of SIRT1 Enhances Elastase-induced Emphysema In Mice
        1566. SIRT1 ACTIVATION SEEMS TO PROMOTE APOPTOSIS OF HUMAN OSTEOSARCOMA CELLS
        1567. Characterization of the role of SIRT1 and its potential as a chemotherapeutic target in breast cancer
        1568. SIRT1 Regulates the Mouse Gastric Emptying and Intestinal Growth
        1569. Roles of SIRT1 in neuronal oxidative damage and brain function
        1570. Negative Regulation of STAT3-mediated Cellular Respiration by SIRT1
        1571. SIRT1 Inhibits VSMC Proliferation and Migration Underlying Neointima Formation Following Vascular Injury
        1572. Effects of calorie restriction on expression of SIRT1 and SIRT2
        1573. SIRT1 modulates E2/ERα-associated oncogenic signaling in human breast cancer
        1574. The Research Progression of NAD~+, Nampt and SIRT1 [J]
        1575. Phosphorylation of Thr522 activates SIRT1 and is required for DYRK‐mediated cell survival in response to DNA damage
        1576. #VALUE!
        1577. Establishment of Stable SIRT1 Gene-Downregulated Hepatocarcinoma Cell Lines by Lentiviral Vector
        1578. Constitutive SIRT1 Overexpression Impairs Mitochondrial Function in Mice
        1579. SIRT1 deacetylation regulates NFAT transcriptional activity
        1580. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
        1581. FoxO1 Mediates an Auto-feedback Loop Regulation of SIRT1 Expression
        1582. PPARalpha-SIRT1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
        1583. Effects of silencing SIRT1 gene expression on proliferation and apoptosis of pancreatic cancer cell line PANC1
        1584. SIRT1 Is Critical for Pdx1 Transcription and β‐Cell Formation
        1585. Th lf Si t1 i The role of SIRT1 in restricted energy intake
        1586. Involvement of SIRT1 in ultraviolet radiation mediated damages and transformation of skin keratinocytes
        1587. SIRT1 Regulates Hyperglycemia-Induced Vascular Senescence
        1588. Expressions of SIRT1 as prognostic biomarker on resectable gastric cancer patient
        1589. Expression of SIRT1 during axonal degeneration by NAD.
        1590. Muscle‐Specific Disruption of SIRT1 Reduces Mitochondrial Function and Increases Reactive Oxygen Species Production
        1591. SIRT1 Is Required for Mouse Embroyonic Stem Cell Commitment to Hematopoietic Cell Differentiation.
        1592. Expression of SIRT1 mRNA in abdominal aorta in rats with spontaneous type 2 diabetic mellitus
        1593. Growth factor deprivation induces cytosolic translocation of SIRT1
        1594. SIRT1 Mediates Pressure Overload-Induced Cardiac Hypertrophy and Failure in vivo
        1595. SIRT1-Dependent and-Independent Effects of Resveratrol on Cardiovascular Oxidative Stress
        1596. Nutrient and hormonal control of the protein deacetylase SIRT1
        1597. The Development of Choroidal Neovascular Membranes in Patients With AMD Is a SIRT1-Independent Process
        1598. SIRT1 Activation Affects the Transmission of Photoperiodic Information by Melatonin
        1599. SIRT1 and AMPK: the Seesaw Effect in Regulating Endothelial Sene-scence
        1600. Effect of SIRT1 and telomerase on stem cells
        1601. Histone deacetylase SIRT1 promotes the differentiation of P19CL6 cells into cardiomyocytes
        1602. Research Progress of the Nonalcoholic Fatty Liver Based on the SIRT1 Target Spot
        1603. SIRT1 REGULATES CIGARETTE SMOKE-MEDIATED IMPAIRMENT OF ENDOTHELIAL CELL SIGNALING
        1604. The pro-apoptotic effect of vitamin C on colon cancer cell lines, HCT116 via the regulation of SIRT1 expression (165.11)
        1605. Stress and survival: Possible role of SIRT1 in the diencephalon during fasting
        1606. Role of the longevity gene hSir2 (SIRT1) in cancer resistance to chemotherapy
        1607. SIRT1 Decreases Lox-1 Mediated Foam Cell Formation in Atherogenesis
        1608. Transcriptional control of glucose homeostasis through SIRT1 and PGC-1alpha
        1609. HIGH LEVELS OF E-SELECTIN ARE ASSOCIATED WITH A REDUCTION OF SIRT1 EXPRESSION IN LYMPHOMONOCYTES FROM SUBJECTS WITH METABOLIC …
        1610. SIRT1 Overexpression Modulates Cardiac Metabolic Genes Expression and Induces Dilated Cardiomyopathy
        1611. Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
        1612. Resveratrol upregulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
        1613. Overexpression of SIRT1 and induction of apoptosis by its inhibition in adult T-cell leukemia cells
        1614. Investigation on SIRT1 in Peripheral Blood Mononuclear Cell (PBMC) and Relationship with Pathogenesis of Psoriasis
        1615. Primary study on the association of expression between SIRT1 and FOXO1 in B cells of islet in rat.
        1616. #VALUE!
        1617. Regulation of the NAD+‐dependent histone deacetylase SIRT1 in conditions of muscle use and disuse
        1618. Regulation of SIRT1 protein in cancer metabolism and ribosome biogenesis
        1619. Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
        1620. Characterization and investigation of seven SIRT proteins in human cell aging: down-regulation of SIRT1 extends cellular lifespan
        1621. Role of SIRT1 and Sirt6 Expression in the Pathophysiology of the rd10 Mouse Retinal Degeneration
        1622. Alcohol consumption and Western style diet alter colonic SIRT1 gene expression during aging
        1623. SIRT1 is expressed in prostatic adenocarcinomas and increases tumor cell invasion when overexpressed in DU145 cells
        1624. SIRT1 Stabilizes PML promoting its Sumoylation
        1625. Transcription Regulator SIRT1 Protects Choroidal Endothelial Cells from Oxidative Stress
        1626. Effects of resveratrol on cardiomyocyte apoptosis induced by anoxia and the expression of SIRT1
        1627. Modulation of Angiogenesis and Postnatal Vascular Growth by the NAD-Dependent Histone Deacetylase SIRT1
        1628. SIRT1 Activation Restores Cardioprotection in the Aged Heart Against Ischemia/Reperfusion Injury
        1629. PPARalpha-SIRT1 Complex Downregulates Mitochondrial Gene Expression Through Suppression of the ERR Response Element in the Heart Under Pressure …
        1630. Selenoprotein S Suppression Enhances the Late Stage Differentiation of Proerythrocytes Via SIRT1
        1631. The Longevity Factor SIRT1 Exacerbates LV Dysfunction and Energy Depletion in Response to Pressure Overload
        1632. SIRT1 represses MMP13 expression in human articular chondrocytes.
        1633. The role of TNFα in circadian rhythmic responses and regulation of metabolic regulator SIRT1 in liver
        1634. Effects of CR on H2O2-induced stress injury and expression of SIRT1 in PC12 cells.
        1635. Aging and vascular endothelial cell senescence: potential role of SIRT1 in development of inflammation and dysfunction
        1636. Abstract P233: PPARα-SIRT1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
        1637. NAD-Dependent Histone Deacetylase, SIRT1, Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells.
        1638. Impaired Nucleocytoplasmic Shuttling of SIRT1 in the Senescent Heart in Response to Ischemic Stress
        1639. SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein
        1640. SIRT1 ACTIVATES CELL PROLIFERATION ACTIVITY OF HUMAN INTERVERTEBRAL DISC BOTH IN LOW NUTRITIONAL AND CHEMICAL HYPOXIC CONDITIONS …
        1641. SIRT1 blocks apoptosis in human chondrocytes via activation of the IGF-1 Receptor/Akt pathway
        1642. Uncoupling Insulin: SIRT1 boosts insulin release by blocking mitochondrial protein
        1643. The Role of SIRT1 Activation of AMP-Activated Protein Kinase in the Effect of Polyphenols on Lipid Metabolism in HepG2 Cells Exposed to High Glucose.
        1644. SIRT1 deficiency compromises mouse embryonic stem cell differentiation, and embryonic and adult hematopoiesis in the mouse
        1645. Impaired Nucleocytoplasmic Shuttling and Activity of SIRT1 in Response to Ischemic Stress in the Senescent Heart
        1646. Identification of novel mechanisms regulating the NAD+-dependent deacetylase SIRT1
        1647. The SIRT1 activator resveratrol inhibits the mTOR-p70/S6K pathway
        1648. GENETIC VARIANTS IN THE SIRT1 GENE MAY AFFECT DIABETES RISK IN INTERACTION WITH PRENATAL EXPOSURE TO FAMINE: 7E. 01
        1649. p63 overexpression induces downregulation of SIRT1 and accelerated aging phenotypes in the mouse
        1650. Oral SIRT1 Activators Are Neuroprotective for Retinal Ganglion Cells in Experimental Optic Neuritis
        1651. Increased Nuclear Translocation of SIRT1 and MnSOD Up-regulation in Failing Hearts: A Novel Mechanism of the Cardiomyocyte Death Suppression
        1652. AMPKα2 deletion leads to marked alterations in SIRT1 activity, CPT1 expression and basal FA muscle metabolism in high‐fat‐fed mice
        1653. The protective effect of resveratrol on myocardial ischemia-reperfusion injury by SIRT1-p53 pathway in rats
        1654. SIRT1 Activator 3 Potently Induces Apoptosis in Multiple Myeloma Cell Lines and in Primary Human Multiple Myeloma Cells.
        1655. Construction and identification of eukaryotic plasmid expression vectors encoding the short hairpin RNA targeting human SIRT1
        1656. Resveratrol and Other SIRT1 Activators Exert Similar Neuroprotective Effects in Experimental Optic Neuritis
        1657. The NAD-dependent protein deacetylase SIRT1 regulates POMC transcription and ACTH synthesis
        1658. Sirtuin histone deacetylases SIRT1 and SIRT2 as novel targets for the management of prostate cancer
        1659. Interactions between SIRT1 and AP1 reveal a mechanistic insight into the growth promoting properties of alumina…
        1660. The effect of resveratrol intervention on the expression of SIRT1 in the atrial tissues in pigs with chronic atrial fibrillation induced by right atrial tachypacing
        1661. Effect of High Fat and High Energy Diet on Expression of SIRT1/FOXO1 in White Fat Tissue of Young Rats
        1662. Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its
        1663. The NAD-dependent protein deacetylase SIRT1 is present in the human anterior pituitary gland where it plays a role in GH transcription
        1664. AMP-Activated Protein Kinase Activity Is Altered by Changes in Redox State in HepG2 Cells by a SIRT1-Dependent Mechanism.
        1665. Identification of cofactor network, including SIRT1 and SRC-3, which converges on energy expenditure through PGC-1α
        1666. SIRT1 Limits Endothelial Notch Signaling During Blood Vessel Growth Through NICD Deacetylation
        1667. Effects of SIRT1 inhibition by lentivirus-mediated shRNA vector on apoptosis of porcine preadipocytes.
        1668. A targeted knockdown of sirtuin histone deacetylase SIRT1 imparts significant growth inhibitory effects in human prostate cancer cells.
        1669. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity Swami R. Narala, Richard C. Allsopp† …
        1670. SIRT1 activator SRT1720 promotes tumor cell migration and lung metastasis in mouse models of breast cancer
        1671. The role of NAMPT/SIRT1/FOXO3a pathway for the leukemic transformation in severe congenital neutropenia (CN) patients.
        1672. p22phox-Based Nox4 Regulates Cellular Survival by Modulating FOXO3A Activity and SIRT1 Expression
        1673. Expression of senescence-associated miR-34c and SIRT1 in premature senescence of human skin fibroblasts induced by ultraviolet B
        1674. Regulatory Role of Resveratrol on SIRT1-mediated Metabolic Syndrome and Significance of SIRT Family Proteins for Prevention and Treatment of Metabolic …
        1675. Role of the SIRT1 Deacetylase in Survival and Imatinib Resistance of CML CD34+ Progenitors.
        1676. Activation of the Longevity Factor, SIRT1 Deacetylase Blocks the Phenylephrine-induced Cardiomyocyte Hypertrophy
        1677. Effects of SIRT1 Hyper-expression Induced by Calorie Restriction on Life Span of β Cells and Insulin Secretion
        1678. Atorvastatin Affects Expression of SIRT1 via Microrna-34a in Circulating Their Progenitor Cells Get Pirated From be with Coronary Artery Disease
        1679. SIRT1 Mediated Deacetylation of Foxo1 Is Involved in Starvation Induced Autophagy in the Heart
        1680. Signal-Responsive Repression of Notch1 Signaling by the SIRT1 Deacetylase Regulates Sprouting Angiogenesis
        1681. Dual role of SIRT1 as a regulator of retinal development and a therapeutic target in age-related macular degeneration
        1682. SIRT1 signalling promotes lipopolysaccharide-induced TNF-a expression in cardiomyocytes
        1683. Endothelial Biology/Homeostasis: The Roles of AMPK and SIRT1 in eNOS Phosphorylation and Deacetylation
        1684. Erratum to “SIRT1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol”[Exp. Mol. Path. 85 (2008) 155–159]
        1685. Fetal Hepatic SIRT1, a Histone H3 Deacetylase, Is Decreased in a Nonhuman Primate Model of Maternal Obesity.
        1686. Treatment with a SIRT1 Activator Resveratrol Prevents Cardiomyopathy in Dystrophin-Deficient Mice
        1687. Cisplatin induces SIRT1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
        1688. Activation of SIRT1, a Longevity Gene, Prevents the Development of Diabetic Vasculopathy by Inhibiting Endothelial Senescence
        1689. Expression and function of SIRT1, Sirt4, and glutamate dehydrogenase 1 within the central nervous system
        1690. Nicotinamide Phosphoribosyltransferase (Nampt) Induces NAD+ / SIRT1 Mediated Deacetylation of p53 in Myeloid Cells.
        1691. Activation of a Protein Deacetylase, SIRT1, by Resveratrol Suppresses Progression of Heart Failure and Improves Survival by Up-Regulation of Mn-SOD
        1692. Melatonin, a novel SIRT1 inhibitor, imparts anti-proliferative effects against PCa in vitro in cell culture and in vivo in transgenic adenocarcinoma of mouse prostate …
        1693. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγgamma Activity through Deacetylation of Specific Lysine Residues in Mammals
        1694. Enhanced cell viability and decreased expression of a senescence marker exhibited in SIRT1-induced human skin cells Claude dal Farra, PhD, Vincience, Sophia …
        1695. Nicotinamide Phosphoribosyltransferase (Nampt) Induces NAD+/SIRT1 Mediated Deacetylation of FOXO3a in Myeloid Cells.
        1696. Activation of a Class-III Histone Deacetylase, SIRT1, Prevents the Oxidative-stress Mediated Cell-death by Suppressing the Activity of Poly (ADP) Ribose Polymerase …
        1697. Long-Term Treatment with the SIRT1 Activator Resveratrol Ameliorates Cardiomyopathy in Dystrophin-Deficient Mice
        1698. Control of Notch Signaling by Reversible Acetylation Through the Antagonistic Activities of p300/PCAF and SIRT1 in Endothelial Cells
        1699. Activation of SIRT1 Suppresses Hypertrophic Response of Cardiomyocytes by Inhibition of H3K9 Acetylation via Proteasome-mediated p300 Degradation.
        1700. Modulation of the longevity proteins FOXO3a and SIRT1 by chorionic gonadotropin prevents hepatocellular injury during acute liver inflammation
        1701. Down‐regulation of MnSOD via SIRT1/FoxO3a complex increase oxidative stress with cardiac overexpression of Type 5 Adenylyl Cyclase
        1702. Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph− Acute Lymphoblastic Leukemia Cells Alone and in …
        1703. Increased SIRT1 following repetitive hypoxic preconditioning: A mechanism for mediating long-term tolerance (LTT) to focal stroke in adult mouse brain
        1704. Apo-10′-lycopenoic acid increases both mRNA and protein levels of SIRT1 as well as decreasing the fat accumulation in the livers of ob/ob mice
        1705. Hepatitis B virus X (HBX) Protein Inhibits the Expression of SIRT1 Deacetylase, Leading to Up-regulation of Survivin for the Survival of Hepatocellular Carcinoma Cells
        1706. Nicotinamide activates the p53/miR-34a/SIRT1 tumor suppressor network leading to apoptosis of chronic lymphocytic leukemia cells
        1707. Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation
        1708. Resveratrol Induces Cell Growth Arrest and Cell Death of Adult T-Cell Leukemia Cells Via Deacetylation of STAT3 by SIRT1
        1709. … protein kinase α1 silencing provides evidence for a Metformin‐induced decrease in FA uptake and oxidation and increase in glucose uptake and SIRT1 activity in L6 …
        1710. Endothelial Cell Polyploidization Induces an Atherogenic Phenotype and is Prevented by Activating the Nampt-SIRT1 Axis
        1711. 441 INTRAUTERINE GROWTH RETARDATION MODULATES SIRT1 DEACETYLASE, FOXO3 TRANSCRIPTION FACTOR, AND SUPEROXIDE DISMUTASE 2 …
        1712. Acetyltransfer in gene regulation: Structural and biochemical studies of human SIRT1 deacetylase, its FoxO1 substrate, and archaeal PAT acetyltransferase
        1713. Nicotinamide Promotes Apoptosis In Chronic Lymphocytic Leukemia through Activation of the p53/Mir-34a/SIRT1 Tumor Suppressor Network
        1714. Cardiac protective effects of resveratrol and SIRT1 in old rat with emphysema induced by cigarette smoke-expose and lipopolysaccharide instillation: attenuation of …
        1715. Abstract# 183: SIRT1 contributes to tumorigenicity and radioresistance in glioblastoma CD133+ cells
        1716. SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
        1717. SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via …
        1718. Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007)
        1719. 875 RESVERATROL, A POLYPHENOLIC SIRT1 ACTIVATOR, IMPROVES ERECTILE FUNCTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS
        1720. TR-FRET Assay for Sirtuin 1 (SIRT1) Inhibitor Screening
        1721. Co-Upregulation of Peroxisome Proliferator-Activated Receptor-Alpha (PPARalpha) and Silent Information Regulator 1 (SIRT1) Negatively Regulates Cardiac Function …
        1722. Sirtuin 1 (SIRT1) regulates the HSF1-dependent pro-survival mechanism in neurons
        1723. Interplay Between Hypoxia-inducible Factor 1 [alpha] and SIRT1 Protein Deacetylase in Hypoxic Cancer Cells
        1724. 57: Histone deacetylase SIRT1 alterations parallel fetal epigenetic and metabolic reprogramming in response to a maternal high fat (MHF) diet
        1725. Abstract# 3569: Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates\# 946;-Catenin signaling and NF\# 954; B-specific transcription activity leading …
        1726. 032 A REDUCTION IN SIRT1 LEVELS IN OA ARTICULAR CARTILAGE IS ASSOCIATED WITH AN INCREASE IN PTP1B, MMP13 AND CHONDROCYTE APOPTOSIS
        1727. Regulation of the transcription factor GATA-3 within T cells-Involvement of SIRT1, a class III histone deacetylase
        1728. Activation of the AKT Pathway Mediates Upregulation of Hif-1α and SIRT1 via Downregulation of miR-199a and is Neutralized by Beta-adrenergic Stimulation
        1729. Abstract LB-427: Differential effects of resveratrol-induced SIRT1 in prostate cancer: A novel therapeutic target
        1730. Influence of AP endonuclease 1 deacetylation by protein deacetylase SIRT1 on DNA base excision repair
        1731. Microrna-195 Promotes Apoptosis in Cardiomyocytes by Down-Regulating SIRT1
        1732. Influence of Ethnicity in Association of UCP2‐866G/A, PGC1α (Gly 482 Ser) and SIRT1‐1400T/C Polymorphisms in North Indian Punjabi Population Groups
        1733. Abstract LB-185: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1 and polycomb members to promoter CpG islands
        1734. SIRT1 and energy metabolism
        1735. The roles of SIRT1 in cancer
        1736. The ways and means that fine tune SIRT1 activity
        1737. MicroRNA regulation of SIRT1
        1738. Negative regulation of inflammation by SIRT1
        1739. SIRT1 in type 2 diabetes: mechanisms and therapeutic potential
        1740. Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets
        1741. Evidence for a common mechanism of SIRT1 regulation by allosteric activators
        1742. Crosstalk between oxidative stress and SIRT1: impact on the aging process
        1743. The role of SIRT1 in ocular aging
        1744. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress
        1745. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
        1746. SIRT1: new avenues of discovery for disorders of oxidative stress
        1747. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
        1748. SIRT1, metabolism and cancer
        1749. Identification of a SIRT1 mutation in a family with type 1 diabetes
        1750. Regulation of SIRT1 by microRNAs
        1751. Targeting cardiovascular disease with novel SIRT1 pathways
        1752. SIRT1 and SIRT2: emerging targets in neurodegeneration
        1753. Janus-faced role of SIRT1 in tumorigenesis
        1754. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
        1755. Redox regulation of SIRT1 in inflammation and cellular senescence
        1756. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
        1757. Stress inducibility of SIRT1 and its role in cytoprotection and cancer
        1758. Regulation of SIRT1 activity by genotoxic stress
        1759. Emerging roles of SIRT1 in cancer drug resistance
        1760. Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets
        1761. SIRT1 is required for long-term growth of human mesenchymal stem cells
        1762. Towards elucidating the role of SIRT1 in osteoarthritis.
        1763. Roles of SIRT1 in leukemogenesis
        1764. SIRT1: regulator of p53 deacetylation
        1765. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
        1766. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
        1767. SIRT1 in metabolic syndrome: where to target matters
        1768. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
        1769. Brown remodeling of white adipose tissue by SIRT1-dependent deacetylation of Pparγ
        1770. Brain activation of SIRT1: role in neuropathology
        1771. SIRT1 activation by resveratrol is substrate sequence-selective
        1772. Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways
        1773. High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction
        1774. The effects of SIRT1 on Alzheimer’s disease models
        1775. SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis
        1776. Deacetylation by SIRT1 reprograms inflammation and cancer
        1777. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
        1778. Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo
        1779. SIRT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex
        1780. SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
        1781. SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis
        1782. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
        1783. SIRT1 protects against α-synuclein aggregation by activating molecular chaperones
        1784. MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
        1785. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
        1786. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
        1787. SIRT1 expression is associated with good prognosis in colorectal cancer
        1788. Metabolic actions of hypothalamic SIRT1
        1789. SIRT1 regulates dendritic development in hippocampal neurons
        1790. SIRT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain
        1791. SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60
        1792. Peripheral blood monocyte SIRT1 expression is reduced in patients with coronary artery disease
        1793. Dilated cardiomyopathy and mitochondrial dysfunction in SIRT1-deficient mice: a role for SIRT1-Mef2 in adult heart
        1794. Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions
        1795. Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
        1796. The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
        1797. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
        1798. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
        1799. SIRT1-deficient mice exhibit an altered cartilage phenotype
        1800. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity
        1801. SIRT1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
        1802. Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
        1803. SIRT1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
        1804. SIRT1 contains N-and C-terminal regions that potentiate deacetylase activity
        1805. Anti-aging molecule, SIRT1: a novel therapeutic target for diabetic nephropathy
        1806. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex
        1807. Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
        1808. Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
        1809. Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
        1810. SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
        1811. SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
        1812. SIRT1 regulation modulates stroke outcome
        1813. Renal tubular SIRT1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
        1814. The role of SIRT1 in muscle mitochondrial turnover
        1815. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction
        1816. A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis
        1817. Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
        1818. SIRT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
        1819. SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
        1820. SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
        1821. Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
        1822. SIRT1: Def-eating senescence?
        1823. SIRT1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3
        1824. Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium
        1825. SIRT1-an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis
        1826. SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas
        1827. Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation
        1828. Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SIRT1 mice
        1829. USP22 antagonizes p53 transcriptional activation by deubiquitinating SIRT1 to suppress cell apoptosis and is required for mouse embryonic development
        1830. New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity
        1831. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
        1832. A maternal high‐fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
        1833. SIRT1 is a highly networked protein that mediates the adaptation to chronic physiological stress
        1834. SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
        1835. SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
        1836. Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
        1837. SIRT1 signaling as potential modulator of skeletal muscle diseases
        1838. Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
        1839. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
        1840. SIRT1 Polymorphism, Long-Term Survival and Glucose Tolerance in the General Population
        1841. SIRT1 enhances matrix metalloproteinase‐2 expression and tumor cell invasion in prostate cancer cells
        1842. A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers
        1843. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging
        1844. High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
        1845. SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines
        1846. SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions
        1847. Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation
        1848. SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
        1849. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
        1850. SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-κB/Cyclin D1 signaling
        1851. Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
        1852. SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
        1853. SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells
        1854. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
        1855. SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth
        1856. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
        1857. SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC
        1858. The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
        1859. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
        1860. Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
        1861. SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
        1862. Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action
        1863. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
        1864. Neuronal SIRT1 deficiency increases insulin sensitivity in both brain and peripheral tissues
        1865. Genetic analysis of the SIRT1 gene promoter in myocardial infarction
        1866. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
        1867. Genetic analysis of SIRT1 gene promoter in sporadic Parkinson’s disease
        1868. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
        1869. Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas
        1870. SIRT1 regulates endothelial Notch signaling in lung cancer
        1871. SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway
        1872. Autophagy induced by the class III histone deacetylase SIRT1 prevents prion peptide neurotoxicity
        1873. Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway
        1874. Extranuclear localization of SIRT1 and PGC-1α: an insight into possible roles in diseases associated with mitochondrial dysfunction
        1875. Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of SIRT1
        1876. PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells
        1877. Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
        1878. Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation
        1879. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells
        1880. Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways
        1881. Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
        1882. SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
        1883. Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of SIRT1
        1884. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
        1885. SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity
        1886. SIRT1 regulates cd40 expression induced by tnf-α via nf-ĸb pathway in endothelial cells
        1887. Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
        1888. Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction
        1889. Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4,PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver
        1890. Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and …
        1891. SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice
        1892. The loss of SIRT1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing
        1893. Resveratrol‐mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
        1894. Cross-talk between SIRT1 and p66Shc in vascular diseases
        1895. Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
        1896. SIRT1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
        1897. SIRT1 promotes RGC survival and delays loss of function following optic nerve crush
        1898. SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
        1899. Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
        1900. SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients
        1901. Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
        1902. Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle
        1903. Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
        1904. NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
        1905. Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
        1906. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway
        1907. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway
        1908. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
        1909. Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a SIRT1-dependent manner
        1910. Resveratrol activates SIRT1 in a Lamin A-dependent manner
        1911. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human …
        1912. SIRT1 gene polymorphisms are associated with growth traits in Nanyang cattle
        1913. Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer
        1914. Identification of a small molecule activator of SIRT1 gene expression
        1915. SIRT1, p66Shc, and Set7/9 in vascular hyperglycemic memory: bringing all the strands together
        1916. Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high‐fat‐diet feeding
        1917. BCL6 controls neurogenesis through SIRT1-dependent epigenetic repression of selective Notch targets
        1918. SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
        1919. SIRT1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenanceSIRT1 in adult stem cell homeostasis
        1920. Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine
        1921. Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal SIRT1
        1922. Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway
        1923. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
        1924. SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase …
        1925. Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation
        1926. PPARα and SIRT1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders
        1927. Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells
        1928. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
        1929. SIRT1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis
        1930. Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance
        1931. SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein
        1932. SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
        1933. Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects
        1934. Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes
        1935. Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle
        1936. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1
        1937. Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase
        1938. Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway
        1939. Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate
        1940. Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1
        1941. CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1
        1942. Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear …
        1943. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells
        1944. Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis
        1945. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
        1946. SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression
        1947. Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating SIRT1
        1948. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
        1949. Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1
        1950. SIRT1 regulates adaptive response of the growth hormone–insulin-like growth factor-I axis under fasting conditions in liver
        1951. Regulation of SIRT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability
        1952. SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration
        1953. mIGF‐1/JNK1/SIRT1 signaling confers protection against oxidative stress in the heart
        1954. Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression
        1955. Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence
        1956. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
        1957. Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein*[S]
        1958. TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes
        1959. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
        1960. SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence
        1961. The role of SIRT1 on angiogenic and odontogenic potential in human dental pulp cells
        1962. SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway
        1963. Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1
        1964. The Interactive Effect of SIRT1 Promoter Region Polymorphism on Type 2 Diabetes Susceptibility in the North Indian Population
        1965. Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
        1966. Terpenylated Coumarins As SIRT1 Activators Isolated from Ailanthus altissima
        1967. Resveratrol induces SIRT1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
        1968. The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent
        1969. Fortifying the link between SIRT1, resveratrol, and mitochondrial function
        1970. SIRT1 prevents atherosclerosis via liver‑X‑receptor and NF‑κB signaling in a U937 cell model
        1971. Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice
        1972. Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice
        1973. Association of SIRT1 expression with shear stress induced endothelial progenitor cell differentiation
        1974. The involvement of SIRT1 and transcription factor NF-κB (p50/p65) in regulation of porcine ovarian cell function
        1975. Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC+/min Mouse Model
        1976. The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response
        1977. Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3, 2′-quinazolines
        1978. Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
        1979. SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β …
        1980. SIRT1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure
        1981. A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes
        1982. Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis
        1983. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1
        1984. … protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1
        1985. Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in …
        1986. Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1–AMPK signaling pathway
        1987. SIRT1 as a novel potential treatment target for vascular aging and age-related vascular diseases
        1988. 17‐β Oestradiol prevents cardiovascular dysfunction in post‐menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation
        1989. SIRT1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway
        1990. Nicotinamide‑mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis
        1991. SIRT1 attenuates diabetic albuminuria
        1992. Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice
        1993. … in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 …
        1994. Overexpression of SIRT1 Promotes High Glucose–Attenuated Corneal Epithelial Wound Healing via p53 Regulation of the IGFBP3/IGF-1R/AKT Pathway
        1995. Pharmacological activation of SIRT1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy
        1996. Suppression of ERR targets by a PPARα/SIRT1 complex in the failing heart
        1997. SIRT1 represses estrogen-signaling, ligand-independent ERα-mediated transcription, and cell proliferation in estrogen-responsive breast cells
        1998. SIRT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions
        1999. Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway
        2000. SIRT1-mediated FoxO1 deacetylation is essential for multidrug resistance-associated protein 2 expression in tamoxifen-resistant breast cancer cells
        2001. Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation
        2002. SIRT1 regulates the human alveolar epithelial A549 cell apoptosis induced by Pseudomonas aeruginosa lipopolysaccharide
        2003. Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1
        2004. The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
        2005. Effects of SIRT1 on DNA methylation and expression of genes affected by dietary restriction
        2006. SIRT1 inhibits akt2-mediated porcine adipogenesis potentially by direct protein-protein interaction
        2007. The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel …
        2008. When is SIRT1 activity bad for dying neurons?
        2009. Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
        2010. Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair
        2011. IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARδ, SIRT1, PGC-1α, and PGC-1β expression in male mice
        2012. Identification and characterization of novel indole based small molecules as anticancer agents through SIRT1 inhibition
        2013. Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SIRT1 axis
        2014. Enantioselective Synthesis of Cyclohepta[b]indoles: Gram-Scale Synthesis of (S)-SIRT1-Inhibitor IV
        2015. Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1
        2016. Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway
        2017. Rejuvenating SIRT1 activators
        2018. Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: a pilot study
        2019. Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase
        2020. Metabolic energy sensors (AMPK and SIRT1), protein carbonylation and cardiac failure as biomarkers of thermal stress in an intertidal limpet: linking energetic …
        2021. The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats
        2022. c-MYC and SIRT1 locked in a vicious cycle
        2023. SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats
        2024. The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells
        2025. Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation
        2026. SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation
        2027. SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells
        2028. SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue
        2029. Involvement of SIRT1 in hypoxic down-regulation of c-Myc and β-catenin and hypoxic preconditioning effect of polyphenols
        2030. WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1
        2031. The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes
        2032. Carvacrol protects against hepatic steatosis in mice fed a high-fat diet by enhancing SIRT1-AMPK signaling
        2033. SIRT1 Regulation—It Ain’t All NAD
        2034. β-Cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
        2035. Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by SIRT1 Protein-mediated Deacetylation♦
        2036. Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
        2037. Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice
        2038. Expression of SIRT1 and DBC1 in developing and adult retinas
        2039. Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats
        2040. Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1
        2041. Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients
        2042. Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins
        2043. Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways
        2044. SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling
        2045. Expression of SIRT1 in choroidal neovascular membranes
        2046. Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro
        2047. Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro
        2048. Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late …
        2049. Activation of SIRT1 by resveratrol requires lamin A
        2050. Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells
        2051. Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi
        2052. MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
        2053. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κ B/STAT3 complex to its promoter in …
        2054. PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1
        2055. Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?
        2056. Anti-correlation between longevity gene SIRT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease
        2057. MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS
        2058. Exendin-4 improves steatohepatitis by increasing SIRT1 expression in high-fat diet-induced obese C57BL/6J mice
        2059. DBC1 does not function as a negative regulator of SIRT1 in liver cancer
        2060. SIRT1–Claudin-1 crosstalk regulates renal function
        2061. Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma
        2062. PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway
        2063. SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: implications for cell survival after irradiation
        2064. Molecular architecture of the human protein deacetylase SIRT1 and its regulation by AROS and resveratrol
        2065. Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic …
        2066. Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
        2067. SIRT1 inhibits the mouse intestinal motility and epithelial proliferation
        2068. … and anti‐inflammatory effects of melatonin in hydrogen peroxide‐stimulated CHON‐001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 …
        2069. Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis
        2070. Vitamin D protects human endothelial cells from H 2 O 2 oxidant injury through the Mek/Erk-SIRT1 axis activation
        2071. The identification of the SIRT1 activator SRT2104 as a clinical candidate
        2072. The brain: A new organ for the metabolic actions of SIRT1
        2073. SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells
        2074. SIRT1 and the clock gene machinery in colorectal cancer
        2075. Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer
        2076. Molecular dissection of the interaction between HIC1 and SIRT1
        2077. Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation
        2078. Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats
        2079. … Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 …
        2080. Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor …
        2081. Expression of SIRT1 in ocular surface squamous neoplasia
        2082. SIRT1 inhibits resistin expression in aortic stenosis
        2083. Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
        2084. Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise
        2085. Modeling miRNA regulation in cancer signaling systems: miR-34a regulation of the p53/SIRT1 signaling module
        2086. Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/SIRT1 signaling in mice
        2087. Insulin signal meets SIRT1 at Akt
        2088. SIRT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells
        2089. hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SIRT1
        2090. #VALUE!
        2091. Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats
        2092. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
        2093. SIRT1, p53, and p38MAPK Are Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells with Max Expression Ablation
        2094. Androgen depletion in humans leads to cavernous tissue reorganization and upregulation of SIRT1–eNOS axis
        2095. The time-dependent autophagy protects against apoptosis with possible involvement of SIRT1 protein in multiple myeloma under nutrient depletion
        2096. Activation of AMPK–SIRT1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects
        2097. SIRT1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes
        2098. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism
        2099. SIRT1 mediates the protective function of Nkx2. 5 during stress in cardiomyocytes
        2100. Metabolic stress modulates Alzheimer’s β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
        2101. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
        2102. Pentamethylquercetin reduces fat deposition via SIRT1-mediated pathways in male obese mice induced by a high fat diet
        2103. The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a SIRT1‐dependent mechanism in mice
        2104. Late-onset running biphasically improves redox balance, energy-and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus
        2105. The expression of SIRT1 and DBC1 in laryngeal and hypopharyngeal carcinomas
        2106. An autoregulatory loop reverts the mechanosensitive SIRT1 induction by EGR1 in skeletal muscle cells
        2107. SIRT1 attenuates neointima formation by inhibiting HIF-1α expression in neointimal lesion of a murine wire-injured femoral artery
        2108. MiR-34a is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation through the SIRT1/NFκB pathway
        2109. Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study
        2110. SIRT1 deacetylates SATB1 to facilitate MAR HS2 -MAR ε interaction and promote ε-globin expression
        2111. Diet-induced obesity promotes murine gastric cancer growth through a nampt/SIRT1/c-myc positive feedback loop
        2112. MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
        2113. Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1 …
        2114. SIRT1 exerts anti-inflammatory effects and promotes steroidogenesis in Leydig cells
        2115. The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of SIRT1 in hepatocellular carcinoma
        2116. SIRT1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells
        2117. SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis
        2118. The mitochondrial SIRT1–PGC-1α axis in podocyte injury
        2119. SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for …
        2120. Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of SIRT1 and AMPK in rats
        2121. SIRT1 and Connexin40 Mediate the normal shear stress-induced inhibition of the proliferation of endothelial cells co-cultured with vascular smooth muscle cells
        2122. Growth inhibition and apoptosis-inducing effects of cudraflavone B in human oral cancer cells via MAPK, NF-κB, and SIRT1 signaling pathway
        2123. Synergistic actions of insulin-sensitive and SIRT1-mediated pathways in the differentiation of mouse embryonic stem cells to osteoblast
        2124. α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
        2125. Investigation of silent information regulator 1 (SIRT1) agonists from Traditional Chinese Medicine
        2126. Involvement of SIRT1–AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet
        2127. MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1
        2128. Genetic analysis of the SIRT1 gene promoter in ventricular septal defects
        2129. Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1
        2130. SIRT1 activators: the evidence STACks up
        2131. Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta
        2132. miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in …
        2133. Omentin-1, a new adipokine, promotes apoptosis through regulating SIRT1-dependent p53 deacetylation in hepatocellular carcinoma cells
        2134. SIRT1 expression and activity are up-regulated in the brain tissue of epileptic patients and rat models
        2135. The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels …
        2136. Active regulator of SIRT1 is required for ribosome biogenesis and function
        2137. Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells
        2138. … -associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells
        2139. Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes
        2140. Sirt7 promotes adipogenesis by binding to and inhibiting SIRT1
        2141. Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells
        2142. Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells
        2143. Angiogenic Dysfunction in Bone Marrow‐Derived Early Outgrowth Cells from Diabetic Animals Is Attenuated by SIRT1 Activation
        2144. Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced …
        2145. SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer
        2146. Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression
        2147. MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
        2148. Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation
        2149. Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells
        2150. Identification of benzofuran-3-yl (phenyl) methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action
        2151. Bisdemethoxycurcumin increases SIRT1 to antagonize t-BHP-induced premature senescence in WI38 fibroblast cells
        2152. Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1
        2153. Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau
        2154. Effect of breed on the expression of Sirtuins (SIRT1-7) and antioxidant capacity in porcine brain
        2155. Ginkgolide B reduces LOX-1 expression by inhibiting Akt phosphorylation and increasing SIRT1 expression in oxidized LDL-stimulated human umbilical vein …
        2156. Lentivirus-mediated SIRT1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway
        2157. Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells
        2158. Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver
        2159. Functional Complementation of sir2Δ Yeast Mutation by the Human Orthologous Gene SIRT1
        2160. Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
        2161. Fragmentation studies of SIRT1‐activating drugs and their detection in human plasma for doping control purposes
        2162. Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation
        2163. Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and …
        2164. Inverse Regulation of the Cytosolic Ca2+ Buffer Parvalbumin and Mitochondrial Volume in Muscle Cells via SIRT1/PGC-1α Axis
        2165. SIRT1 suppresses cellular accumulation of β-TrCP E3 ligase via protein degradation
        2166. Novel SIRT1 mutation linked to autoimmune diabetes in humans
        2167. Upregulation of SIRT1 in carbon-tetrachloride–induced acute liver injury
        2168. Hypothalamic SIRT1 and regulation of food intake
        2169. Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice
        2170. Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene
        2171. MicroRNA-217 promotes angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A
        2172. Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer
        2173. Methods to investigate the role of SIRT1 in endothelial senescence
        2174. Electroconvulsive shock increases SIRT1 immunoreactivity in the mouse hippocampus and hypothalamus
        2175. SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett’s esophagus
        2176. Resveratrol-poor red wines modulate SIRT1 in human renal cells
        2177. SRT1720, a SIRT1 activator, aggravates bleomycin-induced lung injury in mice
        2178. Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is SIRT1-independent
        2179. Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS
        2180. SILAC-based quantification of SIRT1-responsive lysine acetylome
        2181. MicroRNAs in the growth plate are responsive to nutritional cues: association between miR-140 and SIRT1
        2182. Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells
        2183. Dissecting the Roles of the N‐and C‐Flanking Residues of Acetyllysine Substrates for SIRT1 Activity
        2184. RETRACTED ARTICLE: MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting SIRT1
        2185. Accelerating cancer evolution: a dark side of SIRT1 in genome maintenance
        2186. Commentaries on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments …
        2187. MicroRNA-142 reduces monoamine oxidase A expression and activity in neuronal cells by downregulating SIRT1
        2188. Nephroprotective action of sirtuin 1 (SIRT1)
        2189. Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation
        2190. #VALUE!
        2191. Measles virus nucleocapsid protein, a key contributor to Paget’s disease, increases IL-6 expression via down-regulation of FoxO3/SIRT1 signaling
        2192. Mechanism of temozolomide-induced anti-tumor effects on glioblastoma cells in vitro is via ROS-dependent SIRT1 signaling pathway
        2193. GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (SIRT1)
        2194. Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes
        2195. Relative quantitative comparison between lipotoxicity and glucotoxicity affecting the PARP-NAD-SIRT1 pathway in hepatocytes
        2196. Metformin, metabolic stress, and mitochondria. Focus on “A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein …
        2197. Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
        2198. Deacetylase SIRT1 and vascular endothelial function
        2199. PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1
        2200. Involvement of SIRT1 in Zn2+, streptozotocin, non-obese diabetic, and cytokine-mediated toxicities of β-cells
        2201. Cloning expression and purification of human truncated SIRT1
        2202. #VALUE!
        2203. SIRT1 inhibits p53 but not NF-κB transcriptional activity during differentiation of mouse embryonic stem cells into embryoid bodies
        2204. Yet another role for SIRT1: reduction of α-synuclein aggregation in stressed neurons
        2205. #VALUE!
        2206. #VALUE!
        2207. Last Word on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?
        2208. SIRT1 and anxiety
        2209. A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation
        2210. Resveratrol stimulates extracellular matrix synthesis in degenerative nucleus pulposus cells via upregulation of SIRT1
        2211. SIRT1 suppresses activating transcription factor 4 (ATF4) expression in response to proteasome inhibition
        2212. Incretin-stimulated interaction between β-cell Kv1. 5 and Kvβ2 channel proteins involves acetylation/deacetylation by CBP/SIRT1
        2213. Discovery and Characterization of Protein‐Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors
        2214. SIRT1 negatively regulates the protein stability of HIPK2
        2215. Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo
        2216. Expression and significance of SIRT1 and survivin in endometrial carcinoma
        2217. Effects of exercise training duration on SIRT1 and eNOS expression in rat aortas
        2218. #VALUE!
        2219. SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model
        2220. Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver
        2221. miR-520c and miR-373 target mTOR and SIRT1, activate the Ras/Raf/MEK/Erk pathway and NF-κB, with up-regulation of MMP9 in human fibrosarcoma cells
        2222. The modulation of SIRT1 expression by different types of high fat state in hepatocytes
        2223. AMPK-SIRT1-PGC-1α signaling regulates mitochondrial function in human articular chondrocytes
        2224. Role of SIRT1 in Resistance Exercise‐Induced Changes in Vascular Function
        2225. SIRT1 knockout impairs the differentiation of adipocyte in C57BL/6J mice and its underlying mechanism
        2226. Research progress of SIRT1 and osteoporosis
        2227. Implications of a novel point mutation of SIRT1 in T1DM
        2228. The role of SIRT1 in the activation of innate immune responses during RSV infection (68.6)
        2229. Expressions and clinical significance of SIRT1, P53 and P-gp in gastric carcinoma.
        2230. SIRT1 Activators in Development
        2231. SIRT1‐independent epigenetic effects of resveratrol mediated through the estrogen receptor
        2232. Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis …
        2233. Is a deceptive role of IGF-1 in SIRT1–PARP1 interactions the primary step of postnatal regression of hypertrophic cardiomyopathy in infants of diabetic mothers?
        2234. Role of SIRT1/UCP2 signaling pathway in resveratrol-induced inhibition of oxidative injury in vascular endothelial cells
        2235. Reproductive effects of SIRT1 expression in astrocytes
        2236. Abstract P2-06-02: Pparg deacetylation by SIRT1 determines breast tumor lipid synthesis and growth
        2237. Mammalian target of rapamycin (mTOR) sigaling pathway involved in the inhibition of silence information regulator1 (SIRT1) on fat deposition of mice.
        2238. Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of MnSOD via the SIRT1/FoxO3a pathway
        2239. Mutual inhibition between miR-34a and SIRT1 contributes to regulation of DNA double-strand break repair
        2240. Importance of NAMPT-mediated NAD-biosynthesis and NAD-dependent deacetylase SIRT1 in the crosstalk between circadian rhythm and metabolism
        2241. Electrochemical Immunosensor Based on AuNPs/PDDA-GO for Detection of SIRT1
        2242. Expression of SIRT1 and P55PIK in Gastric Cancer and Clinical Significance
        2243. SIRT1 deacetylase is essential for hematopoietic stem cell activity
        2244. Metformin modulates hyperglycemia‐induced endothelial dysfunction through SIRT1
        2245. PPARalpha/SIRT1 Complex is Involved in the Deterioration of Fatty Acid Metabolism During the Pathological Development of Heart Failure
        2246. SIRT1 protects cortical neurons from shear stress induced mechanical injury
        2247. GSPE enhance eNOS expression through AMPK/SIRT1–KLF2 pathway and modulate blood pressure in ouabain induced hypertensive rats
        2248. Inhibition of SIRT1 Transcription in Resveratrol-differentiated Medulloblastoma Cells
        2249. Construction of recombinant lentiviral vector of shRNA targeting SIRT1 gene and its effects on the proliferation of breast cancer cell
        2250. SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3.
        2251. The role of melatonin in SIRT1 and p-AMPK regulation in HT-29 cell line
        2252. Inhibition studies of SIRT1
        2253. Leucine modulation of AMPK and mitochondrial biogenesis in C2C12 myotubes is SIRT1 dependent
        2254. Relationship between SIRT1 expression in atrial tissue and atrial fibrosis in patients with atrial fibrillation
        2255. #VALUE!
        2256. Research on the Morphological Changes of Ischemic Cell Mediated via SIRT1 Pathway in the Intervention with Xuefu Zhuyu Capsules
        2257. Conjugated linoleic acid (CLA) activates PGC‐1alpha via AMPK and SIRT1 in C2C12 myotubes
        2258. Hepatic deletion of SIRT1 decreases HNF1α/FXR signaling and induces formation of cholesterol gallstones in mice
        2259. Caloric restriction ameliorates myocardial ischemia/reperfusion injury by suppressing complement activation in a SIRT1-dependent manner
        2260. Research on Effect of SIRT1 on Ameliorating Lipid Metabolism Disorder of Type 2 Diabetic Rats after Exercise and Oral Resveratrol [J]
        2261. Ezetimibe Inhibit Hyperacetylation of SREBP-1c in Lipid-Loaded Cells Derived from VSMC Required for SIRT1 [J]
        2262. Tafluprost Protects Human Trabecular Meshwork Cells From Oxidative Stress Through The Activation Of C-myc/SIRT1 Transcription Pathway
        2263. The Role of SIRT1 in Central Nervous System
        2264. Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI …
        2265. Adiponectin induces autophagic cell death in breast cancer cells through SIRT1 mediated deacetylation of LKB1 leading to ATG1 activation.
        2266. Effects of SIRT1 on material metabolism and influence factors
        2267. #VALUE!
        2268. Abstract A37: Beta-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J …
        2269. THU0033 SET7/9 and SIRT1 induce promoter-driven collagen 2ALPHA1 expression in 3D cultured human chodrocytes
        2270. SIRT1 limits the function and fate of myeloid-derived suppressor cells in
        2271. SIRT1 as a Potential Therapeutic Target in Breast Cancer
        2272. Research progress of SIRT1 in suppressing inflammatory response.
        2273. Activation of SIRT1 by an N-terminal Regulatory Domain
        2274. Examination of the reproductive effects of SIRT1 expression in neurons
        2275. The deacetylase SIRT1 is down-regulated in gastric cancer and leads to G1 phase
        2276. Role of SIRT1 in inflammation-associated carcinogenesis
        2277. SIRT1: A novel target for treatment in cardiovascular diseases
        2278. Roles of SIRT1 in tumorigenesis and tumor progression
        2279. Expression of SIRT1 in tissues of patients with gastric carcinoma
        2280. GW24-e2135 SIRT1 significantly influences Old sourced MSCs aging and proliferation
        2281. Deciphering the role of 75kDa SIRT1 fragment in osteoarthritis
        2282. The Role of SIRT1 in Preventing Mitochondrial Dysfunction with Obesity and Aging
        2283. Research advances in SIRT1 regulating microRNA
        2284. SIRT1-mediated suppression of cell death in breast cancer.
        2285. Co-location of SIRT1 and IR in the adult mouse brain
        2286. SIRT1 against breast cancer through downregulating Bcl-2 protein.
        2287. Unravelling New Roles for SIRT1 in Mitochondrial Biollogy
        2288. GW24-e3662 The comparative study on expression of SIRT1 signal transduction by Xuefuzhuyu capsule
        2289. Functional complementation of sir2Δ yeast mutation by the human orthologous gene SIRT1
        2290. THE LIPID SECOND MESSENGER PHOSPHATIDYLINOSITOL-5-PHOSPHATE STIMULATES SIRT1 DEACETYLASE ACTIVITY
        2291. Isolation and Characterization of New Sirtuin1 (SIRT1) Activators from Medicinal Plants
        2292. SIRT1 Inactivation Reduces Tumor Growth in Colon Cancer Model
        2293. Role of adipose SIRT1 in regulating systemic energy metabolism
        2294. Constitutive SIRT1 overexpression impairs mitochondria and
        2295. Influence of Mailuoning on SIRT1 expression of brain tissue in Alzheimer′ s disease rat model
        2296. The impact of SIRT1 inhibition on zebrafish morphology and behavior
        2297. Recent Advances of Deacetylase SIRT1 on Apoptosis Regulation
        2298. FLT3-ITD+ AML Stem/Progenitor Cells Demonstrate Increased SIRT1 Expression and Enhanced Sensitivity to SIRT1 Inhibition
        2299. Supression of SIRT1 in angiogenesis of endothelial cells induced by HCMV infection
        2300. Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
        2301. PPARdelta-SIRT1 Interaction Protects Endothelial Function in Diabetic Mice
        2302. The neuroprotective effects of SIRT1 on NMDA-induced excitotoxicity
        2303. Red Wine Molecule Makes a Comeback to Activate SIRT1
        2304. Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus
        2305. SIRT1 Mediated Mitochondrial Biogenesis for The Protection of RGC-5 Cell During Oxidative Stress
        2306. Leptin-induced SIRT1 expression: a potential linker between obesity and cancer
        2307. Role of SIRT1 in regulation of hepatic gene expression by thyroid hormone
        2308. The Role Of SIRT1 In The Pathogenesis Of Dry Age-related Macular Degeneration
        2309. The Effects of SIRT1 SiRNA on the Bloodfat and Actived Platelets in Insulin Resistance Mice
        2310. SIRT1 enhances Th17 cell generation by deacetylating RORγt (P1163)
        2311. Expression of SIRT1 and p27 during progression of human cervical cancer
        2312. Transgenic Mice Lacking SIRT1 or SIRT1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia
        2313. SIRT1 enhances endothelium‐dependent relaxation through an eNOS‐independent mechanism
        2314. Original article SIRT1-deficient mice exhibit an altered cartilage phenotype
        2315. Immunomodulation and Mechanism of Protein Deacetylase SIRT1
        2316. Screening of SIRT1 activating compounds and their cytotoxicity in prostate cancer cell lines.
        2317. PPARa Activation Inhibits Inflammatory Response in Endothelial Cells via the SIRT1-dependent Signaling Pathway
        2318. Contrasting Effects of Enhanced SIRT1 Activity in Normal and BCR-ABL1-Depedent Haematopoiesis
        2319. Regularity analysis of deacetylase SIRT1 expression in different pig organs and tissues
        2320. Keratinocyte-specific deletion in mice reveals gene dose-dependent function of SIRT1 in tumorigenesis.
        2321. Variant analysis of the Sirtuin [SIRT1] gene in multiple sclerosis
        2322. AMPK-SIRT1 axis: a potential therapeutic target for prostate cancer management.
        2323. Cloning and prokaryotic expression of SIRT1 gene from torafugu Takifugu rubripes
        2324. SIRT1 silencing confers neuroprotection through IGF-1 pathway activation
        2325. Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF
        2326. Interactions of SIRT1 with Acetyl Substrate, NAD+ or Nicotinamide
        2327. Adipocyte-selective disruption of SIRT1 accelerates high fat diet
        2328. Does resveratrol act independently of SIRT1 to affect genes relevant to ageing?
        2329. Preliminary research of the relationship between coronary artery atherosclerosis and the genetic expression of AMPK and SIRT1
        2330. MicroRNA-29c functions as a tumor suppressor by direct targeting endogenous SIRT1 in hepatocarcinogenesis
        2331. SIRT1 Delays RGC Loss Following Optic Nerve Crush By Reducing Oxidative Stress
        2332. SIRT1 links tumor suppressive NOTCH signaling to p53
        2333. Mechanism of anti-proliferative effects of SIRT1 inhibition in melanoma cells: a proteomics approach.
        2334. Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus
        2335. INHIBITION OF SIRT1 INDUCES APOPTOSIS IN BREAST CANCER STEM CELLS; POSTER PRESENTATION
        2336. The signal pathway of SIRT1 underlying the neuroprotection in NMDA-induced excitotoxicity
        2337. The novel SIRT1 activator srt3025 provides atheroprotection through increased hepatic low-density lipoprotein receptor expression
        2338. Regulation of Skeletal Muscle Insulin Action by SIRT1 and STAT3
        2339. Impact of SIRT1 silencing on DNA damage repair and chemoradiotherapy resistance in human pancreatic cancer
        2340. Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1ᴳ⁹³ᴬ transgenic mice as an in vivo model of amyotrophic …
        2341. Amelioration of Age-Related Vascular Dysfunction with SIRT1 Activation
        2342. Changes of PGC-1α and SIRT1 expression in hippocampus of type 2 diabetes mellitus rats and its significance
        2343. Effects of Endurance Exercise on Hepatic SIRT1 and PGC-1α Protein Expression in Ovariectomized Rats
        2344. Metformin regulates hyperglycemia-induced vascular senescence through SIRT1
        2345. Anti-aging Effects of Simvastatin on ox-LDL Induced Endothelial Cells Via Upregulation of SIRT1
        2346. Strategies of SIRT1 enhancement against frailty in aging and neurodegeneration
        2347. CDK5-MEDIATED HYPERPHOSPHORYLATION CONTRIBUTES TO THE LOSS-OF-SIRT1 FUNCTION DURING THE DEVELOPMENT OF ENDOTHELIAL …
        2348. FRI0036 Epigallocatechin gallate modulates SIRT1 expression in CPP crystal-induced inflammation
        2349. SIRT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1a complex in vascular endothelial cells
        2350. Evaluation of energy requirement in growing Lanyu pigs and the role of hepatic SIRT1 under different caloric levels.
        2351. Neuroprotective Role of Sirtuin (SIRT1) Against Hypoxia in Retinal Ganglion Cells
        2352. GW24-e0624 Impairted cardiac SIRT1 activity by carbonyl stress increase susceptibility of aged hearts to ischaemia reperfusion injury
        2353. Obesity Accelerates Ovarian Follicle Development and Loss through Supressing SIRT1 Signaling in Rats
        2354. The Relation between Resveratrol, SIRT1, mTOR and Autophagy
        2355. SIRT1 Protects Against Lung Endothelial Cell Dysfunction Following Particulate Matter Exposure
        2356. Influence of chidamide on proliferation, apoptosis with expression of Notch1 and SIRT1 in gastric carcinoma cell line SGC-7901
        2357. Eicosapentaenoic acid enhances nitric oxide production through up‐regulating SIRT1 expression in human endothelial cells
        2358. Disruption of SIRT1 in chondrocytes causes accelerated development of osteoarthritis induced by joint instability in the mouse
        2359. SIRT1 acutely modulates glucose sensing of POMC neurons in the hypothalamus
        2360. SIRT1 Regulation of the Heat Shock Response in an HSF1-Dependent Manner and the Impact of Caloric Restriction
        2361. Exploring the Possibility of Changes in SIRT1 Activity in Lipotoxicity-mediated β-cell Dysfunction
        2362. Correction: SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
        2363. Improvement Of Corneal Staining By A SIRT1 Activator In A Mouse Model Of Dry Eye
        2364. NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
        2365. MicroRNA-34a regulates diabetes-induced impaired angiogenesis: Role of SIRT1
        2366. Significance and expression of SIRT1 gene in human cervical endplate chondrocyte in vitro degeneration
        2367. Silencing of Pericyte MicroRNA-132 Reduces Renal Fibrosis and Myofibroblast Proliferation and is Associated with Altered SIRT1 and Cox2 Expression
        2368. The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells.
        2369. Expression Of FLT3-ITD Dysregulates The DBC1-SIRT1-p53 Signaling and Promotes Therapy Resistance
        2370. Targeted inhibition of SIRT1 histone deacetylase by small-molecule inhibitor Tenovin-1 imparts significant anti-proliferative effects in human melanoma cells
        2371. Cloning and prokaryotic expression of SIRT1 gene from torafugu Takifugu rubripes.
        2372. The CREB SIRT1 axis mediates Neural Stem Cells modulation by nutrient availability
        2373. Duration-and concentration-dependent induction of SIRT1 on human degenerative endplate chondrocytes by Resveratrol
        2374. Supplementary Figures The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
        2375. The Histone Deacetylase SIRT1 Modulates STAT3 Activity and Prevents De-differentiation and Proliferation of Vascular Smooth Muscle Cells
        2376. Sirtuin1 (SIRT1) regulates HBV transcription and replication by targeting transcription factor AP-1.
        2377. OP0256 SIRT1 Regulates Cigarette Smoke-Induced IL8 Expression and TNFA-Mediated Il6 Release in Rheumatoid Arthritis Synovial Fibroblasts
        2378. SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
        2379. New molecular insights in APE1 binding to nCaRE elements of gene promoters: identification of SIRT1 as novel target gene
        2380. Abolished Daily Expression Patterns of SIRT1, SIRT2, and SIRT5 in Human Chronic Myeloid Leukemia
        2381. SIRT1 is Associated with Age-related Susceptibility to Acute Kidney Injury caused by Ischemia-reperfusion in Mice
        2382. The growth arrest and apoptosis of adult T-cell leukemia cell lines MT2 induced by SIRT1 deacetylases inhibitor.
        2383. Moderate alcohol consumption alters hepatic AdipoR1/SREBP‐1c and SIRT1 activity in rats with pre‐existing NASH
        2384. SIRT1 regulates cigarette smoke-induced production of reactive oxygen species in myocardial mitochondria: Role of resveratrol [J]
        2385. Correlation between estrogen secretion and SIRT1 gene expression levels in porcine ovarian granulosa cells.
        2386. SIRT1 Activators Attenuate RGC Cell Loss By Reducing Oxidative Stress In MHV-A59 Induced Optic Neuritis
        2387. PGE2 cigarette smoke-induced modulates endothelial tissue factor: role of EP1 receptor and SIRT1
        2388. Combined Effect of Flow‐Mediated Shear Stress and Resveratrol on SIRT1/PGC‐1α Pathway in Vascular Endothelial Cells.
        2389. A SUMOylation-dependent pathway regulates SIRT1 transcription and cancer metastasis
        2390. Dimer Conversion of PPARalpha/RXR To PPARalpha/SIRT1 Suppresses Fatty Acid Oxidation Genes
        2391. Abstract A86: SIRT1 regulates Rac1-GTPase activation via the guanine nucleotide exchange factor TIAM1
        2392. SIRT1 antagonizes Stra13 Mediated p53 Acetylation and Senescence
        2393. Overcoming of radiochemoresistance in glioblastoma stem cells via inhibition of lipid catabolism and SIRT1 deacetylase.
        2394. Fullerenol Protects RPE cells from Oxidative-stress Induced Premature Senescence via Activation of SIRT1
        2395. Accelerated Senescence of Cord Blood Endothelial Progenitor Cells From Premature Neonates is Driven by SIRT1 Decreased Expression
        2396. Sirtuin (SIRT1/Sirt2) protect human pluripotent stem cells from DNA damage-induced apoptosis
        2397. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver
        2398. Age-Associated Reduction of SIRT1 in Vascular Smooth Muscle Accelerates Angiotensin II-Induced Vascular Aging and Abdominal Aortic Aneurysm in Mice
        2399. SIRT1 Activation with SRT1720 Reverses Impaired Endothelium‐Dependent Dilation in Old Mice by Augmenting COX‐2 Mediated Vasodilation
        2400. The Role of SIRT1 in Exercise-and Resveratrol-induced Muscle Mitochondrial Biogenesis
        2401. Inflammation and apoptosis in the synovium of patients with rheumatoid arthritis: the role of SIRT1 and microRNA-34a
        2402. Resveratrol Displays Cardioprotection in Postinfarction Remodeling Through Autophagic Activation Associated With Ampk but not SIRT1 Pathway
        2403. Epigenetic Regulation of p66Shc by SIRT1 Causes Persistent Myocardial Oxidative Stress and Inflammation Despite Optimal Glycemic Control in Diabetes
        2404. Quercetin can increase mRNA expression of PGC-1α and SIRT1, and mtDNA and cytochrome c in both skeletal muscle and brain.
        2405. Thrombosis Protection In Klkb1-/- (Prekallikrein KO) Mice Is Mediated By Increased Renal Mas Receptor, Plasma Prostacyclin, and Aortic SIRT1
        2406. Inhibition of SIRT1 Sensitizes TRAIL-Resistant MCF-7 Cells by Upregulation of DR5 and Inhibition of c-FLIP
        2407. The stability and bifurcation of modeling micro RNA regulation in signaling networks: miR-34a regulation of the p53/SIRT1 module
        2408. NAMPT/NAD+/SIRT1-Triggered Deacetylation Of Hematopoietic Cell-Specific Lyn-Substrate 1 (HCLS1) In Congenital Neutropenia
        2409. Resveratrol-induced activation of the SIRT1/AMPK axis in human CD4 T cells triggers replicative stress and an ATR-dependent cell cycle arrest
        2410. Abstract LB-133: A novel tumor suppressor role for SIRT1 inhibiting mitophagy in prostate mouse tissue.
        2411. Abstract LB-266: SIRT1 governs GnRH neuron migration and The Kallmann syndrome phenotype.
        2412. H2S and L‐Cysteine Increase the Glucose Utilization via the PIP3 Mediated Insulin Dependent (PI3K/AKT) and the Insulin Independent (SIRT1/AMPK/PPAR gamma) …
        2413. 496 Transgenic Mice Lacking SIRT1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia
        2414. Lycopene metabolite, apo‐10′‐lycopenoic acid, inhibits diet‐induced obesity‐promoted liver carcinogenesis via the up‐regulation of SIRT1 signaling and the …
        2415. POLY (ADP‐RIBOSE) POLYMERASE‐2 DEPLETION REDUCES DOXORUBICIN‐INDUCED DAMAGE THROUGH SIRT1 INDUCTION
        2416. Hematopoietic-specific lyn-substrate 1 (HCLS) is deacetylated by NAMPT/NAD+/SIRT1 pathway
        2417. HEMATOPOIETIC-SPECIFIC LYN-SUBSTRATE 1 (HCLS) IS DEACETYLAT-ED BY NAMPT/NAD+/SIRT1 PATHWAY
        2418. Phosphodiesterase-5 (PDE-5) Inhibitor, Tadalafil, Activates NO/SIRT1/PGC-1 Signaling And Attenuates Mitochondrial Dysfunction In Type 2 Diabetic Hearts
        2419. Linking lipids to acetylation novel roles of of PI (5) P and PIP4K in SIRT1 regulation and development
        2420. PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4 KINASE BETA (PIP4Kβ) BINDS TO AND IS DEACETYLATED BY SIRT1
        2421. Resveratrol Inhibits IL-6-induced STAT3 Activation in Human Colon Epithelial Cells: SIRT1 as a Potential Target
        2422. the effects of GLP-1 on SIRT1 and on the related metabolic pathways in vascular endothelial cells: potential effects on vascular injury in diabetic patients
        2423. Effect of crocin-1 on learning, memory, and expression of SIRT1 in hippocampus of rats under acute hypoxia
        2424. Angiogenesis Inhibitor Vasohibin-1 Prevents Paraquat-Induced Lung Injury Via The Induction Of SOD2 And SIRT1
        2425. Linking the pro‐oxidant influences of epigallocatechin gallate (EGCG) to intestinal cholesterol metabolism via alterations in sirtuin 1 (SIRT1) using Caco‐2 cells
        2426. Set7/9 represses SIRT1 to induce collagen type II expression in 3D cultured human chodrocytes
        2427. Identification of Novel Acetylation Sites in Nrf1 (NFE2L1) and Their Regulation by Sirtuin 1 (SIRT1)
        2428. Endothelial Overexpression of LOX-1 Protects From in vivo Arterial Thrombosis and Modulates Oct-1 and SIRT1 Expression
        2429. TP 40 Implication of SIRT1 and its downstream pathways in dystrophic process
        2430. … pancreatic beta cells from cytokine-induced apoptosis by both alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2\2013HO-1 and SIRT1
        2431. Sharp-1 Mediates p53-dependent cellular senescence through antagonism of SIRT1
        2432. Structural and functional analysis of human SIRT1
        2433. SIRT1 and other sirtuins in metabolism
        2434. SIRT1 in cardiovascular aging
        2435. Multifaceted modulation of SIRT1 in cancer and inflammation
        2436. SIRT1 in neurodevelopment and brain senescence
        2437. SIRT1 metabolic actions: integrating recent advances from mouse models
        2438. Small molecule SIRT1 activators for the treatment of aging and age-related diseases
        2439. SIRT1: role in cardiovascular biology
        2440. The role of SIRT1 in cancer: the saga continues
        2441. SIRT1 and NAD as regulators of ageing
        2442. The role of SIRT1 in diabetic kidney disease
        2443. SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases
        2444. SIRT1 in cerebral ischemia
        2445. Diverse roles of SIRT1 in cancer biology and lipid metabolism
        2446. SIRT1 and kidney function
        2447. SIRT1 is decreased during relapses in patients with multiple sclerosis
        2448. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
        2449. SIRT1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy
        2450. A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human
        2451. Downregulation of SIRT1 as aging change in advanced heart failure
        2452. Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
        2453. High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
        2454. SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress
        2455. P53 and SIRT1: routes of metabolism and genome stability
        2456. SIRT1 deacetylates RORγt and enhances Th17 cell generation
        2457. Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
        2458. An exploratory double‐blind, randomized clinical trial with selisistat, a SIRT1 inhibitor, in patients with H untington’s disease
        2459. Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
        2460. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21
        2461. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
        2462. Molecular links between caloric restriction and Sir2/SIRT1 activation
        2463. The N-terminal domain of SIRT1 is a positive regulator of endogenous SIRT1-dependent deacetylation and transcriptional outputs
        2464. NAD+-dependent activation of SIRT1 corrects the phenotype in a mouse model of mitochondrial disease
        2465. SIRT1 restrains lung inflammasome activation in a murine model of sepsis
        2466. SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
        2467. SIRT1/PGC1α-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer
        2468. SIRT1 in the brain—connections with aging-associated disorders and lifespan
        2469. MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
        2470. Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
        2471. Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
        2472. Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
        2473. Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
        2474. Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
        2475. SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
        2476. SIRT1 activation ameliorates renal fibrosis by inhibiting the TGF‐β/Smad3 pathway
        2477. Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes
        2478. Disruption of SIRT1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
        2479. SIRT1 suppresses doxorubicin-induced cardiotoxicity by regulating the oxidative stress and p38MAPK pathways
        2480. The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer
        2481. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: A mechanism including AMPKα1/SIRT1 [S]
        2482. Adversity in childhood and depression: linked through SIRT1
        2483. SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging
        2484. SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
        2485. Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis
        2486. SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
        2487. Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
        2488. Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut
        2489. Age-related loss of SIRT1 expression results in dysregulated human vascular smooth muscle cell function
        2490. The NAD+-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells
        2491. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through SIRT1 protein stabilization
        2492. SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer
        2493. Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
        2494. A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators
        2495. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
        2496. Spinal SIRT1 activation attenuates neuropathic pain in mice
        2497. Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells
        2498. Shear stress regulates endothelial cell autophagy via redox regulation and SIRT1 expression
        2499. Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice
        2500. Identification, stability and expression of SIRT1 antisense long non-coding RNA
        2501. A high-fat diet and NAD+ activate SIRT1 to rescue premature aging in cockayne syndrome
        2502. SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
        2503. SIRT1 is required in the male germ cell for differentiation and fecundity in mice
        2504. Relationship between mitochondrial DNA copy number and SIRT1 expression in porcine oocytes
        2505. Role of SIRT1 during the ageing process: relevance to protection of synapses in the brain
        2506. Age-dependent tissue expression patterns of SIRT1 in senescence-accelerated mice
        2507. Expression of SIRT1 and oxidative stress in diabetic dry eye
        2508. SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
        2509. Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats
        2510. Effects of exercise and body temperature on eNOS, SIRT1, SIRT3 and Hsp70 expression in rat plantaris muscles (1164.6)
        2511. The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
        2512. SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD+ and function in mice
        2513. SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β
        2514. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
        2515. Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
        2516. SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation
        2517. Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1
        2518. NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells
        2519. SIRT1 expression is associated with poor prognosis of lung adenocarcinoma
        2520. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
        2521. Intercellular interplay between SIRT1 signalling and cell metabolism in immune cell biology
        2522. mTOR, AMPK, and SIRT1: key players in metabolic stress management
        2523. Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver
        2524. Dual role of SIRT1 in UVB-induced skin tumorigenesis
        2525. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia
        2526. AMPK-dependent phosphorylation of GAPDH triggers SIRT1 activation and is necessary for autophagy upon glucose starvation
        2527. Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
        2528. SIRT1 protects pig oocyte against in vitro aging
        2529. Radioprotective and antioxidant effect of resveratrol in hippocampus by activating SIRT1
        2530. Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
        2531. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264. 7 cells
        2532. New indole–isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studies
        2533. Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
        2534. SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: an insight into endoplasmic reticulum stress response mechanism
        2535. SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma
        2536. SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer
        2537. Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes
        2538. Resveratrol activates duodenal SIRT1 to reverse insulin resistance in rats through a neuronal network
        2539. NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
        2540. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
        2541. SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells
        2542. Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
        2543. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
        2544. Role of SIRT1 in autoimmune demyelination and neurodegeneration
        2545. Association of genetic variants of SIRT1 with type 2 diabetes mellitus
        2546. SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo
        2547. Expression of SIRT1 and SIRT3 varies according to age in mice
        2548. Caloric restriction, resveratrol and melatonin: role of SIRT1 and implications for aging and related-diseases
        2549. Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia
        2550. SIRT1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury
        2551. SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α–dependent glycolysis
        2552. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1‐BMAL1 pathway
        2553. SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
        2554. A randomized, placebo-controlled study of SRT2104, a SIRT1 activator, in patients with moderate to severe psoriasis
        2555. … resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and …
        2556. SIRT1 directly regulates SOX2 to maintain self‐renewal and multipotency in bone marrow‐derived mesenchymal stem cells
        2557. The SIRT1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
        2558. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
        2559. Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells
        2560. SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
        2561. SIRT1 in B [a] P-induced lung tumorigenesis
        2562. The deacetylase SIRT1 is an essential regulator of Aire-mediated induction of central immunological tolerance
        2563. SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens
        2564. Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy
        2565. SIRT1 and AMPK mediate hypoxia-induced resistance of non–small cell lung cancers to cisplatin and doxorubicin
        2566. SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells
        2567. SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
        2568. Age-associated weight gain, leptin, and SIRT1: a possible role for hypothalamic SIRT1 in the prevention of weight gain and aging through modulation of leptin …
        2569. SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and …
        2570. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
        2571. The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy
        2572. SIRT1 knockdown promotes neural differentiation and attenuates the heat shock response
        2573. Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness
        2574. ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling
        2575. SIRT1 regulates lamellipodium extension and migration of melanoma cells
        2576. SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow
        2577. Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance
        2578. Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and SIRT1
        2579. Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
        2580. In vivo RNA interference models of inducible and reversible SIRT1 knockdown in kidney cells
        2581. PRMT1 and PRMT4 regulate oxidative stress-induced retinal pigment epithelial cell damage in SIRT1-dependent and SIRT1-independent manners
        2582. SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer
        2583. A phase II, randomized, placebo‐controlled, double‐blind, multi‐dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes
        2584. Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
        2585. SIRT1 counteracted the activation of STAT3 and NF-κB to repress the gastric cancer growth
        2586. Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression
        2587. Differential roles of SIRT1 in HIF-1α and HIF-2α mediated hypoxic responses
        2588. Sirtuin1 (SIRT1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors
        2589. Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a SIRT1‐independent manner
        2590. SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells
        2591. Fasting protects liver from ischemic injury through SIRT1-mediated downregulation of circulating HMGB1 in mice
        2592. The p53/miR-34a/SIRT1 positive feedback loop in quercetin-induced apoptosis
        2593. Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1
        2594. Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
        2595. Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
        2596. SIRT1 protects against oxidative stress‐induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation
        2597. Piceatannol and its metabolite, isorhapontigenin, induce SIRT1 expression in THP-1 human monocytic cell line
        2598. Oxidative stress-induced inhibition of SIRT1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
        2599. Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SIRT1 and AMPK
        2600. The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1
        2601. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway
        2602. Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
        2603. Association between the SIRT1 mRNA expression and acute coronary syndrome
        2604. SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells
        2605. Overexpression of SIRT1 induced by resveratrol and inhibitor of miR-204 suppresses activation and proliferation of microglia
        2606. SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis
        2607. Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic …
        2608. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression
        2609. NAD+-dependent SIRT1 deactivation has a key role on ischemia–reperfusion-induced apoptosis
        2610. Attenuation of β‐amyloid‐induced tauopathy via activation of CK2α/SIRT1: Targeting for cilostazol
        2611. Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5
        2612. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating SIRT1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat …
        2613. Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1
        2614. Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway
        2615. Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease
        2616. Linking DNA damage, NAD+/SIRT1, and aging
        2617. SIRT1 plays a protective role in intervertebral disc degeneration in a puncture-induced rodent model
        2618. Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat
        2619. Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue …
        2620. Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma
        2621. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis
        2622. Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/SIRT1/PGC-1α signaling
        2623. Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice
        2624. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
        2625. Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of SIRT1 and Mn-SOD pathway
        2626. SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation
        2627. SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease
        2628. Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-κB activation
        2629. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the SIRT1/AMPK and the Nrf2/antioxidant defense pathways in a …
        2630. Metformin induces microRNA-34a to downregulate the SIRT1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress …
        2631. Ligand and structure-based approaches for the identification of SIRT1 activators
        2632. Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis
        2633. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
        2634. Resveratrol protects against doxorubicin‐induced cardiotoxicity in aged hearts through the SIRT1‐USP7 axis
        2635. Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet
        2636. Ketosis may promote brain macroautophagy by activating SIRT1 and hypoxia-inducible factor-1
        2637. Specific turn-on fluorescent probe with aggregation-induced emission characteristics for SIRT1 modulator screening and living-cell imaging
        2638. SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
        2639. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis
        2640. Over-expression of SIRT1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC)
        2641. Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through SIRT1‐mediated deacetylation
        2642. MicroRNA-34a induces vascular smooth muscle cells senescence by SIRT1 downregulation and promotes the expression of age-associated pro-inflammatory …
        2643. Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes
        2644. Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells
        2645. Safety, pharmacokinetics, pharmacogenomics and QT concentration− effect modelling of the SIRT1 inhibitor selisistat in healthy volunteers
        2646. Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype
        2647. Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1
        2648. Resveratrol induced premature senescence is associated with DNA damage mediated SIRT1 and SIRT2 down-regulation
        2649. … -specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways
        2650. Reduced thrombosis in Klkb1−/− mice is mediated by increased Mas receptor, prostacyclin, SIRT1, and KLF4 and decreased tissue factor
        2651. Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the SIRT1 …
        2652. … of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways
        2653. SIRT1 is a tumor promoter in lung adenocarcinoma
        2654. Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation
        2655. Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis
        2656. SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus
        2657. High glucose induces renal tubular epithelial injury via SIRT1/NF-kappaB/microR-29/Keap1 signal pathway
        2658. SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization
        2659. SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
        2660. Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
        2661. Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α
        2662. Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats
        2663. Polydatin alleviates small intestine injury during hemorrhagic shock as a SIRT1 activator
        2664. Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway
        2665. Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss
        2666. SIRT1-deficiency causes defective protein quality control
        2667. Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/SIRT1 activation
        2668. Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach
        2669. Loss of SIRT1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer
        2670. Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model
        2671. SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling
        2672. Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1/p300/p53/p21 pathway
        2673. Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1
        2674. miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
        2675. Minireview: central SIRT1 regulates energy balance via the melanocortin system and alternate pathways
        2676. SIRT1 relays nutritional inputs to the circadian clock through the Sf1 neurons of the ventromedial hypothalamus
        2677. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1
        2678. The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy
        2679. Pyrroloquinoline quinone increases the expression and activity of SIRT1 and-3 genes in HepG2 cells
        2680. A divergent role of the SIRT1-TopBP1 axis in regulating metabolic checkpoint and DNA damage checkpoint
        2681. SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression
        2682. SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth
        2683. TNF‐α and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells
        2684. Macrophage‐specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP‐9 pathways
        2685. miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
        2686. Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis
        2687. Hypothalamic SIRT1 in aging
        2688. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation
        2689. Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia
        2690. The SIRT1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response
        2691. High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased …
        2692. Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure
        2693. Effect of resveratrol, a SIRT1 activator, on the interactions of the CLOCK/BMAL1 complex
        2694. A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population
        2695. … acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
        2696. Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease
        2697. Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
        2698. SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation
        2699. Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes
        2700. Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort
        2701. Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovary
        2702. Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts
        2703. SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss
        2704. α-Mangostin regulates hepatic steatosis and obesity through SIRT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice
        2705. Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin 3
        2706. Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide
        2707. Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc …
        2708. Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis
        2709. SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection in angiotensin II-induced heart hypertrophy
        2710. SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage
        2711. Loss of SIRT1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria
        2712. Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice
        2713. Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress
        2714. SIRT1 suppresses human T-cell leukemia virus type 1 transcription
        2715. SIRT1 Polymorphisms Associate with Seasonal Weight Variation, Depressive Disorders, and Diastolic Blood Pressure in the General Population
        2716. MiR-34a inhibits migration and invasion by regulating the SIRT1/p53 pathway in human SW480 cells
        2717. Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1
        2718. SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids
        2719. A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling
        2720. SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes
        2721. The effect of alcohol on SIRT1 expression and function in animal and human models of hepatocellular carcinoma (HCC)
        2722. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity
        2723. Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis
        2724. Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation
        2725. AROS has a context-dependent effect on SIRT1
        2726. Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis
        2727. … antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of SIRT1-Sirt3-Foxo3-PINK1 …
        2728. SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells
        2729. Liquid fructose downregulates SIRT1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
        2730. Involvement of AMPK/SIRT1 pathway in anti-allodynic effect of troxerutin in CCI-induced neuropathic pain
        2731. Simiao pill ameliorates renal glomerular injury via increasing SIRT1 expression and suppressing NF-κB/NLRP3 inflammasome activation in high fructose-fed rats
        2732. FoxM1 regulates SIRT1 expression in glioma cells
        2733. Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1
        2734. Fullerenol protects retinal pigment epithelial cells from oxidative stress–induced premature senescence via activating SIRT1
        2735. … SIRT1 activators SRT2183 and SRT3025 inhibit RANKL-induced osteoclastogenesis in bone marrow-derived macrophages and down-regulate Sirt3 in SIRT1 …
        2736. AGEs-RAGE system down-regulates SIRT1 through the ubiquitin-proteasome pathway to promote FN and TGF-β1 expression in male rat glomerular mesangial cells
        2737. SIRT1-metabolite binding histone macroH2A1. 1 protects hepatocytes against lipid accumulation
        2738. SIRT1 inhibition affects angiogenic properties of human MSCs
        2739. Intestine-specific deletion of SIRT1 in mice impairs DCoH2–HNF-1α–FXR signaling and alters systemic bile acid homeostasis
        2740. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of SIRT1-mediated apoptosis
        2741. Short‑term calorie restriction activates SIRT1‑4 and‑7 in cardiomyocytes in vivo and in vitro
        2742. Curcumin attenuates hydrogen peroxide-induced premature senescence via the activation of SIRT1 in human umbilical vein endothelial cells
        2743. Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors
        2744. Pancreas-specific SIRT1-deficiency in mice compromises beta-cell function without development of hyperglycemia
        2745. Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes
        2746. HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA
        2747. SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27
        2748. Isocaloric pair-fed high-carbohydrate diet induced more hepatic steatosis and inflammation than high-fat diet mediated by miR-34a/SIRT1 axis in mice
        2749. Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation
        2750. Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRα signaling in THP-1 macrophage-derived foam cells
        2751. Regulation of cell cycle regulators by SIRT1 contributes to resveratrol-mediated prevention of pulmonary arterial hypertension
        2752. Nutraceutical activators of AMPK/SIRT1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection
        2753. Investigating the role of SIRT1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson’s disease
        2754. Humulus japonicus extract exhibits antioxidative and anti‑aging effects via modulation of the AMPK‑SIRT1 pathway
        2755. SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing
        2756. SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling
        2757. KAP1 deacetylation by SIRT1 promotes non-homologous end-joining repair
        2758. SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis
        2759. Histone/protein deacetylase SIRT1 is an anticancer therapeutic target
        2760. New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng
        2761. The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin
        2762. Cilostazol upregulates autophagy via SIRT1 activation: reducing amyloid-β peptide and APP-CTFβ levels in neuronal cells
        2763. SIRT1 gene variants are related to risk of childhood obesity
        2764. Set7/9 Impacts COL2A1 Expression Through Binding and Repression of SIRT1 Histone Deacetylation
        2765. Defective mitophagy in XPA via PARP-1 hyperactivation and NAD+/SIRT1 reduction
        2766. Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax ginseng
        2767. Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer …
        2768. Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet …
        2769. MicroRNAs and SIRT1: a strategy for stem cell renewal and clinical development?
        2770. Calorie restriction prevents metabolic aging caused by abnormal SIRT1 function in adipose tissues
        2771. The metabolic sensors FXRα, PGC‐1 α, and SIRT1 cooperatively regulate hepatitis B virus transcription
        2772. Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells
        2773. Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent SIRT1 upregulation
        2774. Aspirin targets SIRT1 and AMPK to induce senescence of colorectal carcinoma cells
        2775. SIRT1 and FOXO mediate contractile differentiation of vascular smooth muscle cells under cyclic stretch
        2776. SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner
        2777. Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis
        2778. Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β‐amyloid through activation of SIRT1/Akt1 pathway
        2779. Antagonistic crosstalk between SIRT1, PARP-1, and-2 in the regulation of chronic inflammation associated with aging and metabolic diseases
        2780. Protective effects of icariin‑mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion‑induced acute lung injury
        2781. Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice
        2782. SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through …
        2783. Fisetin induces SIRT1 expression while inhibiting early adipogenesis in 3T3-L1 cells
        2784. Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition
        2785. Modulation of the AMPK/SIRT1 axis during neuronal infection by herpes simplex virus type 1
        2786. Electroacupuncture upregulates SIRT1-dependent PGC-1α expression in SAMP8 Mice
        2787. Peripheral leukocyte expression of the potential biomarker proteins Bdnf, SIRT1, and Psen1 is not regulated by promoter methylation in Alzheimer’s disease patients
        2788. Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling
        2789. Prognostic role of SIRT1 in hepatocellular carcinoma
        2790. Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells
        2791. Palmitate inhibits SIRT1-dependent BMAL1/CLOCK interaction and disrupts circadian gene oscillations in hepatocytes
        2792. Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death
        2793. Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin
        2794. TNFα regulates SIRT1 cleavage during ocular autoimmune disease
        2795. Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway
        2796. SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: effect of starvation
        2797. SIRT1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation
        2798. MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of SIRT1
        2799. Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway
        2800. Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of SIRT1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells
        2801. Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1
        2802. Chronic pancreatitis and pancreatic cancer demonstrate active epithelial–mesenchymal transition profile, regulated by miR-217-SIRT1 pathway
        2803. Visfatin/Nampt and SIRT1
        2804. Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1
        2805. BET inhibition upregulates SIRT1 and alleviates inflammatory responses
        2806. SIRT1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet
        2807. SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner
        2808. Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia
        2809. Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure
        2810. Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation
        2811. Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure
        2812. Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors
        2813. Programmed hyperphagia secondary to increased hypothalamic SIRT1
        2814. Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle
        2815. Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance
        2816. Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i
        2817. The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells
        2818. Differential SIRT1 expression in hepatocellular carcinomas and cholangiocarcinoma of the liver
        2819. Guignardins A–F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp. KcF8 as a new class of PTP1B and SIRT1 inhibitors
        2820. Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo
        2821. Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats
        2822. Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1
        2823. SIRT1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration
        2824. Fentanyl increases colorectal carcinoma cell apoptosis by inhibition of NF-κB in a SIRT1-dependent manner
        2825. Vitamin C protected human retinal pigmented epithelium from oxidant injury depending on regulating SIRT1
        2826. The miR-29b–SIRT1 axis regulates self-renewal of mouse embryonic stem cells in response to reactive oxygen species
        2827. Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
        2828. CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression
        2829. Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway
        2830. Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders
        2831. SIRT1 and STAT3 protect retinal pigmented epithelium cells against oxidative stress
        2832. SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes
        2833. SIRT1 gene is associated with cardiovascular disease in the Iranian population
        2834. SIRT1 Overexpression Maintains Cell Phenotype and Function of Endothelial Cells Derived from Induced Pluripotent Stem Cells
        2835. Coumestrol induces mitochondrial biogenesis by activating SIRT1 in cultured skeletal muscle cells
        2836. The comparative study on expression of SIRT1 signal transduction by Xuefuzhuyu capsule
        2837. Globular adiponectin causes tolerance to LPS-induced TNF-α expression via autophagy induction in RAW 264.7 macrophages: involvement of SIRT1/FoxO3A …
        2838. Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells
        2839. Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1
        2840. The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/SIRT1/PGC-1α signaling
        2841. Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1
        2842. Effect of shikonin on multidrug resistance in HepG2: The role of SIRT1
        2843. SIRT1 rescues the obesity induced by insulin‐resistant constitutively‐nuclear FoxO1 in POMC neurons of male mice
        2844. Licochalcone suppresses LXRα-induced hepatic lipogenic gene expression through AMPK/SIRT1 pathway activation
        2845. Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, SIRT1 and mitogen-activated protein kinase signalling …
        2846. Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice
        2847. Acetylcholinesterase inhibitors and compounds promoting SIRT1 expression from Curcuma xanthorrhiza
        2848. Correction: SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
        2849. Butyric acid-induced rat jugular blood cytosolic oxidative stress is associated with SIRT1 decrease
        2850. … ‐3‐glucoside protects human umbilical vein endothelial cells against oxidized low‐density lipoprotein‐induced injury by autophagy upregulation via the AMPK/SIRT1 …
        2851. MicroRNA-204-5p–mediated regulation of SIRT1 contributes to the delay of epithelial cell cycle traversal in diabetic corneas
        2852. … functions as a potent suppressor of oncogene‐induced senescence in prostate cancer via its transcriptional co‐regulation of the CDKN1A (p21WAF1/CIP1) and SIRT1 …
        2853. SIRT1 mediates a primed response to immune challenge after traumatic lung injury
        2854. SIRT1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers
        2855. Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β
        2856. Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway
        2857. SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II–V functions in individual …
        2858. The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle
        2859. Silent information regulator 1 (SIRT1) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway
        2860. Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats
        2861. MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function
        2862. RhNRG-1β protects the myocardium against irradiation-induced damage via the ErbB2-ERK-SIRT1 signaling pathway
        2863. The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest
        2864. Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial …
        2865. A novel role of SIRT1 in gammaherpesvirus latency and replication
        2866. Cooperative action of Cdk1/cyclin B and SIRT1 is required for mitotic repression of rRNA synthesis
        2867. SIRT1 mediates the effects of a short-term high-fat diet on the heart
        2868. Celecoxib Sensitizes Staphylococcus aureus to Antibiotics in Macrophages by Modulating SIRT1
        2869. Silencing angiopoietin‐like protein 4 (ANGPTL4) protects against lipopolysaccharide‐induced acute lung injury via regulating SIRT1/NF‐kB pathway
        2870. Dysregulated miR-34a–SIRT1–acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of …
        2871. Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes
        2872. Hepatic SIRT1-dependent gain of function of stearoyl-CoA desaturase-1 conveys dysmetabolic and tumor progression functions
        2873. Endoplasmic reticulum (ER) stress induces sirtuin 1 (SIRT1) expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury
        2874. Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation and mitochondrial dysfunction in the testis
        2875. SIRT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation
        2876. The SIRT1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice
        2877. Reversible acetylation of Lin28 mediated by PCAF and SIRT1
        2878. WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance
        2879. Visfatin is involved in TNFα-mediated insulin resistance via an NAD+/SIRT1/PTP1B pathway in 3T3-L1 adipocytes
        2880. SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing
        2881. SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells
        2882. SIRT1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice
        2883. SIRT1 synchs satellite cell metabolism with stem cell fate
        2884. Fructose mediated non-alcoholic fatty liver is attenuated by HO-1-SIRT1 module in murine hepatocytes and mice fed a high fructose diet
        2885. Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis
        2886. A novel mutation in SIRT1-AS leading to a decreased risk of HCC
        2887. Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
        2888. Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress
        2889. Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells
        2890. Effects of nitric oxide synthase inhibition on fiber-type composition, mitochondrial biogenesis, and SIRT1 expression in rat skeletal muscle
        2891. SIRT1 activation ameliorates aldara-induced psoriasiform phenotype and histology in mice
        2892. Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells
        2893. Potato protein hydrolysate attenuates high fat diet-induced cardiac apoptosis through SIRT1/PGC-1a/Akt signalling
        2894. Functional sequence variants within the SIRT1 gene promoter in indirect inguinal hernia
        2895. Central SIRT1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced …
        2896. Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells
        2897. AAV8-mediated SIRT1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease
        2898. Enhancement in efferocytosis of oxidized low‑density lipoprotein-induced apoptotic RAW264. 7 cells through SIRT1-mediated autophagy
        2899. Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat
        2900. Gene expression profiling of SIRT1, FoxO1, and PPARγ in backfat tissues and subcutaneous adipocytes of Lilu bulls
        2901. Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer
        2902. Methylation gets into rhythm with NAD+-SIRT1
        2903. Quantitative insights for the design of substrate-based SIRT1 inhibitors
        2904. SIRT1 regulates autophagy and diploidization in parthenogenetic haploid embryonic stem cells
        2905. Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival
        2906. Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis
        2907. Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer
        2908. Stem cell transplantation upregulates SIRT1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice
        2909. Regulation of HepG2 cell apoptosis by hepatitis C virus (HCV) core protein via the SIRT1–p53–bax pathway
        2910. Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews
        2911. 5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-SIRT1 axis
        2912. Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy
        2913. Resveratrol relieves hydrogen peroxide-induced premature senescence associated with SIRT1 in human mesenchymal stem cells
        2914. Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord
        2915. Molecular characterization, expression profiles, and analysis of Qinchuan cattle SIRT1 gene association with meat quality and body measurement traits (Bos taurus)
        2916. Endothelial cell senescence increases traction forces due to age-associated changes in the glycocalyx and SIRT1
        2917. SIRT1 modulates miRNA processing defects in p53-mutated human keratinocytes
        2918. Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, SIRT1, and mitochondrial function
        2919. Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc
        2920. Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer
        2921. Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract
        2922. Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1
        2923. SIRT1 interacts with and deacetylates ATP6V1B2 in mature adipocytes
        2924. Central SIRT1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced …
        2925. Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs
        2926. Acetylome analysis identifies SIRT1 targets in mRNA-processing and chromatin-remodeling in mouse liver
        2927. Resveratrol Regulates the Quiescence‐Like Induction of Activated Stellate Cells by Modulating the PPARγ/SIRT1 Ratio
        2928. Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of SIRT1
        2929. Suppression of RANKL-induced osteoclast differentiation by cilostazol via SIRT1-induced RANK inhibition
        2930. MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic …
        2931. Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy
        2932. Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora
        2933. Nicotinamide and resveratrol regulate bovine adipogenesis through a SIRT1-dependent mechanism
        2934. Mass spectrometric studies on the in vivo metabolism and excretion of SIRT1 activating drugs in rat urine, dried blood spots, and plasma samples for doping control …
        2935. Expression of SIRT1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: implications for immune dysregulation, prognosis and …
        2936. JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression
        2937. The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling
        2938. Taurine attenuates amyloid β 1–42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells
        2939. Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
        2940. MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular …
        2941. MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1
        2942. Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro
        2943. Myeloid-specific deletion of SIRT1 increases hepatic steatosis and hypothalamic inflammation in mice fed a high-fat diet
        2944. The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells
        2945. Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway
        2946. Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway
        2947. Effect of nasal CPAP on SIRT1 and endothelial function in obstructive sleep apnea syndrome
        2948. SIRT1 and HMGB1 Regulate the AGE-Induced Pro-Inflammatory Cytokines in Human Retinal Cells.
        2949. miR-27b overexpression improves mitochondrial function in a SIRT1-dependent manner
        2950. CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a SIRT1-independent manner
        2951. Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model
        2952. Myeloid-specific SIRT1 deletion aggravates hepatic inflammation and steatosis in high-fat diet-fed mice
        2953. Role of SIRT1 in the protection of intestinal epithelial barrier under hypoxia and its mechanism
        2954. SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair
        2955. Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation
        2956. SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma
        2957. … peroxisome proliferator-activated receptor-δ and-γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1
        2958. SIRT1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis
        2959. Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of SIRT1/Mn-SOD and GRP78/caspase-12 pathways
        2960. … ‑enriched exopolysaccharides produced by Enterobacter cloacae Z0206 alleviate adipose inflammation in diabetic KKAy mice through the AMPK/SIRT1 …
        2961. Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities
        2962. Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells
        2963. Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target
        2964. Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/SIRT1/Pgc1α pathway
        2965. Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1alpha pathway in mice with NASH
        2966. Alteration in bioenergetic regulators, SIRT1 and Parp1 expression precedes oxidative stress in rats subjected to transient cerebral focal ischemia: molecular and …
        2967. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1
        2968. Fuzhisan, a chinese herbal medicine, suppresses beta-secretase gene transcription via upregulation of SIRT1 expression in N2a-APP695 cells
        2969. SIRT1 is reduced in gastric adenocarcinoma and acts as a potential tumor suppressor in gastric cancer
        2970. Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem
        2971. Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma
        2972. Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals: A Case …
        2973. CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase
        2974. Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-κB pathways and expressions of IGF-1R, SIRT1, COX-2, and FASN in peripheral …
        2975. SIRT1 regulates microtubule dynamics through negative regulation of Plk1 in mitosis
        2976. Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD+/NADH Ratio and SIRT1
        2977. … the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-deacetylase and peroxisome …
        2978. The Effect of SIRT1 Gene Polymorphisms on Ambulatory Blood Pressure of Hypertensive Patients in the Kazakh Population
        2979. Interaction between NLRP3 inflammasome and SIRT1/6: metabolomics approach
        2980. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1
        2981. IL-15 is required for postexercise induction of the pro-oxidative mediators PPARδ and SIRT1 in male mice
        2982. The effect of SIRT1 protein knock down on PGC-1α acetylation during skeletal muscle contraction
        2983. Role of SIRT1 in Streptococcus pneumoniae-induced human β-defensin-2 and interleukin-8 expression in A549 cell
        2984. The role of SIRT1 in bile acid regulation during calorie restriction in mice
        2985. #VALUE!
        2986. A Nampt inhibitor FK866 mimics vitamin B 3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD+-SIRT1 signaling
        2987. SIRT1 promote GTM cell DSBs repair and resist cellular senescence
        2988. PPARα agonist WY-14643 induces SIRT1 activity in rat fatty liver ischemia-reperfusion injury
        2989. 3, 5, 4′-Tri-O-acetylresveratrol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via MAPK/SIRT1 pathway
        2990. VEGF receptor-2–linked PI3K/calpain/SIRT1 activation mediates retinal arteriolar dilations to VEGF and shear stress
        2991. Resveratrol: brain effects on SIRT1, GPR50 and photoperiodic signaling
        2992. Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced …
        2993. Differential effect of estradiol and bisphenol A on Set8 and SIRT1 expression in prostate cancer
        2994. Nontoxic-dose of deguelin induce NPMC+ aml cell differentiation by selectively targeting MT NPM1/SIRT1 instead of HDAC1/3
        2995. Inflammation contributes to NKX3. 1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression
        2996. Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and SIRT1 expression
        2997. CYP epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity through SIRT1
        2998. … acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon …
        2999. Vitamin D (VD) prevents oxidative stress via regulating NOX4/Nrf2/Trx signaling cascade and upregulates SIRT1‐mediated AMPK/IRS1/GLUT4 pathway and glucose …
        3000. The effect of the SIRT1 2827 A> G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease
        3001. Up-regulation of the Sirtuin 1 (SIRT1) and Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Genes in White Adipose Tissue of Id1 Protein-deficient …
        3002. Photobiomodulation on Bax and Bcl-2 Proteins and SIRT1/PGC-1α Axis mRNA Expression Levels of Aging Rat Skeletal Muscle
        3003. Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells
        3004. The SIRT1 promoter polymorphic site rs12778366 increases IL-6 related human mortality in the prospective study “Treviso Longeva (TRELONG)”
        3005. Upregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy
        3006. Improved Expression of SIRT1 on Thymic Epithelial Cells of SAMP10 after Intrabone Marrow–Bone Marrow Transplantation
        3007. β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
        3008. SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights
        3009. MiR-34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte FGF21 signaling and SIRT1 function
        3010. SIRT1 silencing suppresses prostate cancer growth and metastasis in an orthotopic prostate cancer mouse model
        3011. SIRT1 inhibition suppresses multiple sclerosis
        3012. The cytokine homeostasis was regulated by over-expression of SIRT1 in collagen-induced arthritis mice
        3013. The role of SIRT1 in the treatment of diabetic nephropathy
        3014. Structure–activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole
        3015. The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1α (Gly482Ser), UCP2− 866 G/A and SIRT1− 1400 T/C polymorphisms with T2D in …
        3016. Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue
        3017. Effects of Vam3 on sodium nitroprusside-induced apoptosis and SIRT1 and p53 expression in rat articular chondrocytes
        3018. RETRACTED: Role of mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes
        3019. Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
        3020. SIRT1 and rRNA in the nucleolus: regulating the regulator
        3021. Effect of SIRT1 on cellular apoptosis and steroidogenesis in bovine ovarian granulosa cells in vitro
        3022. Effects of single and combined genotypes of SIRT1 and SIRT2 genes on meat quality traits in Qinchuan cattle.
        3023. Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA …
        3024. CD150− Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1
        3025. Docosahexaenoic acid inhibits white Adipogenesis and enhances mitochondrial biogenesis through SIRT1 and Hh signaling
        3026. SIRT1 and Osteoarthritis. Comments on the Paper by Gabay Et Al.:” SIRT1-deficient Mice Exhibit an Altered Cartilage Phenotype”, Joint Bone Spine 2013
        3027. Novel therapies for cancer treatment: designing high affinity and selectivity ligands against SIRT1
        3028. A knockout Combo: eradicating AML Stem Cells with TKI plus SIRT1 inhibition
        3029. Valproic acid suppresses SIRT1 inducing hepatotoxicity
        3030. SIRT1, IGFBP-3 and CAV1 promoter DNA methylation in aging
        3031. Benzothiazole derivatives upregulate SIRT1 and relevant genes in high-fat fed C57BL/6J mice
        3032. Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity
        3033. Synthesis of four SIRT1 activators based on an imidazo [1, 2-b] thiazole structure, in vitro derived metabolites and deuterated analogs
        3034. Cigarette smoke impairs SIRT1 activity and promotes pro-inflammatory responses in bronchial epithelial cells
        3035. microRNA‐34a mediates impaired angiogenesis in diabetes: role of SIRT1 and metformin (1051.2)
        3036. Effect of a new dietary SIRT1 activator on high fat diet‐induced obesity and the involvement of microRNAs
        3037. Cinnamon polyphenols increase oxygen‐glucose deprivation of decreased PGE2 production by upregulation of SIRT1 and alleviation of the anti‐inflammatory effects …
        3038. Correlation between polymorphisms of SIRT1 gene and carcass traits in beef cattle.
        3039. Mammary gland-specific deletion of SIRT1 delays mammary tumor growth and progression
        3040. Analysis of expression Of SIRT1 gene in patients with chronic myeloid leukemia resistant to imatinib mesylate
        3041. Correction: SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264. 7 Cells
        3042. High dose of epigallocatechin-3-gallate inhibits proliferation and induces apoptosis of H9C2 cardiomyocytes through down-regulation of SIRT1
        3043. A TiO 2-Au–polymer hybrid system for the photoelectrochemical immunoassay of SIRT1
        3044. SIRT1 as a key factor for histone code establishment in early embryo, from a perspective of assisted reproduction
        3045. Danshensu delays the senescence of rat aortic endothelial cells via activation of SIRT1-SOD pathway
        3046. GW25-e1653 SIRT1 enhances therapeutic efficacy of aged mesenchymal stem cells in rat myocardial infarction via lightening MSCs aging and heightening stress …
        3047. Genistein promotes a gene expression profile characteristic of brown rather than white adipocytes and increases SIRT1 expression in mouse NIH3T3‐L1 cells (372.7)
        3048. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1
        3049. 17β-Estradiol attenuates hematoma expansion through ERα/SIRT1/NF-κB pathway in hyperglycemic intracerebral hemorrhage mice
        3050. GW25-e2369 Lipoic acid inhibits oxidative stress-induced premature senescence via upregulation of SIRT1 in human umbilical vascular endothelial cells
        3051. OP0216 Resveratrol ameliorates pulmonary fibrosis and inhibits human lung fibroblasts activation VIA modulating SIRT1 and GLI1 signaling
        3052. Research progress on SIRT1-FoxO-autophagy pathway
        3053. Crystallographic Structure of a Small Molecule SIRT1 Activator/Enzyme Complex
        3054. Correction: Globular Adiponectin Causes Tolerance to LPS-Induced TNF-α Expression via Autophagy Induction in RAW 264.7 Macrophages: Involvement of SIRT1 …
        3055. SIRT1 and Inflammaging in Chronic Obstructive Pulmonary Disease
        3056. P79 SIRT1 modulates endoplasmic reticulum stress-induced autophagy in heart.
        3057. Effects of dietary restriction on antioxidant capacity and SIRT1 expression in hyperlipideima mice
        3058. Construction of elderly SIRT1 gene knockout mouse models of knee osteoarthritis
        3059. Tetramethylpyrazine (TMP) switches energy signalling from the PKCζ-GLUT4-glucose pathway back to the SIRT1-CD36-fatty acid pathway similar to …
        3060. PPARα Association With SIRT1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart
        3061. AB199. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
        3062. Jamming Up the “β-Staple”: Regulation of SIRT1 Activity by Its C-Terminal Regulatory Segment (CTR)
        3063. GW25-e3514 resveratrol alleviates diabetic cardiomyopathy through improvement of mitochondrial biogenesis and function in a SIRT1-dependent manner
        3064. Protective effect of SIRT1 on rat mesangial cells by decreasing high glu-cose-induced acetylation of NF-κB p65
        3065. Hyperoxia induces reactive oxygen species production and promotes SIRT1 nucleocytoplasmic shuttling of peripheral blood mononuclear cells in premature infants in …
        3066. Podocyte SIRT1 Deficiency Contributes to Albuminuria and Renal Fibrosis in Diabetic Kidney Damage in Mice
        3067. Research progression of SIRT1
        3068. SIRT1 inhibits related protein expression of endoplasmic reticulum stress in myocardial ischemic/reperfusion by activation of ERK1/2 pathway in rat
        3069. Expression of SIRT1, Sirt2, Sirt5, and Sirt6 in the Mouse Testis
        3070. ChREBP, SIRT1 and ethanol metabolism–a complicated network in alcohol-induced hepatic steatosis
        3071. A high-fat meal alters post-prandial mRNA expression of SIRT1, SIRT4, and SIRT6
        3072. Expression of SIRT1 in mouse testes
        3073. Leucine-Metformin Synergy Activates the AMPK/SIRT1 Pathway to Increase Insulin Sensitivity in Skeletal Muscle and Glucose and Lipid Metabolism and Lifespan …
        3074. Upregulation of Cardiac MicroRNA 34a, SIRT1, and Notch1 Following Oral Ingestion of Beetroot Juice and Doxorubicin Treatment: A Novel Protective Signaling Against …
        3075. Synthesis of a SIRT1 Inhibitor
        3076. SIRT1 in vascular related diseases: its progress
        3077. Functional mechanism of SIRT1 gene in tumor
        3078. Prognostic role of SIRT1 in hepatocellular carcinoma
        3079. Expression and clinical significance of SIRT1 in hepatocellular carcinoma
        3080. Research Progress of SIRT1 in Hepatic Injury
        3081. Abstract P2-06-08: SIRT1 inhibitors significantly reduce cancer stem cells and block epithelial mesenchymal transformation in breast cancer cells
        3082. Expression and its significance of SIRT1-FL and its alternative splicing variant SIRT1-△ Exon7 in rat hippocampus and cortex
        3083. AB200. SIRT1 expression is elevated in human prostate cancer
        3084. Construction of SIRT1 promoter expression vector and its activity analysis as well as influence of AML1-ETO on transcriptional regulation of SIRT1 gene
        3085. SIRT1: A New Promising Drug Target
        3086. The expression of SIRT1 in brainstem of rats in different types of hypoxia and its significance
        3087. Study on the Differential Expressions of SIRT1 Gene in Ovine Tissues and Organs
        3088. Construction and verification of SIRT1 and its mutant T200I, E420K eukaryotic expression vector
        3089. The role of SIRT1 for regulating VEGF in human RPE
        3090. SIRT1 is decreased during relapses in patients with multiple sclerosis
        3091. Role of SIRT1 in Vascular Complications of Diabetes
        3092. Expression of SIRT1 in bone marrow biopsy tissues and its clinical significance among children with acute myeloid leukemia
        3093. A novel small-molecule SIRT1 inhibitor induces apoptosis in leukemic cell lines
        3094. The progress in the study of SIRT1 effect on the bone repair of mesenchymal stem cells
        3095. MicroRNA-455 targets SIRT1
        3096. The Study of SIRT1 Regulatory Mechanism in DNA Repair Pathway Choice
        3097. SIRT1 Negatively Regulates Cardiac Inflammation Induced by Metabolic Stress
        3098. Effect of Estrogen on Expression of SIRT1 in Ovariectomized Rats
        3099. SIRT1 differently regulates oncogenesis by diverse p53 types in hepatocellular carcinoma
        3100. Age-related Expression of SIRT1 in the Cochlea of C57BL/6 Mice
        3101. Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
        3102. Corrigendum to “SIRT1 Inhibition Affects Angiogenic Properties of Human MSCs”
        3103. Effect of SIRT1 siRNA interference on the expression of IL-6 after radiation
        3104. Research Progress of Estrogen Upregulation of SIRT1 Activity in Anti-aging
        3105. The roles played by the transcriptional regulators PPARalpha, HIF-1alpha and SIRT1 in the control of cardiac metabolism
        3106. Progress in Stat3 and SIRT1 gene in the pathogenesis of rheumatoid arthristis
        3107. Regulation of Acute KSHV Infection by SIRT1
        3108. 1, 25 Dihydroxyvitamin D3 protects the heart against pressure overload-induced hypertrophy without affecting SIRT1 mRNA level
        3109. SIRT1 Overexpression Together with EX527 Reduce Excitotoxicity-Induced Neuronal Loss in Cortical Neurons
        3110. Action machanism of SIRT1 involves TNF-α-induced intestinal epithelial barrier destroy
        3111. SIRT1 nutrient signaling regulates fetal programming of nephrogenesis (1033.10)
        3112. SIRT1, A Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
        3113. Loss of SIRT1 Function Improves Intestinal Anti-Bacterial Defense and Protects
        3114. Protein Deacetylases SIRT1 and Epigenetic Modification of Matrix Metalloproteinase-9 in Diabetic Retinopathy
        3115. SIRT1 mRNA Phasic Expresson During C2C12 Myoblast Proliferation
        3116. SIRT1 gene variants are related to risk of childhood obesity
        3117. Suppression of HTLV-1 transcription by SIRT1 deacetylase
        3118. Effects of SIRT1 mutation or over-expression in astrocytes on metabolism and reproduction
        3119. Effect of SIRT1 on cell proliferation and senescence of human pancreaticβ-cells CRL-1837
        3120. Role of genetic variations at SIRT1 and FOXO1 genes in carotid atherosclerosis
        3121. The nuclear protein bovine SIRT1 is regulated by resveratrol and nicotinamide
        3122. Dysregulation of SIRT1 Activity in the Pathogenesis of Huntington’s Disease
        3123. Maturation conditions do not affect Myst1, Hat1, and SIRT1 mRNA abundance in horse oocytes
        3124. Preventing disease and preserving health with moxibustion and ‘longevity gene’SIRT1
        3125. Role of SIRT1 During the Ageing Process: Relevance to Protection of Synapses in the Brain
        3126. Differential roles of SIRT1 in HIF‐1a and HIF‐2a mediated hypoxic responses (LB269)
        3127. Expression of SIRT1 and Related Oxidative Stress in Diabetic Dry Eye Mouse
        3128. P0913Astrocytic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Extremely Low Frequency Electromagnetic Field through Modulating SIRT1
        3129. Evaluating cathepsin activity and SIRT1 cleavage in experimental osteoarthritis
        3130. The role of an NAD-dependent deacetylase SIRT1 in cellular response to kidney injury
        3131. SIRT1 upregulators from high‐throughput screening as anti‐proliferation and anti‐migration agents in vascular smooth muscle cells (654.2)
        3132. Cardiac SIRT1 Deficiency Sensitizes Myocardium to Ischemia and Reperfusion Injury
        3133. DNA sequences differentially associated with SIRT1 and Dnmt3b during melanoma progression
        3134. Expression of c-Myc, SIRT1 and acetyl-p53 in breast carcinoma and prognostic significance
        3135. Relationship between expression of SIRT1 and SIRT6 genes and the response to ovarian stimulation
        3136. SIRT1 contributes to LPS-induced lung injury through interaction with mitochondrial ROS generation
        3137. GW26-e1360 Effects of SIRT1 on Protection Against Atherosclerosis Plaque via Anti-angiogenesis in Mice
        3138. Apolipoprotein E4 and SIRT1 Interaction in Alzheimer’s Disease
        3139. Modulating the Vascular Healing Response via SIRT1 Transgene Delivery
        3140. Targeting SIRT1 and Its Pathway for Therapeutic Intervention of Cancer: Drug Design and Biological Evaluation
        3141. The Protective Role of SIRT1 Activator in Renal Tubulointerstitial Fibrosis and Its Mechanism
        3142. ANALYSIS OF EXPRESSION OF SIRT1 GENE IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA RESISTANT TO IMATINIB MESYLATE
        3143. Metformin alleviates hepatosteatosis through SIRT1-mediated autophagy induction
        3144. Correction: Functional Complementation of sir2Δ Yeast Mutation by the Human Orthologous Gene SIRT1
        3145. The tissue specific role of SIRT1 in joint inflammation and anabolic cartilage gene expression
        3146. SRT1720, a SIRT1 activator, Attenuates Organ Injury and Inflammatory Response in Sepsis
        3147. Synthesis and SIRT1 modulation studies of amides and hydrazides of benzoic acid incorporating a (2-trifluoromethylpyridin-4-yl) amino moiety
        3148. #VALUE!
        3149. The role of SIRT1 on the crosstalk of p65 and NFATS in U937 monocytes under hyperosmotic stress
        3150. Effect of SIRT1 regulating cholesterol synthesis in repairing retinal ganglion cells after optic nerve injury in rats
        3151. SIRT1 as a Novel Regulator of Cardiac Na+ Channels: A Potential Therapeutic Target for Arrhythmia
        3152. B46 HEALTH EFFECTS OF AIR POLLUTION AND NANOPARTICLES: SIRT1 Protects Against Particulate Matter-Induced Lung Injury
        3153. Survival of colorectal cancer cells following chemotherapy relies on a SIRT1-dependent increase in oxidative phosphorylation
        3154. The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation SIRT1
        3155. Research on Effect of SIRT1 on Ameliorating Hepatic Lipid Metabolism Disorder of APOE~(-/-) after Aerobic Exercise
        3156. SIRT1 in the Cardiomyocyte Counteracts Doxorubicin Cardiotoxicity in vivo
        3157. SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
        3158. Role of SIRT1 in renal ischemia-reperfusion injury and its effect on NF-κBp65-PGC-1α signal pathway in mice
        3159. A novel potential prognostic marker SIRT1 on tumor invasion and metastasis, and tumor recurrence in triple negative breast cancer
        3160. Moderate SIRT1 Overexpression Protects against High Fat Diet Induced Insulin Resistance and Mitochondrial Dysfunction
        3161. OP0267 SIRT1 Regulates Canonical Tgf-Beta Signaling to Control Fibroblast Activation and Tissue Fibrosis
        3162. Effects of NLRP3 and IL-1β on radiation-induced expression through SIRT1 gene silencing
        3163. Design and Synthesis of 2-Arylbenzothiazole Analogues as Novel SIRT1 Activators
        3164. Starvation-Mediated Autophagy Attenuates Liver Ischemia Reperfusion Injury By SIRT1 in Mice.: Abstract# C1644
        3165. Danshensu Delays the Senescence of Rat Aortic Endothelial Cells through SIRT1-SOD Signal Pathway
        3166. #VALUE!
        3167. Differential roles of SIRT1 in HIF-1αand HIF-2αmediated hypoxic responses
        3168. A Clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy
        3169. Expression of apoptosis factors in porcine ovarian granulosa cells affected by SIRT1.
        3170. SIRT1 Expression Is Higher in Human Follicular Lymphoma and Correlates with Ki67 and Bcl-6 Overexpression
        3171. Functional analysis of SIRT1-interacting protein JAZ (Znf346) in neurons
        3172. Sirtuin1 (SIRT1) is a Neuroprotectin D1 (NPD1) target in retinal pigment epithelial cell survival signaling
        3173. A60 OUTCOMES OF SLEEP DISORDERED BREATHING AND SLEEP LOSS: Effect Of Treatment By Nasal Cpap On SIRT1 And Endothelial Function In Obstructive …
        3174. SIRT1 Regulates Cell Survival, Collagen VI Expression of Human TM Cells and Permeability Of Endothelial Cells of Schlemm’s Canal
        3175. The effects of SIRT1 on hypoxia induced by cobalt chloride in human fetal retinal pigment epithelial cells
        3176. SIRT1 overexpression ameliorates TGF-β_1-induced human kidney proximal tubular cell apoptosis by inhibiting CTGF
        3177. A21 THE MESENCHYME AND THE EPITHELIUM IN AIRWAY INFLAMMATION: SIRT1 Attenuates Nasal Polypogenesis By Suppressing Hypoxia-Inducible Factor-1 …
        3178. SIRT1 deacetylates RORγt and enhances Th17 cell generation
        3179. SIRT1 activators promote neuronal differentiation in human bone marrow mesenchymal stem cells
        3180. SIRT1 overexpression protects against high fat diet‐induced cerebral artery endothelial dysfunction (1070.10)
        3181. The Protective Role of AMPK/SIRT1/PGC-1α Signalling in Retinal Astrocytes
        3182. SIRT1 Expression in B-Cell Acute Lymphoblastic Leukemia and Dose-Dependent Effect of Vorinostat
        3183. SIRT1 in the Ventromedial Hypothalamus: A Nutrient Sensor Input Into the Internal Timekeeper
        3184. Investigating the Potential Role of SIRT1 in Glioblastoma Multiforme: A Comparison Between Glioma and Normal Astrocyte Cells in Culture
        3185. Effect of SIRT1 on high glucose-induced NF-κB p65 subunit acetylation and MCP-1 expression in rat mesangial cells
        3186. Abstract PR10: Inhibition of deacetylase SIRT1 offers a novel treatment option in metastatic Ewing sarcoma
        3187. SIRT1 and SIRT2 Gene Expression in Peripheral Blood Mononuclear Cells of Obese Children and Adolescents and their Relationship with Metabolic …
        3188. SIRT1-responsive microRNA-182 contributes to a regulatory loop for recovery of peripheral nerve injury in experimental diabetic neuropathy
        3189. Identification of SIRT1 as a novel regulator of NFAT5 dependent aldose reductase expression under osmatic stress
        3190. Atorvastatin Inhibits High Glucose-induced Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells by SIRT1/NADPH Oxidase Pathway
        3191. THU0471 Myeloid Deletion of SIRT1 Suppresses Collagen-Induced Arthritis in Mice by Modulating Dendritic Cell Function
        3192. PPARalpha/SIRT1 Heterodimer Suppresses Fatty Acid Oxidation Genes in the Heart Under Pressure Overload
        3193. EXOGENOUS SIRT1 INHIBITION OF APOPTOSIS VIA AUTOPHAGY UNDER LOW NUTRITIONAL CONDITION IN HUMAN NUCLEUS PULPOSUS CELLS: GP52.
        3194. SIRT1 Suppresses Self-Renewal of Adult Hippocampal Neural Stem Cells
        3195. Changes in expression of Ac-H3 and SIRT1 in dorsal root ganglions in a rat model of negative phenotype neuropathic pain
        3196. Expression of deacetylase SIRT1 in porcine different developmental stages of follicular granulosa cells.
        3197. Epigallocatechin gallate inhibited proliferation and induced apoptosis of nasopharyngeal carcinoma cells by inhibiting expression of SIRT1
        3198. Resveratrol protects oxygen-glucose deprivation rat cortical neurons by regulating SIRT1/AMPK signaling pathways
        3199. KSY-PH1 Prevents UVB-Induced Damage and Promotes Wound Healing In Skin Cells via Coregulation of SIRT1 and Pin1
        3200. SIRT1 Expression Related with Sarcoma Growth after Stem Cell Transplantation Combined with Depletion of Myeloid-Derived Suppressor Cells
        3201. Abstract T P247: Neuronal SIRT1 Activation Negatively Regulates Rho Kinase in Photothrombotic Stroke
        3202. Insulin Antagonizes SIRT1 and NF‐κB Signaling in Skeletal Muscle of Neonatal Pigs during Chronic Infection
        3203. C108 AGING: THE COMMON DENOMINATOR: SIRT1 eduction Is Involved In Clock Dysfunction, Telomere Attrition, And Inflammosenescence In COPD
        3204. The SIRT1 Activator, SRT1720, Attenuates Cardiac Hypertrophy and Fibrosis in a Rodent Pressure Overload Model
        3205. Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
        3206. SIRT1-Mediated Inhibition of p66shc Expression Alleviates Liver Ischemia/Reperfusion Injury
        3207. Study on Effect of Buqi-Tongluo-Jiedu Decoction on Protein Concentration of HIC1/SIRT1 of Pancreatic Cancer Model Mice
        3208. SIRT1 regulates the function of the KRAB-associated protein 1 (KAP1) in DNA damage response signaling
        3209. SIRT1 activator SRT3025 provides atheroprotection in ApoE⁻/⁻ mice by increasing hepatic LDL receptor
        3210. SIRT1 Modulates Varicella Zoster Virus Replication in the Rat Dorsal Root Ganglion Neurons
        3211. GW26-e0716 Forestalling SIRT1 Carbonyl Stress by ALDH2 Restores Autophagy in Aged Heart
        3212. Shear Stress-Induced SIRT1 Activation: Effects on Mitochondrial Biogenesis and Endothelial Senescence.
        3213. Protective Effect of Photoreceptor Outer Segments Phagocytosis for Retinal Pigment Epithelial Cells by PGC-1α/SIRT1
        3214. Activation of C/EBPa Myeloid-Specific Transcription Factor By NAMPT/SIRT1-Triggered Deacetylation
        3215. Melatonin improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha
        3216. ATGL‐catalyzed lipolysis regulates SIRT1 to control PGC‐1a/PPAR‐a signaling
        3217. Metabolic adaptation of tumor cells under chronic acidosis: role of the SIRT1/HIF2alpha axis to drive reductive glutamine metabolism
        3218. Design and Synthesis of 2-Arylbenzimidazole Analogues as Novel SIRT1 Activators for the Treatment of Type II Diabetes
        3219. Increased p53 Acetylation By SIRT1 Inhibition Is Required for Optimal Activation of p53 Activity and Significantly Enhances the Ability of HDM2 Inhibitors to Target …
        3220. Metabolic adaptation of tumor cells under chronic acidosis: a shift towards reductive glutamine metabolism driven by the SIRT1/HIF2α axis
        3221. C71 THORACIC CANCER: PATHOGENESIS, PREVENTION, AND TREATMENT: Down-Regulated SIRT1 By Non-Steroidal Anti-Inflammatory Drugs Is To Inhibit Tgf …
        3222. Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via SIRT1
        3223. Cardiac SIRT1 Mediates the Cardioprotective Effect of Caloric Restriction by Suppressing Local Complement System Activation after Ischemia/Reperfusion
        3224. ANTI-APOPTOTIC EFFECT OF FERULIC ACID THROUGH MODIFICATION OF SIRT1, SIRT7 AND CASPASE 6 GENE EXPRESSION
        3225. Decreased PGC‐1α‐SIRT1 Signaling Leads to Impaired Angiogenesis in Persistent Pulmonary Hypertension of the Newborn (PPHN)
        3226. GW25-e1534 SIRT1 protects against oxidative stress-induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation
        3227. α-Mangostin Regulates Hepatic Steatosis and Obesity through SIRT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice
        3228. … IMPROVES INSULIN SENSITIVITY IN HIGH-FAT-DIET-INDUCED INSULIN RESISTANCE RATS VIA ACTIVATION OF SIRT1 AND GLUT4 IN QUADRICEPS …
        3229. NMN, a NAD+ Precursor, Can Rescue Age-associated Susceptibility to Cisplatin-induced Acute Kidney Injury in a SIRT1-dependent Manner
        3230. High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased …
        3231. 1018: SIRT1 ACTIVATORS ALTER TRANSCRIPTIONAL PROFILES OF INFLAMMATORY RESPONSE & IMPROVE OUTCOME IN SEPSIS
        3232. Fast Track: Editor’s choice: The SIRT1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr …
        3233. Low-Dose Deguelin, Selective Targeting of Mt NPM1, Induces Differentiation in NPMc+ AML Cells By Regulation the Axis of SIRT1/CEBPβ/G-CSFR, Instead …
        3234. Correction: Nurr1 Represses Tyrosine Hydroxylase Expression via SIRT1 in Human Neural Stem Cells
        3235. Nicotinic acid synergizes with leucine to stimulate AMPK/SIRT1 signaling and regulates lipid accumulation and lifespan in C. elegans (269.7)
        3236. GW26-e1025 Fenofibrate Prevention of Diabetic Cardiomyopathy Is Mediated by FGF21 Via SIRT1-Dependent Autophagy Modulation
        3237. Liquid fructose downregulates SIRT1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
        3238. Regulatory interactions between the metabolic sensors SIRT1 and AMPK in modulating PPARα linked functions, in obesity-dependent type 2 diabetes mellitus
        3239. GW25-e4428 Exogenous Hydrogen Sulfide Delays Nicotinamide-Induced Premature Senescence via SIRT1 pathway in Human Umbilical Vein Endothelial Cells
        3240. SIRT1, SIRT2, SIRT6 and P21 gene expression in the lungs of mice chronically exposed to ambient particulate matter
        3241. … fibrosis and atrial fibrillation in a canine atrial tachycardia model with left ventricular dysfunction: association with p53-microRNA34a-SIRT1 feedback-loop pathway
        3242. Effects of core temperature on exercise-induced mitochondrial biogenesis: Potential role of PGC-1α, AMPK eNOS, SIRT1, and SIRT3
        3243. Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced …
        3244. Resveratrol stimulation of SIRT1 & exogenous delivery of FGF21 mimics metformin’s ability to alleviate non-alcoholic fatty liver disease caused by diet-induced obesity
        3245. Thematic Poster: TP-30; SIRT1 Contributes to the Pathogenesis of LPS-Induced Lung Injury through the Modulation of PI3K-HIF-VEGF Pathway
        3246. SIRT1 dependent IRS1 phosphorylation mediates the effect of vitamin D on GLUT4 translocation and glucose utilization via PI3K/PTEN/PTP1B/PIP3/AKT/PKCζ/λ …
        3247. PS-1570; Pulmonary Infection: SIRT1 Contributes to the Pathogenesis of LPS-Induced Lung Injury through the Modulation of PI3K-HIF-VEGF Pathway
        3248. Adiponectin suppress T helper 17 differentiation and limits autoimmune CNS inflammation via SIRT1/PPARγ/RORγt singling
        3249. RNA interference of silent mating type information regulation 2 homolog 1 SIRT1 arrests cell cycle progress of prostate cancer PC3 cells
        3250. OP-144 Attenuated SIRT1 Expression Correlates with Enhanced Oxidative Stress in Compensated and Decompensated Heart Failure
        3251. Arginase 1 regulates SIRT1 activity and endothelial senescence in diabetes (1051.1)
        3252. 7: Increased SIRT1 Positive Lymphocytes in Acute Cellular Cardiac Allograft Rejection: Contributor to Pathogenesis and a Therapeutic Target
        3253. Abstract LB-167: The role of SIRT1 in tumorigenesis
        3254. Calycosin Promotes Apoptosis of Breast Cancer Cells MCF-7 through Inhibiting SIRT1
        3255. HO‐1 Induction Attenuates Fructose Mediated Non‐alcoholic Fatty Liver in Hepatocytes and Obese Mice: Involves SIRT1
        3256. Free Paper Presentation: F-141; Mitochondrial ROS Induces Up-regulation of SIRT1 in LPS-Induced Acute Lung Injury
        3257. Slide Session: OS-115; Pulmonary Infection: The Interplay Between Mitochondrial ROS and SIRT1 in LPS-Induced Lung Injury of Mice
        3258. Free Paper Presentation: OS-115; The Interplay Between Mitochondrial ROS and SIRT1 in LPS-Induced Lung Injury of Mice
        3259. Role of silent information regulator 1 (SIRT1) in the malignant biological behavior of prostate cancer
        3260. The Korean Academy of Tuberculosis and Respiratory Diseases: Slide Session; OS-066: Lung Cancer; Down-Regulated SIRT1 by Non-Steroidal Anti-Infl ammatory …
        3261. Free Paper Presentation: OS-66; Down-Regulated SIRT1 by Non-Steroidal Anti-Inflammatory Drugs Is to Inhibit TGF-β1-Induced Epithelial-Mesenchymal Transition …
        3262. 1, 25 dihydroxyvitamin D3 protects the heart against pressure overload-induced hypertrophy without affecting SIRT1 mRNA level
        3263. #VALUE!
        3264. Expression of silence information regulator 1 (SIRT1) in B cells in peripheral venous blood of subacute cutaneous lupus erythematosus
        3265. Homology modeling, Molecular Dynamic Simulation and in silico screening of Activator for the Intensification of human sirtuin type 1 (SIRT1) by novel 1, 3, 4 …
        3266. Endothelial LOX-1 Protects Against Arterial Thrombosis via Activation of the Oct-1/SIRT1 Pathway
        3267. GW26-e2385 Tetrahydroxystilbene Involve HSP-70 and SIRT1 in Preventing the Progression of Diabetic Cardiomyopathy
        3268. … Receptor 2 improves therapeutic efficacy of Adipose-Derived Mesenchymal Stem Cells to alleviate myocardial ischemia injury through AMPK/SIRT1 and TLR4/NF-κB …
        3269. 3, 5, 4 [variant prime]-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway
        3270. Taurine attenuates amyloid β 1â 42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells
        3271. Effects of metformin on SIRT1, Nrf2 and AhR expression in cancer cells
        3272. SIRT1 and the mitochondria
        3273. SIRT1 and insulin resistance
        3274. Emerging roles of SIRT1 in fatty liver diseases
        3275. The role of SIRT1 in epileptogenesis
        3276. SIRT1 inhibits oxidative stress in vascular endothelial cells
        3277. Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis
        3278. The role of SIRT1 in diabetic cardiomyopathy
        3279. SIRT1: role under the condition of ischemia/hypoxia
        3280. How much successful are the medicinal chemists in modulation of SIRT1: A critical review
        3281. Obesity weighs down memory through a mechanism involving the neuroepigenetic dysregulation of SIRT1
        3282. The protective role of SIRT1 in vascular tissue: its relationship to vascular aging and atherosclerosis
        3283. SIRT1, 2, 3 protect mouse oocytes from postovulatory aging
        3284. SIRT1 regulates macrophage self‐renewal
        3285. Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species
        3286. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells
        3287. LncRNA HULC triggers autophagy via stabilizing SIRT1 and attenuates the chemosensitivity of HCC cells
        3288. SIRT1 mediates depression-like behaviors in the nucleus accumbens
        3289. The prognostic role of SIRT1 expression in solid malignancies: a meta-analysis
        3290. Down-Regulation of SIRT1 Gene Expression in Major Depressive Disorder
        3291. SIRT1 as a therapeutic target for Alzheimer’s disease
        3292. SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis
        3293. Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells
        3294. Negative reciprocal regulation between SIRT1 and Per2 modulates the circadian clock and aging
        3295. SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease
        3296. SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson’s disease
        3297. SIRT1 regulates DNA methylation and differentiation potential of embryonic stem cells by antagonizing Dnmt3l
        3298. SIRT1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis
        3299. Association between SIRT1 gene polymorphisms and breast cancer in Egyptians
        3300. SIRT1 enhances the survival of human embryonic stem cells by promoting DNA repair
        3301. Histone deacetylase SIRT1 negatively regulates the differentiation of interleukin-9-producing CD4+ T cells
        3302. SIRT1 promotes epithelial–mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression
        3303. Effect of exercise training on skeletal muscle SIRT1 and PGC-1α expression levels in rats of different age
        3304. Aquatide activation of SIRT1 reduces cellular senescence through a SIRT1-FOXO1-autophagy axis
        3305. SIRT1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells
        3306. SIRT1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice
        3307. SIRT1 activation by resveratrol alleviates cardiac dysfunction via mitochondrial regulation in diabetic cardiomyopathy mice
        3308. SIRT1 inhibits the catabolic effect of IL-1β through TLR2/SIRT1/NF-κB pathway in human degenerative nucleus pulposus cells
        3309. Overexpression of SIRT1 is associated with poor outcomes in patients with ovarian carcinoma
        3310. SIRT1 improves VSMC functions in atherosclerosis
        3311. The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
        3312. SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells
        3313. SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells
        3314. O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
        3315. Specific SIRT1 activator-mediated improvement in glucose homeostasis requires SIRT1-independent activation of AMPK
        3316. SIRT1/3 activation by resveratrol attenuates acute kidney injury in a septic rat model
        3317. QSAR differential model for prediction of SIRT1 modulation using Monte Carlo method
        3318. SIRT1 protects the heart from ER stress-induced cell death through eIF2 α deacetylation
        3319. Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation
        3320. Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of SIRT1
        3321. mTORC1 and SIRT1 cooperate to foster expansion of gut adult stem cells during calorie restriction
        3322. SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2
        3323. Mitochondria elongation is mediated through SIRT1-mediated MFN1 stabilization
        3324. CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice
        3325. ATGL promotes autophagy/lipophagy via SIRT1 to control hepatic lipid droplet catabolism
        3326. SIRT1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a
        3327. Activation and overexpression of SIRT1 attenuates lung fibrosis via P300
        3328. Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits
        3329. Quercetin improves glucose and lipid metabolism of diabetic rats: involvement of Akt signaling and SIRT1
        3330. Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts
        3331. Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro
        3332. SIRT1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms
        3333. Epidermal SIRT1 regulates inflammation, cell migration, and wound healing
        3334. Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes
        3335. Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1, and eNOS
        3336. Mir-29b regulates oxidative stress by targeting SIRT1 in ovarian cancer cells
        3337. SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving …
        3338. Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression
        3339. SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats
        3340. Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of SIRT1 signaling
        3341. SIRT1 inhibition promotes atherosclerosis through impaired autophagy
        3342. SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia–reperfusion injury
        3343. SIRT1 promotes metastasis of human osteosarcoma cells
        3344. SIRT1 activates the expression of fetal hemoglobin genes
        3345. SIRT1 and neural cell fate determination
        3346. SIRT1 regulates the chemoresistance and invasiveness of ovarian carcinoma cells
        3347. Celastrol ameliorates liver metabolic damage caused by a high-fat diet through SIRT1
        3348. SIRT1‐mediated transcriptional regulation of SOX2 is important for self‐renewal of liver cancer stem cells
        3349. The anti-ageing molecule SIRT1 mediates beneficial effects of cardiac rehabilitation
        3350. Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice
        3351. The NAD+/PARP1/SIRT1 axis in aging
        3352. Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through SIRT1-dependent autophagy induction
        3353. SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy
        3354. Modulation of mitochondrial membrane potential and ROS generation by nicotinamide in a manner independent of SIRT1 and mitophagy
        3355. SIRT1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins
        3356. Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With SIRT1
        3357. Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver
        3358. O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway
        3359. HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism
        3360. Expression and clinical significance of SIRT1 in colorectal cancer
        3361. SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p
        3362. Berberine suppresses LPS-induced inflammation through modulating SIRT1/NF-κB signaling pathway in RAW264. 7 cells
        3363. SIRT1 suppresses adipogenesis by activating Wnt/β-catenin signaling in vivo and in vitro
        3364. SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway
        3365. Reduction in podocyte SIRT1 accelerates kidney injury in aging mice
        3366. The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model
        3367. SIRT1 was involved in TNF-α-promoted osteogenic differentiation of human DPSCs through Wnt/β-catenin signal
        3368. Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development
        3369. SIRT1 protects endothelial cells against LPS-induced barrier dysfunction
        3370. Role of SIRT1 plays in nucleus pulposus cells and intervertebral disc degeneration
        3371. Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1
        3372. Sirtuin1 (SIRT1) in the acetylation of downstream target proteins
        3373. SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
        3374. Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
        3375. Moving to the rhythm with clock (circadian) genes, autophagy, mTOR, and SIRT1 in degenerative disease and cancer
        3376. Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway
        3377. Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
        3378. Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription
        3379. Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome
        3380. Resveratrol inhibits proliferation and migration through SIRT1 mediated post‑translational modification of PI3K/AKT signaling in hepatocellular carcinoma …
        3381. MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting SIRT1
        3382. Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway
        3383. SIRT1 in endothelial cells as a novel target for the prevention of early vascular aging
        3384. Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway
        3385. SIRT1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
        3386. Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes
        3387. Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat …
        3388. SIRT1 limits adipocyte hyperplasia through c-Myc inhibition
        3389. The SIRT1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress
        3390. BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1
        3391. Interactions between SIRT1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo
        3392. Screening SIRT1 activators from medicinal plants as bioactive compounds against oxidative damage in mitochondrial function
        3393. Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats
        3394. The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
        3395. Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis
        3396. SIRT1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat
        3397. Neuronal SIRT1 (silent information regulator 2 homologue 1) regulates glycolysis and mediates resveratrol-induced ischemic tolerance
        3398. Resveratrol alleviates MPTP‐induced motor impairments and pathological changes by autophagic degradation of α‐synuclein via SIRT1‐deacetylated LC3
        3399. Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress
        3400. SIRT1 may play a crucial role in overload‐induced hypertrophy of skeletal muscle
        3401. miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway
        3402. Cellular localization of NRF2 determines the self-renewal and osteogenic differentiation potential of human MSCs via the P53–SIRT1 axis
        3403. SIRT1 polymorphisms and serum-induced SIRT1 protein expression in aging and frailty: the CHAMP study
        3404. The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia
        3405. Use of the Monte Carlo Method for OECD Principles‐Guided QSAR Modeling of SIRT1 Inhibitors
        3406. Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: Role of SIRT1‐mediated autophagy regulation
        3407. Salmonella Typhimurium disrupts SIRT1/AMPK checkpoint control of mTOR to impair autophagy
        3408. Harnessing the power of SIRT1 and non-coding RNAs in vascular disease
        3409. The epigenetic regulation of HIF-1α by SIRT1 in MPP+ treated SH-SY5Y cells
        3410. SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro
        3411. Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer
        3412. AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia
        3413. The effect of lead exposure on expression of SIRT1 in the rat hippocampus
        3414. SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride
        3415. Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of SIRT1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning
        3416. Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity
        3417. SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis
        3418. KRAS activation and over-expression of SIRT1/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance
        3419. miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling
        3420. Resveratrol enhances autophagic flux and promotes Ox-LDL degradation in HUVECs via upregulation of SIRT1
        3421. MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis
        3422. Circulating SIRT1 increases after intragastric balloon fat loss in obese patients
        3423. SIRT1‐mediated ERβ suppression in the endothelium contributes to vascular aging
        3424. LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive …
        3425. SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells
        3426. Regulation of SIRT1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity
        3427. Galangin induces autophagy via deacetylation of LC3 by SIRT1 in HepG2 cells
        3428. Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect
        3429. Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats
        3430. An agonist of the protective factor SIRT1 improves functional recovery and promotes neuronal survival by attenuating inflammation after spinal cord injury
        3431. SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis
        3432. Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy
        3433. Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway
        3434. SIRT1 ameliorates systemic sclerosis by targeting the mTOR pathway
        3435. NAMPT regulates senescence, proliferation, and migration of endothelial progenitor cells through the SIRT1 AS lncRNA/miR-22/SIRT1 pathway
        3436. Histone deacetylase SIRT1 controls proliferation, circadian rhythm, and lipid metabolism during liver regeneration in mice
        3437. SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells
        3438. CKII-SIRT1-SM22α loop evokes a self-limited inflammatory response in vascular smooth muscle cells
        3439. Epigenetic regulation through SIRT1 in podocytes
        3440. The effect of exercise, resveratrol or their combination on Sarcopenia in aged rats via regulation of AMPK/SIRT1 pathway
        3441. SIRT1 disruption in human fetal hepatocytes leads to increased accumulation of glucose and lipids
        3442. Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs
        3443. Ginsenoside Rb2 alleviates hepatic lipid accumulation by restoring autophagy via induction of SIRT1 and activation of AMPK
        3444. Association of SIRT1 and HMGA1 expression in non-small cell lung cancer
        3445. Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice
        3446. Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats
        3447. Inflammation downregulates UCP1 expression in brown adipocytes potentially via SIRT1 and DBC1 interaction
        3448. LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes
        3449. SIRT1 regulates Mxd1 during malignant melanoma progression
        3450. Weight Loss Is Associated With Increased NAD+/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue
        3451. Melatonin facilitates adipose‐derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway
        3452. The prognostic role of SIRT1-autophagy axis in gastric cancer
        3453. Overexpression of SIRT1 prevents hypoxia‑induced apoptosis in osteoblast cells
        3454. SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions
        3455. Silibinin restores NAD+ levels and induces the SIRT1/AMPK pathway in non-alcoholic fatty liver
        3456. Lysophosphatidic acid promotes epithelial to mesenchymal transition in ovarian cancer cells by repressing SIRT1
        3457. Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity
        3458. SIRT1 regulates cognitive performance and ability of learning and memory in diabetic and nondiabetic models
        3459. MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1
        3460. SIRT1: a novel target for the treatment of muscular dystrophies
        3461. SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid
        3462. Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways
        3463. Restoration of SIRT1 function by pterostilbene attenuates hypoxia-reoxygenation injury in cardiomyocytes
        3464. miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation
        3465. SIRT1/HSF1/HSP pathway is essential for exenatide‐alleviated, lipid‐induced hepatic endoplasmic reticulum stress
        3466. Activation of miR-34a-5p/SIRT1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity
        3467. A CREB-SIRT1-Hes1 circuitry mediates neural stem cell response to glucose availability
        3468. The crosstalk between SIRT1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular …
        3469. Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway
        3470. IRF8 is the target of SIRT1 for the inflammation response in macrophages
        3471. SIRT1/adenosine monophosphate-activated protein kinase α signaling enhances macrophage polarization to an anti-inflammatory phenotype in rheumatoid …
        3472. SIRT1 gain of function does not mimic or enhance the adaptations to intermittent fasting
        3473. From the Cover: l-Carnitine via PPARγ- and SIRT1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by …
        3474. Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
        3475. SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model
        3476. SIRT1 regulates the inflammatory response of vascular adventitial fibroblasts through autophagy and related signaling pathway
        3477. miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway
        3478. SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review
        3479. SIRT1 functions as a negative regulator of eukaryotic poly (A) RNA transport
        3480. SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status
        3481. Vitamin D insufficiency exacerbates adipose tissue macrophage infiltration and decreases AMPK/SIRT1 activity in obese rats
        3482. Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1
        3483. SIRT1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
        3484. The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening
        3485. Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer
        3486. Dioscin alleviates BDL-and DMN-induced hepatic fibrosis via SIRT1/Nrf2-mediated inhibition of p38 MAPK pathway
        3487. Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in …
        3488. SIRT1 deacetylates the cardiac transcription factor Nkx2. 5 and inhibits its transcriptional activity
        3489. Cilostazol modulates autophagic degradation of β-amyloid peptide via SIRT1-coupled LKB1/AMPKα signaling in neuronal cells
        3490. Suppression of SIRT1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis
        3491. Berberine protects against ischemia/reperfusion injury after orthotopic liver transplantation via activating SIRT1/FoxO3α induced autophagy
        3492. Forkhead transcription factor FOXO1 inhibits angiogenesis in gastric cancer in relation to SIRT1
        3493. Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients
        3494. USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway
        3495. Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: involvement of SIRT1 and SIRT6
        3496. Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling
        3497. Resveratrol prevents ROS-induced apoptosis in high glucose-treated retinal capillary endothelial cells via the activation of AMPK/SIRT1/PGC-1α pathway
        3498. CD38 deficiency protects the heart from ischemia/reperfusion injury through activating SIRT1/FOXOs-mediated antioxidative stress pathway
        3499. Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SIRT1 axis
        3500. Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of SIRT1 in hippocampus
        3501. Reducing Smad3/ATF4 was essential for SIRT1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue
        3502. The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity
        3503. Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1
        3504. SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy
        3505. SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells
        3506. SIRT1‐SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide
        3507. Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of …
        3508. Up-regulation of SIRT1 reduces endoplasmic reticulum stress and renal fibrosis
        3509. Resveratrol ameliorates palmitate‐induced inflammation in skeletal muscle cells by attenuating oxidative stress and JNK/NF‐κB pathway in a SIRT1‐independent …
        3510. Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia
        3511. Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice: an in vitro and in vivo study
        3512. Effect of genistein on expression of pancreatic SIRT1, inflammatory cytokines and histological changes in ovariectomized diabetic rat
        3513. Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats
        3514. SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury
        3515. Activation of SIRT1/FXR signaling pathway attenuates triptolide-induced hepatotoxicity in rats
        3516. SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α-and β-zearalenol through an autophagy-dependent pathway
        3517. SIRT1 protects human lens epithelial cells against oxidative stress by inhibiting p53-dependent apoptosis
        3518. The neuroprotective effects of SIRT1 on NMDA-induced excitotoxicity
        3519. Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury
        3520. miR-133b inhibits glioma cell proliferation and invasion by targeting SIRT1
        3521. P66 Shc-SIRT1 Regulation of Oxidative Stress Protects Against Cardio-cerebral Vascular Disease
        3522. SIRT1 enzymatically potentiates 1, 25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation
        3523. iNOS as a driver of inflammation and apoptosis in mouse skeletal muscle after burn injury: possible involvement of SIRT1 S-nitrosylation-mediated acetylation …
        3524. Polydatin protecting kidneys against hemorrhagic shock-induced mitochondrial dysfunction via SIRT1 activation and p53 deacetylation
        3525. miR-200a-3p promotes β-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer’s disease
        3526. Exendin-4 upregulates adiponectin level in adipocytes via SIRT1/Foxo-1 signaling pathway
        3527. … glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting SIRT1 and Sirt3 expression
        3528. SIRT1-activating compounds (STAC) negatively regulate pancreatic cancer cell growth and viability through a SIRT1 lysosomal-dependent pathway
        3529. SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening
        3530. Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity
        3531. LncRNA H19 promotes the differentiation of bovine skeletal muscle satellite cells by suppressing SIRT1/FoxO1
        3532. SIRT1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease
        3533. SIRT1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice [S]
        3534. Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating SIRT1/AMPKα/SREBP1 signaling pathway
        3535. SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis
        3536. Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration
        3537. Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as …
        3538. Early-life exposure to lead induces cognitive impairment in elder mice targeting SIRT1 phosphorylation and oxidative alterations
        3539. Genistein ameliorates ischemia/reperfusion-induced renal injury in a SIRT1-dependent manner
        3540. The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells
        3541. Melatonin protects premature ovarian insufficiency induced by tripterygium glycosides: role of SIRT1
        3542. Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats
        3543. Salidroside attenuates ventilation induced lung injury via SIRT1-dependent inhibition of NLRP3 inflammasome
        3544. Rutin protects rat articular chondrocytes against oxidative stress induced by hydrogen peroxide through SIRT1 activation
        3545. Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the SIRT1/AMPK/PGC-1α pathway
        3546. The deacetylase SIRT1 regulates the replication properties of human papillomavirus 16 E1 and E2
        3547. Suppression of miR-34a expression in the myocardium protects against ischemia–reperfusion injury through SIRT1 protective pathway
        3548. Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells
        3549. Mir‐217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via SIRT1/HIF‐1α signaling pathway
        3550. A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53
        3551. Combination treatment with quercetin and resveratrol attenuates high fat diet‑induced obesity and associated inflammation in rats via the AMPKα1/SIRT1 …
        3552. Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling
        3553. Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer
        3554. Tucum-do-Cerrado (Bactris setosa Mart.) may promote anti-aging effect by upregulating SIRT1-Nrf2 pathway and attenuating oxidative stress and inflammation
        3555. Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer
        3556. Protective effect of trans-δ-viniferin against high glucose-induced oxidative stress in human umbilical vein endothelial cells through the SIRT1 pathway
        3557. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway
        3558. SIRT1 regulates apoptosis and extracellular matrix degradation in resveratrol‑treated osteoarthritis chondrocytes via the Wnt/β‑catenin signaling pathways
        3559. Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway
        3560. Effects of BMAL1–SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS
        3561. Inhibition of microRNA-449a prevents IL-1β-induced cartilage destruction via SIRT1
        3562. SIRT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16
        3563. Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer’s disease
        3564. Mechanism of SIRT1 NAD+-dependent protein deacetylase inhibition by cysteine S-nitrosation
        3565. Sir2/SIRT1 links acute inebriation to presynaptic changes and the development of alcohol tolerance, preference, and reward
        3566. Lipopolysaccharide modulates p300 and SIRT1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron
        3567. Pharmacological SIRT1 activation improves mortality and markedly alters transcriptional profiles that accompany experimental sepsis
        3568. Upregulated miR‐132 in Lgr5+ gastric cancer stem cell‐like cells contributes to cisplatin‐resistance via SIRT1/CREB/ABCG2 signaling pathway
        3569. TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression
        3570. Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1
        3571. Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease
        3572. Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization
        3573. Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300
        3574. Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction
        3575. Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS/SIRT1 pathway
        3576. Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1
        3577. SIRT1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice
        3578. The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo
        3579. Resveratrol attenuates triglyceride accumulation associated with upregulation of SIRT1 and lipoprotein lipase in 3T3-L1 adipocytes
        3580. Inactivation of SIRT1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κ B
        3581. Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats
        3582. A study of SIRT1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis
        3583. SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells
        3584. Pterostilbene alleviates polymicrobial sepsis-induced liver injury: possible role of SIRT1 signaling
        3585. Capsaicin inhibits multiple bladder cancer cell phenotypes by inhibiting tumor-associated NADH oxidase (tNOX) and sirtuin1 (SIRT1)
        3586. Obesity-linked phosphorylation of SIRT1 by casein kinase 2 inhibits its nuclear localization and promotes fatty liver
        3587. Activation of the AMPK/SIRT1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism …
        3588. Synthesis and assay of SIRT1-activating compounds
        3589. Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/SIRT1 Pathway in Hyperglycemic Middle Cerebral Artery …
        3590. Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus
        3591. Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury
        3592. Glycyrrhizic acid prevents diabetic nephropathy by activating AMPK/SIRT1/PGC-1α signaling in db/db mice
        3593. Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264. 7 cells and peritoneal macrophages
        3594. … ameliorates non‐alcoholic fatty liver disease by enhancing mitochondrial architecture and promoting autophagy through the SIRT1/SIRT3–FOXO3a pathway
        3595. CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1α activation
        3596. SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients
        3597. Prognostic and clinicopathological significance of SIRT1 expression in NSCLC: a meta-analysis
        3598. Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation
        3599. Melatonin attenuates early brain injury via the melatonin receptor/SIRT1/NF-κB signaling pathway following subarachnoid hemorrhage in mice
        3600. Knockdown of SIRT1 suppresses bladder cancer cell proliferation and migration and induces cell cycle arrest and antioxidant response through FOXO3a …
        3601. Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells
        3602. Short-term starvation attenuates liver ischemia-reperfusion injury (IRI) by SIRT1-autophagy signaling in mice
        3603. Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro
        3604. SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells
        3605. Berberine alleviates oxidative stress in islets of diabetic mice by inhibiting miR‐106b expression and up‐regulating SIRT1
        3606. … Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide–Dependent SIRT1 Activity
        3607. Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 …
        3608. SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway
        3609. The polyphenol oleuropein aglycone modulates the PARP1-SIRT1 interplay: an in vitro and in vivo study
        3610. Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis
        3611. MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling
        3612. MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells …
        3613. Effect of SIRT1 gene on epithelial-mesenchymal transition of human prostate cancer PC-3 cells
        3614. Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation
        3615. Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster
        3616. FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression
        3617. Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability
        3618. SIRT1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription
        3619. Brown and white adipose tissue expression of IL6, UCP1 and SIRT1 are associated with alterations in clinical, metabolic and anthropometric parameters in obese …
        3620. Olmesartan prevents microalbuminuria in db/db diabetic mice through inhibition of angiotensin II/p38/SIRT1-induced podocyte apoptosis
        3621. SIRT1: a novel guardian of brown fat against metabolic damage
        3622. β2‐AR activation induces chemoresistance by modulating p53 acetylation through upregulating SIRT1 in cervical cancer cells
        3623. Vitamin D receptor deficit induces activation of renin angiotensin system via SIRT1 modulation in podocytes
        3624. SIRT1 negatively regulates FcεRI-mediated mast cell activation through AMPK-and PTP1B-dependent processes
        3625. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways
        3626. Silencing of HJURP induces dysregulation of cell cycle and ROS metabolism in bladder cancer cells via PPARγ-SIRT1 feedback loop
        3627. SIRT1, a class III histone deacetylase, regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol
        3628. CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
        3629. The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition
        3630. Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels
        3631. … augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1
        3632. SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer
        3633. An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3
        3634. Common variants in SIRT1 and human longevity in a Chinese population
        3635. SIRT1 activity is linked to its brain region-specific phosphorylation and is impaired in Huntington’s disease mice
        3636. SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway
        3637. Cardiac SIRT1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion
        3638. SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease
        3639. Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway
        3640. Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma
        3641. Resveratrol promotes human embryonic stem cells self-renewal by targeting SIRT1-ERK signaling pathway
        3642. Resveratrol ameliorates contrast induced nephropathy through the activation of SIRT1-PGC-1α-Foxo1 signaling in mice
        3643. … crocetin and the synthetic tellurium compound AS101 protect the ovary against cyclophosphamide by modulating SIRT1 and mitochondrial markers
        3644. Prognostic and clinical value of SIRT1 expression in gastric cancer: A systematic meta-analysis
        3645. SIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet
        3646. Nampt expression decreases age-related senescence in rat bone marrow mesenchymal stem cells by targeting SIRT1
        3647. (–)-Epicatechin suppresses angiotensin II-induced cardiac hypertrophy via the activation of the SP1/SIRT1 signaling pathway
        3648. Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice
        3649. Resveratrol enhances HBV replication through activating SIRT1-PGC-1α-PPARα pathway
        3650. Dysregulation of the SIRT1/OCT6 axis contributes to environmental stress-induced neural induction defects
        3651. The metabolic sensor SIRT1 and the hypothalamus: Interplay between peptide hormones and pro-hormone convertases
        3652. A novel role of SIRT1/FGF-21 in taurine protection against cafeteria diet-induced steatohepatitis in rats
        3653. Identification of a tissue-restricted isoform of SIRT1 defines a regulatory domain that encodes specificity
        3654. Regulation of stem cell aging by SIRT1–Linking metabolic signaling to epigenetic modifications
        3655. Salidroside inhibits HMGB1 acetylation and release through upregulation of SIRT1 during inflammation
        3656. Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells
        3657. Role of SIRT1 as a Regulator of Autophagy
        3658. VISFATIN (NAMPT) improves in vitro IGF1-induced steroidogenesis and IGF1 receptor signaling through SIRT1 in bovine granulosa cells
        3659. miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age-related hearing loss
        3660. Capsaicin protects cardiomyocytes against anoxia/reoxygenation injury via preventing mitochondrial dysfunction mediated by SIRT1
        3661. Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1
        3662. The UCA1/miR-204/SIRT1 axis modulates docetaxel sensitivity of prostate cancer cells
        3663. … proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1 …
        3664. Treadmill exercise attenuates α-synuclein levels by promoting mitochondrial function and autophagy possibly via SIRT1 in the chronic MPTP/P-induced mouse model …
        3665. Resveratrol attenuates microglial activation via SIRT1-SOCS1 pathway
        3666. Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery …
        3667. Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock …
        3668. MicroRNA-200a is up-regulated in aged rats with erectile dysfunction and could attenuate endothelial function via SIRT1 inhibition
        3669. Identification of new inhibitors for human SIRT1: an in-silico approach
        3670. Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1
        3671. … PC12 cells from tunicamycin-mediated cell death via reactive oxygen species scavenging and modulation of Nrf2-driven gene expression, SIRT1 and MAPK signaling …
        3672. Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma
        3673. Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1
        3674. SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes
        3675. Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and SIRT1
        3676. SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells
        3677. Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenous β-defensin expression through the SIRT1/ERK/90RSK pathway
        3678. SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-κB signaling pathway
        3679. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development
        3680. Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo
        3681. Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients
        3682. hnRNP A1 antagonizes cellular senescence and senescence‐associated secretory phenotype via regulation of SIRT1 mRNA stability
        3683. SIRT1 confers protection against ischemia/reperfusion injury in cardiomyocytes via regulation of uncoupling protein 2 expression
        3684. SIRT1-mediated deacetylation of PGC1α attributes to the protection of curcumin against glutamate excitotoxicity in cortical neurons
        3685. Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, SIRT1
        3686. HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells
        3687. Identifying human SIRT1 substrates by integrating heterogeneous information from various sources
        3688. Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway
        3689. Long non-coding RNA TUG1 promotes cervical cancer progression by regulating the miR-138-5p-SIRT1 axis
        3690. Adiponectin protects against glutamate-induced excitotoxicity via activating SIRT1-dependent PGC-1 expression in HT22 hippocampal neurons
        3691. Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis
        3692. Acute treatment of resveratrol alleviates doxorubicin-induced myotoxicity in aged skeletal muscle through SIRT1-dependent mechanisms
        3693. SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22
        3694. ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy
        3695. Mst1 regulates hepatic lipid metabolism by inhibiting SIRT1 ubiquitination in mice
        3696. 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via SIRT1 in …
        3697. … compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via SIRT1/PGC-1α pathway
        3698. Carbon Monoxide Potentiation of L-Type Ca2+ Channel Activity Increases HIF-1α-Independent VEGF Expression via an AMPKα/SIRT1-Mediated PGC-1α/ERRα …
        3699. MicroRNA-34a negatively regulates efferocytosis by tissue macrophages in part via SIRT1
        3700. SIRT1 suppresses Wnt/βCatenin signaling in liver cancer cells by targeting βCatenin in a PKAα-dependent manner
        3701. Visfatin attenuates the ox-LDL-induced senescence of endothelial progenitor cells by upregulating SIRT1 expression through the PI3K/Akt/ERK pathway
        3702. Protection of CD4+ T cells from hepatitis C virus infection‐associated senescence via ΔNp63–miR‐181a–SIRT1 pathway
        3703. SIRT1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats
        3704. Adiponectin suppresses T helper 17 cell differentiation and limits autoimmune CNS inflammation via the SIRT1/PPARγ/RORγt pathway
        3705. NFAT5 protects astrocytes against oxygen–glucose–serum deprivation/restoration damage via the SIRT1/Nrf2 pathway
        3706. MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway
        3707. The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway
        3708. Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients
        3709. Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet‐fed middle‐aged mice via a SIRT1‐dependent mechanism
        3710. Hepatitis C virus core protein impairs metabolic disorder of liver cell via HOTAIR-SIRT1 signalling
        3711. SIRT1 increases YAP-and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma
        3712. The SIRT1/NF-kB signaling pathway is involved in regulation of endothelin type B receptors mediated by homocysteine in vascular smooth muscle cells
        3713. Retinoic acid ameliorates high-fat diet-induced liver steatosis through SIRT1
        3714. Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver
        3715. Treatment with NAD+ inhibited experimental autoimmune encephalomyelitis by activating AMPK/SIRT1 signaling pathway and modulating Th1/Th17 immune …
        3716. Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression
        3717. Resveratrol attenuates Aβ 25–35 caused neurotoxicity by inducing autophagy through the TYrRS-PARP1-SIRT1 signaling pathway
        3718. Depigmenting effect of resveratrol is dependent on FOXO3a activation without SIRT1 activation
        3719. Assessing colonic exposure, safety, and clinical activity of SRT2104, a novel oral SIRT1 activator, in patients with mild to moderate ulcerative colitis
        3720. SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation
        3721. Vav1 regulates mesenchymal stem cell differentiation decision between adipocyte and chondrocyte via SIRT1
        3722. Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway
        3723. … myocardial ischemia–reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 …
        3724. Resveratrol inhibits adventitial fibroblast proliferation and induces cell apoptosis through the SIRT1 pathway
        3725. AMPK↔ SIRT1: from a signaling network to a combination drug
        3726. Fibroblast growth factor 21 (FGF21) promotes formation of aerobic myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α pathway
        3727. Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3
        3728. Mesenchymal stem cells with SIRT1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment
        3729. Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: Role of AMPK, SIRT1, and mitochondrial function
        3730. Resveratrol attenuated TNF-α–induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway
        3731. Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
        3732. Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as SIRT1/2 Inhibitor
        3733. MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization
        3734. Mangiferin protects retinal ganglion cells in ischemic mouse retina via SIRT1
        3735. SIRT1 gene polymorphisms and risk of lung cancer
        3736. Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress
        3737. Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through SIRT1/PGC-1α/Mn-SOD signaling pathways
        3738. Ampelopsin attenuates the atrophy of skeletal muscle from d-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade
        3739. miR‐204‐5p targeting SIRT1 regulates hepatocellular carcinoma progression
        3740. Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways
        3741. MicroRNA-133b inhibits cell proliferation and invasion in osteosarcoma by targeting SIRT1
        3742. Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-cell chronic lymphocytic leukemia (CLL)
        3743. Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity
        3744. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway
        3745. Resveratrol protects against high-fat diet induced renal pathological damage and cell senescence by activating SIRT1
        3746. Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling
        3747. Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and …
        3748. microRNA-182 mediates SIRT1-induced diabetic corneal nerve regeneration
        3749. Hydrogen rich water attenuates renal injury and fibrosis by regulation transforming growth factor-β induced SIRT1
        3750. Anti-fibrotic effect of losartan, an angiotensin II receptor blocker, is mediated through inhibition of ER stress via up-regulation of SIRT1, followed by induction of HO-1 …
        3751. Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway
        3752. Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus
        3753. 1, 4-Dihydropyridines active on the SIRT1/AMPK pathway ameliorate skin repair and mitochondrial function and exhibit inhibition of proliferation in cancer cells
        3754. Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation
        3755. Melatonin inhibits SIRT1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis
        3756. Hydrogen sulfide attenuates inflammatory hepcidin by reducing IL-6 secretion and promoting SIRT1-mediated STAT3 deacetylation
        3757. Emodin suppresses silica-induced lung fibrosis by promoting SIRT1 signaling via direct contact
        3758. Biogenesis of pro-senescent microparticles by endothelial colony forming cells from premature neonates is driven by SIRT1-dependent epigenetic regulation …
        3759. HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis
        3760. Extremely low-frequency electromagnetic field promotes astrocytic differentiation of human bone marrow mesenchymal stem cells by modulating SIRT1 expression
        3761. Underlying mechanism of SIRT1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes
        3762. Rehabilitation training and resveratrol improve the recovery of neurological and motor function in rats after cerebral ischemic injury through the SIRT1 signaling …
        3763. SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma
        3764. Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA
        3765. Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
        3766. Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells
        3767. Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion
        3768. Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory‑fibrosis through the NF‑κB p65 and SIRT1 pathway; NMN alleviates …
        3769. Sevoflurane ameliorates myocardial cell injury by inducing autophagy via the deacetylation of LC3 by SIRT1
        3770. Sirtuin 1 (SIRT1) overexpression in BaF3 cells contributes to cell proliferation promotion, apoptosis resistance and pro-inflammatory cytokine production
        3771. Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise
        3772. The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells
        3773. Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/β-catenin signaling pathway mediated by SIRT1
        3774. SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium
        3775. Juglone up-regulates SIRT1 in skin cells under normal and UVB irradiated conditions
        3776. Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products
        3777. The nutrient and energy sensor SIRT1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the prohormone convertase 2 (PC2) …
        3778. mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway
        3779. Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1
        3780. Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC zeta-GLUT4-glucose pathway in …
        3781. Targeting SIRT1 in a rat model of high‑fat diet‑induced non‑alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol
        3782. miR-543 promotes gastric cancer cell proliferation by targeting SIRT1
        3783. Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-α in patients with obstructive sleep apnea
        3784. Adiponectin upregulates filaggrin expression via SIRT1-mediated signaling in human normal keratinocytes
        3785. Over-expression of heat shock protein 70 protects mice against lung ischemia/reperfusion injury through SIRT1/AMPK/eNOS pathway
        3786. TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence
        3787. Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-κB and activating SIRT1
        3788. Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways
        3789. PDE5 inhibition ameliorates visceral adiposity targeting the miR-22/SIRT1 pathway: evidence from the CECSID trial
        3790. microRNA‑34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma Corrigendum in/10.3892/ol. 2019.11048
        3791. Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas
        3792. Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells
        3793. AML1–ETO promotes SIRT1 expression to enhance leukemogenesis of t (8; 21) acute myeloid leukemia
        3794. Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated …
        3795. MiR-21 regulates TNF-α-induced CD40 expression via the SIRT1-NF-κB pathway in renal inner medullary collecting duct cells
        3796. High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC‐1α/SIRT1 signaling pathway
        3797. Protective effects of isorhamnetin on cardiomyocytes against anoxia/reoxygenation-induced injury is mediated by SIRT1
        3798. … sepsis‑induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF‑α and myocardial apoptosis via activation of SIRT1
        3799. Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
        3800. Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic β cells from apoptosis
        3801. SIRT1 activity is decreased in lesional psoriatic skin
        3802. AAV-mediated SIRT1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance
        3803. Inhibitory effects of SRT1720 on the apoptosis of rabbit chondrocytes by activating SIRT1 via p53/bax and NF-κB/PGC-1α pathways
        3804. Mesenchymal stem cells overexpressing SIRT1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages
        3805. Resveratrol improved the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating SIRT1
        3806. Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent Manner
        3807. Bivalent SIRT1 inhibitors
        3808. miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting SIRT1
        3809. GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1
        3810. SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5′ UTR RNA
        3811. Resveratrol promotes recovery of hearing following intense noise exposure by enhancing cochlear SIRT1 activity
        3812. Leucine-nicotinic acid synergy stimulates AMPK/SIRT1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia …
        3813. Response of BAX, Bcl-2 proteins, and SIRT1/PGC-1α mRNA expression to 8-week treadmill running in the aging rat skeletal muscle
        3814. SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells
        3815. MiR-138-5p promotes TNF-α-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling
        3816. SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the …
        3817. … present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD+/NADH ratio and activating PPARα, AMPK and SIRT1 …
        3818. Alteration of muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscle of growing pigs fed low-protein diets with varying branched …
        3819. Inhibiting microRNA-449 attenuates cisplatin-induced injury in NRK-52E cells possibly via regulating the SIRT1/P53/BAX pathway
        3820. Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice
        3821. … : Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating the SIRT1 …
        3822. Reversible modulation of SIRT1 activity in a mouse strain
        3823. Expression profiles of SIRT1 and APP genes in human neuroblastoma SK-N-SH cells treated with two epigenetic agents
        3824. SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets
        3825. De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells
        3826. miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1
        3827. SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1
        3828. Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1
        3829. Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats
        3830. Resveratrol exerts protective effects on anoxia/reoxygenation injury in cardiomyocytes via miR-34a/SIRT1 signaling pathway
        3831. MicroRNA-141 targets SIRT1 and inhibits autophagy to reduce HBV replication
        3832. MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
        3833. Zerumbone ameliorates high-fat diet-induced adiposity by restoring AMPK-regulated lipogenesis and microRNA-146b/SIRT1-mediated adipogenesis
        3834. … implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly (ADP …
        3835. NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity
        3836. CHFR negatively regulates SIRT1 activity upon oxidative stress
        3837. Omega-3 polyunsaturated fatty acids alleviate hepatic steatosis-induced inflammation through SIRT1-mediated nuclear translocation of NF-κB p65 subunit in …
        3838. CR6-interacting factor 1 deficiency impairs vascular function by inhibiting the SIRT1-endothelial nitric oxide synthase pathway
        3839. Methylene blue alleviates experimental autoimmune encephalomyelitis by modulating AMPK/SIRT1 signaling pathway and Th17/Treg immune response
        3840. Communication from tubular epithelial cells to podocytes through SIRT1 and nicotinic acid metabolism
        3841. MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1
        3842. Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma
        3843. Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1
        3844. The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1
        3845. Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through SIRT1/ERK1/2 signaling pathway
        3846. SIRT1 signaling pathway mediated the protective effects on myocardium of rats after endurance training and acute exhaustive exercise
        3847. miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting SIRT1
        3848. Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients
        3849. 1,25(OH)2D3 improves cardiac dysfunction, hypertrophy, and fibrosis through PARP1/SIRT1/mTOR‐related mechanisms in type 1 diabetes
        3850. Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?
        3851. miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1
        3852. miR-204 regulates the proliferation of dairy goat spermatogonial stem cells via targeting to SIRT1
        3853. miR-22 inhibits mouse ovarian granulosa cell apoptosis by targeting SIRT1
        3854. Lin28a protects against postinfarction myocardial remodeling and dysfunction through SIRT1 activation and autophagy enhancement
        3855. Highly sensitive electrochemical immunoassay integrated with polymeric nanocomposites and enhanced SiO2@ Au core-shell nanobioprobes for SIRT1 determination
        3856. Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1
        3857. Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS
        3858. AdipoR1-mediated miR-3908 inhibits glioblastoma tumorigenicity through downregulation of STAT2 associated with the AMPK/SIRT1 pathway
        3859. Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1α and serum antioxidant enzymes in patients with coronary artery …
        3860. Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review
        3861. MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
        3862. SIRT1‑mediated regulation of oxidative stress induced by Pseudomonas aeruginosa lipopolysaccharides in human alveolar epithelial cells
        3863. Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing’s sarcoma cells: resveratrol suppresses and SRT1720 enhances …
        3864. In patients with coronary artery disease and type 2 diabetes, SIRT1 expression in circulating mononuclear cells is associated with levels of inflammatory …
        3865. SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi’s sarcoma-associated herpesvirus transformed cells
        3866. A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t (8; 21) acute myeloid leukemia
        3867. SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells
        3868. SIRT1 regulates accumulation of oxidized LDL in HUVEC via the autophagy-lysosomal pathway
        3869. Central metabolic sensing remotely controls nutrient-sensitive endocrine response in Drosophila via Sir2/SIRT1–upd2–IIS axis
        3870. The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control
        3871. Metabolism of 20 (S)-Ginsenoside Rg2 by rat liver microsomes: bioactivation to SIRT1-activating metabolites
        3872. Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma
        3873. Differential effects of estradiol and bisphenol A on SET8 and SIRT1 expression in ovarian cancer cells
        3874. … of extracellular calcium influx results in enhanced IL-12 production in LPS-treated murine macrophages by downregulation of the CaMKK-AMPK-SIRT1 …
        3875. Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice
        3876. The aldehyde group of gossypol induces mitochondrial apoptosis via ROS-SIRT1-p53-PUMA pathway in male germline stem cell
        3877. Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1
        3878. Localization of sirtuins (SIRT1-7) in the aged mouse inner ear
        3879. Sirtuin1 (SIRT1) regulates tumor necrosis factor-alpha (TNF-α-Induced) aquaporin-2 (AQP2) expression in renal medullary collecting duct cells through …
        3880. Suppression of miR-301a alleviates LPS-induced inflammatory injury in ATDC5 chondrogenic cells by targeting SIRT1
        3881. Beraprost sodium, a prostacyclin analogue, reduces fructose-induced hepatocellular steatosis in mice and in vitro via the microRNA-200a and SIRT1 signaling …
        3882. Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline
        3883. microRNA-199a-5p mediates high glucose-induced reactive oxygen species production and apoptosis in INS-1 pancreatic ß-cells by targeting SIRT1
        3884. Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors
        3885. Breast cancer metastasis suppressor 1 modulates SIRT1-dependent p53 deacetylation through interacting with DBC1
        3886. Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator
        3887. 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop
        3888. MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1
        3889. Polymorphism in the SIRT1 gene and parameters of metabolic syndrome in a sample of the adult Brazilian population
        3890. MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting SIRT1
        3891. Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius …
        3892. mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy
        3893. Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: A probable linkage between obesity and coronary arterial disease
        3894. SIRT1 expression is refractory to hypoxia and inflammatory cytokines in nucleus pulposus cells: Novel regulation by HIF‐1α and NF‐κB signaling
        3895. SIRT1 controls cell proliferation by regulating contact inhibition
        3896. … (3D-QSAR) modeling combined with virtual screening to identify novel small-molecule inhibitors of silent mating-type information regulation 2 homologue 1 (SIRT1)
        3897. Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (SIRT1)
        3898. Protective effect of unacylated ghrelin on compression-induced skeletal muscle injury mediated by SIRT1-signaling
        3899. Obesity accelerates murine gastric cancer growth by modulating the SIRT1/YAP pathway
        3900. DJ-1 activates SIRT1 through its direct binding to SIRT1
        3901. #VALUE!
        3902. microRNA‑494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer
        3903. Carnosic acid attenuates acute ethanol-induced liver injury via a SIRT1/p66Shc-mediated mitochondrial pathway
        3904. SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
        3905. Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia
        3906. Differential expression of circadian genes in leukemia and a possible role for SIRT1 in restoring the circadian clock in chronic myeloid leukemia
        3907. Is SIRT6 activity neuroprotective and how does it differ from SIRT1 in this regard?
        3908. PU. 1-deficient mice are resistant to thioacetamide-induced hepatic fibrosis: PU. 1 finely regulates SIRT1 expression via transcriptional promotion of miR-34a …
        3909. Tat-mediated induction of miRs-34a &-138 promotes astrocytic activation via downregulation of SIRT1: implications for aging in HAND
        3910. Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1)
        3911. Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression
        3912. Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1
        3913. CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells
        3914. Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting SIRT1
        3915. Overcoming ATM deficiency by activating the NAD+/SIRT1 axis
        3916. G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE−/− mice
        3917. Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK …
        3918. Acetylome study in mouse adipocytes identifies targets of SIRT1 deacetylation in chromatin organization and RNA processing
        3919. NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
        3920. Tris (2‐chloroethyl) phosphate‐induced cell growth arrest via attenuation of SIRT1‐independent PI3K/Akt/mTOR pathway
        3921. Altered microRNA-9 expression level is directly correlated with pathogenesis of nonalcoholic fatty liver disease by targeting Onecut2 and SIRT1
        3922. Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating SIRT1
        3923. Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
        3924. Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK
        3925. Transcriptional coactivator p300 and silent information regulator 1 (SIRT1) gene polymorphism associated with diabetic kidney disease in a Chinese cohort
        3926. Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change
        3927. The silent information regulator 1 (SIRT1) is a positive regulator of the Notch pathway in Drosophila
        3928. Understanding genetic heterogeneity in type 2 diabetes by delineating physiological phenotypes: SIRT1 and its gene network in impaired insulin secretion
        3929. The gender association of the SIRT1 rs7895833 polymorphism with pediatric obesity: a 3-year panel study
        3930. Effect of daisaikoto on expressions of SIRT1 and NF-kappaB of diabetic fatty liver rats induced by high-fat diet and streptozotocin
        3931. 1, 2, 3-Triazole-dithiocarbamate hybrids, a group of novel cell active SIRT1 inhibitors
        3932. To Stay Happy, Keep Your SIRT1 Active
        3933. Paliperidone Protects SH-SY5Y Cells Against MK-801-Induced Neuronal Damage Through Inhibition of Ca2+ Influx and Regulation of SIRT1/miR-134 Signal …
        3934. SIRT1 gene polymorphisms associated with carcass traits in Luxi cattle
        3935. Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine
        3936. Lycium barbarum polysaccharides enhances SIRT1 expression and decreases MMP-9 and HIF-1α expressions in hypoxic pulmonary vascular smooth muscle cells
        3937. SIRT1 Influences the sensitivity of A549 non-small cell lung cancer cell line to cisplatin via modulating the Noxa expression
        3938. Suppressive effect of microRNA-138 on the proliferation and invasion of osteosarcoma cells via targeting SIRT1
        3939. Activation of SIRT1 deacetylase as a therapeutic approach for myelodysplastic syndromes by restoring TET2 function
        3940. miR-138 promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through the SIRT1/p-STAT3 pathway
        3941. Resveratrol suppresses P-selectin, PSGL-1, and VWF through SIRT1 signaling pathway
        3942. Effect of Kangshuanyihao Formula on the Inflammatory Reaction and SIRT1/TLR4/NF-κB Signaling Pathway in Endothelial Injury
        3943. The impact of a 48-h fast on SIRT1 and GCN5 in human skeletal muscle
        3944. Giardia duodenalis GlSir2. 2, homolog of SIRT1, is a nuclear-located and NAD+-dependent deacethylase
        3945. SIRT1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus
        3946. FOXO3a & haematopoietic stem cells: Goodbye PI3K, hello SIRT1?
        3947. A novel Ubc9-dependent pathway regulates SIRT1-ER-α Axis and BRCA1-associated TNBC lung metastasis
        3948. SIRT1-positive lymphocytes in acute cellular cardiac allograft rejection: contributor to pathogenesis and a therapeutic target
        3949. SIRT1 gene polymorphisms and its protein level in colorectal cancer
        3950. Morphoproteomics identifies SIRT1 and EZH2 pathways as commonalities in B-cell acute lymphoblastic leukemia: pathogenetic implications and opportunities for …
        3951. B31 SIRT1 expression, regulation and activity in R6/2 mice
        3952. Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1
        3953. GW28-e0635 Quercetin retards progression of Diabetic cardiomyopathy through modulations of SIRT1 and AMP-activated protein kinase
        3954. The effects of siRNA SIRT1 on the proliferation of human cervical cancer cells
        3955. #VALUE!
        3956. Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease
        3957. KDM2B is a histone H3K79 demethylase and induces transcriptional repression via SIRT1-mediated chromatin silencing
        3958. Protective effects and mechanism of SIRT1 for the regulation of p38 MAPK pathway on retinal ganglion cells in rats with diabetic retinopathy
        3959. Updated roles of SIRT1 in prostate diseases
        3960. SIRT1 in metabolic health and disease
        3961. Guttiferone A aggregates modulate silent information regulator 1 (SIRT1) activity
        3962. SAT0046 Regulation of SIRT1 Maybe A Pioneering Strategy in Treatment of Rheumatoid Arthritis
        3963. SIRT1 puts an embargo on mRNA export
        3964. Alteration of Wnt/β-catenin signaling pathway in type2 diabetic rats’ aorta and regulation of SIRT1
        3965. Loss of SIRT1 impairs autophagy in chondrocytes and is associated with accelerated cartilage aging and experimental osteoarthritis
        3966. #VALUE!
        3967. Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice
        3968. Propofol alleviates hepatic ischemia/reperfusion injury via the activation of the SIRT1 pathway
        3969. Whey Protein Attenuates Angiotensin II-Primed Premature Senescence of Vascular Smooth Muscle Cells through Upregulation of SIRT1
        3970. Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
        3971. Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/SIRT1/NF-κB signaling pathway in aging rats
        3972. SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
        3973. Morphoproteomics identifies the EZH2 and SIRT1 pathways as potential blocks to differentiation in yolk sac tumor of the ovary and provides therapeutic options: A …
        3974. Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease
        3975. Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through SIRT1 pathway
        3976. Multi-allele dipstick assay for visual genotyping of four novel SIRT1 gene variant alleles as candidate biomarkers for sporadic Parkinson disease
        3977. Corrigendum to” Restoration of SIRT1 Function by Pterostilbene Attenuates Hypoxia-Reoxygenation Injury in Cardiomyocytes”[Eur. J. Pharmacol. 776 (2016) 26-33]
        3978. Expression of AMPK, SIRT1, and ACC differs between winter-and summer-acclimatized Djungarian Hamsters
        3979. Construction of lentiviral vector containing SIRT1 gene and its expression in retinal ganglion cell
        3980. Anti-inflammatory effect of Chikusetsu oleanane saponin on Raw264. 7 cell through regulating SIRT1 activity
        3981. PPAR gamma coactivator 1 beta (PGC-1β) reduces mammalian target of rapamycin (mTOR) expression via a SIRT1-dependent mechanism in neurons
        3982. Effect of SIRT1 gene silencing on radiosensitivity of diffuse large B-cell lymphoma cells
        3983. AB0107 The modulation of macrophage polarization by SIRT1 maybe new target therapy in rheumatoid arthritis
        3984. Effect of SIRT1 deficiency on function of brown adipose tissue in obese mice
        3985. Role of SIRT1 in C5b-9 mediated oligodendrocyte cell cycle activation
        3986. Survivin and SIRT1: can be two prognostic factors in chronic myeloid leukemia?
        3987. Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers
        3988. The Impact of Ramadan Fasting on SIRT1 mRNA Expression in Peripheral Blood Mononuclear Cells
        3989. A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy …
        3990. SIRT1 is downregulated during peripheral blood stem cell mobilization in healthy donors by granulocyte-colony stimulating factor
        3991. 3 SIRT1—A POSSIBLE MARKER FOR REPRODUCTIVE AGING OF IN VIVO-DERIVED BOVINE OOCYTES?
        3992. SIRT1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response
        3993. Cardiac SIRT1 Has a Protective Role in Lipotoxic Cardiomyopathy through Maintaining Membrane Fatty Acid Composition
        3994. Effect of Qinggan Zishen Chinese Medicine on SIRT1 Protein Expression in Liver Tissue of Spontaneously Hypertensive Rats Fed with High Fat Diet
        3995. Roles of NAD in Protection of Axon against Degeneration via SIRT1 Pathways
        3996. Allosteric SIRT1 activators as putative anti-aging drugs
        3997. AB059. MiR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
        3998. SIRT1 Activator II Protects against Myocardial Injury in High Fat Diet‐Induced Diabetic Mice
        3999. Analysis of silent information regulator 1 (SIRT1) gene polymorphisms in antituberculosis-drug-induced hepatotoxicity in a prospective cohort study
        4000. D-4F decreases the expression of Aβ protein through up-regulating long non coding RNA SIRT1-as in SAMP8 mice
        4001. Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) …
        4002. Myeloid cell-specific SIRT1 knockout impairs innate immune responses against intracellular bacteria infection
        4003. Enhanced Targeting of FLT3-ITD+ AML Stem Cells through Combined Inhibition of SIRT1 and Autophagic Flux
        4004. PI3 K/Akt/SIRT1 signaling pathway mediated hydrogen sulfide postconditioning-induced protection against I/R injury
        4005. Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation
        4006. SIRT1 modulates AID expression, class switch DNA recombination and somatic hypermutation by repressing NF-kB activity
        4007. Effect of telmisartan and insulin on endoplasmic reticulum stress and the expression of SIRT1 in testis of type 1 diabetic rats
        4008. Different patterns of SIRT1, KLF4, DAPK1 and SPG20 methylation in B lymphocytes correlate with the clinical parameters of non-Hodgkin lymphoma subtypes
        4009. Hypermethylation of HIC1 and aberrant expression of HIC1/SIRT1 contribute to papillary thyroid carcinoma
        4010. Corrigendum: transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis
        4011. Effects of Chaihu Shugan powder on hepatic lipid metabolism and AMPK/SIRT1 pathway in rats with non-alcoholic fatty liver disease
        4012. MP369 D PINITOL ALLEVIATES CYCLOSPORINE-INDUCED RENAL FIBROSIS VIA THE ACTIVATION OF SIRT1 AND NRF2 ANTIOXIDANT PATHWAYS
        4013. SIRT1 modulates immunoglobulin class switch DNA recombination and somatic hypermutation by regulating B lymphocyte Aicda expression through NF-kB …
        4014. Mir-217 promotes inflammation and fibrosis induced by high glucose in rat glomerular mesangial cells via SIRT1/HIF-1αsignal pathway
        4015. Gaba-betaine modulates SIRT1 and p16INK4A expression during high-glucose induced endothelial cell senescence
        4016. SIRT1 and tumor resistance
        4017. ROLE OF SIRT1 IN CANCER: A REVIEW
        4018. Silent mating-type information regulator 2 homolog 1 (SIRT1) in Alzheimer’s disease: an update on potential mechanisms
        4019. Consecutive stimulation of HBsAg promotes the viability of the human B lymphoblastoid cell line IM‑9 through regulating the SIRT1‑NF‑κB pathway
        4020. Dihydroartemisinin enhances antitumor effect of 5-fluorouracil against gastric cancer by down-regulating SIRT1 expression
        4021. Synthesis of potential SIRT1 activators
        4022. Baicalin treatment regulates hyperactivity of HPA axis and alters SIRT1 related inflammation in the hypothalamus in a model of depression
        4023. … Angelica Sinensis Ameliorates High-Fat Diet and STZ-induced Hepatic Oxidative Stress and Inflammation in Diabetic Mice by Activating SIRT1-AMPK Pathway”[JNB 43 …
        4024. E1231, an activator of SIRT1, regulates cholesterol and lipid metabolism through SIRT1-LXRALPHA-ABCA1 pathway
        4025. The correlation between SIRT1 and Muller cells in the development of CNV
        4026. The Role of SIRT1 in Muscle Hypertrophy
        4027. Effect of SIRT1 on the proliferation of ovarian cancer CAOV3 cells and its possible mechanism
        4028. GW28-e0071 The Effect of Mild Hypothermia on Neurons Autophagy after Cerebral Ischemia Reperfusion in SIRT1 Knockout Mice
        4029. SIRT1 regulates Mxd1 throughout melanoma progression
        4030. SIRT1 Increases the Expression of Fetal Hemoglobin Genes in Human Adult and Cord Blood Erythroblasts
        4031. The role of SIRT1 in the formation of retinal miroaneurysms during aging
        4032. MODULATION OF SIRT1 AS AN ANTI-AGEING TARGET
        4033. The effect of shRNA interference lentivirus vector targeting rat SIRT1 gene on the expression of SIRT1 in retinal ganglion cell
        4034. Combined Determination of Carbohydrate Antigen 199 and SIRT1 Based on an Electrochemiluminescence Immunosensor
        4035. THE ROLE OF SIRT1 IN AGEING AND FRAILTY
        4036. GW28-e0612 Liver X receptor agonist T0901317 ameliorates sepsis-induced myocardial injury and dysfunction: the role of SIRT1 signaling
        4037. The Impact of Catalytically Inactive SIRT1 on Age-Associated Cardio-Renal Dysfunction
        4038. P220 Depigmenting effect of resveratrol is not dependent on SIRT1 activation
        4039. A role of SIRT1 in the Notch signalling pathway
        4040. Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2, 9 via AMPK-SIRT1 pathway in a non-small cell lung cancer
        4041. ASSOCIATION OF SIRT1 RS3740051 GENE POLYMORPHISM WITH PITUITARY ADENOMA
        4042. Exploring cellular actions and interactions of SIRT1 that may counteract ageing
        4043. SIRT1: Expression in the cornea and its role in corneal wound healing
        4044. Expression Changes and Significance of SIRT1 Alternative Splicing Variants of SIRT1-Exon8 mRNA in the Hippocampus of Young and Aged Mice
        4045. Effects of maternal lead exposure on expression of 8-OHd G and SIRT1 in brain tissue of mice offspring
        4046. SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
        4047. #VALUE!
        4048. Spatial Dynamics of SIRT1 Relates to Metabolic Transitions in the Cell Nucleus
        4049. Assessment of SIRT1 gene expression in patients with chronic myeloid leukemia by real time pcr method
        4050. Expression of SIRT1 in a Uveal Melanoma Animal Model
        4051. The Role of SIRT1 In Breast Cancer Stem Cells
        4052. Non-canonical activation of AR signaling by histone deacetylase SIRT1
        4053. Computational model of circadian oscillator in mammals: Interaction with NAD+/SIRT1 system and age-related changes in the expression of circadian oscillator genes
        4054. Influence of EGFR in B [a] P-induced SIRT1 activation in human bronchial epithelial cells
        4055. SIRT1 and Age-Related Macular Degeneration
        4056. SIRT1 activators induced neuroprotection of photoreceptors in rd10 mice
        4057. The effect of SIRT1 inhibition by EX527 on uveal melanoma cells
        4058. Association of SIRT1 rs3740051 gene polymorphism with pituitary adenoma
        4059. Role of variants at SIRT1 gene in pituitary adenoma
        4060. SIRT1 inhibition exhibits decreased pluripotency in cancer stem cells of glioma
        4061. The effects of SIRT1 inhibitors nicotinamide and Ex-527 on lymphoma cells
        4062. #VALUE!
        4063. Novel therapies for cancer treatment: designing high affinity selective ligands against SIRT1 enzyme
        4064. Does SIRT1 or cytostasis underlie the anti-ageing activity of trans-stilbenes?
        4065. SIRT1 in Trophoblast Differentiation and Placental Development
        4066. THE ASSOCIATION BETWEEN SIRT1 RS3740051 AND AGE-RELATED MACULAR DEGENERATION
        4067. Knockdown of SIRT1 enhances the sensitivity to cisplatin by inhibiting autophagy in A549 cells
        4068. Effect of supplemental Erchen decoction on role of oxidative stress and SIRT1 in rats with chronic obstructive pulmonary disease
        4069. NAD+-Dependent SIRT1 Reprograms CD11c+ Dendritic Cells and Cd4+ T Cells to Control Immune Polarity During Sepsis
        4070. SIRT1 decreases TLR2-mediated Mac-1 expression in atherosclerosis
        4071. Association of single nucleotide polymorphism of SIRT1 gene with age-related cataract
        4072. Effect of SIRT1 on dynamic expression of AQP4 in early stage of cerebral ischemia in rats
        4073. Spatial Dynamics of SIRT1 Dictate Metabolic Transitions in the Cell Nucleus
        4074. SIRT1 plays a pivotal role in TLR2‐mediated Mac‐1 expression in monocytes
        4075. SIRT1 Regulates the Inflammator\Response of Vascular Adventitial Fibroblasts through Autophag\and Related Signaling Pathwa\
        4076. Persistent global inflammation caused by the loss of SIRT1 protects against experimental osteoarthritis
        4077. Exploring the SIRT1/P53 Pathway in Adipocytes Hyperplasia
        4078. Endothelial SIRT1 Is Required for PGC1α-Induced Angiogenesis in Skeletal Muscle Tissue
        4079. The study of the inhibition effects of SIRT1 on the apoptosis induced by Galangin in HepG2 cells
        4080. Relationship between mechanism of SIRT1-mediated mitophagy in myocardium and Mfn2 in diabetic rats
        4081. SIRT1, 2, 3 protect mouse oocytes from postovulatory aging
        4082. Regulation of IL-4 Gene Expression By SIRT1 in Human Mast Cell
        4083. Aging-related change of erectile function and the expression of SIRT1
        4084. SIRT1 was involved in TNF-α-promoted osteogenic differentiation of human DPSCs through Wnt/β-catenin signal Animal
        4085. Interactions between SIRT1 and STAT3 in the retinal pigmented epithelium cell
        4086. Endothelial-specific SIRT1 Deletion Inhibits Retinal Vascular Endothelial Cell Migration
        4087. SIRT1 suppresses atherosclerosis induced by TLR2-mediated monocyte adhesion to endothelium through MAC-1 expression
        4088. Serum SIRT1 level is higher in male patient with isolated hypogonadotropic hypogonadism: The first study in human
        4089. SIRT1 negatively regulates the expression of Prl2C3, a senescence-associated protein
        4090. The Association between SIRT1 rs3740051 and age-related macular degeneration
        4091. SIRT1 Attenuates Nasal Polypogenesis By Suppressing Epithelial-to-Mesenchymal Transition
        4092. Celastrol protects against fatty liver through SIRT1
        4093. ROS Induced Mitochondrioal Dysfunction Causes Endothelial Dyfunction by Downregulation Of SIRT1
        4094. Effects of Buyang Huanwu Decoction against oxidative stress of rBMECs by up-regulating SIRT1
        4095. Correlation analysis of SIRT1 gene variant and susceptibility to chronic obstructive pulmonary disease
        4096. SIRT1 Activity Is Required For The Protective Effects Of The Female Sex In The Response To Chronic Hypoxia
        4097. Recurrent cigarette smoke exposure impairs SIRT1 shuttling in bronchial epithelial cells
        4098. Effect of SIRT1 on the expression and phosphorylation of Tau protein in neuroblastoma SK-N-SH cells
        4099. CAY10591, a SIRT1 Activator, Suppresses Malignancy of Gingival Epithelial Carcinoma Cells
        4100. SIRT1 Maintains PGC-1α Function Through Periodic Promoter Release
        4101. Endothelial SIRT1 as a drug target for vascular ageing-related diseases.
        4102. ASSESSMENT OF SIRT1 GENE EXPRESSION IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA BY REAL TIME PCR METHOD
        4103. miR-199a-5p enhances expression of myocardial fibrosis-related genes by targeting SIRT1
        4104. Role of SIRT1 in the adaptive response of mouse ovaries to radiotherapy (X ray radiations)
        4105. Impact of expression of SIRT1 and SIRT2 on outcome in the very elderly patients with colorectal cancer.
        4106. SIRT1 Regulates Acrosome Biogenesis by Modulating Autophagic Flux During Spermiogenesis in Mice
        4107. Studies on the mechanism of SIRT1/AMPK signaling pathway between hepatocytes and hepatic stellate cells
        4108. Resveratrol: An Epigenetic Regulator of SIRT1–Is It a Magic Tool to Prevent Cardiovascular Disease?
        4109. Anti‐vascular ageing effects of endothelial SIRT1‐communicating with smooth muscle cells of the arteries
        4110. Age-related structural changes in the liver of old mice with SIRT1 overexpression in conjunction with NMN supplementation
        4111. SIRT1 rs7896005 polymorphism may be related to coronary artery disease in Caucasians with type 2 diabetes, without affecting all-cause mortality.
        4112. #VALUE!
        4113. Oscillatory Gene Promoter Regulation by Pgc-1α and SIRT1 in Cardiac Energy Metabolism
        4114. Effects of SIRT1 gene knockout on chronic kidney disease induced by 5/6 nephrectomy in mice and VEGF/Flk-1 signaling pathway
        4115. Regulation of SIRT1 by SREBP-1 in Adipogenic Differentiation of Mesenchymal Stem Cells
        4116. The role of SIRT1 in LPS-induced lung endothelial barrier dysfunction and lung injury in vivo
        4117. SIRT1 protects against radiation-induced lung injury via de-acetylating the Ku70 and P65
        4118. Decreased SIRT1 expression is related to bronchopulmonary dysplasia in premature infants after oxygen exposure
        4119. SIRT1 overexpression inhibits tunicamycin-induced endoplasmic reticulum stress in chondrocytes
        4120. Correction for Shah et al.,“A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of …
        4121. Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease
        4122. Inhibition of CML Development Following Conditional SIRT1 Deletion in Transgenic BCR-ABL Mice
        4123. SIRT1 expression is associated with formation of atherosclerotic plaques in diabetic patients
        4124. ACTIVATION OF THE SIRT1-LXR SIGNALLING PATHWAY IN RETINAL PIGMENTED EPITHELIAL CELLS PROMOTES CHOLESTEROL METBOLISM
        4125. SIRT1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response
        4126. Effect of Helicobacter pylori infection on SIRT1 and Sirt2 gene expression in human gastritis samples
        4127. Circulating SIRT1 Protects Against Atherosclerosis Through Its Modulation of Pcsk9 Activity
        4128. Glycine decarboxylase inhibits proliferation of ovarian cancer cells via SIRT1-mediated apoptosis
        4129. Glycolysis promotes MDSCs and cancer stemness through the interaction between SIRT1 and C/EBPb
        4130. A clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy.
        4131. Effect of Vitamin E on the Expression of SIRT1 and PGC-1α in Mice with Nonalcoholic Fatty Liver Disease
        4132. The evaluation of gene expression and enzyme activity of SIRT1 in peripheral blood mononuclear cells isolated from patients with relapsing-remitting multiple …
        4133. Abstract WMP41: Neuronal SIRT1 is Required for Resveratrol Preconditioning Induced Ischemic Tolerance
        4134. Effect Of Oral Appliance On Circulating Leukocyte Telomere Length And SIRT1 In Obstructive Sleep Apnea Syndrome
        4135. Loss of the longevity gene SIRT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy
        4136. Observation of the articular cartilage of osteoarthritis in SIRT1 gene knock-out mice through single staining and compound staining
        4137. Alleviation of inflammation in human RPE cells by bromodomain inhibitors is independent of SIRT1
        4138. Monomethylfumarate induces NAD+ and SIRT1 in Human Retinal Pigment Epithelial Cells: Relevance to Development of New Therapies for Dry AMD
        4139. Non-invasive molecular imaging of SIRT1-mediated epigenetic regulation in cancer using PET/CT with a novel substrate-type radiotracer 2-[18F] PhAHA
        4140. Adiponectin promotes normal human epidermal keratinocyte differentiation and calcium influx via SIRT1
        4141. Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulatingdendritic cell maturation
        4142. Cardiomyocyte SIRT1 Deficiency Alters Cardiac Substrate Metabolism and Sensitizes Myocardium to Ischemic Insults
        4143. The relationship between serum SIRT1 and EGR1 and other inflammatory cytokines in type 2 diabetic patients with different stages of diabetic nephropathy
        4144. D57 DON’T BE A DO-BADDER: NEW INTERVENTIONS FOR OSA: Effects Of Nasal Cpap On Exhaled SIRT1 And Tumor Necrosis Factor-[alpha] In Patients With …
        4145. Computational Modeling of Calorie Restriction (CR) Mimetics for Age-Related Diseases: Ligands of SIRT1 Target.
        4146. SIRT1 mediates the actions of PPARδ on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells
        4147. Downregulation of the SIRT1 and Liver X Receptor α/β signaling axis promotes diabetic retinopathy pathogenesis
        4148. Down-Regulation of Erk and SIRT1 Signaling May Lead to Reduced Fgf-21 Sensitivity in a Mouse Model of Diabetes
        4149. … to “Rehabilitation Training and Resveratrol Improve the Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through the SIRT1 …
        4150. Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of hippocampal SIRT1
        4151. SIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet
        4152. Anti-tumor effects of metformin: Effects of metformin on SIRT1, Nrf2 and AhR expression in cancer cells
        4153. Inhibition of p53 with its specific inhibitor pifithrin‐α prevents hepatic oxidative stress and inflammation, probably via up‐regulating SIRT1/Nrf2 pathway
        4154. SIRT1 regulates low oxygen induced bovine granulosa cell proliferation through interaction with VEGF-AKT-mTOR pathway
        4155. Computational model for mammalian circadian oscillator: interacting with NAD+/SIRT1 pathway and age-related changes in gene expression of circadian oscillator
        4156. Immunoprecipitation of SIRT1, sirt3 and PGC-1A from rat gastrocnemius and soleus with magnetic beads
        4157. TET2 Activity Is Modulated By SIRT1-Mediated Protein Deacetylation: A Potential Therapeutic Target in Myelodysplastic Syndrome
        4158. Caloric Restriction Increases the Resistance of Aged Heart to Myocardial Ischemia/Reperfusion Injury via Modulating AMPK-SIRT1 Signaling Pathway
        4159. Cardiomyocyte Specific Deletion of SIRT1 Gene Alters Substrate Metabolism and Sensitizes Myocardium to Ischemia and Reperfusion Injury
        4160. SIRT1 Enhances Oxidized Low-density Lipoprotein Induced Autophagy in Human Valve Interstitial Cells
        4161. EFFECT OF HELICOBACTER PYLORI INFECTION ON SIRT1 AND SIRT2 GENE EXPRESSION IN HUMAN GASTRITIS SAMPLES
        4162. Role of SIRT1/FoxO3α signaling pathway in berberine pretreatment-induced reduction of hypoxia/reoxygenation-caused injury to hepatic parenchymal cells
        4163. Oligonol Induces the Expression of the Anti-aging Molecule, SIRT1, via the AMPK-Autophagy Pathway
        4164. GW27-e0410 Effect of astaxanthin intervention on contrast induced acute kidney injury through the SIRT1/FOXO3a signal
        4165. SIRT1 Deacetylase Mediates Klotho Gene Deficiency-induced Arterial Remodeling and Stiffness
        4166. Platycodin D (PD) attenuates myocardial apoptosis mediated by JNK-SIRT1-HSF1-IGF-IIR-Caspase-3 signaling in hypertensive conditions
        4167. Activation of SIRT1 Attenuates Klotho Deficiency‐induced Arterial Stiffness and Hypertension via Enhancing AMPKα and eNOS activity
        4168. Activation of SIRT1 Deacetylase Attenuates Klotho Deficiency-induced Arterial Stiffness and Hypertension
        4169. … ] CALORIC RESTRICTION CAN IMPROVE LEARNING AND MEMORY OF C57/BL MICE PROBABLY VIA REGULATION OF THE SIRT1/AMPK SIGNALING PATHWAY
        4170. Oxidative Stress-Induced Mir-200c Disrupts SIRT1, Foxo1 and Enos Regulatory Loop, Causing Endothelial Dysfunction and Oxidative Stress Increase
        4171. The non-flavonoid polyphenol resveratrol induces anti-obesity effects via SIRT1 dependent improved mitochondrial functioning
        4172. Role of Autophagy Inhibition in Regulating Hepatic Lipid Metabolism: Molecular Cross Talk Between Proteasome Activator REGγ and SIRT1 Signaling
        4173. Associations of SIRT1 rs12778366, FGFR2 rs2981582 and STAT3 rs744166 polymorphisms with early age-related macular degeneration development
        4174. HGF and bFGF Secretion by Human Adipose-derived Stem cells improve Ovarian Function of Natural Aging through Activation of SIRT1-FOXO1 Signaling Pathway
        4175. Tongluo Xingnao Effervescent Tablets ameliorates cognitive function of SAMP8 mice via Nampt/SIRT1/FOXO3 pathway
        4176. TM4SF1 regulates cell cycle and ROS status in bladder cancer cells by targeting FOXO3a via PPARγ-SIRT1 negative feedback loop
        4177. RGS2 and SIRT1 Link Renin Angiotensin Aldosterone System to Alzheimer’s Disease
        4178. Hypermethylation of HIC1 and aberrant expression of HIC1/SIRT1 contribute to papillary thyroid carcinoma
        4179. SIRT1 facilitates initial recruitment of primordial follicles through activating mTOR and AKT transcription
        4180. SIRT1 represses PKC-zeta activation via regulating its acetylation and phosphorylation modification in cardiac hypertrophy
        4181. Effect of SIRT1/nf-κb signal axis on delaying hematopoietic stem cell and progenitor cell senescence with ginsenoside r1 in aging model rat induced by d-galactose
        4182. 100 SIRT1 Activation: A Strategy for Harnessing Endogenous Protection Against SAH-induced Neurovascular Dysfunction
        4183. miR-34a augments immune response through triggering NF-κB/B7-H3/TNF-α feedforward loop via SIRT1 in colorectal carcinoma
        4184. Gallotannin induces senescence and autophagy leading to cell death via SIRT1 inhibition and AMPK activation in hepatocellular carcinoma cells
        4185. Myocardial Senescence Induced by Inactivation Aldh2-SIRT1-GATA4 Pathway Involves in Heart Remolding After Acute Infarction
        4186. Inhibition of glycolysis abolishes microglial inflammatory activation via suppression of TBK1/NF-κB and HIF1α/SIRT1/p65 acetylation
        4187. SIRT1 Inhibitor Enhances Hsp90 Inhibitor-mediated Abrogation of Hsp90 Chaperone Function and Potentiates the Cytotoxicity of Hsp90 Inhibitor in Chemo-resistant …
        4188. Mir-217 promotes inflammation and fibrosis induced by high glucose in rat glomerular mesangial cells via SIRT1/HIF-1α signal pathway
        4189. miR-21 Regulates TNF-α-Induced CD40 Expression via SIRT1-NF-κB Pathway in Renal Inner Medulla Collecting Duct Cells
        4190. PS 07-12 UPREGULATED SGLT2 REDUCES PROXIMAL TUBULAR SIRT1 AND AUGMENTS RENAL GLUCONEOGENESIS IN EARLY STAGE DIABETIC …
        4191. Muscle Through SIRT1-Dependent Mechanisms Thomas K. Sin, Bjorn T. Tam, Angus P. Yu, Shea P. Yip, Benjamin Y. Yung, Lawrence W. Chan, Cesar S. Wong, John …
        4192. Abstract P2-03-06: Dysregulation of miR-34a-SIRT1 axis reduced breast cancer stemness
        4193. Deciphering the PACS-2–SIRT1 interaction site and its relevance in vivo
        4194. MMP-9, HIF-1 and SIRT1 in acute lung injury: a review
        4195. MiR-486 Regulates the Glycometabolism of Hematopoietic Cells by Targeting SIRT1
        4196. EP-2041: Vitamin D protects HUVEC from RT-induced senescence and apoptosis by modulating MAPK/SIRT1 axis
        4197. MicroRNA-9 represses sirtuin 1 (SIRT1) in human keratinocytes
        4198. #VALUE!
        4199. Association of serum Mir-217 level with SIRT1 and HIF-1αin type 2 diabetic patients with different urinary albumin excretion rates
        4200. Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma
        4201. THE EFFECT OF 10 WEEKS OF HIGH INTENSITY INTERVAL TRAINING AND GREEN TEA SUPPLEMENTS ON SERUM LEVELS OF SIRT1 AND PGC-1? IN …
        4202. The effect of 10 weeks of high intensity interval training and green tea supplements on serum levels of SIRT1 and PGC-1α in overweight women
        4203. MicroRNA-34a promotes apoptosis of human lens epithelial cells through down-regulation of Bcl-2 and SIRT1
        4204. 3D-QSAR modeling and analysis of Thieno [3, 2-d] pyrimidine-6-carboxamides as potent SIRT1-3 inhibitors
        4205. Abstract P141: GYY4137, a H2S Donor, Normalizes miR-132 Targeted SIRT1 and Ace2 Expression to Improve Kidney Function in Hypertension
        4206. Relationship between microRNA-369-3p, SIRT1, and IL-22 in psoriasis vulgaris
        4207. PS 04-13 CR6-INTERACTING FACTOR 1 DEFICIENCY IMPAIRS VASCULAR FUNCTION BY INHIBITING THE SIRT1-eNOS PATHWAY
        4208. Effects of microRNA-33-agonist and-antagonist on AMPK, SIRT1 & SREBP-2 expression in AMPK-SIRT1 pathway in mice liver
        4209. F-72 Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2, 9 via AMPK-SIRT1 pathway in a non-small cell lung cancer
        4210. Allosteric SIRT1 activators as putative anti-aging drugs
        4211. The role of SIRT1 in diabetic retinopathy
        4212. SIRT1: a guardian of the development of diabetic retinopathy
        4213. Role and possible mechanisms of SIRT1 in depression
        4214. SIRT1 and HIF1α signaling in metabolism and immune responses
        4215. SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection
        4216. Computational and experimental insights into the circadian effects of SIRT1
        4217. SIRT1 as a therapeutic target in diabetic complications
        4218. Brain SIRT1 mediates metabolic homeostasis and neuroprotection
        4219. SIRT1 antisense long noncoding RNA promotes cardiomyocyte proliferation by enhancing the stability of SIRT1
        4220. Metformin is a direct SIRT1-activating compound: computational modeling and experimental validation
        4221. The role of SIRT1 in ischemic stroke: pathogenesis and therapeutic strategies
        4222. SIRT1 deacetylates tau and reduces pathogenic tau spread in a mouse model of tauopathy
        4223. SIRT1 promotes formation of breast cancer through modulating Akt activity
        4224. SIRT1 and microRNAs: The role in breast, lung and prostate cancers
        4225. SIRT1 is a potential drug target for treatment of diabetic kidney disease
        4226. High levels of SIRT1 expression as a protective mechanism against disease-related conditions
        4227. Resveratrol boosts cognitive function by targeting SIRT1
        4228. An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds
        4229. The essential role of SIRT1 in hypothalamic-pituitary axis
        4230. A SIRT1-centered circuitry regulates breast cancer stemness and metastasis
        4231. SIRT1 in secretory organ cancer
        4232. Effects of resveratrol and other polyphenols on SIRT1: relevance to brain function during aging
        4233. SIRT1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia
        4234. SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model
        4235. The interplay of SIRT1 and Wnt signaling in vascular calcification
        4236. Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense
        4237. Resveratrol modulates SIRT1 and DNMT functions and restores LINE-1 methylation levels in ARPE-19 cells under oxidative stress and inflammation
        4238. SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression
        4239. Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer’s disease
        4240. SIRT1 controls acetaminophen hepatotoxicity by modulating inflammation and oxidative stress
        4241. Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’
        4242. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease
        4243. Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial–mesenchymal transition in cancer cells
        4244. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1
        4245. Cardiomyocyte-specific deletion of SIRT1 gene sensitizes myocardium to ischaemia and reperfusion injury
        4246. SIRT1 mediates obesity-and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
        4247. SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway
        4248. SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice
        4249. SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells
        4250. SIRT1 activation disrupts maintenance of myelodysplastic syndrome stem and progenitor cells by restoring TET2 function
        4251. LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1
        4252. SIRT1 and estrogen signaling cooperation for breast cancer onset and progression
        4253. SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA
        4254. Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2-and SIRT1-dependent pathways
        4255. CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of SIRT1
        4256. Histone deacetylase SIRT1 targets Plk2 to regulate centriole duplication
        4257. Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells
        4258. Breaking down the contradictory roles of histone deacetylase SIRT1 in human breast cancer
        4259. SIRT1/PGC-1α signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats
        4260. Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats
        4261. Chlorogenic acid protects against oxLDL‐induced oxidative damage and mitochondrial dysfunction by modulating SIRT1 in endothelial cells
        4262. Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation
        4263. SIRT1 regulates nuclear number and domain size in skeletal muscle fibers
        4264. Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1
        4265. Geniposide protects against obesity-related cardiac injury through AMPKα-and SIRT1-dependent mechanisms
        4266. Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1
        4267. SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation
        4268. Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats
        4269. SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma
        4270. Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and …
        4271. Resveratrol improves glucose uptake in insulin-resistant adipocytes via SIRT1
        4272. LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/SIRT1/HIF-1α signaling
        4273. MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma
        4274. H2S to Mitigate Vascular Aging: a SIRT1 connection
        4275. Inflammatory cytokines and SIRT1 levels in subcutaneous abdominal fat: relationship with cardiac performance in overweight pre-diabetics patients
        4276. Oxidative stress induces imbalance of adipogenic/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions
        4277. Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy
        4278. Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD
        4279. Buyang Huanwu decoction targets SIRT1/VEGF pathway to promote angiogenesis after cerebral ischemia/reperfusion injury
        4280. Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SIRT1/PGC-1α/mitochondrial biosynthesis pathway
        4281. MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1
        4282. Disruption of the circadian clock alters antioxidative defense via the SIRT1-BMAL1 pathway in 6-OHDA-induced models of Parkinson’s disease
        4283. Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK
        4284. SIRT1/Nrf2 pathway is involved in oocyte aging by regulating Cyclin B1
        4285. Overexpression of SIRT1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
        4286. Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity
        4287. Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK
        4288. SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway
        4289. Mitochondrial fission is required for angiotensin II-induced cardiomyocyte apoptosis mediated by a SIRT1-p53 signaling pathway
        4290. The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure
        4291. miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy
        4292. Exercise training augments SIRT1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
        4293. Resveratrol ameliorates lipid droplet accumulation in liver through a SIRT1/ATF6-dependent mechanism
        4294. Targeting estrogen receptor beta (ERβ) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ERβ expression and functionality
        4295. Transcriptional regulation of metabolism by SIRT1 and SIRT7
        4296. Thymoquinone attenuates myocardial ischemia/reperfusion injury through activation of SIRT1 signaling
        4297. Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib
        4298. Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
        4299. NAMPT is a potent oncogene in colon cancer progression that modulates cancer stem cell properties and resistance to therapy through SIRT1 and PARP
        4300. SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
        4301. Phenolic plant extracts induce SIRT1 activity and increase antioxidant levels in the rabbit’s heart and liver
        4302. Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway
        4303. miR-30a suppresses lung cancer progression by targeting SIRT1
        4304. Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1
        4305. High-fat diet mediates anxiolytic-like behaviors in a time-dependent manner through the regulation of SIRT1 in the brain
        4306. Regulation of apoptosis and radiation sensitization in lung cancer cells via the SIRT1/NF-κB/Smac pathway
        4307. SIRT1 protects from K‐Ras‐driven lung carcinogenesis
        4308. SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer
        4309. … myocardial ischemia/reperfusion injury in type 1 diabetic rats by reducing oxidative stress and apoptosis through activating the SIRT1-Nrf2 signaling pathway
        4310. Baicalin regulates SIRT1/STAT3 pathway and restrains excessive hepatic glucose production
        4311. SIRT1 protects against oxidative stress-induced apoptosis in fibroblasts from psoriatic patients: A new insight into the pathogenetic mechanisms of psoriasis
        4312. Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells
        4313. SIRT1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4
        4314. Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling …
        4315. Acetylation-dependent regulation of Notch signaling in macrophages by SIRT1 affects sepsis development
        4316. PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis
        4317. MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1
        4318. High glucose up-regulates microRNA-34a-5p to aggravate fibrosis by targeting SIRT1 in HK-2 cells
        4319. The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemia
        4320. Icariin, a flavonoid with anti-cancer effects, alleviated paclitaxel-induced neuropathic pain in a SIRT1-dependent manner
        4321. Ube2v1-mediated ubiquitination and degradation of SIRT1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy
        4322. SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes
        4323. Resveratrol suppresses rotenone‐induced neurotoxicity through activation of SIRT1/Akt1 signaling pathway
        4324. Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression
        4325. Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice
        4326. SIRT1 increases cardiomyocyte binucleation in the heart development
        4327. A p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function
        4328. An insulin-responsive sensor in the SIRT1 disordered region binds DBC1 and PACS-2 to control enzyme activity
        4329. Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway
        4330. Chronic silymarin, quercetin and naringenin treatments increase monoamines synthesis and hippocampal SIRT1 levels improving cognition in aged rats
        4331. Hypothalamic SIRT1 protects terminal Schwann cells and neuromuscular junctions from age‐related morphological changes
        4332. miR-34a promotes vascular smooth muscle cell calcification by downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)
        4333. Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via SIRT1/Nrf2 and p38 MAPK pathways
        4334. Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri
        4335. Novel SIRT1 inhibitor 15-deoxy-Δ12, 14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in …
        4336. Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice
        4337. Long-term l-serine administration reduces food intake and improves oxidative stress and SIRT1/NFκB signaling in the hypothalamus of aging mice
        4338. Physical exercise improves aging-related changes in angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra
        4339. SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis
        4340. Moderate exercise suppresses NF-κB signaling and activates the SIRT1-AMPK-PGC1α axis to attenuate muscle loss in diabetic db/db mice
        4341. Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: SIRT1/miR-134 signalling pathway regulates CREB/BDNF expression in …
        4342. Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington’s disease model
        4343. Spontaneous up‐regulation of SIRT1 during osteogenesis contributes to stem cells’ resistance to oxidative stress
        4344. Paeonol ameliorates diabetic renal fibrosis through promoting the activation of the Nrf2/ARE pathway via up-regulating SIRT1
        4345. Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation
        4346. SIRT1 activity in peripheral blood mononuclear cells correlates with altered lung function in patients with chronic obstructive pulmonary disease
        4347. Inverse association of circulating SIRT1 and adiposity: a study on underweight, normal weight, and obese patients
        4348. Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-κB signaling pathway
        4349. Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1
        4350. SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons
        4351. Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
        4352. PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 …
        4353. Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between …
        4354. Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via SIRT1/AMPK pathway
        4355. SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity
        4356. Flavonones from Penthorum chinense ameliorate hepatic steatosis by activating the SIRT1/AMPK pathway in HepG2 cells
        4357. SIRT1: A novel way to target tau?
        4358. 18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the SIRT1/FXR signaling pathway
        4359. ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via SIRT1/Nrf2 pathway
        4360. FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via SIRT1/AMPK/β1-integrin pathway
        4361. Tangshen formula improves inflammation in renal tissue of diabetic nephropathy through SIRT1/NF-κB pathway
        4362. Fisetin protects against hepatic steatosis through regulation of the SIRT1/AMPK and fatty acid β-oxidation signaling pathway in high-fat diet-induced obese mice
        4363. Enhanced articular cartilage regeneration with SIRT1-activated MSCs using gelatin-based hydrogel
        4364. Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice
        4365. Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells
        4366. SIRT1 inhibits TGF‐β‐induced endothelial‐mesenchymal transition in human endothelial cells with Smad4 deacetylation
        4367. Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase …
        4368. Upregulation of SIRT1 inhibits H2O2‑induced osteoblast apoptosis via FoxO1/β‑catenin pathway
        4369. Tomato powder inhibits hepatic steatosis and inflammation potentially through restoring SIRT1 activity and adiponectin function independent of carotenoid cleavage …
        4370. Bergenin, acting as an agonist of PPARγ, ameliorates experimental colitis in mice through improving expression of SIRT1, and therefore inhibiting NF-κB …
        4371. TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARγ-SIRT1 feedback loop in human bladder cancer cells
        4372. Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1 α complex to activate its deacetylase function
        4373. Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia
        4374. Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through the SIRT1-mediated signaling pathway
        4375. Upregulation of SIRT1 by kartogenin enhances antioxidant functions and promotes osteogenesis in human mesenchymal stem cells
        4376. Geniposide alleviates isoproterenol-induced cardiac fibrosis partially via SIRT1 activation in vivo and in vitro
        4377. … exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial SIRT1 and subsequent Akt …
        4378. SIRT1 contributes to neuroendocrine differentiation of prostate cancer
        4379. … from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1
        4380. SIRT1/HERC4 Locus Associated With Bisphosphonate‐Induced Osteonecrosis of the Jaw: An Exome‐Wide Association Analysis
        4381. Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and SIRT1
        4382. AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol
        4383. Cdk5 suppression blocks SIRT1 degradation via the ubiquitin-proteasome pathway in Parkinson’s disease models
        4384. … the proliferation and migration of human non-small cell lung carcinoma (NSCLC) cells, A549 and H1299, by activating the SIRT1/AMPK signaling pathway
        4385. Chikusetsusaponin V inhibits LPS-activated inflammatory responses via SIRT1/NF-κB signaling pathway in RAW264. 7 cells
        4386. Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated SIRT1/AMPK signaling pathway
        4387. SIRT1 activation attenuates α cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice
        4388. Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions
        4389. MicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated SIRT1/JAK/STAT3 signaling
        4390. … against high fat diet-induced obesity cardiomyopathy and defective autophagy: Role of CaM kinase II, histone H3K9 methyltransferase SUV39H, SIRT1, and PGC-1α …
        4391. SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1)
        4392. Resveratrol induces apoptosis and inhibits adipogenesis by stimulating the SIRT1-AMPKα-FOXO1 signalling pathway in bovine intramuscular adipocytes
        4393. … natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling …
        4394. Activation of the Nrf2-ARE pathway ameliorates hyperglycemia-mediated mitochondrial dysfunction in podocytes partly through SIRT1
        4395. Cudratricusxanthone A attenuates sepsis‐induced liver injury via SIRT1 signaling
        4396. Nrf2 activation induced by SIRT1 ameliorates acute lung injury after intestinal ischemia/reperfusion through NOX4-mediated gene regulation
        4397. Reciprocal regulation between Smad7 and SIRT1 in the gut
        4398. Berberine improves cognitive deficiency and muscular dysfunction via activation of the AMPK/SIRT1/PGC-1a pathway in skeletal muscle from naturally aging rats
        4399. SIRT1 activation by post-ischemic treatment with lumbrokinase protects against myocardial ischemia-reperfusion injury
        4400. Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway
        4401. Upregulation of SIRT1 contributes to the cardioprotective effect of Rutin against myocardial ischemia-reperfusion injury in rats
        4402. 17β-Estradiol via SIRT1/Acetyl-p53/NF-kB signaling pathway rescued postnatal rat brain against acute ethanol intoxication
        4403. Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis
        4404. Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injury
        4405. SIRT1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice
        4406. Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit
        4407. Roles of SIRT1/FoxO1/SREBP-1 in the development of progestin resistance in endometrial cancer
        4408. Deacetylation of NAT10 by SIRT1 promotes the transition from rRNA biogenesis to autophagy upon energy stress
        4409. Resolvin D1 promotes SIRT1 expression to counteract the activation of STAT3 and NF-κB in mice with septic-associated lung injury
        4410. Resveratrol Mitigates High-Fat Diet–Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and SIRT1/ER Pathway
        4411. SIRT1‐dependent anti‐senescence effects of cell‐deposited matrix on human umbilical cord mesenchymal stem cells
        4412. HGF and BFGF secretion by human adipose-derived stem cells improves ovarian function during natural aging via activation of the SIRT1/FOXO1 signaling pathway
        4413. SIRT1 mediates apelin-13 in ameliorating chronic normobaric hypoxia-induced anxiety-like behavior by suppressing NF-κB pathway in mice hippocampus
        4414. SIRT1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice
        4415. Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy
        4416. Stimulation of SIRT1 attenuates the level of oxidative stress in the brains of APP/PS1 double transgenic mice and in primary neurons exposed to oligomers of the …
        4417. Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways
        4418. Gastrodin inhibits high glucose‑induced human retinal endothelial cell apoptosis by regulating the SIRT1/TLR4/NF‑κBp65 signaling pathway
        4419. Resveratrol ameliorates microcystin-LR-induced testis germ cell apoptosis in rats via SIRT1 signaling pathway activation
        4420. Role of p53/miR-155-5p/SIRT1 loop in renal tubular injury of diabetic kidney disease
        4421. Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: a pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF …
        4422. SIRT1 mediates salidroside‐elicited protective effects against MPP+‐induced apoptosis and oxidative stress in SH‐SY5Y cells: involvement in suppressing MAPK …
        4423. SIRT1 involved in the regulation of alternative splicing affects the DNA damage response in neural stem cells
        4424. miR449a/SIRT1/PGC-1α is necessary for mitochondrial biogenesis induced by T-2 toxin
        4425. Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1/AMPK pathway of glucose …
        4426. Erythropoietin alleviates hepatic steatosis by activating SIRT1-mediated autophagy
        4427. Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats
        4428. Protective effect of isoliquiritigenin against ethanol-induced hepatic steatosis by regulating the SIRT1-AMPK pathway
        4429. Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo via the regulation of SIRT1/FOXO3a expression
        4430. SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF‑κB pathway in mouse kupffer cells
        4431. SIRT1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation
        4432. SIRT1-regulated abnormal acetylation of FOXP3 induces regulatory T-cell function defect in Hashimoto’s thyroiditis
        4433. Dysregulation of BSEP and MRP2 may play an important role in isoniazid-induced liver injury via the SIRT1/FXR pathway in rats and HepG2 cells
        4434. … and glycolipid metabolism of blunt snout bream Megalobrama amblycephala fed high-carbohydrate diets by activating the AMPK–SIRT1–PGC-1α network
        4435. Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer’s disease like pathology via maintaining oxidative balance through SIRT1 pathway
        4436. Resveratrol alleviates early brain injury following subarachnoid hemorrhage: possible involvement of the AMPK/SIRT1/autophagy signaling pathway
        4437. Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis
        4438. SIRT1 and NRF2 gene transfer mediate distinct neuroprotective effects upon retinal ganglion cell survival and function in experimental optic neuritis
        4439. SIRT1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway
        4440. Generation and characterization of a site-specific antibody for SIRT1 O-GlcNAcylated at serine 549
        4441. Hypermethylated in cancer 1 (HIC1) mediates high glucose induced ROS accumulation in renal tubular epithelial cells by epigenetically repressing SIRT1 …
        4442. Sitagliptin reduces insulin resistance and improves rat liver steatosis via the SIRT1/AMPKα pathway
        4443. Resveratrol and SIRT1 activators for the treatment of aging and age-related diseases
        4444. Pseudoginsengenin DQ exhibits therapeutic effects in cisplatin-induced acute kidney injury via SIRT1/NF-κB and caspase signaling pathway without compromising its …
        4445. Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria
        4446. SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease
        4447. Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of the SIRT1/NF-κB signaling pathway
        4448. Heme oxygenase-1 induction by rosiglitazone via PKCα/AMPKα/p38 MAPKα/SIRT1/PPARγ pathway suppresses lipopolysaccharide-mediated pulmonary …
        4449. miR-128 targets the SIRT1/ROS/DR5 pathway to sensitize colorectal cancer to TRAIL-induced apoptosis
        4450. RNA interference-mediated knockdown of SIRT1 and/or SIRT2 in melanoma: Identification of downstream targets by large-scale proteomics analysis
        4451. Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy
        4452. Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1
        4453. SIRT1 deacetylates SC35 and suppresses its function in Tau Exon 10 inclusion
        4454. SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-κB …
        4455. … A against oxygen‐glucose deprivation/reperfusion in rat primary cortical neurons by attenuating oxidative stress injury and inflammatory response via the SIRT1/Nrf2 …
        4456. Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation
        4457. AMPK regulates energy metabolism through the SIRT1 signaling pathway to improve myocardial hypertrophy
        4458. Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke
        4459. Amelioration of Huntington’s disease phenotypes by Beta-Lapachone is associated with increases in SIRT1 expression, CREB phosphorylation and PGC-1α …
        4460. Resveratrol activated sonic hedgehog signaling to enhance viability of NIH3T3 cells in vitro via regulation of SIRT1
        4461. CD 38 deficiency suppresses adipogenesis and lipogenesis in adipose tissues through activating SIRT1/PPAR γ signaling pathway
        4462. Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression
        4463. A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKAy mice
        4464. Luteolin decreases atherosclerosis in LDL receptor‑deficient mice via a mechanism including decreasing AMPK‑SIRT1 signaling in macrophages
        4465. SIRT1 deacetylates KLF4 to activate Claudin‐5 transcription in ovarian cancer cells
        4466. Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the …
        4467. D‑Pinitol alleviates cyclosporine A‑induced renal tubulointerstitial fibrosis via activating SIRT1 and Nrf2 antioxidant pathways
        4468. Novel role of PKR in palmitate-induced SIRT1 inactivation and endothelial cell senescence
        4469. Tetrahydroxystilbene glucoside delayed senile symptoms in old mice via regulation of the AMPK/SIRT1/PGC-1α signaling cascade
        4470. SIRT1 rs3758391 and major depressive disorder: new data and meta-analysis
        4471. Functional role of SIRT1-induced HMGB1 expression and acetylation in migration, invasion and angiogenesis of ovarian cancer
        4472. Overexpressed SIRT1 in MSCs promotes dentin formation in Bmi1-deficient mice
        4473. Agathisflavone isolated from Anacardium occidentale suppresses SIRT1‐mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe‐transfected SH …
        4474. Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A
        4475. Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway
        4476. Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans
        4477. SIRT1/Nrf2 signalling pathway prevents cognitive impairment in diabetic rats through anti‑oxidative stress induced by miRNA‑23b‑3p expression
        4478. Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease
        4479. … fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of …
        4480. 1, 25 (OH) 2-vitamin D 3 upregulates glucose uptake mediated by SIRT1/IRS1/GLUT4 signaling cascade in C2C12 myotubes
        4481. Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the SIRT1/LKB1/AMPK pathway
        4482. Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway
        4483. Improvement of lipid and glucose metabolism by capsiate in palmitic acid-treated HepG2 cells via activation of the AMPK/SIRT1 signaling pathway
        4484. SIRT1/Foxo Axis plays a crucial role in the mechanisms of therapeutic effects of Erzhi pill in ovariectomized rats
        4485. Salvianolic acid a attenuates endoplasmic reticulum stress and protects against cholestasis-induced liver fibrosis via the SIRT1/HSF1 pathway
        4486. Neuroprotective mechanisms of resveratrol in Alzheimer’s disease: role of SIRT1
        4487. Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells
        4488. Receptor for advanced glycation end products reveals a mechanism regulating thyroid hormone secretion through the SIRT1/Nrf2 pathway.
        4489. The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis
        4490. Hsp90 Stabilizes SIRT1 orthologs in mammalian cells and C. elegans
        4491. A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer
        4492. Hepatitis C virus core protein induces hepatic steatosis via SIRT1‐dependent pathway
        4493. Berberine protects renal tubular cells against hypoxia/reoxygenation injury via the SIRT1/p53 pathway
        4494. Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK–eIF-2α–CHOP pathway in the unfolded protein response
        4495. Intravenous Vitamin C attenuates hemorrhagic shock-related renal injury through the induction of SIRT1 in rats
        4496. SIRT1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice
        4497. The variable role of SIRT1 in the maintenance and differentiation of mesenchymal stem cells
        4498. Rolipram attenuates early brain injury following experimental subarachnoid hemorrhage in rats: possibly via regulating the SIRT1/nf-κb pathway
        4499. Correlations between SIRT1 gene polymorphisms and diabetic kidney disease
        4500. SIRT1 deletion impairs retinal endothelial cell migration through downregulation of VEGF-A/VEGFR-2 and MMP14
        4501. Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on SIRT1/NRF2 signaling pathways
        4502. The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 …
        4503. BML-111 reduces neuroinflammation and cognitive impairment in mice with sepsis via the SIRT1/NF-κB signaling pathway
        4504. SA1/SA2 cohesion proteins and SIRT1-NAD+ deacetylase modulate telomere homeostasis in cumulus cells and are eligible biomarkers of ovarian aging
        4505. Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via SIRT1/p38 MAPK expression
        4506. Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration
        4507. BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis
        4508. Probing the mechanism of SIRT1 activation by a 1, 4-dihydropyridine
        4509. Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway
        4510. Revert the SIRT: normalizing SIRT1 activity in myelodysplastic stem cells
        4511. MicroRNA-204 protects H9C2 cells against hypoxia/reoxygenation-induced injury through regulating SIRT1-mediated autophagy
        4512. Detection of insertions/deletions within SIRT1, SIRT2 and SIRT3 genes and their associations with body measurement traits in cattle
        4513. HOTAIR participates in hepatic insulin resistance via regulating SIRT1
        4514. Electroacupuncture: A feasible SIRT1 promoter which modulates metainflammation in diet-induced obesity rats
        4515. … of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1‐mediated deacetylation of FXR …
        4516. Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma …
        4517. Tongguan capsule mitigates post-myocardial infarction remodeling by promoting autophagy and inhibiting apoptosis: role of SIRT1
        4518. Flavonoid extract from propolis inhibits cardiac fibrosis triggered by myocardial infarction through upregulation of SIRT1
        4519. CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation
        4520. SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng
        4521. ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition
        4522. Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer
        4523. JAK1-mediated SIRT1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway
        4524. SIRT1 in Colorectal Cancer: A Friend or Foe?
        4525. Fluorofenidone inhibits UV‐A induced senescence in human dermal fibroblasts via the mammalian target of rapamycin‐dependent SIRT1 pathway
        4526. SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression
        4527. Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype
        4528. The association between SIRT1 genetic variation and type 2 diabetes mellitus is influenced by dietary intake in elderly Chinese
        4529. SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent …
        4530. CD38 deficiency promotes inflammatory response through activating SIRT1/NF-κB-mediated inhibition of TLR2 expression in macrophages
        4531. Long non-coding RNA H19 contributes to hypoxia-induced CPC injury by suppressing SIRT1 through miR-200a-3p
        4532. SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
        4533. Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1–nuclear factor-κB/p65 pathway in …
        4534. 17β-estradiol promotes apoptosis in airway smooth muscle cells through CD38/SIRT1/p53 pathway
        4535. Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ-and STZ+ niacinamide-induced diabetic rats
        4536. Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and SIRT1 expression
        4537. FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain Retraction in/10.3892/mmr …
        4538. Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1
        4539. A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage
        4540. Cellular uptake and bioavailability of tocotrienol-rich fraction in SIRT1-inhibited human diploid fibroblasts
        4541. Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 …
        4542. miR‐221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin‐1 (SIRT1)
        4543. Repetitive transcranial magnetic stimulation inhibits SIRT1/MAO-A signaling in the prefrontal cortex in a rat model of depression and cortex-derived astrocytes
        4544. A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1
        4545. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with …
        4546. ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway
        4547. MiR-138/SIRT1 axis is implicated in impaired learning and memory abilities of cerebral ischemia/reperfusion injured rats
        4548. Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats
        4549. Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The …
        4550. SIRT1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264. 7 cells and endotoxemic mice
        4551. miR-221 participates in the airway epithelial cells injury in asthma via targeting SIRT1
        4552. Delayed puberty by ziram is associated with down regulation of testicular phosphorylated AKT1 and SIRT1/PGC-1α signaling
        4553. The expression and mechanism of SIRT1 and AMPK in nonsmall cell lung cancer
        4554. SIRT1 activation: A potential strategy for harnessing endogenous protection against delayed cerebral ischemia after subarachnoid hemorrhage
        4555. Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1
        4556. Salidroside attenuates hypoxia/reoxygenation‑induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3α pathway
        4557. … efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway
        4558. The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders
        4559. SIRT1 gene expression and gastric epithelial cells tumor stage in patients with Helicobacter pylori infection
        4560. Effect of scuba diving on the oxidant/antioxidant status, SIRT1 and SIRT3 expression in recreational divers after a winter nondive period
        4561. Expression of SIRT1 and P53 in rat Lens epithelial cells in experimentally induced DM
        4562. Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population
        4563. SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population
        4564. … sulfate promotes arterial thrombosis in rat model via increased levels of complex TF/VII, PAI-1, platelet activation as well as decreased contents of SIRT1 and …
        4565. MiR-155 is involved in major depression disorder and antidepressant treatment via targeting SIRT1
        4566. Extra view: SIRT1 acts as a gatekeeper of replication initiation to preserve genomic stability.
        4567. Onjisaponin B (OB) is neuroprotective during cognitive loss through immune-mediated and SIRT1 pathways
        4568. Expression of microRNA-448 and SIRT1 and prognosis of obese type 2 diabetic mellitus patients after laparoscopic bariatric surgery
        4569. Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas
        4570. Anti-SIRT1 autoantibody is elevated in ankylosing spondylitis: a potential disease biomarker
        4571. γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction
        4572. Lutein suppresses hyperglycemia‐induced premature senescence of retinal pigment epithelial cells by upregulating SIRT1
        4573. The role of SIRT1 in autophagy in lipopolysaccharide-induced mouse type II alveolar epithelial cells
        4574. MicroRNA-138 aggravates inflammatory responses of macrophages by targeting SIRT1 and regulating the NF-κB and AKT pathways
        4575. CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2
        4576. All trans retinoic acid attenuates markers of neuroinflammation in rat brain by modulation of SIRT1 and NFκB
        4577. PKA regulates HMGB1 through activation of IGFBP-3 and SIRT1 in human retinal endothelial cells cultured in high glucose
        4578. The role of forkhead box class O3A and SIRT1 gene variants in early-onset psoriasis
        4579. Resveratrol suppresses hyperoxia-induced nucleocytoplasmic shuttling of SIRT1 and ROS production in PBMC from preterm infants in vitro
        4580. Better Nutritional Status Is Positively Associated with mRNA Expression of SIRT1 in Community-Dwelling Older Adults in the Toledo Study for Healthy Aging
        4581. SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition
        4582. Down-regulated miR-448 relieves spinal cord ischemia/reperfusion injury by up-regulating SIRT1
        4583. Food anticipatory activity on a calorie-restricted diet is independent of SIRT1
        4584. Inhibition of mTOR/S6K1/4E-BP1 signaling by nutraceutical SIRT1 modulators
        4585. SIRT7 inhibits SIRT1-mediated activation of SUV39H1
        4586. Targeting endothelial SIRT1 for the prevention of arterial aging
        4587. Elevated levels of serum MiR-152 and miR-24 in uterine sarcoma: potential for inducing autophagy via SIRT1 and deacetylated LC3
        4588. microRNA-212 promotes lipid accumulation and attenuates cholesterol efflux in THP-1 human macrophages by targeting SIRT1
        4589. 2, 3, 5, 4′‐Tetrahydroxystilbene‐2‐O‐β‐glucoside potentiates self‐renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis
        4590. … impairs both non-homologous end joining and homologous recombination DNA damage repair through SHP-1 induced dephosphorylation of SIRT1 in adult T-cell …
        4591. 20 (S)-Ginsenoside Rg2 attenuates myocardial ischemia/reperfusion injury by reducing oxidative stress and inflammation: Role of SIRT1
        4592. 15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxia
        4593. Expression and significance of SIRT1 in renal allografts at the early stage of chronic renal allograft dysfunction
        4594. Insulin PACS a Punch in SIRT1 Activity
        4595. Qing gan zi shen tang alleviates adipose tissue dysfunction with up-regulation of SIRT1 in spontaneously hypertensive rat
        4596. Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic …
        4597. Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 …
        4598. Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1
        4599. Adipoinductive effect of extracellular matrix involves cytoskeleton changes and SIRT1 activity in adipose tissue stem/stromal cells
        4600. Resveratrol down-regulates endothelin type B receptors in vascular smooth muscle cells via SIRT1/ERK1/2/NF-кB signaling pathways
        4601. Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner
        4602. High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of SIRT1
        4603. Correction to: regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’
        4604. Effect of Resveratrol Dimers and Tetramers Isolated from Vitaceous and Dipterocarpaceous Plants on Human SIRT1 Enzyme Activity
        4605. Consensus QSAR modelling of SIRT1 activators using simplex representation of molecular structure
        4606. Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1
        4607. MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1
        4608. BK channel deacetylation by SIRT1 in dentate gyrus regulates anxiety and response to stress
        4609. Downregulation of miR-155 attenuates sepsis-induced acute lung injury by targeting SIRT1
        4610. Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature
        4611. Effect of microRNA-34a/SIRT1/p53 signal pathway on notoginsenoside R₁ delaying vascular endothelial cell senescence
        4612. Integrated ligand and structure-based investigation of structural requirements for silent information regulator 1 (SIRT1) activation
        4613. MiR-449 overexpression inhibits osteogenic differentiation of bone marrow mesenchymal stem cells via suppressing SIRT1/Fra-1 pathway in high glucose and free fatty …
        4614. SIRT1 exhibits antioxidative effects in HT22 cells induced by tert‐butyl alcohol
        4615. Loss of histone deacetylase 2 inhibits oxidative stress induced by high glucose via the HO-1/SIRT1 pathway in endothelial progenitor cells
        4616. Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin
        4617. Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway
        4618. Compounds from the Roots of Codonopsis pilosula and Their SIRT1 Regulatory Activity
        4619. NK cells of the oldest seniors represent constant and resistant to stimulation high expression of cellular protective proteins SIRT1 and HSP70
        4620. … -like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest …
        4621. Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice
        4622. Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through SIRT1 activation
        4623. Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes
        4624. SIRT1 deficiency in CD4+ T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
        4625. The Effect of Eight Weeks of Water Training on SIRT1, Pgc-1α and Body Fat Percentage in Obese Men
        4626. Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation
        4627. … and reperfusion of pancreas-induced acute pancreatitis and remote lung injury through suppressing oxidative stress and inflammation and activation of SIRT1
        4628. SIRT1 protects neural stem cells from apoptosis by decreasing acetylation of histone 3K9
        4629. Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin
        4630. Inhibitory effect of naringenin on LPS-induced skin senescence by SIRT1 regulation in HDFs
        4631. A novel dressing seeded with embryonic artery CD133+ cells and loaded with the SIRT1 agonist SRT1720 accelerates the healing of diabetic ischemic ulcers
        4632. The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma
        4633. Saponins from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the SIRT1/Foxo1/Pgc-1α and Nrf2/antioxidant …
        4634. Resveratrol improves endothelial function in diabetic and obese mice through SIRT1-PPARδ
        4635. Hyperbaric oxygen effects towards SIRT1 level in Sprague dawley with endothelial dysfunction by high-cholesterol diet
        4636. Obesity-induced upregulation of miR-361-5p promotes hepatosteatosis through targeting SIRT1
        4637. Alterations of SIRT1 and mTOR activities in mouse gastrocnemius muscle with sarcopenia
        4638. miR-224 suppresses HBV replication posttranscriptionally through inhibiting SIRT1-mediated autophagy
        4639. SIRT1 Mediates Enhanced Mitochondrial Oxidative Phosphorylation in Chronic Myelogenous Leukemia Stem Cells
        4640. … of dietary fiber from sweet potato (Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways
        4641. Polydatin inhibits cell proliferation and expressions of inflammatory cytokines in THP-1 cells induced by ox-LDL via up-regulating SIRT1
        4642. 2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the …
        4643. Effect of total triterpenoids of Chaenomeles speciosa on PPARγ/SIRT1/NF-κBp65 signaling pathway and intestinal mucosal barrier of ulcerative colitis induced by DSS …
        4644. Total Flavonoids of Epimedium Reduce Inflammatory Reaction via AMPK/SIRT1/NFκB Signaling Pathway in Testes of Natural Aging Rats
        4645. Modulating SIRT1 activity variously affects thymic lymphoma development in mice
        4646. Molecular Dynamics Simulation of SIRT1 Inhibitor from Indonesian Herbal Database
        4647. Osthole enhances doxorubicin-induced apoptosis in p53-wildtype prostate cancer cells by down-regulating SIRT1 expression
        4648. … Attenuates Lung Ischemia and Reperfusion-Induced Pulmonary Barrier Function Impairment by Reducing Oxidative Stress and Activating SIRT1 in an Isolated …
        4649. SIRT1 participates in epithelial-mesenchymal transition of EC-9706 and Eca-109 cells in vitro by regulating Snail expression
        4650. SIRT1 activators and their effects on atherosclerosis progression
        4651. GW29-e0611 Acacetin inhibits doxorubicin–induced cardiotoxicity by activating SIRT1/AMPK/Nrf2 pathway
        4652. P2795 The role of SIRT1 activity in patients with chronic heart failure
        4653. Effect of a period of swimming exercise on SIRT1 and FoxO3a genes expression in lung tissue of wistar rats
        4654. Defective NO/cGMP/PKG signaling downregulates SIRT1 expression in aged osteoblasts
        4655. Data highlighting the expression of two miR-132/212 target genes—SIRT1 and Pten—after chronic stress
        4656. Does SIRT1 gene polymorphisms play a role in pituitary adenoma recurrence?
        4657. The role of SIRT1 in the pathogenesis of Spondyloarthritides
        4658. Effect of LXR agonist T0901317 and miR-33inhibitor on SIRT1-AMPK and circulating HDL-C levels
        4659. Estrogen Protects Artery From Senescence via SIRT1/AMPK/Rab9—Mediated Mitophagy
        4660. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s
        4661. A NEW MOUSE MODEL TO UNRAVEL THE MECHANISM OF SIRT1 ACTIVATION
        4662. … to: PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity
        4663. [Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain
        4664. Effect of Electroacupuncture at Tinggong and Yifeng on D-galactose-induced Aging of Auditory Cortex through SIRT1/PGC-1α Pathway in Guinea Pigs
        4665. Saturated fat‐enriched diet decreases SIRT1 expression in the mouse hippocampus‐The SIRTain effects of saturated fat in the brain
        4666. Sal B attenuates rat hepatocytes injury induced by hypoxia/reoxygenation via modulation of SIRT1/NF-κB/p53 pathway
        4667. Hydrogen sulfide attenuates human umbilical vein endothelial cell senes-cence via modulation of SIRT1/eNOS pathway
        4668. … DREGS ENHANCES GLUCOSE UPTAKE AND MITIGATES INSULIN RESISTANCE IN HUMAN LIVER CANCER CELL (HEPG2) MODEL VIA AMPK/SIRT1 …
        4669. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development
        4670. A11086 Study on the signal pathway related to the upregulation of SIRT1 to decrease the apoptosis of human umbilical vein endothelial cells
        4671. MicroRNA 181a-5p reprogrammed glucose and lipid metabolism in lung cancer though regulating SIRT1 and ACSL4
        4672. Role of SIRT1 in mesenchymal stem cell differentiation
        4673. High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
        4674. GW29-e0596 Geniposide protects against pathological cardiac fibrosis in vivo and in vitro: the role of SIRT1 activation
        4675. IDENTIFICATION AND CHARACTERIZATION OF SIRT1 AS A NOVEL TARGET OF NSAIDS CHEMOPREVENTION
        4676. Publisher Correction: SIRT1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice
        4677. Curcumin inhibits colon cancer progression through direct interaction with SIRT1
        4678. GW29-e1860 RSV decreased infarction area in mouse heart via SIRT1 dependent inhibition of senescence and inflammasome
        4679. ROLES OF SIRT1 IN CANCER/AGEING
        4680. A52 SIRT1 is increased in affected brain regions in huntington disease impacting hypothalamic metabolic pathways
        4681. The Investigation of the Apoptose Structural Effects and Mechanism in Leukemic Cells of SIRT1 Inhibitor Sirtinol
        4682. GW29-e0847 CTRP3 protects cardiomyocytes against hypoxia-induced injury by activating SIRT1-mediated autophagy
        4683. Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, SIRT1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and …
        4684. Role of SIRT1 and SIRT6 for the preservation of genetic stability
        4685. The role of SIRT1 activity in patients with chronic heart failure
        4686. DIVERGENT REGULATION OF SIRT1 MEDIATES THE ENDOCRINE RESPONSE TO CALORIE RESTRICTION
        4687. The role of SIRT1 in avoiding AIM2-mediated antiviral defense in cervical cancer
        4688. P2668 Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells
        4689. Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats
        4690. Significant association of SIRT1 rs12765828 T allele with risk of early-onset ischemic stroke
        4691. Novel role for SIRT1 in non-canonical activation of AR signaling
        4692. Visualizing the function of hydroxyl radicals via SIRT1 in brains of mice with stress-induced depression related behaviours
        4693. A6799 Ginsenoside Rb1 alleviate ox-LDL induced HUVEC senescence via SIRT1/Beclin-1/autophagy axis
        4694. Rev1 contributes to proper mitochondrial function via the PARP-NAD (+)-SIRT1-PGC1 alpha axis (vol 7, 2017)
        4695. Technolgical approaches for immortaliztion of human dermal fibrolasts therough SIRT1 and the in volvement of micro-rna
        4696. PKM2 Promotes Malignant Proliferation of Human Liver Cancer Stem Cells by C-myc Through SIRT1-autophagy-premir675-pCDK4 Signaling Pathway
        4697. Mitophagy confers the nephroprotective effect of Berberine in hyperglycemic NRK-52E cells via SIRT1-FoxO3a-Bnip3 axis
        4698. Evaluation of SIRT1 and P53 expression in hepatocellular carcinoma
        4699. Expression of SIRT1 in Synovium of Temporomandibular Joint Osteoarthritis
        4700. #VALUE!
        4701. P268 Sex differences in age-related AMPK-SIRT1 axis alteration in human heart
        4702. #VALUE!
        4703. Expression levels of SIRT1 and oxidative stress injury markers in a mouse model of deep venous thrombosis
        4704. Effects of Hydroalcoholic Extract of Sargassum Oligocystum on Serum Concentration of SIRT1 and FGF21 in Streptozotocin Induced Diabetic Rat
        4705. Exendin-4 alleviates diabetic cardiomyopathy in mice by regulating SIRT1/PGC1α
        4706. Therapeutic ultrasound potentiates the anti-nociceptive and anti-inflammatory effects of curcumin to postoperative pain via SIRT1/NF-κB signaling pathway
        4707. Prognostic and Clinicopathological Value of SIRT1 Expression in Female Reproductive System Cancer
        4708. #VALUE!
        4709. Hepatitis C Virus Core Protein Induces Hepatic Steatosis via SIRT1-Dependent Pathway
        4710. SIRT1 and mTOR interplay in bladder cancer: a potential therapeutic target
        4711. Loss of SIRT1 alters the secretome of breast cancer cells by impairing lysosomal integrity
        4712. Concurrent overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not alter mitochondrial function or insulin sensitivity in mice
        4713. Hyperglycemia Inhibits SIRT1 Expression to Promote Drp1-Mediated Mitochondrial Fission in Diabetic Hearts
        4714. Aberrant renal expression of peroxisome coactivator PGC-1α and its regulators (SIRT1 & GSK3β) in rats with diabetic nephropathy
        4715. Preconditioning of SIRT1 activator improves chondrogenic differentiation potential of mesenchymal stem cell
        4716. Pleiotropic treatment of pro-atherogenic endothelium: are SIRT1 and EZH2 promising candidates?
        4717. Effect of Resveratrol Supplementation and Aerobic Exercise on the Protein SIRT1 and PGC-1α Skeletal Muscle and Subcutaneous Fat Tissue’s UCP-1 Levels in …
        4718. Defective NO/cGMP/PKG Signaling Downregulates SIRT1 Expression in Aging-Associated Osteoporotic Mouse Model
        4719. New drug targets for slowing vascular ageing: SIRT1, SIRT5, JunD and p66Sch
        4720. Functional role of the silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas
        4721. The amelioration on the vascular inflammatory response by evogliptin, a novel dipeptidyl peptidase 4 inhibitor via regulation of SIRT1/NF-KAPPAB interaction
        4722. CR6 INTERACTING FACTOR 1 DEFICIENCY PROMOTES ENDOTHELIAL INFLAMMATION BY SIRT1 DOWNREGULATION
        4723. Effect of a period of submaximal swimming training on SIRT1 and FoxO3a genes expression in lung tissue of wistar rats
        4724. miR-34a inhibits the proliferation and invasion of colon cancer stem cells by regulating SIRT1 expression
        4725. Deletion of SIRT1 in the cardiomyocyte exacerbates doxorubicin-induced cardiotoxicity in mice
        4726. SIRT1 Activation Restores Mitophagy-Mediated Clearance of Damaged Mitochondria and Ameliorates Dystrophic Cardiomyopathy in Mice
        4727. SIRT1 dependent modulation of neuroinflammation led neuroexcitotoxicity in aging rats.
        4728. Influence of Tangshenfang on diabetic liver injury and the expression of SIRT1 and PGC-1αin the liver tissue
        4729. Corrigendum to” Fisetin Induces SIRT1 Expression While Inhibiting Early Adipogenesis in 3T3-L1 Cells”[Biochem. Biophys. Res. Commun. 467 (4)(2015) 638-644]
        4730. A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function
        4731. The knockout of aldose reductase accelerates liver regeneration through AMPK/SIRT1/PGC-1α network
        4732. Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
        4733. Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
        4734. Modulating Effects and Mechanisms of p53-miR-34a-SIRT1 Feedback Loop on Reproductive Senescence of Vascular Endothelial Progenitor Cells
        4735. Relationship between SIRT1-ERK1∕ 2 pathway and chikusetsu saponin IVa-induced reduction of isoflurane-elicited neurotoxicity in fetal rats: an in vitro experiment
        4736. SIRT1 represses PKC-zeta activity via regulating interplay of acetylation and phosphorylation in cardiac hypertrophy
        4737. Lymphoid enhancer binding factor 1-mediated Matrix metalloproteinase 13 gene expression is repressed by SIRT1 in human chondrocytes
        4738. Reactivation of visual cortical plasticity by caloric restriction mediated by AMPK-SIRT1 pathway from monocular deprivation in adult mice
        4739. The Effect of 14 Weeks of Aerobic Training Together with Resveratrol Supplementation on Protein Levels of UCP-1, SIRT1, PGC-1α in Liver Tissue, Subcutaneous Fat …
        4740. 0056 Abnormal Clock Gene Oscillation And Decreased SIRT1 Expression Causes Abnormal Circadian Rhythms In Epileptic Kv1. 1 Knock Out Mice
        4741. The protective effect of Sedum sarmentosum Bunge against DMN-induced liver fibrosis via SIRT1-AMPK-LXR signaling pathway
        4742. Correction to: Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular …
        4743. GENE-03. WILD-TYPE Tp53 UNDERGOES A CELL TYPE-SPECIFIC INACTIVATION BY SIRT1 IN DE NOVO GLIOBLASTOMA
        4744. PO-020 Aerobic Exercise Attenuates Myocardial Injury Through Activation of SIRT1 Signaling in T2DM Rats
        4745. miR-338-5p/SIRT1 signaling pathway involved in black raspberry anthocyanin colorectal cancer chemoprevention
        4746. PO-132 Exogenous VD3 alleviates chronic fatigue syndrome by activating MEKs/ERKs-SIRT1 signaling pathway in skeletal muscle
        4747. Resveratrol Restores LINE-1 Methylation Levels by Modulating SIRT1 and DNMTs Functions in Cellular Models of Age-Related Macular Degeneration
        4748. Paeonol attenuates high glucose-induced expression of FN and ICAM-1 by promoting the activation of Nrf2/ARE pathway via upregulation of SIRT1 in GMCs
        4749. The effect of high-intensity interval training on the expression levels of mir-149 and SIRT1, PGC1α and Nrf2 genes in doxorubicin-induced cardiac injury in rats
        4750. Retraction notice to:” Role of Mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes” MCE Volume 382, Issue 1, 25 …
        4751. The role of SIRT1 on DNA damage response and epigenetic alterations in cancer
        4752. The role of different SIRT1-mediated signaling pathways in toxic injury
        4753. circ-SIRT1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle …
        4754. SIRT1 regulates metabolism and leukemogenic potential in CML stem cells
        4755. The role of SIRT1 in skeletal muscle function and repair of older mice
        4756. SIRT1 modulators in experimentally induced liver injury
        4757. SIRT1 in the Development and Treatment of Hepatocellular Carcinoma
        4758. RNA-binding protein RPS3 contributes to hepatocarcinogenesis by post-transcriptionally up-regulating SIRT1
        4759. SIRT1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress
        4760. The beneficial roles of SIRT1 in drug-induced liver injury
        4761. 17β-estradiol modulates SIRT1 and halts oxidative stress-mediated cognitive impairment in a male aging mouse model
        4762. Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)
        4763. Dual PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction
        4764. SIRT1–hypoxia‐inducible factor‐1α interaction is a key mediator of tubulointerstitial damage in the aged kidney
        4765. SIRT1 in astrocytes regulates glucose metabolism and reproductive function
        4766. The role and mechanism of SIRT1 in resveratrol-regulated osteoblast autophagy in osteoporosis rats
        4767. SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition
        4768. Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?
        4769. Depressive symptoms in schizophrenia patients: a possible relationship between SIRT1 and BDNF
        4770. Protection of the myocardium against ischemia/reperfusion injury by punicalagin through an SIRT1-NRF-2-HO-1-dependent mechanism
        4771. Berberine ameliorates doxorubicin-induced cardiotoxicity via a SIRT1/p66Shc-mediated pathway
        4772. Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization
        4773. SIRT1 promotes osteogenic differentiation and increases alveolar bone mass via Bmi1 activation in mice
        4774. The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery
        4775. Sorafenib-induced apoptosis in hepatocellular carcinoma is reversed by SIRT1
        4776. Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure
        4777. Adipose-specific knockdown of SIRT1 results in obesity and insulin resistance by promoting exosomes release
        4778. lncRNA miat functions as a ceRNA to upregulate SIRT1 by sponging miR-22-3p in HCC cellular senescence
        4779. Improved motor nerve regeneration by SIRT1/Hif1a-mediated autophagy
        4780. Tetrahydrocurcumin ameliorates diabetic cardiomyopathy by attenuating high glucose-induced oxidative stress and fibrosis via activating the SIRT1 pathway
        4781. Hydroxytyrosol NO regulates oxidative stress and NO production through SIRT1 in diabetic mice and vascular endothelial cells
        4782. Long noncoding RNA FLRL2 alleviated nonalcoholic fatty liver disease through Arntl‐SIRT1 pathway
        4783. Insulin/IGF-1R, SIRT1, and FOXOs pathways—an intriguing interaction platform for bone and osteosarcoma
        4784. A SIRT1 agonist reduces cognitive decline in type 2 diabetic rats through antioxidative and anti‑inflammatory mechanisms
        4785. CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1
        4786. The SIRT1/P53 axis in diabetic intervertebral disc degeneration pathogenesis and therapeutics
        4787. Generation of human fatty livers using custom-engineered induced pluripotent stem cells with modifiable SIRT1 metabolism
        4788. SIRT1 inhibits gouty arthritis via activating PPARγ
        4789. Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice
        4790. SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury
        4791. Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway
        4792. Bergenin activates SIRT1 as a novel therapeutic agent for osteogenesis of bone mesenchymal stem cells
        4793. Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
        4794. Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1–PGC-1α–TFAM pathway
        4795. Catalpol alleviates adriamycin‐induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro
        4796. Premature myocardial infarction: genetic variations in SIRT1 affect disease susceptibility
        4797. miR-9-5p modulates the progression of Parkinson’s disease by targeting SIRT1
        4798. Exercise activates lysosomal function in the brain through AMPK‐SIRT1‐TFEB pathway
        4799. Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR‐181a to modulate SIRT1 expression
        4800. SIRT1 regulates lysosome function and exosome secretion
        4801. Dietary melatonin attenuates chromium-induced lung injury via activating the SIRT1/Pgc-1α/Nrf2 pathway
        4802. CircRNA has_circ_0001946 promotes cell growth in lung adenocarcinoma by regulating miR-135a-5p/SIRT1 axis and activating Wnt/β-catenin signaling …
        4803. Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells
        4804. Pharmacological activation of SIRT1 ameliorates cisplatin-induced acute kidney injury by suppressing apoptosis, oxidative stress, and inflammation in mice
        4805. SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high‐fat feeding
        4806. TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage
        4807. Resveratrol promotes diabetic wound healing via SIRT1-FOXO1-c-Myc signaling pathway-mediated angiogenesis
        4808. SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3
        4809. SIRT1 and gender differences in atherosclerotic cardiovascular disease
        4810. Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy
        4811. SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake
        4812. Characterization of SIRT1/DNMTs functions and LINE-1 methylation in patients with age-related macular degeneration
        4813. SIRT1 promotes a thermogenic gene program in bone marrow adipocytes: from mice to (wo) men
        4814. A Comparative Linear Interaction Energy and MM/PBSA Study on SIRT1–Ligand Binding Free Energy Calculation
        4815. Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis
        4816. MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis
        4817. SIRT1 deficiency interferes with membrane resealing after cell membrane injury
        4818. SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer
        4819. Effect of autophagy regulated by SIRT1/FoxO1 pathway on the release of factors promoting thrombosis from vascular endothelial cells
        4820. In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database
        4821. Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats
        4822. SIRT1: a potential tumour biomarker and therapeutic target
        4823. Deacetylation of β-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells
        4824. Catechin attenuates TNF-α induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes
        4825. SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes
        4826. LncRNA SNHG12 inhibits miR-199a to upregulate SIRT1 to attenuate cerebral ischemia/reperfusion injury through activating AMPK signaling pathway
        4827. SIRT1 knock-in mice preserve ovarian reserve resembling caloric restriction
        4828. Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs
        4829. SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary
        4830. SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP‐13 signaling
        4831. Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse …
        4832. SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease
        4833. Tangshen formula alleviates hepatic steatosis by inducing autophagy through the AMPK/SIRT1 pathway
        4834. SIRT1 protects against apoptosis by promoting autophagy in the oxygen glucose deprivation/reperfusion-induced injury
        4835. LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/SIRT1 pathway
        4836. Aldose reductase regulates hyperglycemia-induced HUVEC death via SIRT1/AMPK-α1/mTOR pathway
        4837. Inducible cardiac-specific deletion of SIRT1 in male mice reveals progressive cardiac dysfunction and sensitization of the heart to pressure overload
        4838. A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks
        4839. Knockout of longevity gene SIRT1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span
        4840. Protective effect of resveratrol against ischemia-reperfusion injury via enhanced high energy compounds and eNOS-SIRT1 expression in type 2 diabetic female rat …
        4841. LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR‐34a in diabetic cardiomyopathy
        4842. Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on SIRT1/Nrf2 signaling pathways
        4843. Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats
        4844. Arbutin attenuates LPS-induced lung injury via SIRT1/Nrf2/NF-κBp65 pathway
        4845. Evidence for SIRT1 mediated HMGB1 release from kidney cells in the early stages of hemorrhagic shock
        4846. Protective effects of dioscin against doxorubicin-induced hepatotoxicity via regulation of SIRT1/FOXO1/NF-κb signal
        4847. MHY2233 attenuates replicative cellular senescence in human endothelial progenitor cells via SIRT1 signaling
        4848. A PARP1–BRG1–SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites
        4849. … environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1/miR-134 signaling …
        4850. SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494
        4851. Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway
        4852. Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα
        4853. Salidroside stimulates the SIRT1/PGC-1α axis and ameliorates diabetic nephropathy in mice
        4854. SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress
        4855. Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells
        4856. Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling*[S]
        4857. Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation
        4858. Quercetin attenuates oxidative stress‐induced apoptosis via SIRT1/AMPK‐mediated inhibition of ER stress in rat chondrocytes and prevents the progression of …
        4859. Melatonin inhibits apoptosis and oxidative stress of mouse Leydig cells via a SIRT1-dependent mechanism
        4860. Suppression of SIRT1 in diabetic conditions induces osteogenic differentiation of human vascular smooth muscle cells via RUNX2 signalling
        4861. Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/β-catenin signaling …
        4862. Ferulic acid regulates muscle fiber type formation through the SIRT1/AMPK signaling pathway
        4863. SIRT1 modulates the sensitivity of prostate cancer cells to vesicular stomatitis virus oncolysis
        4864. … with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha …
        4865. Anagliptin ameliorates high glucose-induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1
        4866. Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells
        4867. SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: a possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic …
        4868. miR‐23b‐3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells
        4869. N-palmitoylethanolamide-oxazoline protects against middle cerebral artery occlusion injury in diabetic rats by regulating the SIRT1 pathway
        4870. Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway
        4871. Down-regulation of SIRT1 expression by mir-23b contributes to lipid accumulation in HepG2 cells
        4872. LncRNA LEGLTBC functions as a ceRNA to antagonize the effects of miR-34a on the downregulation of SIRT1 in glucolipotoxicity-induced INS-1 beta cell …
        4873. Effects of metformin and exenatide on insulin resistance and AMPKα-SIRT1 molecular pathway in PCOS rats
        4874. Melatonin effects on non-alcoholic fatty liver disease are related to microRNA-34a-5p/SIRT1 axis and autophagy
        4875. Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability
        4876. Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway
        4877. Switch of NAD salvage to de novo biosynthesis sustains SIRT1-RelB-dependent inflammatory tolerance
        4878. SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription
        4879. SIRT1 attenuates kidney disorders in male offspring due to maternal high-fat diet
        4880. Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged …
        4881. Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1α pathway
        4882. SIRT1-inducible deacetylation of p21 promotes cardiomyocyte proliferation
        4883. The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in …
        4884. LncRNA MNX1-AS1 promotes progression of esophageal squamous cell carcinoma by regulating miR-34a/SIRT1 axis
        4885. Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1/PGC‐1α/PI3K/Akt signaling
        4886. SIRT1 protects against urban particulate matter-induced airway inflammation
        4887. LncRNA-ANRIL inhibits cell senescence of vascular smooth muscle cells by regulating miR-181a/SIRT1
        4888. Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the SIRT1‐autophagy pathway
        4889. Activators of SIRT1 in wound repair: an animal model study
        4890. PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades
        4891. Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC‐1α mediated attenuation of mitochondrial oxidative stress
        4892. LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis
        4893. Molecular and cellular characterization of SIRT1 allosteric activators
        4894. Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent manner
        4895. EGCG enhances cancer cells sensitivity under 60Coγ radiation based on miR-34a/SIRT1/p53
        4896. SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway

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