PRISTIMERIN
January 22, 2020IL-6/STAT3
January 22, 2020- 225Ac-Cd33 Radioimmunotherapy Potently Increases The Sensitivity Of Resistant Acute Myeloid Leukemia Lines To The Bcl-2 Inhibitor Venetoclax By Mediating A …
- 613 Poster Gx15-070, A Small Molecule Bcl-2 Family Inhibitor, Induces Apoptosis And Enhances Cisplatin-Induced Apoptosis In Non-Small Cell Lung Cancer …
- 8-Chrysoeriol, As A Potential Bcl-2 Inhibitor Triggers Apoptosis Of Sw1990 Pancreatic Cancer Cells
- A Functionally Improved Locked Nucleic Acid Antisense Oligonucleotide Inhibits Bcl-2 And Bcl-Xl Expression And Facilitates Tumor Cell Apoptosis
- A Literature Review Of The Patent Publications On Venetoclax–A Selective Bcl-2 Inhibitor: Discovering The Therapeutic Potential Of A Novel Chemotherapeutic Agent
- A Novel Bcl-2 Inhibitor, Bm-1197, Induces Apoptosis In Malignant Lymphoma Cells Through The Endogenous Apoptotic Pathway
- A Novel Bcl-2 Small Molecule Inhibitor 4-(3-Methoxy-Phenylsulfannyl)-7-Nitro-Benzofurazan-3-Oxide (Mnb)-Induced Apoptosis In Leukemia Cells
- A Novel Small Molecule Inhibitor Targeted At Bcl-2
- A Phase 1B/2 Clinical Study Of Targeted Idh1 Inhibition With Ivosidenib, In Combination With The Bcl-2 Inhibitor Venetoclax, For Patients With Idh1-Mutated (Midh1) …
- A Phase I Study Of The Pan Bcl-2 Family Inhibitor Obatoclax Mesylate In Patients With Advanced Hematologic Malignancies
- A Phase I Trial Of The Small Molecule Pan-Bcl-2 Inhibitor Obatoclax (Gx15–070) In Combination With Docetaxel In Patients With Relapsed Non-Small Cell Lung Cancer …
- A Phase Ib/Ii Study Of The Bcl-2 Inhibitor Venetoclax In Combination With Standard Intensive Aml Induction/Consolidation Therapy With Flag-Ida In Patients With …
- A Safety And Schedule Seeking Trial Of Bcl-2 Inhibitor Obatoclax In Previously Untreated Older Patients With Acute Myeloid Leukemia (Aml)
- A Small Molecule Inhibitor Of Bcl-2, Ha14-1, Also Inhibits Ceramide Glucosyltransferase
- A Small Molecule Pan-Bcl-2 Family Inhibitor, Gx15-070, Induces Apoptosis And Enhances Cisplatin-Induced Apoptosis In Non-Small Cell Lung Cancer Cells
- A64 Cells Run A-Muc: Mucin Biology In The Lung: A Small Molecule Bcl-2 Inhibitor Switches Il-13 To A Cell Death Inducer For Allergen-Induced Metaplastic …
- Aberrantly Expressed Fra-1 By Il-6/Stat3 Transactivation Promotes Colorectal Cancer Aggressiveness Through Epithelial–Mesenchymal Transition
- Absorption, Metabolism, And Excretion Of A Novel Bcl-2 Inhibitor Venetoclax In Humans
- Abstract A245: Combination Of The Glycoengineered Type Ii Cd20 Antibody Obinutuzumab (Ga101), And The Novel Bcl-2 Selective Inhibitor, Abt-199 (Gdc-0199) …
- Abstract A30: Inhibition Of Pmca4 As A Strategy To Increase The Effectiveness Of Bcl-2 Inhibitor-Mediated Cell Death In Breast Cancer Cells.
- Abstract A77: Repression Of Mtorc1 Activity In Notch1 Mutant T-All Results In Sensitivity To The Bcl-2 Inhibitor Abt-263
- Abstract B4: A Microrna Screen To Identify Modulators Of Sensitivity To Bcl-2 Inhibitor Abt-263
- Abstract Ct069: Correlative Biomarkers Of Clinical Activity Of The Bcl-2 Inhibitor, Venetoclax (Abt-199/Gdc-0199), In Acute Myeloid Leukemia Patients
- Abstract Lb-212: Mcl-1 And Fbw7 Control A Dominant Survival Pathway Underlying Hdac And Bcl-2 Inhibitor Synergy In Squamous Cell Carcinoma.
- Abstract Lb-72: An Immunoassay Detecting Bcl-2: Bim And Mcl-1: Bim Complexes In The Phase 1 Monotherapy Study Of The Bcl-2 Inhibitor, Abt-199/Gdc-0199, In …
- Abstract Pd1-06: A Phase 1B Dose-Escalation And Expansion Study Of The Bcl-2 Inhibitor Venetoclax Combined With Tamoxifen In Er And Bcl-2–Positive Metastatic …
- Abstract# 3990: The Pan-Bcl-2 Family Inhibitor Abt-737 Synergizes With Dna Damaging Agents By Enhancing Apoptosis In Acute Lymphoblastic Leukemia Cells
- Abt-199, A Potent And Selective Bcl-2 Inhibitor, Achieves Antitumor Activity While Sparing Platelets
- Abt-737, An Inhibitor Of Bcl-2 Family Proteins, Is A Potent Inducer Of Apoptosis In Multiple Myeloma Cells
- Abt-737: A Small Molecule Inhibitor Of Bcl-2 With Dramatic Anti-Tumor Activity In Xenograft Models Of Small Cell Lung Cancer
- Abt‐199 (Venetoclax), A Bh3‐Mimetic Bcl‐2 Inhibitor, Does Not Cause Ca2+‐Signalling Dysregulation Or Toxicity In Pancreatic Acinar Cells
- Abt‐199 Selectively Inhibits Bcl-2 But Not Bcl-2 L 1 And Efficiently Induces Apoptosis Of Chronic Lymphocytic Leukaemic Cells But Not Platelets
- Acquisition Of Resistance To Trastuzumab In Gastric Cancer Cells Is Associated With Activation Of Il-6/Stat3/Jagged-1/Notch Positive Feedback Loop
- Activation Of Stat3 In Human Gastric Cancer Cells Via Interleukin (Il)-6-Type Cytokine Signaling Correlates With Clinical Implications
- Activity Of Vincristine, L-Asparaginase, And Dexamethasone Against Acute Lymphoblastic Leukemia Was Enhanced By The Bcl-2 Inhibitor Abt-737 In Vitro And In Vivo
- An Anti-Apoptotic Bcl-2 Family Protein Index Predicts The Response Of Leukemic Cells To The Pan-Bcl-2 Inhibitor S1.
- An Efficient Synthesis Of Abt-263, A Novel Inhibitor Of Antiapoptotic Bcl-2 Proteins
- An Inhibitor Of Bcl-2 Family Proteins Induces Regression Of Solid Tumours
- Anti-Allergic And Anti-Inflammatory Effects Of The Bcl-2 Inhibitor Abt-737 On Experimental Allergic Rhinitis Models
- Antiangiogenic Effect Of Tw37, A Small-Molecule Inhibitor Of Bcl-2
- Anticancer Effect Of Icaritin Inhibits Cell Growth Of Colon Cancer Through Reactive Oxygen Species, Bcl‑2 And Cyclin D1/E Signaling
- Antitumor Effects Of Sorafenib, Bevacizumab And Cetuximab As Single Agents Or In Combination With An Mek, Mtor Or Bcl-2 Inhibitor, In A Snu-398 Human …
- Apogossypolone, A Small-Molecule Inhibitor Of Bcl-2, Induces Radiosensitization Of Nasopharyngeal Carcinoma Cells By Stimulating Autophagy
- Apoptosis And Cell Cycle Arrest In Human Hepatocellular Carcinoma Cells And Enhance Chemosensitivity To Paclitaxel, Docetaxel, Doxorubicin And The Bcl-2 Inhibitor …
- Apoptosis And Cell Cycle Arrest In Human Hepatocellular Carcinoma Cells And Enhance Chemosensitivity To Paclitaxel, Docetaxel, Doxorubicin And The Bcl–2 Inhibitor …
- Apoptosis-Based Treatment Of Glioblastomas With Abt-737, A Novel Small Molecule Inhibitor Of Bcl-2 Family Proteins
- Arsenic Trioxide Synergistically Enhances The Antileukemia Activity Of Bcl-2 Inhibitor Abt-199 In Acute Myeloid Leukemia
- Aspirin Induces Apoptosis Through The Blockade Of Il-6-Stat3 Signaling Pathway In Human Glioblastoma A172 Cells
- Aspirin Promotes Apoptosis In A Murine Model Of Colorectal Cancer By Mechanisms Involving Downregulation Of Il-6–Stat3 Signaling Pathway
- At-101, A Pan-Bcl-2 Inhibitor, Leads To Radiosensitization Of Non-Small Cell Lung Cancer
- Autocrine Il-6-Induced Stat3 Activation Contributes To The Pathogenesis Of Lung Adenocarcinoma And Malignant Pleural Effusion
- Autophagy Eliminates Er Membrane Reorganization Induced By Bcl-2 Inhibitor In Hela Cells
- Autophagy Inhibition Enhances Pan-Bcl-2 Inhibitor At-101-Induced Apoptosis In Non-Small Cell Lung Cancer.
- Bcl-2 Family Regulation By The 20S Proteasome Inhibitor Bortezomib
- Bcl-2 Gene Silencing By Rna Interference Inhibits The Growth Of The Human Gallbladder Carcinoma Cell Line Gbc-Sd In Vitro And In Vivo
- Bcl-2 Inhibitor Abt-737 Enhances The Cisplatin-Induced Apoptosis In Breast Cancer T47D Cells
- Bcl-2 Inhibitor Ha14-1 And Genistein Together Adeptly Down Regulated Survival Factors And Activated Cysteine Proteases For Apoptosis In Human Malignant …
- Bcl-2 Inhibitor Scaffolds That Are Preorganized Along An Axis Of Chirality; The Effect Of Atropisomerism On Protein Binding
- Bcl-2 Inhibitor Uploaded Upconversion Nanophotosensitizers To Overcome The Photodynamic Therapy Resistance Of Cancer Through Adjuvant Intervention Strategy
- Bcl-2 Inhibitor Venetoclax Enhances Temozolomide Sensitivity In Aml
- Bcl-2 Selective Inhibitor Abt-199 Primes Rhabdomyosarcoma Cells To Histone Deacetylase Inhibitor-Induced Apoptosis
- Bcl‐2 Inhibitors Enhance Fgfr Inhibitor‐Induced Mitochondrial‐Dependent Cell Death In Fgfr2‐Mutant Endometrial Cancer
- Bevacizumab Synergizes With The Bcl-2 Inhibitor Venetoclax To Effectively Treat B‐Cell Non‐Hodgkin’S Lymphoma
- Bi-33, A Novel And Potent Pan-Bcl-2 Inhibitor, Induces Apoptosis In Cancer Cells And Shows Combinational Effect With Chemo Drugs
- Binding Of A Bcl-2 Family Inhibitor To Bovine Serum Albumin: Fluorescence Quenching And Molecular Docking Study
- Bortezomib Induces Oxidative Stress And Apoptosis That Are Synergistically Enhanced By A Bcl-2 Inhibitor In Human Pancreatic Cancer Cells
- Breast Cancer Cells Can Evade Apoptosis-Mediated Selective Killing By A Novel Small Molecule Inhibitor Of Bcl-2
- Chemoresistance To Concanamycin A1 In Human Oral Squamous Cell Carcinoma Is Attenuated By An Hdac Inhibitor Partly Via Suppression Of Bcl-2 Expression
- Clinical Experience With The Bcl-2‐Inhibitor Venetoclax In Combination Therapy For Relapsed And Refractory Acute Myeloid Leukemia And Related Myeloid Malignancies
- Co-Administration Of The Mtorc1/Torc2 Inhibitor Ink128 And The Bcl-2/Bcl-Xl Antagonist Abt-737 Kills Human Myeloid Leukemia Cells Through Mcl-1 Down …
- Combination Bcl-2 Inhibitor Therapy With Venetoclax And Navitoclax In Patients With Relapsed/Refractory Acute Lymphoblastic …
- Combination Of Guanine Arabinoside And Bcl‐2 Inhibitor Yc 137 Overcomes The Cytarabine Resistance In Hl‐60 Leukemia Cell Line
- Combination Of The Glycoengineered Type Ii Cd20 Antibody Obinutuzumab (Ga101) And The Novel Bcl-2 Selective Inhibitor Gdc-0199 Results In Superior In Vitro And …
- Combining A Gsi And Bcl-2 Inhibitor To Overcome Melanoma’S Resistance To Current Treatments
- Critical Upstream Signals Of Cytochrome C Release Induced By A Novel Bcl-2 Inhibitor
- Cycling1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance And Inhibition Of Bcl-2 Pathway Reverses The Resistance
- Deletion Of The Innate Immune Nlrp3 Receptor Abolishes Cardiac Ischemic Preconditioning And Is Associated With Decreased Il-6/Stat3 Signaling
- Development Of A Convergent Large-Scale Synthesis For Venetoclax, A First-In-Class Bcl-2 Selective Inhibitor
- Dipg-62. Carboplatin Synergizes With Bcl-2 Inhibitor To Potentiate Killing Of Dipg Cells
- Discovery Of A Potent And Selective Bcl-2 Inhibitor Using Sar By Nmr
- Dna Damage Induces The Il-6/Stat3 Signaling Pathway, Which Has Anti-Senescence And Growth-Promoting Functions In Human Tumors
- Down-Regulation Of The Apoptosis-Inducing Factor Or Bcl-2 Inhibitor Of Transcription By Rna Interference Can Alleviate Tap63Γ-Induced Apoptosis In Esophageal …
- Dysregulated Mir-124 And Mir-200 Expression Contribute To Cholangiocyte Proliferation In The Cholestatic Liver By Targeting Il-6/Stat3 Signalling
- Early Data Promising For Pan-Bcl-2 Inhibitor In Hematologic Malignancies
- Effect Of A Small Molecule Bcl‐2 Inhibitor On Immune Function And Use With A Recombinant Vaccine
- Effect Of Ketoconazole, A Strong Cyp3A Inhibitor, On The Pharmacokinetics Of Venetoclax, A Bcl‐2 Inhibitor, In Patients With Non‐Hodgkin Lymphoma
- Effect Of Low‐And High‐Fat Meals On The Pharmacokinetics Of Venetoclax, A Selective First‐In‐Class Bcl‐2 Inhibitor
- Effect Of Rifampin On The Pharmacokinetics, Safety And Tolerability Of Navitoclax (Abt‐263), A Dual Inhibitor Of Bcl‐2 And Bcl‐Xl, In Patients With Cancer
- Efficacy And Safety Of Bcl-2 Inhibitor Venetoclax In Hematological Malignancy: A Systematic Review And Meta-Analysis Of Clinical Trials
- Efficacy Of The Pan-Bcl-2 Inhibitor (Obatoclax) As A Single Agent To Treat Myeloproliferative Neoplasm In Jak2V617F Murine Transplantation Model
- Elevated Expression Of S100A8 And S100A9 Correlates With Resistance To The Bcl-2 Inhibitor Venetoclax In Aml
- Embelin Reduces Colitis-Associated Tumorigenesis Through Limiting Il-6/Stat3 Signaling
- Epigenetic Alterations In Cholangiocarcinoma-Sustained Il-6/Stat3 Signaling In Cholangio-Carcinoma Due To Socs3 Epigenetic Silencing
- Evaluation Of Rifampin’S Transporter Inhibitory And Cyp3A Inductive Effects On The Pharmacokinetics Of Venetoclax, A Bcl‐2 Inhibitor: Results Of A Single‐And Multiple …
- Evaluation Of The Bcl-2 Inhibitor Abt-199 In Xenograft Models Of Acute Lymphoblastic Leukemia By The Pediatric Preclinical Testing Program
- Exploring The Selectivity Of Inhibitor Complexes With Bcl-2 And Bcl-Xl: A Molecular Dynamics Simulation Approach
- Exposure-Response Analyses Of The Effects Of Venetoclax, A Selective Bcl-2 Inhibitor, On B-Lymphocyte And Total Lymphocyte Counts In Women With Systemic …
- Extended Phase I Trial Of The Oral Pan-Bcl-2 Inhibitor At-101 By Multiple Dosing Schedules In Patients With Advanced Cancers
- Fcn-338, A Novel And Selective Bcl-2 Inhibitor, Exhibits Potent Anti-Tumor Activity In B-Cell Lymphoma
- Fenretinide Via Noxa Induction, Enhanced Activity Of The Bcl-2 Inhibitor Venetoclax In High Bcl-2–Expressing Neuroblastoma Preclinical Models
- Genomic Analysis Of Small-Cell Lung Carcinomas: Discovery Of A Candidate Stratification Biomarker For A Bcl-2 Inhibitor
- Gx15–070 (Obatoclax), A Bcl-2 Family Proteins Inhibitor Engenders Apoptosis And Pro-Survival Autophagy And Increases Chemosensitivity In Neuroblastoma
- Hematologic Tumor Cell Resistance To The Bcl-2 Inhibitor Venetoclax: A Product Of Its Microenvironment?
- Hepatic Acute Phase Proteins–Regulation By Il-6-And Il-1-Type Cytokines Involving Stat3 And Its Crosstalk With Nf-Κb-Dependent Signaling
- Hmgb1-Il-23-Il-17-Il-6-Stat3 Axis Promotes Tumor Growth In Murine Models Of Melanoma
- Hsp90 Inhibitor (Nvp-Auy922) Enhances Anti-Cancer Effect Of Bcl-2 Inhibitor (Abt-737) In Small Cell Lung Cancer
- Hsp90 Inhibitor (Nvp-Auy922) Enhances The Anti-Cancer Effect Of Bcl-2 Inhibitor (Abt-737) In Small Cell Lung Cancer Expressing Bcl-2
- Ibrutinib Combined With Car-T Cells In The Treatment Of Del (17P) Chronic Lymphocytic Leukemia With Bcl-2 Inhibitor Resistance: A Case Report And Literature Review
- Identification Of A Novel Bcl-2 Inhibitor By Ligand-Based Screening And Investigation Of Its Anti-Cancer Effect On Human Breast Cancer Cells
- Il-17 Induces Akt-Dependent Il-6/Jak2/Stat3 Activation And Tumor Progression In Hepatocellular Carcinoma
- Il-6 Promotes Head And Neck Tumor Metastasis By Inducing Epithelial–Mesenchymal Transition Via The Jak-Stat3-Snail Signaling Pathway
- Il-6 Trans-Signaling Modulates Tlr4-Dependent Inflammatory Responses Via Stat3
- Il-6 Trans-Signaling Via Stat3 Directs T Cell Infiltration In Acute Inflammation
- Il-6–Gp130–Stat3 In T Cells Directs The Development Of Il-17+ Th With A Minimum Effect On That Of Treg In The Steady State
- Il-6/Stat3/Tff3 Signaling Regulates Human Biliary Epithelial Cell Migration And Wound Healing In Vitro
- Immunosensitization With A Bcl-2 Small Molecule Inhibitor
- Immunotoxin And Bcl-2 Inhibitor Combination Therapy Targeting Chondroitin Sulfate Proteoglycan 4.
- Implantation Of Bone Marrow Mesenchymal Stem Cells Inhibits Bcl-2 And Bax-Mediated Neuronal Apoptosis In Rats After Cerebral Ischemic Injury
- In Vitro Analysis Of Pan-Bcl-2 Inhibitor Gx15-070 (Obatoclax) On Human Lymphocytes For The Feasibility Of Combination Immunotherapy.
- In Vivo And In Vitro Inhibition Of Osteosarcoma Growth By The Pan Bcl-2 Inhibitor At-101
- In Vivo Efficacy Of At-101, An Orally Active Pan Bcl-2 Family Protein Inhibitor In Combination With Docetaxel Or Erlotinib For Non Small Cell Lung Cancer Therapy
- In Vivo Efficacy Of Novel Methionine Aminopeptidase 2 Inhibitors, Alone And In Combination With Clinical Drugs And A Novel Bcl-2 Inhibitor
- Inducible Microrna-223 Down-Regulation Promotes Tlr-Triggered Il-6 And Il-1Β Production In Macrophages By Targeting Stat3
- Inducing Apoptosis In Mantle Cell Lymphoma Using Inhibitors Of Cyclin-Dependent Kinases And The Bcl-2 Inhibitor Abt-737
- Induction Of Neutrophil Apoptosis By A Bcl-2 Inhibitor Reduces Particulate Matter-Induced Lung Inflammation
- Induction Of Neutrophil Apoptosis By Bcl-2 Inhibitor Reduces Pm-Induced Airway Inflammation
- Inhibiting Mitochondria Function By Bcl-2 Inhibitor Venetoclax And Complex I Inhibitor Iacs-010759 Eliminate Leukemia Cells In Pre-Clinical Aml Models
- Inhibition Of Chk1 Enhances Cell Death Induced By The Bcl-2-Selective Inhibitor Abt-199 In Acute Myeloid Leukemia Cells
- Inhibition Of Growth Of Human Breast Cancer Cell Lines With The Combination Of An Egfr/Her-2/Neu Tyrosine Kinase Inhibitor And A Bcl-2 Inhibitor
- Inhibition Of Growth Of Human Breast Cancer Cell Lines With The Combination Of An Mtor Inhibitor And A Bcl-2 Inhibitor
- Inhibition Of Il-6/Stat3 Axis And Targeting Axl And Tyro3 Receptor Tyrosine Kinases By Apigenin Circumvent Taxol Resistance In Ovarian Cancer Cells
- Inhibition Of Stat3 Signaling Blocks The Anti-Apoptotic Activity Of Il-6 In Human Liver Cancer Cells
- Interaction Studies To Evaluate 2-Carboxyphenolate Analogues As Inhibitor Of Anti-Apoptotic Protein Bcl-2
- Interim Results From A Dose-Escalation Study Of The Bcl-2 Inhibitor Venetoclax (Abt-199/Gdc-0199) Plus Bendamustine (B) And Rituximab (R) In Patients (Pts) With …
- Jak/Stat3 Pathway Inhibition Blocks Skeletal Muscle Wasting Downstream Of Il-6 And In Experimental Cancer Cachexia
- Lipopolysaccharides Upregulate Hepcidin In Neuron Via Microglia And The Il-6/Stat3 Signaling Pathway
- Lps And Tnfα Induce Socs3 Mrna And Inhibit Il‐6‐Induced Activation Of Stat3 In Macrophages
- Mcl-1 And Bcl-Xl-Dependent Resistance To The Bcl-2 Inhibitor Abt-199 Can Be Overcome By Preventing Pi3K/Akt/Mtor Activation In Lymphoid …
- Mcl-1 And Fbw7 Control A Dominant Survival Pathway Underlying Hdac And Bcl-2 Inhibitor Synergy In Squamous Cell Carcinoma
- Mcl-1 Inhibitor-Induced Killing Of Multiple Myeloma Is Modulated By The Relative Level Of Expression Of Pro-Survival Members Of The Bcl-2 Family And The Proto …
- Mcl-1 Or Bcl-Xl-Dependent Resistance To The Bcl-2 Antagonist (Abt-199) Can Be Overcome By Specific Inhibitor As Single Agents And In Combination With Abt-199 In …
- Mcl-1 Up-Regulation Through Mapk Activation Confers Acquired Resistance To Bcl-2 Inhibitor Abt-199 In Pre-Clinical Aml Models
- Metabolic Changes Associated With Metformin Potentiates Bcl-2 Inhibitor, Venetoclax, And Cdk9 Inhibitor, Bay1143572 And Reduces Viability Of Lymphoma …
- Metformin Synergizes With Bcl-Xl/Bcl-2 Inhibitor Abt-263 To Induce Apoptosis Specifically In P53-Defective Cancer Cells
- Metronomic Small Molecule Inhibitor Of Bcl-2 (Tw-37) Is Antiangiogenic And Potentiates The Antitumor Effect Of Ionizing Radiation
- Mik665/S64315, A Novel Mcl-1 Inhibitor, In Combination With Bcl-2 Inhibitors Exhibits Strong Synergistic Antitumor Activity In A Range Of Hematologic Malignancies
- Mir-143 Is Downregulated In Cervical Cancer And Promotes Apoptosis And Inhibits Tumor Formation By Targeting Bcl-2
- Mir-17-92 Cluster Promotes Cholangiocarcinoma Growth: Evidence For Pten As Downstream Target And Il-6/Stat3 As Upstream Activator
- Mir-1915-3P Inhibits Bcl-2 Expression In The Development Of Gastric Cancer
- Mir‐1915 Inhibits Bcl‐2 To Modulate Multidrug Resistance By Increasing Drug‐Sensitivity In Human Colorectal Carcinoma Cells
- Mitochondrial Targeting By Use Of Lipid Nanocapsules Loaded With Sv30, An Analogue Of The Small-Molecule Bcl-2 Inhibitor Ha14-1
- Molecular Dynamic Simulations On An Inhibitor Of Anti-Apoptotic Bcl-2 Proteins For Insights Into Its Interaction Mechanism For Anti-Cancer Activity
- N-(3-Oxo-Acyl) Homoserine Lactone Inhibits Tumor Growth Independent Of Bcl-2 Proteins
- N′-((2-(6-Bromo-2-Oxo-2H-Chromen-3-Yl)-1H-Indol-3-Yl) Methylene) Benzohydrazide As A Probable Bcl-2/Bcl-Xl Inhibitor With Apoptotic And Anti-Metastatic Potential
- Naringenin-Induced Apoptosis Is Attenuated By Bcl-2 But Restored By The Small Molecule Bcl-2 Inhibitor, Ha 14-1, In Human Leukemia U937 Cells
- Navitoclax, A Targeted High-Affinity Inhibitor Of Bcl-2, In Lymphoid Malignancies: A Phase 1 Dose-Escalation Study Of Safety, Pharmacokinetics, Pharmacodynamics, And …
- Non-Cell-Autonomous Activation Of Il-6/Stat3 Signaling Mediates Fgf19-Driven Hepatocarcinogenesis
- Obatoclax, A Pan-Bcl-2 Inhibitor, Targets Cyclin D1 For Degradation To Induce Antiproliferation In Human Colorectal Carcinoma Cells
- Oocyte-Secreted Growth Differentiation Factor 9 Inhibits Bcl-2-Interacting Mediator Of Cell Death-Extra Long Expression In Porcine Cumulus Cell
- Overcoming Resistance To Ac0010, A Third Generation Of Egfr Inhibitor, By Targeting C-Met And Bcl-2
- Overcoming The Radioresistance Of Prostate Cancer Cells With A Novel Bcl-2 Inhibitor
- P53-Dependent Regulation Of Mcl-1 Contributes To Synergistic Cell Death By Ionizing Radiation And The Bcl-2/Bcl-Xl Inhibitor Abt-737
- Pan-Bcl-2 Inhibitor At-101 Enhances Tumor Cell Killing By Egfr Targeted T Cells
- Pan-Bcl-2 Inhibitor, Gx15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes While Preserving Effector T Lymphocytes: A Rationale For Its Use In Combination …
- Pediatric Preclinical Testing Program (Pptp) Evaluation Of The Bcl-2 Inhibitor Abt-263
- Pharmacokinetics Of The B-Cell Lymphoma 2 (Bcl-2) Inhibitor Venetoclax In Female Subjects With Systemic Lupus Erythematosus
- Pharmacokinetics Of The Bcl-2 Inhibitor Venetoclax In Subjects With Hepatic Impairment
- Pharmacokinetics Of The Bcl‐2 Inhibitor Venetoclax In Healthy Chinese Subjects
- Pharmacokinetics Of Venetoclax, A Novel Bcl‐2 Inhibitor, In Patients With Relapsed Or Refractory Chronic Lymphocytic Leukemia Or Non‐Hodgkin Lymphoma
- Phase 1 Study Of The Safety, Pharmacokinetics, And Antitumour Activity Of The Bcl-2 Inhibitor Navitoclax In Combination With Rituximab In Patients With Relapsed Or …
- Phase I Study Of A Novel Bcl-2 Inhibitor, At-101 In Combination With Lenalidomide And Dexamethasone In Patients With Relapsed And/Or Refractory Multiple Myeloma …
- Phase I Trial Of Escalating Doses Of The Bcl-2 Inhibitor Venetoclax In Combination With Daunorubicin/Cytarabine Induction And High Dose Cytarabine Consolidation In …
- Pmca2 Silencing Potentiates Mda-Mb-231 Breast Cancer Cell Death Initiated With The Bcl-2 Inhibitor Abt-263
- Potential Utility Of The Pan-Bcl-2 Inhibitor Gx15–070 (Obatoclax) In Cancer Immunotherapy
- Pre-Clinical Evaluation Of Bcl-2 Inhibitor Abt-737 In Small Cell Lung Cancer
- Preclinical Evaluation Of Apoptosis Induction By The Novel Small Molecule Bcl-2 Inhibitor, Gx015–070, In Ex Vivo Chronic Lymphoid Leukemia (Cll) Cells
- Preclinical Study Of A Bcl-2 Inhibitor In Neuroblastoma.
- Prediction Of Human Nonlinear Pharmacokinetics Of A New Bcl-2 Inhibitor Using Pbpk Modeling And Interspecies Extrapolation Strategy
- Promise Of Combining A Bcl-2 Family Inhibitor With Bortezomib Or Saha For Adult T-Cell Leukemia/Lymphoma
- Rac1 Mediates Stat3 Activation By Autocrine Il-6
- Radiosensitization By A Novel Bcl-2 And Bcl-Xl Inhibitor S44563 In Small-Cell Lung Cancer
- Rapid Complete Response To Single-Agent Bcl-2 Inhibitor Venetoclax In A Heart-Transplanted Patient With Triple Refractory Immunoglobulin Light-Chain Amyloidosis
- Ras Blockade Inhibits Bcl-2 Modifying Factor (Bmf) Expression And Prevents Hypertension And Tubular Apoptosis In Diabetic Akita Mouse Kidneys
- Removed: Molecular Mechanisms Involved In Resistance Of Cll Cells Towards Abt-737, A Specific Bcl-2 Inhibitor
- Rnai Inhibits Bcl-2 Gene Expression And Enhances Radio-Sensitivity Of Lung Adenocarcinoma Cell Line A549.
- S55746 Is A Novel Orally Active Bcl-2 Selective And Potent Inhibitor That Impairs Hematological Tumor Growth
- Safety, Pharmacokinetics, Pharmacodynamics, And Activity Of Navitoclax, A Targeted High Affinity Inhibitor Of Bcl-2, In Lymphoid Malignancies
- Selective Bcl-2 Inhibitor Probes
- Ser727‐Dependent Transcriptional Activation By Association Of P300 With Stat3 Upon Il‐6 Stimulation
- Small Molecule Bcl-2 Inhibitor Enhances Apoptosis Induction By Gemcitabine Or Sulindac Sulfide In Bxpc-3 Pancreatic Cancer Cells
- Small Molecule Pan-Bcl-2 Inhibitor At-101 Induces Apoptosis In Nsclc By Up-Regulating Noxa And Enhances Antitumor Activity Of Docetaxel Or Targeted Kinase …
- Small-Molecule Bh3 Mimetic And Pan-Bcl-2 Inhibitor At-101 Enhances The Antitumor Efficacy Of Cisplatin Through Inhibition Of Ape1 Repair And Redox Activity In …
- Stat3 Activation By Il-6 From Mesenchymal Stem Cells Promotes The Proliferation And Metastasis Of Osteosarcoma
- Stat3 Activation In Response To Il-6 Is Prolonged By The Binding Of Il-6 Receptor To Egf Receptor
- Stat3 Mediates Il‐6‐Induced Neuroendocrine Differentiation In Prostate Cancer Cells
- Statins Enhance Killing Of Multiple Myeloma Cells By The Bcl-2 Inhibitor Venetoclax And The Mcl-1 Inhibitor S63845
- Sulindac Sulfide–Induced Apoptosis Is Enhanced By A Small-Molecule Bcl-2 Inhibitor And By Trail In Human Colon Cancer Cells Overexpressing Bcl-2
- Survivin Inhibition Is Critical For Bcl-2 Family Inhibitor, Abt-263 To Induce Apoptosis In Liver Cancer Cells
- Survivin Inhibition Is Critical For Bcl-2 Inhibitor-Induced Apoptosis In Hepatocellular Carcinoma Cells
- Synergistic Aml Cell Death Induction By Marine Cytotoxin (+)-1 (R), 6 (S), 1′(R), 6′(S), 11 (R), 17 (S)-Fistularin-3 And Bcl-2 Inhibitor Venetoclax
- Synergistic Combination Of Small Molecule Inhibitor And Rna Interference Against Antiapoptotic Bcl-2 Protein In Head And Neck Cancer Cells
- Synergistic Effect Of Bcl-2 Inhibitor Apg-2575 And Cdk9 Inhibitor In Acute Myeloid Leukemia And Dlbcl Preclinical Tumor Models
- Synergistic Growth Inhibition Of Human Cancer Cells With Atrasentan And A Bcl-2 Inhibitor
- Synergistic Induction Of Apoptosis By The Bcl-2 Inhibitor Abt-737 And Imatinib Mesylate In Gastrointestinal Stromal Tumor Cells
- Synergistic Inhibition Of Breast Cancer Cell Lines With A Dual Inhibitor Of Egfr-Her-2/Neu And A Bcl-2 Inhibitor
- Synergistic Inhibition Of Breast Cancer Cell Lines With The Combination Of A Dual Inhibitor Of Egfr/Her-2/Neu And A Bcl-2 Inhibitor
- Synergistic Inhibition Of Tumor Growth By Combined Treatment With The Pan Bcl-2 Inhibitor At-101 And Docetaxel In Human Cancer Xenograft Models
- Systemic Inhibition Of Il-6/Stat3 Signalling Protects Against Experimental Osteoarthritis
- Tanshinone Iia Inhibits Breast Cancer Stem Cells Growth In Vitro And In Vivo Through Attenuation Of Il‐6/Stat3/Nf‐Kb Signaling Pathways
- Targeted Therapies For Epithelial Cancers: In Vivo Efficacy Of The Bcl-2/Bcl-Xl Inhibitor 2-Meaa
- Targeted Therapy With A Selective Bcl-2 Inhibitor In Older Patients With Acute Myeloid Leukemia
- Targeting 14-3-3 Sensitizes Native And Mutant Bcr-Abl To Inhibition With U0126, Rapamycin And Bcl-2 Inhibitor Gx15-070
- Targeting Aml Through Apoptosis Activation Using Bcl-2/Mcl-1 Or Bcl-2/Hdm2 Inhibitor Combination Therapies
- Targeting Apoptosis And Autophagy By A Novel Bcl-2 Inhibitor, Gx15-070, In Neuroblastoma.
- Targeting Bcl-2 Overexpression In Various Human Malignancies Through Nf-Κb Inhibition By The Proteasome Inhibitor Bortezomib
- Targeting The Il-6/Jak/Stat3 Signalling Axis In Cancer
- Telomerase Inhibitor Imetelstat In Combination With The Bcl-2 Inhibitor Venetoclax Enhances Apoptosis In Vitro And Increases Survival In Vivo In Acute Myeloid …
- The Bcl-2 Inhibitor Abt-199 Enhances Imatinib-Induced Cell Death In Chronic Phase Cml Progenitors
- The Bcl-2 Inhibitor Abt-263 Enhances The Response Of Multiple Chemotherapeutic Regimens In Hematologic Tumors In Vivo
- The Bcl-2 Inhibitor Abt-737 Shows Significant Anti-Tumor Efficacy In A Model Of Non-Hodgkin’S B Cell Lymphoma
- The Bcl-2/Bcl-Xl Inhibitor Abt-737 Promotes Death Of Retinoblastoma Cancer Cells
- The Bcl-2/Bcl-Xl Inhibitor Bh3I-2′ Affects The Dynamics And Subcellular Localization Of Sumoylated Proteins
- The Bcl‐2 Inhibitor Venetoclax Inhibits Nrf2 Antioxidant Pathway Activation Induced By Hypomethylating Agents In Aml
- The Combination Of A Sphingosine Kinase 2 Inhibitor (Abc294640) And A Bcl‐2 Inhibitor (Abt‐199) Displays Synergistic Anti‐Myeloma Effects In Myeloma Cells Without …
- The Cxcr4 Inhibitor Bl-8040 Induces The Apoptosis Of Aml Blasts By Downregulating Erk, Bcl-2, Mcl-1 And Cyclin-D1 Via Altered Mir-15A/16-1 Expression
- The Deubiquitinating Enzyme Inhibitor Pr-619 Enhances The Cytotoxicity Of Cisplatin Via The Suppression Of Anti-Apoptotic Bcl-2 Protein: In Vitro And In Vivo Study
- The Discovery Of Navitoclax, A Bcl-2 Family Inhibitor
- The Dual Pi3K-Δ/Γ Inhibitor Duvelisib In Combination With The Bcl-2 Inhibitor Venetoclax Shows Promising Responses In Richter Syndrome-Pdx Models
- The Ewing Family Of Tumors Relies On Bcl-2 And Bcl-Xl To Escape Parp Inhibitor Toxicity
- The Il-6–Stat3 Axis Mediates A Reciprocal Crosstalk Between Cancer-Derived Mesenchymal Stem Cells And Neutrophils To Synergistically Prompt Gastric …
- The Il-6/Gp130/Stat3 Signaling Axis: Recent Advances Towards Specific Inhibition
- The Il-6/Jak/Stat3 Pathway: Potential Therapeutic Strategies In Treating Colorectal Cancer
- The Irreversible Erbb1/2/4 Inhibitor Neratinib Interacts With The Bcl-2 Inhibitor Venetoclax To Kill Mammary Cancer Cells
- The Novel Antisense Bcl-2 Inhibitor Spc2996 Causes Rapid Leukemic Cell Clearance And Immune Activation In Chronic Lymphocytic Leukemia
- The Novel Imipridone Onc212 Highly Synergizes With The Bcl-2 Inhibitor Abt-199 In Aml And Activates Orphan Receptor Gpr132
- The Pan-Bcl-2 Inhibitor (−)-Gossypol Triggers Autophagic Cell Death In Malignant Glioma
- The Proteasome Inhibitor Bortezomib Promotes Mitochondrial Injury And Apoptosis Induced By The Small Molecule Bcl-2 Inhibitor Ha14-1 In Multiple Myeloma Cells
- The Selective Bcl-2 Inhibitor Abt-199 Induces Cell Death Via The Intrinsic Apoptotic Pathway In Canine B-Cell And T-Cell Lymphoma Cell Lines
- The Sensitivity Of Diffuse Large B-Cell Lymphoma Cell Lines To Histone Deacetylase Inhibitor-Induced Apoptosis Is Modulated By Bcl-2 Family Protein Activity
- The Small Molecule Bcl-2 Inhibitor Ha14-1 Interacts Synergistically With Flavopiridol To Induce Mitochondrial Injury And Apoptosis In Human Myeloma Cells Through A …
- The Small Molecule Bcl-2 Inhibitor Ha14-1 Potentiates The Lethality Of A Regimen Combining Mek1/2 And Chk1 Inhibitors In Multiple Myeloma Cells
- The Small Molecule Bcl-2/Mcl-1 Inhibitor Tw-37 Shows Single-Agent Cytotoxicity In Neuroblastoma Cell Lines
- The Small Molecule Pan-Bcl-2 Inhibitor Gx15-070 Induces Apoptosis In Vitro In Mantle Cell Lymphoma (Mcl) Cells And Exhibits A Synergistic Effect In Combination With …
- The Small-Molecule Bcl-2 Inhibitor Ha14-1 Interacts Synergistically With Flavopiridol To Induce Mitochondrial Injury And Apoptosis In Human Myeloma Cells Through A …
- The Use Of The Bcl-2 Inhibitor In Cll Patients Who Progressed After B-Cell-Receptor Inhibitors: A Retrospective Multicenter …
- Therapeutic Efficacy Of Abt-737, A Bcl-2 Inhibitor, In A Canine Melanoma Cell Line
- Therapeutic Silencing Of Bcl-2 By Systemically Administered Sirna Nanotherapeutics Inhibits Tumor Growth By Autophagy And Apoptosis And Enhances The …
- Therapeutic Targeting Of Il-6 Trans Signaling Counteracts Stat3 Control Of Experimental Inflammatory Arthritis
- Thu0282 Exposure-Response Analyses Of Effects Of Venetoclax, A Selective Bcl-2 Inhibitor, On B And Total Lymphocyte Counts In Female Subjects With Systemic …
- Thu0306 Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of The Bcl-2 Inhibitor Venetoclax (Abt-199) In A Phase 1 Single And Multiple Ascending …
- Thu0382 Venetoclax (Abt-199), A Potent And Selective Bcl-2 Inhibitor, Prevents Nephritis In Lupus Prone Nzb/W F1 Mice By Depleting Selective Lymphocyte …
- To Overcoming Rituximab-Chemotherapy Resistance By Targeting The Autophagy Pathway Using Bortezomib In Combination With The Bcl-2 Inhibitor Obatoclax In Non …
- Transcriptional Inactivation Of Stat3 By Pparγ Suppresses Il-6-Responsive Multiple Myeloma Cells
- Tumor Growth Inhibition Modelling Based On Receptor Occupancy And Biomarker Activity Of A New Bcl-2 Inhibitor In Mice
- Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis Is Inhibited By Bcl-2 But Restored By The Small Molecule Bcl-2 Inhibitor, Ha 14-1, In …
- Tw-37, A Nonpeptidic Small-Molecule Inhibitor Of Bcl-2, Inhibits Cell Invasion And Angiogenesis In Pancreatic Cancer
- Updated Results Of A Phase I First-In-Human Study Of The Bcl-2 Inhibitor Abt-199 (Gdc-0199) In Patients With Relapsed/Refractory Non-Hodgkin Lymphoma (Nhl).
- Venclexta (Venetoclax) First Bcl-2 Inhibitor Approved For High-Risk Relapsed Chronic Lymphocytic Leukemia
- Venetoclax (Abt-199), A Potent And Selective Bcl-2 Inhibitor, Is Efficacious In Nzb/Wf1 Mouse Model Of Lupus Nephritis And Reduces Human Lymphocyte Lifespan In …
- Venetoclax, A Novel Bcl-2 Inhibitor, Induces Cell Growth Suppression, Apoptosis, Cell Cycle Arrest, And Autophagy In Triple Negative Breast Cancer Mda-Mb-231 …
- Vesicular Stomatitis Virus And Bcl-2 Inhibitor Combination Therapy For The Treatment Of Chronic Lymphocytic Leukemia
- Virtual Screening, Sar, And Discovery Of 5‐(Indole‐3‐Yl)‐2‐[(2‐Nitrophenyl) Amino][1, 3, 4]‐Oxadiazole As A Novel Bcl‐2 Inhibitor
- Vsv Oncolysis In Combination With The Bcl-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance In Chronic Lymphocytic Leukemia
