BCL-W, short for B-cell lymphoma-extra-large, plays a critical role in human health and aging by regulating cell survival.It acts as an anti-apoptotic protein, meaning it prevents a form of cell death called apoptosis. This is essential for maintaining healthy tissues and organs throughout the body. Research suggests that BCL-W is involved in longevity pathways. Studies on roundworms and even centenarians have indicated a link between BCL-W function and extended lifespan [MDPI, Bcl-xL as a Modulator of Senescence and Aging].

However, BCL-W’s influence on aging is complex. While it promotes cell survival, excessive BCL-W activity can also lead to the buildup of senescent cells, which are dysfunctional cells that contribute to aging and age-related diseases.Therefore, a delicate balance of BCL-W function seems to be important for healthy aging. Understanding this balance further could offer insights into potential strategies to promote longevity and combat age-related decline.

1. 3-Hydroxy-3′, 4′-Dimethoxyflavone Suppresses Bcl-W-Induced Invasive Potentials And Stemness In Glioblastoma Multiforme
2. 44 Over-Expression Of Microrna-122 (Mir-122) Induces Apoptosis By Targeting Cycling1 And Bcl-W Genes In Vitro
3. A Novel Bcl-2/Bcl-Xl/Bcl-W Inhibitor Abt-737 As Therapy In Multiple Myeloma
4. A Retrograde Neuronal Survival Response: Target-Derived Neurotrophins Regulate Mef2D And Bcl-W
5. Abstract A3: Bcl-W-Induced Invasive Pathways In Gastric Cancer Cells
6. Adeno-Associated Virus-Mediated Delivery Of Bcl-W Gene Improves Outcome After Transient Focal Cerebral Ischemia
7. Akt Regulates Drug-Induced Cell Death Through Bcl-W Downregulation
8. Anti-Apoptotic Functions Of Bcl-W, Mcl-1, And A1 In Mitotic Cell Death
9. Apoptosis Regulator Bcl-W Is Essential For Spermatogenesis But Appears Otherwise Redundant
10. At‐101 Downregulates Bcl 2 And Mcl 1 And Potentiates The Cytotoxic Effects Of Lenalidomide And Dexamethasone In Preclinical Models Of Multiple Myeloma And W …
11. Bcl-2 Family Compensation Regulates T Cell Homeostasis And Reveals A Bim: Bcl-W Axis In T-All
12. Bcl-2 Is A Better Abt-737 Target Than Bcl-Xl Or Bcl-W And Only Noxa Overcomes Resistance Mediated By Mcl-1, Bfl-1, Or Bcl-B
13. Bcl-W (Edding) With Mitochondria
14. Bcl-W Buries Its Tail, Lets Cell Die
15. Bcl-W Deficiency Perturbs Enterocyte Apoptosis And Proliferation
16. Bcl-W Enhances Mesenchymal Changes And Invasiveness Of Glioblastoma Cells By Inducing Nuclear Accumulation Of Β-Catenin
17. Bcl-W Expression And Localization In Brain Ischemia
18. Bcl-W Expression In Colorectal Adenocarcinoma
19. Bcl-W Expression Is Increased In Brain Regions Affected By Focal Cerebral Ischemia In The Rat
20. Bcl-W Forms Complexes With Bax And Bak, And Elevated Ratios Of Bax/Bcl-W And Bak/Bcl-W Correspond To Spermatogonial And Spermatocyte Apoptosis In The Testis
21. Bcl-W Has A Fundamental Role In B Cell Survival And Lymphomagenesis
22. Bcl-W Is A Regulator Of Microtubule Inhibitor-Induced Mitotic Cell Death
23. Bcl-W Is An Important Determinant Of Damage-Induced Apoptosis In Epithelia Of Small And Large Intestine
24. Bcl-W Is Expressed In A Majority Of Infiltrative Gastric Adenocarcinomas And Suppresses The Cancer Cell Death By Blocking Stress-Activated Protein Kinase/C-Jun Nh2 …
25. Bcl-W Promotes Cell Invasion By Blocking The Invasion-Suppressing Action Of Bax
26. Bcl-W Promotes Cell Invasion By Inducing Mitochondrial Ros Production
27. Bcl-W Promotes Gastric Cancer Cell Invasion By Inducing
28. Bcl-W Promotes Gastric Cancer Cell Invasion By Inducing Matrix Metalloproteinase-2 Expression Via Phosphoinositide 3-Kinase, Akt, And Sp1
29. Bcl-W Promotes Gastric Cancer Cell Invasion By Inducing Matrix Metalloprotenase-2 Expression Via Phosphoinositide 3-Kinase, Akt, And Sp1
30. Bcl-W Protects Hippocampus During Experimental Status Epilepticus
31. Bcl-W Significantly Contributes To B-Cell Lymphoma Survival And Development
32. Bcl-W, A Novel Member Of The Bcl-2 Family, Promotes Cell Survival.
33. Bcl-W, A Radio-Resistant Protein, Promotes The Gastric Cancer Cell Migration By Inducing The Phosphorylation Of Focal Adhesion Kinase
34. Cloning And Characterization Of The 5′ Utr Of The Rat Anti-Apoptotic Bcl-W Gene
35. Co-Crystallization With Conformation-Specific Designed Ankyrin Repeat Proteins Explains The Conformational Flexibility Of Bcl-W
36. Co-Inhibition Of Bcl-W And Bcl2 Restores Antiestrogen Sensitivity Through Becn1 And Promotes An Autophagy-Associated Necrosis
37. Crystal Structure Of A Bcl-W Domain-Swapped Dimer: Implications For The Function Of Bcl-2 Family Proteins
38. Design Of Druglike Small Molecules For Possible Inhibition Of Antiapoptotic Bcl-2, Bcl-W, And Bfl-1 Proteins
39. Detergent N-Octyl-Β-D-Maltoside (Om) Induces Both Monomerization And Oligomerization Of Bcl-W
40. Developmental Regulation Of The Bcl-2 Family During Spermatogenesis: Insights Into The Sterility Of Bcl-W−/− Male Mice
41. Differential Expression Of Bcl-W And Bcl-X Messenger Rna In The Developing And Adult Rat Nervous System
42. Directed Elimination Of Senescent Cells By Inhibition Of Bcl-W And Bcl-Xl
43. Dynamic Changes Of The Anti‐And Pro‐Apoptotic Proteins Bcl‐W, Bcl‐2, And Bax With Smac/Diablo Mitochondrial Release After Photothrombotic Ring Stroke In Rats
44. Effect Of Iodide On Fas, Fas-Ligand And Bcl-W Mrna Expression In Thyroid Of Nod Mice Pretreated With Methimazole
45. Effect Of Massive Small Bowel Resection On The Bax/Bcl-W Ratio And Enterocyte Apoptosis
46. Epidermal Growth Factor Alters The Bax: Bcl-W Ratio Following Massive Small Bowel Resection
47. Epidermal Growth Factor Receptor Signaling Regulates Bax And Bcl-W Expression And Apoptotic Responses During Intestinal Adaptation In Mice
48. Estrogen Regulates Bcl-W And Bim Expression: Role In Protection Against Β-Amyloid Peptide-Induced Neuronal Death
49. Expression Of Bcl-W In Gastric Carcinoma And Associated Clinicopathologic Factors
50. Expression Of Bcl-W Protein In Human Small Intestinal Adenocarcinoma And Effect Of Bcl-W Sirna On Apoptosis In Intestinal Adenocarcinoma Hutu-80 Cells
51. Expression Of Concern: Akt Regulates Drug-Induced Cell Death Through Bcl-W Downregulation
52. Functional Characterization Of Two Splice Variants Of Rat Bad And Their Interaction With Bcl-W In Sympathetic Neurons
53. Functional Investigation Of The Bcl-W Promoter During Neuronal Differentiation And Survival
54. Hypermethylation Of Mir-205-5P By Ir Governs Aggressiveness And Metastasis Via Regulating Bcl-W And Src
55. Increased Bcl-W Expression Following Focally Evoked Limbic Seizures In The Rat
56. Inhibition Of Neurotensin Receptor 1 Induces Intrinsic Apoptosis Via Let-7A-3P/Bcl-W Axis In Glioblastoma
57. Lncrna Rp11-436H11. 5, Functioning As A Competitive Endogenous Rna, Upregulates Bcl-W Expression By Sponging Mir-335-5P And Promotes …
58. Long Noncoding Rna Hotair Modulates Mir-206-Mediated Bcl-W Signaling To Facilitate Cell Proliferation In Breast Cancer
59. Met/Hgf Receptor Modulates Bcl-W Expression And Inhibits Apoptosis In Human Colorectal Cancers
60. Microrna Alteration After H_2O_2-Induced Pc12 Cells Apoptosis And Regulatory Mechanism Of Bcl-W
61. Microrna-125B Promotes Apoptosis By Regulating The Expression Of Mcl-1, Bcl-W And Il-6R
62. Microrna-203 Is A Prognostic Indicator In Bladder Cancer And Enhances Chemosensitivity To Cisplatin Via Apoptosis By Targeting Bcl-W And Survivin
63. Microrna‐203 Suppresses Bladder Cancer Development By Repressing Bcl‐W Expression
64. Microrna-335 Acts As A Metastasis Suppressor In Gastric Cancer By Targeting Bcl-W And Specificity Protein 1
65. Mir-122 Targets An Anti-Apoptotic Gene, Bcl-W, In Human Hepatocellular Carcinoma Cell Lines
66. Mir-133B Regulates Bladder Cancer Cell Proliferation And Apoptosis By Targeting Bcl-W And Akt1
67. Mir-335 Inhibits The Proliferation And Invasion Of Clear Cell Renal Cell Carcinoma Cells Through Direct Suppression Of Bcl-W
68. Mir-335 Represents An Invasion Suppressor Gene In Ovarian Cancer By Targeting Bcl-W
69. Mir-340-5P Suppresses Aggressiveness In Glioblastoma Multiforme By Targeting Bcl-W And Sox2
70. Mir-497 Induces Apoptosis Of Breast Cancer Cells By Targeting Bcl-W
71. Mir-93-5P Suppresses Cellular Senescence By Directly Targeting Bcl-W And P21
72. Mirna-107 Enhances Chemosensitivity To Paclitaxel By Targeting Antiapoptotic Factor Bcl-W In Non Small Cell Lung Cancer
73. Mirna-195 Sensitizes Human Hepatocellular Carcinoma Cells To 5-Fu By Targeting Bcl-W
74. Mitochondrial Fragmentation And Neuronal Cell Death In Response To The Bcl-2/Bcl-Xl/Bcl-W Antagonist Abt-737
75. Mitochondrial Morphogenesis, Dendrite Development, And Synapse Formation In Cerebellum Require Both Bcl-W And The Glutamate Receptor Δ2
76. Molecular Docking Studies Of Bioactive Compounds From Annona Muricata Linn As Potential Inhibitors For Bcl-2, Bcl-W And Mcl-1 Antiapoptotic Proteins
77. Neuroprotective Properties Of Bcl‐W In Alzheimer Disease
78. Nf-Κb Activation Fails To Protect Cells To Tnfα-Induced Apoptosis In The Absence Of Bcl-Xl, But Not Mcl-1, Bcl-2 Or Bcl-W
79. Nf-Κb P65/P52 Plays A Role In Gdnf Up-Regulating Bcl-2 And Bcl-W Expression In 6-Ohda-Induced Apoptosis Of Mn9D Cell
80. Of Apoptosis (Tweak)-Fibroblast Growth Factor-Inducible 14 (Fn14) Signaling System Regulates Glioma Cell Survival Via Nfκb Pathway Activation And Bcl-Xl/Bcl-W …
81. Of The Viability Of Cultured Rat Neurons By The Non-Essential Amino Acids L-Serine And Glycine That Upregulates Expression Of The Anti-Apoptotic Gene Product Bcl-W
82. Oral Presentations Op01: Neurodegenerative Diseases. Bcl‐W Plays A Key Neuroprotective Role In Alzheimer’S Disease
83. Overexpression Of Bcl-W In The Testis Disrupts Spermatogenesis: Revelation Of A Role Of Bcl-W In Male Germ Cell Cycle Control
84. Overexpression Of The Cell Death Suppressor Bcl-W In Ischemic Brain: Implications For A Neuroprotective Role Via The Mitochondrial Pathway
85. Oxidative Modification Of Mir-184 Enables It To Target Bcl-Xl And Bcl-W
86. Pathways In Cutaneous Squamous Cell Carcinoma Cells By Diclofenac/Hyaluronic Acid Is Related To Upregulation Of Bad As Well As Downregulation Of Mcl‐1 And Bcl‐W
87. Pharmacological Blockade Of Bcl-2, Bcl-Xl And Bcl-W By The Bh3 Mimetic Abt-737 Has Only Minor Impact On Tumour Development In P53-Deficient Mice
88. Preclinical Evaluation Of Drug Combinations Identifies Co-Inhibition Of Bcl-2/Xl/W And Mdm2 As A Potential Therapy In Uveal Melanoma
89. Pro-And Anti-Apoptogenic Genes In Response To Benzene Exposure: Immunohistochemical Localization Of P53, Bag, Bad, Bax, Bcl-2, And Bcl-W In Lung Epithelia
90. Proapoptotic Bh3-Only Proteins Trigger Membrane Integration Of Prosurvival Bcl-W And Neutralize Its Activity
91. Purified Rat Anti-Bcl-W
92. Reciprocal Developmental Changes In The Roles Of Bcl-W And Bcl-X (L) In Regulating Sensory Neuron Survival
93. Regulation Of Apoptosis By Mir-122 In Pterygium Via Targeting Bcl-W
94. Rna Expression Bcl-W, A New Related Protein Bcl-2 Family, And Caspase-3 In Isolated Sertoli Cells From Pre-Pubertal Rat Testes
95. Sensory Neuropathy Attributable To Loss Of Bcl-W
96. Signaling Components Involved In Bcl-W-Induced Migration Of Gastric Cancer Cells
97. Solution Structure Of Human Bcl-W Modulation Of Ligand Binding By The C-Terminal Helix
98. Specificity Protein 1 Expression Contributes To Bcl-W-Induced Aggressiveness In Glioblastoma Multiforme
99. Src And Epidermal Growth Factor Receptor Mediate The Pro-Invasive Activity Of Bcl-W
100. Structural Model Of The Bcl-W−Bid Peptide Complex And Its Interactions With Phospholipid Micelles,
101. Surface Plasmon Resonance Study Of Apoptotic Regulators Bcl-2, Bcl-W, Bcl-Xl, Mcl-1 And A1 And The Small Molecule Inhibitor (Smi) Tw-37: The Idea Of A Temporal …
102. Survival Activity Of Bcl-2 Homologs Bcl-W And A1 Only Partially Correlates With Their Ability To Bind Pro-Apoptotic Family Members
103. The Anti-Apoptotic Molecules Bcl-Xl And Bcl-W Target Protein Phosphatase 1> To Bad
104. The Anti‐Apoptotic Molecules Bcl‐Xl And Bcl‐W Target Protein Phosphatase 1Α To Bad
105. The Bcl-2/Bcl-Xl/Bcl-W Inhibitor, Navitoclax, Enhances The Activity Of Chemotherapeutic Agents In Vitro And In Vivo
106. The Bcl-W Promoter Is Activated By Β-Catenin/Tcf4 In Human Colorectal Carcinoma Cells
107. The Effects Of Rapamycin On The Symptoms Of Cerebral Ischemia Due To Changing The Expression Of Mir-1 And Its Target Genes, Bad And Bcl-W
108. The Mrna And Protein Expression Of Bcl-W And Its Clinical Value In Breast Cancer
109. The Relationship Between The Expression Of Mir-422A In Peripheral Blood And Bcl-W In Cerebral Cortex And Exercise-Induced Central Fatigue [J]
110. The Structure Of Bcl‐W Reveals A Role For The C‐Terminal Residues In Modulating Biological Activity
111. Tissue Expression And Subcellular Localization Of The Pro-Survival Molecule Bcl-W
112. Tweak-Fn14 Ligand-Receptor System Induces Invasive Glioma Cell Survival Via Upregulation Of Bcl-Xl And Bcl-W Protein
113. Β-Amyloid-Induced Neuronal Apoptosis Involves C-Jun N-Terminal Kinase-Dependent Downregulation Of Bcl-W