CARBAMYLATION
January 21, 2022FASTING MIMICKING DIET
February 2, 2022- Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice
- AGING of Immune System
- Sex-specific components of frailty in C57BL/6 mice
- Long live the queen, the king and the commoner? Transcript expression differences between old and young in the termite Cryptotermes secundus
- Ten years of brainage as a neuroimAGING biomarker of brain AGING: what insights have we gained?
- In vitro model of chronological AGING of adipocytes: interrelationships with hypoxia and oxidation
- Gastrointestinal tract disorders in older age
- Frailty biomarkers in humans and rodents: current approaches and future advances
- Cancer epigenetics in solid organ tumours: A primer for surgical oncologists
- Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow
- LncRNA GASL1 inhibits growth and promotes expression of apoptosis‑associated proteins in prostate carcinoma cells through GLUT‑1
- SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy
- Adult cardiac stem cell AGING: a reversible stochastic phenomenon?
- The mTORC1-autophagy pathway is a target for senescent cell elimination
- Harvard HIV and AGING workshop: perspectives and priorities from Claude D. Pepper Centers and Centers for AIDS Research
- Oxidative stress resistance as a factor in AGING: evidence from an extended longevity phenotype of Drosophila melanogaster
- Gene-environment interaction and Mendelian randomisation
- Natural bioactive compounds as protectors of mitochondrial dysfunction in cardiovascular diseases and AGING
- Adipose-derived mesenchymal stem cells isolated from patients with abdominal aortic aneurysm exhibit senescence phenomena
- Age-associated epigenetic modifications in human DNA increase its immunogenicity
- AGING in the rat hippocampus is associated with widespread reductions in the number of glutamate decarboxylase‐67 positive interneurons but not interneuron …
- Effects Sulforaphane on IMR‐90 Phase II Enzyme Induction and Cell Senescence
- www. impactAGING. com AGING, July 2013, Vol. 5 No 7
- P 132. Modulation of encoding-related networks by intermittent TBS stimulation in healthy AGING
- A Means to an End: The Biological Basis of AGING and Death
- Accelerated AGING in Down’s Syndrome: The Concept of Hierarchical Homeostasis in Relation to Local and Global Failure
- Crosstalk between oxidative stress and SIRT1: impact on the AGING process
- Understanding the Relations among Episodic Memory, Associative Learning, and Fluid Intelligence in Younger and Older Adults
- Electrophysiology and AGING: slowing, inhibition, and aerobic fitness
- AGING-like circadian disturbances in folate-deficient mice
- Influence of controlled dietary restriction on immunologic function and AGING.
- Identifying Morphological and Functional Changes in a Caenorhabditis elegans Neuronal AGING Model of Huntington’s Disease
- Oxidative damage in rat brain during AGING: interplay between energy and metabolic key target proteins
- Metabolism of cholesterol in health and disease of the retina
- AGING-associated decline in innate immunity and therapeutic strategies to counteract it
- Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension
- Inverse occurrence of cancer and Alzheimer disease: a population-based incidence study
- AGING, cellular senescence, and cancer
- Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA
- The quest to extend life and overcome AGING and death: past, present, and future attempts
- AGING-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation
- AGING Induces Titin Oxidation And Increases Passive Cardiomyocyte Stiffness
- Age‐specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro
- Evidence for loss of myelinated input to the spinal cord in senescent rats
- Molecular pathology of AGING and its implications for senescent coronary atherosclerosis
- Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T‐cell AGING
- 22 Hyaluronan and the Process of AGING in Skin
- Injection techniques for revolumization of the perioral region with hyaluronic acid
- Elastin peptides in AGING and pathological conditions
- Omega‐3 fatty acids deficiency aggravates glutamatergic synapse and astroglial AGING in the rat hippocampal CA 1
- The AGING endoplasmic reticulum
- Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the AGING process
- Molecular bases of progeroid syndromes
- The effects of AGING and training on skeletal muscle
- Sarcopenia in older people
- The senescent primate brain
- Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat)
- Multifaceted AGING and rapamycin
- Emerging role of sirtuins on tumorigenesis: possible link between AGING and cancer
- Cognitive function, AGING, and ethical decisions: recognizing change
- Roy L. Walford, Faramarz Naeim, Kathleen Y. Hall
- “The Molecular Basis of AGING”: The Boehringer Ingelheim Fonds 95th International Titisee Conference
- Frailty and chronic diseases in older adults
- Mitochondrial gene mutation: the ageing process and degenerative diseases.
- Decline in self-renewal factors contributes to AGING of the stem cell niche in the Drosophila testis
- Artery changes with AGING: degeneration or adaptation
- The AGING striatal dopamine function
- Reactive oxygen species: relation to AGING and neurotoxic damage.
- Investigation of potential cognitive tests for use with older adults in audiology clinics
- Age-related patterns of body composition and salivary testosterone among Ariaal men of Northern Kenya
- Age-related changes in the hippocampus (loss of synaptophysin and glial–synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide …
- New Cells in Old Mice: The ABCs of Humoral Immunosenescence
- Structure and function of the thymic microenvironment
- Sestrins orchestrate cellular metabolism to attenuate AGING
- Determining if telomeres matter in colon cancer initiation or progression
- Gene expression modifications in Wharton’s Jelly mesenchymal stem cells promoted by prolonged in vitro culturing
- Oxidative damage and cellular defense mechanisms in sea urchin models of AGING
- Methylglyoxal alters the function and stability of critical components of the protein quality control
- Spermidine: a novel autophagy inducer and longevity elixir
- FOXOs attenuate bone formation by suppressing Wnt signaling
- Cellular AGING: symmetry evades senescence
- Zinc supplementation increases zinc status and thymopoiesis in aged mice
- Wholeness of the individual
- A wrinkle in time: Assessing the skin of older patients
- The origin of AGING: imperfectness-driven non-random damage defines the AGING process and control of lifespan
- Viral mediated expression of insulin-like growth factor I blocks the AGING-related loss of skeletal muscle function
- The second international conference “genetics of AGING and longevity”
- The short-lived fish Nothobranchius furzeri as a new model system for AGING studies
- Lipid peroxidation and the AGING process
- High brain lactate is a hallmark of AGING and caused by a shift in the lactate dehydrogenase A/B ratio
- A mouse model of accelerated liver AGING caused by a defect in DNA repair
- A biomarker that identifies senescent human cells in culture and in AGING skin in vivo
- Representative bibliography from Carlos López-Otín’s work
- AGING, rejuvenation, and epigenetic reprogramming: resetting the AGING clock
- Life spanning murine gene expression profiles in relation to chronological and pathological AGING in multiple organs
- Generation and gene expression of CD28-CD8 T-cells in human
- Position statement on human AGING
- Anxiety, AGING and the third emergency reaction
- Interview: Fighting disease from the chromosome end
- The canine as a model of human cognitive AGING: recent developments
- Isometric and isokinetic quadriceps muscle strength in 70-year-old men and women.
- The AGING oocyte—can mitochondrial function be improved?
- Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia
- Premature AGING in mice deficient in DNA repair and transcription
- At loose ends: telomere theories of AGING and cancer begin to converge
- Testing Hypotheses of AGING in the Nematode Caenorhabditis elegans
- A divide-and-conquer assault on AGING: Mainstream at last
- Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate AGING
- Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses
- Iatrogenesis in older individuals
- Modification upon AGING of the density of presynaptic modulation systems in the hippocampus
- Foxo Ladies Squander Their Eggs: Gene might link AGING with early ovarian failure in mice
- A longitudinal study of brain morphometrics using serial magnetic resonance imAGING analysis in a canine model of AGING
- Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span inSaccharomyces cerevisiae
- Dendritic stability in a model of adult-onset IGF-I deficiency
- Metformin increases insulin-stimulated glucose transport in insulin-resistant human skeletal muscle.
- Molecular Mechanisms in Hematopoietic Stem Cell AGING
- Effect of AGING on fertility and pregnancy
- Age-related changes of scleral hydration and sulfated glycosaminoglycans
- AGING of Premature-AGING Syndrome Cells
- C. elegans genetic networks predict roles for O-GlcNAc cycling in key signaling pathways
- Longevity‐assurance mechanisms and caloric restriction
- Where do Alzheimer’s plaques and tangles come from? AGING-induced protein degradation inefficiency
- The role of cellular senescence in skin AGING
- AGING, stem cells and tissue regeneration: lessons from muscle
- AGING-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration
- Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature AGING associated with the deficiency of the circadian protein BMAL1
- The biologic clock: the mitochondria?
- Alterations of circadian rhythmicity and sleep in AGING: endocrine consequences
- Hyperphosphorylated tau in the brains of mice and monkeys with long-term administration of ketamine
- Inositol 1, 4, 5-trisphosphate receptor and ryanodine receptor in the AGING brain of Wistar rats
- Differential shortening rate of telomere length in the development of human fetus
- Expression of miR-146a and miR-16 in peripheral blood mononuclear cells of patients with rheumatoid arthritis and their correlation to the disease activity
- Cytomegalovirus genomes demonstrated by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients.
- Telomere length and cardiovascular AGING: the means to the ends?
- Understanding the biology of AGING: the key to prevention and therapy
- Differential expression of AGING biomarkers at different life stages of the annual fish Nothobranchius guentheri
- Good Timing: Defects in two proteins leave the body’s clock vulnerable to age-related breakdown
- Accurate quantification of more than 4000 mouse tissue proteins reveals minimal proteome changes during AGING
- Wnt signaling: it gets more humorous with age
- Noncanonical Wnt comes of age in hematopoietic stem cells
- Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell AGING
- Mitochondrial dysfunction
- Why do we need to age?
- Perceived age of facial features is a significant diagnosis criterion for age‐related carotid atherosclerosis in Japanese subjects: J‐SHIPP study
- Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span
- Nonhuman primate calorie restriction
- The PKB/FOXO switch in AGING and cancer
- Tissue-specific implications of mitochondrial alterations in AGING
- Detection of cytomegalovirus DNA in cells from synovial fluid and peripheral blood of patients with early rheumatoid arthritis.
- An anti-AGING drug today: from senescence-promoting genes to anti-AGING pill
- Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?
- Cellular and molecular correlates of AGING in the nervous system
- Laboratory Tests for the Anti-AGING Physician
- Senescence of the retinal pigmented epithelium.
- The anti-AGING sweepstakes: catalase runs for the ROSes
- Chromatin structure and transposable elements in organismal AGING
- Characteristics of high and low self-esteem in the elderly
- Effect of AGING on rat tissue peptidase activities
- Healthy ageing, but what is health?
- Rat retinal transcriptome: effects of AGING and AMD-like retinopathy
- Biological markers to determine eligibility in trials for community-acquired pneumonia: a focus on procalcitonin
- Insights into central and peripheral factors affecting the “oxidative performance” of skeletal muscle in AGING
- Oxidative stress and chronological AGING in glycogen-phosphorylase-deleted yeast
- Potential for control of oxidative injury by administration of antioxidants in veterinary medicine
- Mitochondrial DNA deletion mutations and sarcopenia
- Rapamycin extends life-and health span because it slows AGING
- The role of telomeres and telomerase in stem cell AGING
- Lamin B1 loss is a senescence-associated biomarker
- Inhibition of Krebs cycle and activation of glyoxylate cycle in the course of chronological AGING of Saccharomyces cerevisiae. Compensatory role of succinate oxidation
- Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
- A natural product telomerase activator as part of a health maintenance program
- Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during AGING or oxidative stress
- Concurrent trigeminal, abducens, and facial nerve palsies presenting as false localizing signs: case report
- Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats
- Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection
- Human immunodeficiency virus and acquired immunodeficiency syndrome: recent developments and their implications for pediatric surgeons.
- Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imAGING …
- Stems cells and the pathways to AGING and cancer
- The impact of altered p53 dosage on hematopoietic stem cell dynamics during AGING
- Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men
- Protein quality control during AGING involves recruitment of the macroautophagy pathway by BAG3
- Metformin: do we finally have an anti-AGING drug?
- Life-spanning murine gene expression profiles in relation to chronological and pathological AGING in multiple organs
- Calorie restriction extends yeast life span by lowering the level of NADH
- Impaired Muscle Performance
- Redox regulation of tumor suppressor PTEN in cancer and AGING
- Bone Marrow Rejuvenation–An Excellent Potential Therapy for Age-Related Endothelial Dysfunction–
- Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
- Protein homeostasis and AGING: role of ubiquitin protein ligases
- Iron load and redox stress in skeletal muscle of aged rats
- Solving puzzles of AGING: From disposable soma to signal-transduction pathways
- Physical training improves motor performance in people with dementia: a randomized controlled trial
- Caspase-2 deficiency enhances AGING-related traits in mice
- Newly identified roles for an old guardian: profound deficiency of the mitotic spindle checkpoint protein BubR1 leads to early AGING and infertility
- Accumulation of multipotent progenitors with a basal differentiation bias during AGING of human mammary epithelia
- Immunosuppressants in cancer prevention and therapy
- D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid
- A senescence accelerated mouse model to study AGING in the larynx
- Targeting senescence pathways to reverse drug resistance in cancer
- Single-cell analysis: toward the clinic
- Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver
- Loss in oxidative stress tolerance with AGING linked to reduced extracellular signal‐regulated kinase and Akt kinase activities
- AGING is not programmed: genetic pseudo-program is a shadow of developmental growth
- Oxidative stress accumulates in adipose tissue during AGING and inhibits adipogenesis
- Alterations with AGING of the endocrine and neuroendocrine circadian system in humans
- Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents
- Common mechanisms for declines in oxidative stress tolerance and proliferation with AGING
- Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
- Stromal-epithelial interactions in AGING and cancer: senescent fibroblasts alter epithelial cell differentiation
- Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: a safe and easy way to meet goals in the SENS agenda
- Melatonin, hydroxyl radical‐mediated oxidative damage, and AGING: a hypothesis
- Collateral damage: cardiovascular consequences of chronic sympathetic activation with human AGING
- The carbon starvation response of Aspergillus niger during submerged cultivation: insights from the transcriptome and secretome
- Effects of melatonin in elderly patients with sleep disturbance: a pilot study
- Do reaction time measures enhance diagnosis of early-stage dementia of the Alzheimer type
- Yeast longevity and AGING
- Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
- Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats☆
- Molecular and chemical genetic approaches to developmental origins of AGING and disease in zebrafish
- Oxygen, antioxidants and brain dysfunction
- Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models
- An integrated view of oxidative stress in AGING: basic mechanisms, functional effects, and pathological considerations
- AGING in mice reduces the ability to sustain sleep/wake states
- Age‐related alterations in T‐lymphocytes modulate key pathways in prostate tumorigenesis
- Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during AGING
- Decorin expression is important for age-related changes in tendon structure and mechanical properties
- Mitochondrial DNA shifting in older adults following resistance exercise training
- Oxidative protein damage is associated with poor grip strength among older women living in the community
- Impact of AGING and senescence on phenotype and function of murine brain microglia in vitro and in vivo
- Effect of melatonin in selected populations of sleep-disturbed patients
- An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during AGING
- Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow–derived cells can alter the outcome of lung injury in aged …
- possible components of biological AGING. Experimental data are discussed with regard to alterations in myocardial function during the AGING process. Also
- Caloric restriction prevents AGING-associated changes in spike-mediated Ca2+ accumulation and the slow afterhyperpolarization in hippocampal CA1 pyramidal …
- Life Extension in the Short-Lived Fish Nothobranchius furzeri
- The search for evolutionary developmental origins of AGING in zebrafish: a novel intersection of developmental and senescence biology in the zebrafish model system
- Effect of calorie restriction on the metabolic history of chronologically AGING yeast
- Environmental influences on skin AGING and ethnic-specific manifestations
- Changes in primary lymphoid organs with AGING
- Human AGING and melatonin. Clinical relevance
- Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons
- Gliotoxin reverses age‐dependent nuclear morphology phenotypes, ameliorates motility, but fails to affect lifespan of adult Caenorhabditis elegans
- Polycomb group proteins in hematopoietic stem cell AGING and malignancies
- The transcriptome of prematurely AGING yeast cells is similar to that of telomerase-deficient cells
- Chromosomal Instability and AGING: Basic Science and Clinical Implications
- The Olive Constituent Oleuropein Exhibits Proteasome Stimulatory Properties In Vitro and Confers Life Span Extension of Human Embryonic Fibroblasts
- Fat and AGING: a tale of two tissues
- Circulating tumor cells and circulating tumor DNA
- Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
- The great unravelling: chromatin as a modulator of the AGING process
- Age related changes of the extracellular matrix and stem cell maintenance
- 5 Psychosocial and behavioral dimensions of physical frailty
- AGING defined by a chronologic–replicative protein network in Saccharomyces cerevisiae: An interactome analysis
- Cardiac AGING in Female Wistar Rat Models With Sedentary or Physicaly Active Lifestyle
- Lymphoid neogenesis and immune infiltration in aged liver
- Physiological changes, fibroblast cells
- Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
- Do age-related changes in DNA methylation play a role in the development of age-related diseases?
- Neurogenesis in the adult human hippocampus
- Effect of Nanoparticles on the Biochemical and Behavioral AGING Phenotype of the Nematode Caenorhabditis elegans
- THE PHYSIOLOGICAL BASIS OF DORIAN GRAY’S PORTRAIT
- Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age‐related oxidative damage associated with environmental stress
- Regulation of insulin-like growth factor binding protein-1 expression during AGING
- Effect of a traditional Japanese herbal medicine, Hochu-ekki-to (Bu-Zhong-Yi-Qi Tang), on immunity in elderly persons
- Pessimism, age, and cancer mortality.
- Testosterone loss and estradiol administration modify memory in men
- Short‐term, light‐to moderate‐intensity exercise training improves leg muscle strength in the oldest old: a randomized controlled trial
- FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during AGING
- Single cell metabolomics
- Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old
- Alterations to nuclear architecture and genome behavior in senescent cells.
- Mitochondrial membrane lipidome defines yeast longevity
- Brain activation during encoding and recognition of verbal and figural information in older adults
- Current perspective on the global and United States cancer burden attributable to lifestyle and environmental risk factors
- Elevated histone expression promotes life span extension
- Brown adipose tissue thermogenesis during AGING and senescence
- The role of chondrocyte senescence in osteoarthritis
- Industrial Approaches Towards Developing Effective Skin Care Products
- A biodemographic interpretation of life span
- Systemic effects of inflammation on health during chronic HIV infection
- Longevity Regulation in Saccharomyces cerevisiae: Linking Metabolism, Genome Stability, and Heterochromatin
- Distinct signature of altered homeostasis in AGING rod photoreceptors: implications for retinal diseases
- Cellular heterogeneity and molecular evolution in cancer
- Study of DNA damage via the comet assay and base excision repair activities in rat brain neurons and astrocytes during AGING
- Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia
- Muscles–Not Just for Bodybuilders!
- Changes in maximal aerobic capacity with age in endurance-trained women: 7-yr follow-up
- Telomerase and telomere dysregulation in polychlorinated biphenyl (PCB) exposed human skin keratinocytes
- Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans
- Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer
- Reactive oxygen species (ROS) protection via cysteine oxidation in the epidermal cornified cell envelope
- AGING alters PPARγ in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator‐1
- Cancer and inflammation: an old intuition with rapidly evolving new concepts
- Iatrogenic disease in the elderly: risk factors, consequences, and prevention
- Pathophysiology of the AGING kidney and therapeutic interventions
- Effect of antioxidant diets on mitochondrial gene expression in rat brain during AGING
- Engineered culture models for studies of tumor-microenvironment interactions
- Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration
- High-abundance mRNAs in human muscle: comparison between young and old
- Characteristics of Hippocampal Theta, Gamma, and Theta-Gamma Coupling: Effects of AGING, Environmental Change, and Cholinergic Activation
- Vascular smooth muscle cell polyploidy: an adaptive or maladaptive response?
- Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys
- Immune effects of hormone replacement therapy in post-menopausal women
- Tpo1‐mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response
- Early life stress and telomere length: investigating the connection and possible mechanisms: a critical survey of the evidence base, research methodology and basic …
- Mutations arising during repair of chromosome breaks
- Biological and clinical consequences of longitudinal studies in rodents: their possibilities and limitations. An overview
- Molecular mechanism of PPAR in the regulation of age-related inflammation
- AGING does not affect contractile properties of type IIb FDL muscle in Fischer 344 rats
- Skeletal muscle mass and the reduction ofV˙o 2 max in trained older subjects
- Prevention of N-Methyl-N-Nitrosourea-Induced Mammary Carcinogenesis in Rats by 1α-Hydroxyvitamin D5
- Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
- Healthy ageing, but what is health?
- Musical experience strengthens the neural representation of sounds important for communication in middle-aged adults
- Effects of muscle strength training and megestrol acetate on strength, muscle mass, and function in frail older people
- AGING of skeletal muscle: a 12-yr longitudinal study
- Immunology and AGING
- AGING stem cells, latexin and longevity
- Invited review: AGING and sarcopenia
- Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration
- Ageing purpose: another thrifty genotype
- Zinc and the liver: an active interaction
- Autophagy and AGING—importance of amino acid levels
- Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy
- TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
- Myogenic gene expression at rest and after a bout of resistance exercise in young (18–30 yr) and old (80–89 yr) women
- Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans
- The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease
- Cytomegalovirus antibodies in dried blood spots: a minimally invasive method for assessing stress, immune function, and AGING
- Chromosomal aneuploidy in the AGING brain
- Symposium: Popular Literature on AGING
- A randomized trial of weighted vest use in ambulatory older adults: strength, performance, and quality of life outcomes
- Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases
- The adult Drosophila posterior midgut is maintained by pluripotent stem cells
- Cardiovascular effects of AGING in primates—gender differences
- Can O2 Dysregulation Induce Premature AGING?
- Sirtuins, tissue maintenance, and tumorigenesis
- Heart failure in the oldest patients: the impact of comorbid conditions
- Cerebrospinal fluid concentrations of corticotropin‐releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to …
- Cutaneous innervation in Guillain–Barré syndrome: pathology and clinical correlations
- The pathogenesis of susceptibility to acute kidney injury in the elderly
- Circadian clock proteins control adaptation to novel environment and memory formation
- Spend less, live longer. The “thrifty aged” hypothesis
- Statement by the Growth Hormone Research Society on the GH/IGF-I axis in extending health span
- Mechanisms of visual-cognitive AGING: A neural network account
- Identification of mitochondrial dysfunction in Hutchinson–Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture
- Characteristics of muscle fiber type are predictive of skeletal muscle mass and strength in elderly men
- Controversies regarding hormone therapy: Insights from inflammation and hemostasis
- A walking program for nursing home residents: effects on walk endurance, physical activity, mobility, and quality of life
- Reduced muscle oxidative capacity is independent of O 2 availability in elderly people
- Influence of dietary factors on the longevity of Drosophila
- Evidence for the influence of vitamin C on age-and heat exposure-dependent deterioration of biochemical function in rat’s liver and kidney
- Exploring Mechanisms of AGING Retardation by Caloric Restriction: Studies in Model Organisms and Mammals
- Mitochondrial dysfunction in brain AGING: role of oxidative stress and cardiolipin
- Prolongation of Life Span in the Accelerated AGING klotho Mouse Model, by Low-Dose-Rate Continuous γ Irradiation
- Caloric restriction and experimental carcinogenesis
- Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction
- Tissue resident stem cells: till death do us part
- Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation
- Exploring a ‘pro-senescence’approach for prostate cancer therapy by targeting PTEN
- Oxidative stress, mitochondrial bioenergetics, and cardiolipin in AGING
- New targets for the identification of an anti-inflammatory anti-senescence activity
- C/EBPα and β couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation
- Selective anticancer agents suppress AGING in Drosophila
- Oxidative AGING and insulin receptor signaling
- The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation
- Alkaline salts to counteract bone resorption and protein wasting induced by high salt intake: results of a randomized controlled trial
- Expression of inhibin α, glial cell line-derived neurotrophic factor and stem cell factor in Sertoli cell-only syndrome: relation to successful sperm retrieval by …
- Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis
- The cardiocyte in senescence
- Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and AGING
- Physical exercise in the oldest old
- Cognitive and behavioral consequences of impaired immunoregulation in AGING
- Energy intake and leukocyte telomere length in young adults
- Brain cholesterol in normal and pathological AGING
- Identification of longevity genes with systems biology approaches
- Folding proteins in fatal ways
- Aberrant insulin receptor signaling and amino acid homeostasis as a major cause of oxidative stress in AGING
- Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
- Attenuation of cardiovascular adaptations to exercise in frail octogenarians
- Facial rejuvenation and volumization using implants
- Jekyll and Hyde, the p53 protein, pleiotropics antagonisms and the thrifty aged hypothesis of senescence
- Fructose-1, 6-bisphosphatase mediates cellular responses to DNA damage and AGING in Saccharomyces cerevisiae
- Effects of caloric restriction on gene expression along the epididymis of the Brown Norway rat during AGING
- Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory
- The coordination of nuclear and mitochondrial communication during AGING and calorie restriction
- Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with AGING
- Extending lifespan using various prolongevity interventions and their effects on enhancing dna repair activity
- Microarray analysis of gene expression changes in AGING
- The emerging role of IGF-1 deficiency in cardiovascular AGING: recent advances
- Characterization of the androgen-regulated prostate-specific T cell receptor γ-chain alternate reading frame protein (TARP) promoter
- Novel combinations of post-translational modification (PTM) neo-epitopes provide tissue-specific biochemical markers—are they the cause or the consequence of the …
- Why physiology matters in medicine
- Age-dependent spatial memory loss can be partially restored by immune activation
- Effects of epigenetic drugs (vorinostat, decitabine) on metabolism-related pathway factors in leukemic cells
- The influence of UVB radiation on proliferation and Youngs modulus of dermal fibroblasts
- Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone …
- SIRT6 and Premature AGING of Hutchinson-Gilford Progeria Syndrome Fibroblasts.
- Mitochondrial DNA damage level determines neural stem cell differentiation fate
- Adult‐onset deficiency in growth hormone and insulin‐like growth factor‐I alters oligodendrocyte turnover in the corpus callosum
- Identification of biomarkers of human skin ageing in both genders. Wnt signalling-a label of skin ageing?
- Genes encoding longevity: from model organisms to humans
- miR‐182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1
- Pleiotropic cellular functions of PARP1 in longevity and AGING: genome maintenance meets inflammation
- Caspase‐independent cytochrome c release is a sensitive measure of low‐level apoptosis in cell culture models
- Werner syndrome cells escape hydrogen peroxide‐induced cell proliferation arrest
- Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitis
- The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog
- Growth hormone, insulin-like growth factor-1, and the biology of AGING
- C/EBP homologous protein drives pro-catabolic responses in chondrocytes
- Gadd45 proteins: relevance to AGING, longevity and age-related pathologies
- PTEN controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a
- Timing and AGING: slowing of fastest regular tapping rate with preserved timing error detection and correction.
- Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells
- Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1+/− mutants
- Comorbidity: a multidimensional approach
- Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent
- Proteasome function and protein oxidation in the aged retina
- Alcohol use and risk of pancreatic cancer: the NIH-AARP Diet and Health Study
- Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog
- Insulin-like growth factor isoforms in skeletal muscle AGING, regeneration, and disease
- Ileal perforation caused by cytomegalovirus infection in an immunocompetent adult
- Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins
- Melatonin in AGING and disease—multiple consequences of reduced secretion, options and limits of treatment
- Longitudinal changes in aerobic power in older men and women
- Calorie restriction enhances T-Cell–mediated immune response in adult overweight men and women
- Heritability of the retinal microcirculation in Flemish families
- Sirtuins in hematological AGING and malignancy
- Hormonal and growth factor responses to heavy resistance exercise protocols
- mVps34 is activated following high‐resistance contractions
- Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress
- Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
- Expression profile of Wnt isoforms during differentiation of AGING C2C12 myoblast cells.
- 24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma
- Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia
- Micrometric scale measurement of material structure moving utilizing μ-radiographic technique
- Examination of the expanding pathways for the regulation of p21 expression and activity
- Genome-wide analysis of yeast AGING
- Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- DNA methylation: a promising landscape for immune system-related diseases
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- Grade 3/4 neutropenia is a limiting factor in second-line FOLFIRI following FOLFOX4 failure in elderly patients with metastatic colorectal cancer
- Mutations in DNA replication genes reduce yeast life span
- Central role for the Werner syndrome protein/poly (ADP-ribose) polymerase 1 complex in the poly (ADP-ribosyl) ation pathway after DNA damage
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- Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
- Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47
- The involvement of epigenetic silencing of Foxa2 in cellular replicative and premature senescence induced by hydrogen peroxide
- Androgen receptor footprint on the way to prostate cancer progression
- Effects of a mitochondrial mutator mutation in yeast POS5 NADH kinase on mitochondrial nucleotides
- An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women
- Resistance training reduces whole-body protein turnover and improves net protein retention in untrained young males
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- Hemoglobin A1c and arterial and ventricular stiffness in older adults
- Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion
- Towards measurement of the Healthy Ageing Phenotype in lifestyle-based intervention studies
- Autophagy promotes survival in AGING submerged cultures of the filamentous fungus Aspergillus niger
- Spermidine based ameliration of Age-dependent memory impairment under the paradigms of enhanced autophagy and altered epigenome in Drosophila …
- Neural dedifferentiation in relation to risk for Alzheimer’s disease
- Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates
- Circadian rhythms during AGING
- Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
- Poly (ADP-ribosyl) ation, PARP, and AGING
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- Pathways Change in Expression During Replicative AGING in Saccharomyces cerevisiae
- Metabolic Regulation of Gene Silencing and Life Span
- Mitochondria, metabolism, and AGING in yeast
- Age-dependent modulation of cortical transcriptomes in spinal cord injury and repair
- Cellular glucose sensing, energy metabolism, and AGING in Saccharomyces cerevisiae
- Human muscle satellite cells show age-related differential expression of S100B protein and RAGE
- LIF is a contraction-induced myokine stimulating human myocyte proliferation
- Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6
- The malate–aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast
- Prolonged overexpansion of extracellular water in elderly patients with sepsis
- Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction
- Thiol supplementation in aged animals alters antioxidant
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- Cellular degradation machineries in age-related loss of muscle mass (Sarcopenia)
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- Cell AGING: molecular mechanisms and implications for disease
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- Clinical implications of oxidative stress and antioxidant therapy
- Astrocyte elevated gene-1, a novel modulator of astrocyte function: implications for neuroaids, AGING and glioblastoma
- JNK3 perpetuates metabolic stress induced by Aβ peptides
- AGING, Breast Cancer and the Mouse Model
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- It takes nerves to fight infections: insights on neuro-immune interactions from C. elegans
- Involvement of SIRT1 in Zn2+, streptozotocin, non-obese diabetic, and cytokine-mediated toxicities of β-cells
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- Genetic analysis of tissue AGING in Caenorhabditis elegans
- Problems and solutions to the development of vaccines in the elderly
- Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal
- HIDDEN COSTS OF EFFORTFUL LISTENING ON SPEECH COMPREHENSION.
- Selective modulation of protein kinase AI and II reveals distinct roles in thyroid cell gene expression and growth
- The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress
- Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency
- Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes
- Proteostasis as a signaling device and therapeutic target
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- Presbyacusis and presbyastasis
- Diffusion tensor imAGING: technique, clinical and research applications
- Modulation of sirtuins: new targets for antiageing
- A lifetime passion for micronucleus cytome assays—reflections from Down Under
- Effects of estrogen on cognition: Implications for menopause.
- Sleep and diabesity in older adults
- Shifts of the hormonal rhythms of melatonin and cortisol after a 4 h bright‐light pulse in different diurnal types
- Behavioral changes and mechanisms–an experimental study on AGING in rodents
- Forkhead box (O) in control of reactive oxygen species and genomic stability to ensure healthy lifespan
- Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
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- Leads from xenobiotic metabolism genes for Parkinson’s disease among north Indians
- AMPK and SIRT1: a long-standing partnership?
- Stress, infection, and AGING in guppies (Poecilia reticulata): An evolutionary approach
- Using atomic force microscope to investigate the influence of UVB radiation on cell behaviour and elasticity of dermal fibroblasts
- Rubin’s pathology: clinicopathologic foundations of medicine
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- Characterization of the antiAGING effects of apple phytochemicals using the Caenorhabditis elegans model
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- In Pursuit of a Molecular Fountain of Youth: The Identification and Characterization of Lifespan Regulators in Drosophila
- Studies of molecular mechanisms of cranberry mediated healthspan promotion in Caenorhabditis elegans
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- Overview: what are helicases?
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- Regional variations in ABC transporter expression along the mouse intestinal tract
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- Age-related changes in adrenomedullin expression and hypoxia-inducible factor-1 activity in the rat lung and their responses to hypoxia
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- Influenza update: a review of currently available vaccines
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- Age-related alterations in transcriptional regulation of hepatic glutathione synthesis: Remediation by R-alpha-lipoic acid
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- Primary and secondary prevention strategies among older postmenopausal women
- Research Journal of Pharmaceutical, Biological and Chemical Sciences
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- Why adult stem cell functionality declines with age? Studies from the fruit fly Drosophila melanogaster model organism
- Systemic sclerosis-associated fibrosis: an accelerated AGING phenotype?
- MicroRNAs as mediators of the ageing process
- Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer
- Invertebrates as model organisms for research on AGING biology
- Microglial dysfunction in brain AGING and Alzheimer’s disease
- Epigenetics of AGING
- A new 2-phases model of AGING that fits to different organisms
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- Evidence for Premature AGING of (Clonal but also) Non-Clonal Hematopoietic Stem Cells in Patients with Acute Myeloid Leukemia (AML)
- iPSCs as a major opportunity to understand and cure age-related diseases
- Hypertension, aortic valve stenosis, and the aorta: more lessons from TAVR
- Epigenetics of AGING and AGING-related disease
- Impact of nutrition on the ageing process
- Impact of bacterial infections on AGING and cancer: impairment of DNA repair and mitochondrial function of host cells
- The yeast polo kinase Cdc5 regulates the shape of the mitotic nucleus
- Mitochondrial and ubiquitin proteasome system dysfunction in ageing and disease: two sides of the same coin?
- Intervening in ageing to prevent the diseases of ageing
- Accelerating AGING research: how can we measure the rate of biologic AGING?
- A human experimental model of laminopathy based on adult stem cells establishes the relevance of Oct1 transcription factor in the AGING process
- Age-Related Changes to Drosophila m. Male Germline Stem Cells
- The role of macromolecular damage in AGING and age-related disease
- Towards an evidence-based model of AGING
- Antioxidant potential of phycobiliproteins: Role in anti-AGING research
- Silver oncologic tsunami: quality issues in the senior adult oncology population
- Translational research on AGING: clinical epidemiology as a bridge between the sciences
- An emerging interplay between altered human lipid metabolism, lipodystrophy and AGING
- Proteasome function is not impaired in healthy AGING of the lung
- Telomere dynamics and AGING
- Modelizing Drosophila melanogaster longevity curves using a new discontinuous 2-Phases of AGING model
- Biological effects induced by specific advanced glycation end products in the reconstructed skin model of AGING
- Proteome-wide analysis of primary cultures of in situ aged human fibroblasts reveals a moderate age-associated cellular phenotype
- Biologic AGING, frailty, and age-related disease in chronic HIV infection
- Geroscience: linking AGING to chronic disease
- Age and cancer risk: a potentially modifiable relationship
- Defining the general principles of stem cell AGING: lessons from organismal models
- Genomics of Lung AGING and Idiopathic Pulmonary Fibrosis
- Frailty in AGING: Biological, Clinical and Social Implications
- Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively
- Endocannabinoid signalling and the deteriorating brain
- 2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of AGING …
- Premature AGING in chronic kidney disease and chronic obstructive pulmonary disease: similarities and differences
- DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’
- AGING-related inflammation in osteoarthritis
- Proteostasis and longevity: when does AGING really begin?
- The NR4A nuclear receptors as potential targets for anti-AGING interventions
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- AGING of the brain, dementias, role of infectious proteins: facts and theories
- Naive T cell maintenance and function in human AGING
- Frailty for surgeons: review of a national institute on AGING conference on frailty for specialists
- It is time to classify biological AGING as a disease
- A summary of the biological basis of frailty
- Frailty: scaling from cellular deficit accumulation?
- A stress-induced cellular AGING model with postnatal neural stem cells
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- Wnt signaling and osteoporosis
- Somatic mutation in cancer and normal cells
- AGING and uremia: Is there cellular and molecular crossover?
- A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell AGING
- AGING: not all DNA damage is equal
- AGING is not a disease: implications for intervention
- Fibrosis and renal AGING
- Host age is a systemic regulator of gene expression impacting cancer progression
- SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner
- Stress and optimal ageing
- Sirtuin function in AGING heart and vessels
- The epigenetic tracks of AGING
- Computational Biology in Human AGING
- Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster
- AGING: a common driver of chronic diseases and a target for novel interventions
- Why is AGING conserved and what can we do about it?
- Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of AGING and cancer
- Inhibition of PMCA activity by tau as a function of AGING and Alzheimer’s neuropathology
- Lipid profile and cytokines interactions during successful AGING
- The intricate interplay between mechanisms underlying AGING and cancer
- Impact of miRNAs on cardiovascular AGING
- Exploiting tumor cell senescence in anticancer therapy
- Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: a paradigm for axonal degeneration
- A novel method to study AGING in bacteria that reproduce by morphologically symmetric fission
- The interplay between mitochondria and autophagy and its role in the AGING process
- C108 AGING: THE COMMON DENOMINATOR: Hic-5/nox4 Signaling Regulates Proteostasis And Senescence
- Botryllus schlosseri, an emerging model for the study of AGING, stem cells, and mechanisms of regeneration
- Aged Chinese rhesus macaques suffer severe phenotypic T-and B-cell AGING accompanied with sex differences
- Determinants of frailty and longevity: are they the same ones?
- Cardiac AGING—getting to the stem of the problem
- The role of Pycr1 in the pathomechanism of autosomal recessive cutis laxa
- Changes in transcription and metabolism during the early stage of replicative cellular senescence in budding yeast
- Fibrosis: ultimate and proximate causes
- Maintenance of homeostasis in the AGING hypothalamus: the central and peripheral roles of succinate
- Epigenomic profiling of young and aged HSCs reveals concerted changes during AGING that reinforce self-renewal
- Accelerated AGING among cancer survivors: from pediatrics to geriatrics
- The theories of AGING: reactive oxygen species and what else
- Up-regulating telomerase and tumor suppressors: focusing on anti-AGING interventions at the population level
- AGING and liver disease
- AGING research—where do we stand and where are we going?
- DNA repair and AGING: the impact of the p53 family
- Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell
- N-acetylmannosamine improves sleep–wake quality in middle-aged mice: Relevance to autonomic nervous function
- Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of AGING Wistar rats
- Non-lethal ionizing radiation promotes AGING-like phenotypic changes of human hematopoietic stem and progenitor cells in humanized mice
- TERT promoter mutations in cancer development
- AGING and blood disorders: new perspectives, new challenges
- The AGING kidney revisited: a systematic review
- Geroconversion: irreversible step to cellular senescence
- High-throughput analysis of yeast replicative AGING using a microfluidic system
- Efficacy of prophylactic flavan-3-ol in permanent focal ischemia in 12-mo-old mice
- Exome and whole genome sequencing in AGING and longevity
- Comprehensive transcriptional landscape of AGING mouse liver
- Role of noncoding RNAs in cardiovascular AGING
- Translating Gerontology into Practice
- AGING synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function
- Myc mouse and anti-ageing therapy
- The role of protein clearance mechanisms in organismal ageing and age-related diseases
- Human AGING in the post-GWAS era: further insights reveal potential regulatory variants
- Defining AGING in cyborgs: A bio-techno-social definition of AGING
- C108 AGING: THE COMMON DENOMINATOR: AGING In Idiopathic Pulmonary Fibrosis (ipf)-Nothing More Than A Risk Factor? Study On Mitochondrial Dysfunction …
- AGING is neither a failure nor an achievement of natural selection
- Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation
- Genetics and epigenetics of AGING and longevity
- Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats
- Submission PDF
- Molecular aspects of AGING: understanding lung AGING
- Isolating intestinal stem cells from adult Drosophila midguts by FACS to study stem cell behavior during AGING
- Natural compounds and AGING: between autophagy and inflammasome
- Proteostasis and AGING of stem cells
- The AGING-disease false dichotomy: understanding senescence as pathology
- Design of Novel Malar Implant With Dual Plane Adhesion
- TIME-DEPENDENT EFFECT OF TOCOTRIENOL SUPPLEMENTATION ON THE QUALITY OF AGING MOUSE EMBRYO
- L-lactate protects skin fibroblasts against AGING-associated mitochondrial dysfunction via mitohormesis
- AGING and Cell AGING: An Introduction
- Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain AGING–impact of Bcl-2 and NPD-1 like metabolites
- Autophagy: a druggable process that is deregulated in AGING and human disease
- Accelerated ageing of the lung in COPD: new concepts
- Can being ageist harm your older adult patients?
- DNA methylation age of blood predicts future onset of lung cancer in the women’s health initiative
- Frailty: a tale of two concepts
- Cardiovascular physiology in the older adults
- Reconsidering the role of mitochondria in AGING
- Genome sequencing fishes out longevity genes
- Males shorten the life span of C. elegans hermaphrodites via secreted compounds
- Genetics and pharmacology of longevity: the road to therapeutics for healthy AGING
- Mechanisms shaping the naïve T cell repertoire in the elderly—thymic involution or peripheral homeostatic proliferation?
- Current AGING research in China
- Shared signatures of social stress and AGING in peripheral blood mononuclear cell gene expression profiles
- Recurrent turnover of senescent cells during regeneration of a complex structure
- A chaperome subnetwork safeguards proteostasis in AGING and neurodegenerative disease
- AGING and age-related diseases–from endocrine therapy to target therapy
- Siglec receptors impact mammalian lifespan by modulating oxidative stress
- Frailty and social vulnerability
- The biology of AGING and lymphoma: a complex interplay
- Revisiting an age-old question regarding oxidative stress
- Mediation of organismal AGING and somatic proteostasis by the germline
- Genes Revisited: The Biodemography of Social Environmental Variation Through a Functional Genomics Lens
- miRNAs in lung cancer: a link to AGING
- AGING and multimorbidity: new tasks, priorities, and frontiers for integrated gerontological and clinical research
- Sick sinus syndrome: synopsis
- A mitochondrially targeted compound delays AGING in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox …
- AGING and malignant hemopathies
- Telomere regulation in pluripotent stem cells
- A conserved transcriptional signature of delayed AGING and reduced disease vulnerability is partially mediated by SIRT3
- DNA repair defects and genome instability in Hutchinson–Gilford progeria syndrome
- The need to promote AGING research
- Network medicine, multimorbidity and the lung in the elderly
- Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position
- From inflammAGING to healthy AGING by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
- Polysaccharides from medicinal herbs as potential therapeutics for AGING and age-related neurodegeneration
- Potential anti-AGING role of taurine via proper protein folding: a study from taurine transporter knockout mouse
- DNA replication stress as a hallmark of cancer
- Theories and mechanisms of AGING
- Ageing as developmental decay: insights from p16INK4a
- Classifying AGING as a disease in the context of ICD-11
- WIPI-mediated autophagy and longevity
- Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human …
- Sirtuins: guardians of mammalian healthspan
- Resveratrol and Alzheimer’s disease: message in a bottle on red wine and cognition
- A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human AGING
- The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4
- Longevity sticker shock: The one remaining obstacle to widespread credentialed support for rejuvenation biotechnology
- The role of AGING T-lymphocytes in prostate cancer development
- Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver
- Emerging roles of frailty and inflammAGING in risk assessment of age-related chronic diseases in older adults: the intersection between AGING biology and …
- Contemporary approaches to idiopathic pulmonary fibrosis
- Response to the letter from Xue And Varadhan:” What is missing in the validation of frailty instruments?”.
- Can enhanced autophagy be associated with human longevity? Serum levels of the autophagy biomarker beclin-1 are increased in healthy centenarians
- Human telomere biology: a contributory and interactive factor in AGING, disease risks, and protection
- FOXO transcription factors: key regulators of cellular quality control
- Analytical approaches to the diagnosis and treatment of AGING and AGING-related disease: redox status and proteomics
- Effects of extrinsic mortality on the evolution of AGING: a stochastic modeling approach
- Cellular signaling in the AGING immune system
- Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast AGING
- Questioning causal involvement of telomeres in AGING
- Stem cells versus senescence: the yin and yang of cardiac health
- The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan
- A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Fibroblasts From Ipf And From Lungs Of Old Mice Show Impaired Autophagy
- High-throughput sequencing insights into T-cell receptor repertoire diversity in AGING
- Worker senescence and the sociobiology of AGING in ants
- Genética do envelhecimento e seu impacto sobre a longevidade humana: teorias e evidências para prevenção das doenças do envelhecimento
- Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for AGING and cancer prevention: do we really have an antiAGING drug?
- Concurrent purification and antioxidant activity of phycobiliproteins from Lyngbya sp. A09DM: An antioxidant and anti-AGING potential of phycoerythrin in …
- Noncoding transcriptional landscape in human AGING
- Closing the Circle: Stem Cell Rejuvenation and Longevity
- Phycoerythrin extends life span and health span of Caenorhabditis elegans
- Cellular and molecular mechanisms of negligible senescence: insight from the sea urchin
- Adult stem cells and diseases of AGING
- Impact of senescence on bone quality: lessons from animal models of AGING
- Perinatal complications and AGING indicators by midlife
- Cardiorespiratory capacity and leukocyte telomere length among adults in the United States
- AGING and epigenetic drift: a vicious cycle
- Oxidative stress in the AGING process: fundamental aspects and new insights
- Select AGING biomarkers based on telomere length and chronological age to build a biological age equation
- Physical activity, fitness, and gray matter volume
- When anti-AGING studies meet cancer chemoprevention: can anti-AGING agent kill two birds with one blow?
- MicroRNA expression altered by diet: can food be medicinal?
- SIRT6: a promising target for cancer prevention and therapy
- Antagonistic functions of LMNA isoforms in energy expenditure and lifespan
- Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near …
- Growth phase-dependent roles of Sir2 in oxidative stress resistance and chronological lifespan in yeast
- Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development
- Royalactin extends lifespan of Caenorhabditis elegans through epidermal growth factor signaling
- Smoking and interstitial lung diseases
- The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice
- Cell Competition: Roles and Importance as a Central Phenomenon
- Ageing and inflammation–a central role for mitochondria in brain health and disease
- Cellular and molecular longevity pathways: the old and the new
- Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts
- Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients
- Signaling pathway activation drift during AGING: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells
- Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human …
- Metabolomic analyses reveal that anti-AGING metabolites are depleted by palmitate but increased by oleate in vivo
- The ageing process and healthy ageing
- Stress and AGING at the nuclear gateway
- Metabolic effects of caloric restriction
- The inflammTORy powers of senescence
- Effects of polychlorinated biphenyls (PCBs) on telomere maintenance in hematopoietic stem cells and progenitor cells
- Palladium and platinum nanoparticles attenuate AGING-like skin atrophy via antioxidant activity in mice
- On the apparent rarity of epithelial cancers in captive chimpanzees
- Three-dimensional human facial morphologies as robust AGING markers
- Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of AGING
- MARK-AGE biomarkers of ageing
- Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness
- Promoter Polymorphism in the Serotonin Transporter (5-HTT) Gene Is Significantly Associated with Leukocyte Telomere Length in Han Chinese
- Lung cancer: progress in diagnosis and treatments. Topics: III. Treatment; 7. Lung cancer treatment in elderly and/or high risk patients
- Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the AGING process
- Ending AIDS and challenges for Asia
- Longevity extension by phytochemicals
- Cell therapy strategies to combat immunosenescence
- A proposed panel of biomarkers of healthy ageing
- Role of microRNAs in the age-related changes in skeletal muscle and diet or exercise interventions to promote healthy AGING in humans
- AGING and systemic lupus erythematosus-immunosenescence and beyond
- New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses
- Geriatric population and relevant contemplation
- Complex Molecular Networks Promote Longevity
- Effect on ATPase, succinate dehydrogenase and total antioxidant capacity in mice myocardium of fluorosis
- Discovering novel microRNAs and age-related nonlinear changes in rat brains using deep sequencing
- In Search for Anti-AGING Strategy: Can We Rejuvenate Our AGING Stem Cells?
- Better to burn out than it is to rust: coordinating cellular redox states during AGING and stress
- Alpha-synuclein levels in blood plasma decline with healthy AGING
- Humulus japonicus extract exhibits antioxidative and anti‑AGING effects via modulation of the AMPK‑SIRT1 pathway
- Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts
- Towards truly interdisciplinary research on human development
- 22.1 The AOP Concept in the Context of Risk Assessment Procedures
- Nutrient status assessment in individuals and populations for healthy AGING—statement from an expert workshop
- Electrical stimulation counteracts muscle decline in seniors
- Hydrogen sulfide donor protects porcine oocytes against AGING and improves the developmental potential of aged porcine oocytes
- Genetics and epigenetics of human retinoblastoma
- Telomeres shorten more slowly in slow-AGING wild animals than in fast-AGING ones
- Telomerase therapy to reverse cardiovascular senescence
- Functional consequences of neurite orientation dispersion and density in humans across the adult lifespan
- Management of elderly patients with chronic lymphocytic leukemia in the era of targeted therapies
- Telomerase activation: a potential key modulator for human healthspan and longevity
- Mechanisms underlying the anti-AGING and anti-tumor effects of lithocholic bile acid
- Increased DNA methylation in the suicide brain
- Is chronic asthma associated with shorter leukocyte telomere length at midlife?
- polylactic acid Fillers
- Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae
- Comparing 26S Proteasome Efficiency Between Long-Living and Short-Living Rodents
- Ageing neurons need REST
- Metabolic dysfunction consistent with premature AGING results from deletion of Pim kinases
- Skeletal muscle lipid content and oxidative activity in relation to muscle fiber type in AGING and metabolic syndrome
- Tissue-specific ageing of rat tendon-derived progenitor cells
- AGING mesenchymal stem cells fail to protect because of impaired migration and antiinflammatory response
- Physical activity, physical fitness and leukocyte telomere length: the cardiovascular health study
- Chronic obstructive pulmonary disease and cerebrovascular disease: a comprehensive review
- Selective insulin resistance in hepatocyte senescence
- The paradigm of mutant p53-expressing cancer stem cells and drug resistance
- D-galactose induces a mitochondrial complex I deficiency in mouse skeletal muscle: potential benefits of nutrient combination in ameliorating muscle impairment
- Hormetins as novel components of cosmeceuticals and AGING interventions
- Pathogenesis of osteoporosis
- Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation
- Translational Research in the Fastest-Growing Population: Older Adults
- DNA damage response and metabolic disease
- The redox code
- Serum copper to zinc ratio: Relationship with AGING and health status
- REACTIVE OXYGEN SPECIES AND TELOMERE DYSFUNCTION: INVESTIGATING THE UNDERLYING MECHANISMS OF AGING AND RELATED DISEASES
- Studying variability in human brain AGING in a population-based German cohort—rationale and design of 1000BRAINS
- Essential role for autophagy in life span extension
- Mechanisms of AGING: Neuronal Orchestration of Stress Resistance and Protein Homeostasis in the Nematode Caenorhabditis elegans
- Breakdown of epithelial barrier integrity and overdrive activation of alveolar epithelial cells in the pathogenesis of acute respiratory distress syndrome and …
- Measurement of mitochondrial NADH and FAD autofluorescence in live cells
- Telomere length differences between subcutaneous and visceral adipose tissue in humans
- New roles for mitochondrial proteases in health, ageing and disease
- The Neural Progenitor Cell (NPC) Niche in the Adult Brain Provides a Target for Neurotoxicity: A Putative Adverse Outcome Pathway for ROS-Induced NPC …
- Proteasome activation delays AGING in vitro and in vivo
- Increase of oxidation and inflammation in nervous and immune systems with AGING and anxiety
- Impact of age-related neuroglial cell responses on hippocampal deterioration
- Mechanisms by which different functional states of mitochondria define yeast longevity
- Standard laboratory tests to identify older adults at increased risk of death
- Accelerated telomere reduction and hepatocyte senescence in tolerated human liver allografts
- How old is “too old” for translational research?
- INFLUENCE OF GENETIC VARIATIONS IN PHYSICAL FITNESS
- Acoustic and respiratory measures as a function of age in the male voice
- The role of mitochondrial DNA mutation on neurodegenerative diseases
- Decreases in daily physical activity predict acute decline in attention and executive function in heart failure
- Association between maturation and AGING and pulmonary responses in animal models of lung injury: a systematic review
- Alive and well? Exploring disease by studying lifespan
- Ablation of the p16 INK4a tumour suppressor reverses ageing phenotypes of klotho mice
- DNA damage-induced microRNA Let-7 influences both cancer and AGING-associated processes
- Thioredoxin Reductase 2 (Txnrd2) Regulates Mitochondrial Integrity in the Progression of Age‐Related Heart Failure
- Mice with pulmonary fibrosis driven by telomere dysfunction
- Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome
- New biological mechanisms and intervention strategies in AGING and cancer
- Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies
- The P5 disulfide switch: taming the AGING unfolded protein response
- Nuclear matrix, nuclear envelope and premature AGING syndromes in a translational research perspective
- Impact of phosphorus-based food additives on bone and mineral metabolism
- UPRmt-mediated cytoprotection and organismal AGING
- Cell ageing: a flourishing field for neurodegenerative diseases
- Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
- Pharmacogenomic analysis indicates potential of 1, 5-isoquinolinediol as a universal anti-AGING agent for different tissues
- Methylene blue promotes quiescence of rat neural progenitor cells
- The impact of immunosenescence on pulmonary disease
- Mediterranean diet and healthy ageing: a Sicilian perspective
- When rejuvenation is a problem: challenges of modeling late-onset neurodegenerative disease
- Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice
- Stem cell AGING in adult progeria
- Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder
- Consequences of endogenous mitochondrial oxidative stress in the heart
- How stem cells get “turned on”
- Immunomodulatory role of high-density lipoproteins: impact on immunosenescence
- Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious AGING
- Changes in regenerative capacity through lifespan
- Characterization of bone marrow-derived mesenchymal stem cells in AGING
- Stem cell senescence as the memory of past injuries
- Age-related obesity is a heritage of the evolutionary past
- Transcriptomic and epigenetic analyses reveal a gender difference in AGING-associated inflammation: the Vitality 90+ study
- The anti-AGING properties of a human placental hydrolysate combined with dieckol isolated from Ecklonia cava
- Causes and consequences of age-related changes in DNA methylation: a role for ROS?
- Genetic rejuvenation of old muscle
- X chromosome aneuploidy in the Alzheimer’s disease brain
- Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae
- Aneuploidy: implications for protein homeostasis and disease
- Age-related changes in resting energy expenditure in normal weight, overweight and obese men and women
- Can mitochondrial dysfunction be a predictive factor for oxidative stress in patients with obstructive sleep apnea?
- Effects of vitamin E on cognitive performance during ageing and in Alzheimer’s disease
- Uncovering the geroprotective potential of medicinal plants from the Judea region of Israel
- Histone methylation and AGING: lessons learned from model systems
- Selected age-related disorders
- The effects of age and latent cytomegalovirus infection on NK-cell phenotype and exercise responsiveness in man
- The pathological role of adipose tissue AGING in the progression of systemic insulin resistance
- DNA Damage and Checkpoint Responses in Adult Stem Cells
- Tipping the metabolic scales towards increased longevity in mammals
- Lipid replacement therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function
- From inflammAGING to healthy AGING by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
- In vivo imAGING of mitophagy in Caenorhabditis elegans
- Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis
- Characterization of novel markers of senescence and their prognostic potential in cancer
- Epigenetic modifiers of islet function and mass
- Genome-wide gene expression in relation to age in large laboratory cohorts of Drosophila melanogaster
- Candidate genes that affect AGING through protein homeostasis
- AntiAGING phenotype in skeletal muscle after endurance exercise is associated with the oxidative phosphorylation pathway
- Effects of donor age and proliferative AGING on the phenotype stability of rat aortic smooth muscle cells
- The Biology of AGING: Role in Cancer, Metabolic Dysfunction, and Health Disparities
- Expression of virus-responsive genes and their response to challenge with poly (I: C) at different stages of the annual fish Nothobranchius guentheri: Implications for …
- Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes
- Longevity of U cells of differentiated yeast colonies grown on respiratory medium depends on active glycolysis
- Hypothesis on skeletal muscle AGING: mitochondrial adenine nucleotide translocator decreases reactive oxygen species production while preserving coupling …
- Spermidine induces autophagy by inhibiting the acetyltransferase EP300
- Epigenomic programing: a future way to health?
- Replicating through telomeres: a means to an end
- Ujarzmianie starzenia: odm³adzanie komórek, dedyferencjacja i transdyferencjacja AGING subjugation: cell rejuvenation, dedifferentiation and …
- Expression alterations define unique molecular characteristics of spinal ependymomas
- Unmasking the lung cancer epigenome
- Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing
- Modeling signaling networks to advance new cancer therapies
- Chromatin methylation and cardiovascular AGING
- Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats
- Cellular mechanisms of age-related hearing loss
- Epigenetic mechanisms of dietary restriction induced AGING in Drosophila
- Mitochondrial AGING and physical decline: insights from three generations of women
- Response to the Letter to the Editor:“Frailty Consensus: A Call to Action”
- CINcere Modelling: What Have Mouse Models for Chromosome Instability Taught Us?
- Comorbid influences on generic health-related quality of life in COPD: a systematic review
- A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma
- Pushing the limits: defeating leukemia stem cells by depleting telomerase
- New genetic and epigenetic approaches in gerontology
- Age-associated methylation suppresses SPRY1, leading to a failure of re-quiescence and loss of the reserve stem cell pool in elderly muscle
- Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture
- Insights into the evolution of longevity from the bowhead whale genome
- A stitch in time: the needlework of AGING women in antebellum America
- NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats
- The impact of MAO-A in cellular senescence
- Pathological role of adipose tissue dysfunction in cardio-metabolic disorders
- Positive psychological functioning and the biology of health
- New insights into skin stem cell AGING and cancer
- Cellular senescence in type 2 diabetes: a therapeutic opportunity
- Human stem cell models of dementia
- Colorectal cancer surgery remains effective with rising patient age
- Movement-based behaviors and leukocyte telomere length among US adults
- Gene expression in the liver of female, but not male mice treated with rapamycin resembles changes observed under dietary restriction
- Cognitive frailty, a novel target for the prevention of elderly dependency
- High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice
- Synthetic lethal vulnerabilities of cancer
- Early molecular changes in Alzheimer disease: can we catch the disease in its presymptomatic phase?
- Hutchinson–Gilford progeria syndrome
- AGING and cardiovascular diseases: The role of gene–diet interactions
- Peroxisome proliferator–activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP‐activated protein kinase
- Falls in older adults with cancer
- Herpes simplex virus shedding: Biomarker for disease severity and response to antivirals
- Profiling Molecular Changes to Discover New Drivers of AGING in C. Elegans
- Emerging clinical issues related to management of multiorgan comorbidities and polypharmacy
- A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan
- Proteasome-mediated quality control of S-nitrosylated mitochondrial proteins
- Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome
- Gender-and region-dependent changes of redox biomarkers in the brain of successfully AGING LOU/C rats
- Telomere dysfunction in peripheral blood mononuclear cells from patients with primary biliary cirrhosis
- 20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans
- Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human AGING
- Role of cigarette smoke–induced aggresome formation in chronic obstructive pulmonary disease–emphysema pathogenesis
- Jonathan A. Brassard, Natalie Fekete
- Superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes
- Change in N-Glycosylation of Plasma Proteins in Japanese Semisupercentenarians
- ImAGING of cellular AGING in human retinal blood vessels
- Epigenetic Adaptation to Mitochondrial Stress
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
- Mitochondria in health, AGING and diseases: the epigenetic perspective
- Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
- Protective Effects of Unacylated Ghrelin in AGING Mice
- Wnt4 signaling prevents skeletal AGING and inflammation by inhibiting nuclear factor-κB
- GENERAL INTRODUCTION & OUTLINE OF THE THESIS
- The Ras-Erk-ETS-signaling pathway is a drug target for longevity
- Dietary restriction improves vasomotor changes caused by accelerated vascular AGING due to genomic instability
- Inhibition of JAK-STAT signaling stimulates adult satellite cell function
- Asthma in the Elderly
- Cellular mechanisms of somatic stem cell AGING
- Longevity pathways (mTOR, SIRT, Insulin/IGF-1) as key modulatory targets on AGING and neurodegeneration
- Periplasmic Acid Stress Increases Cell Division Asymmetry (Polar AGING) of Escherichia coli
- DDR-mediated crosstalk between DNA-damaged cells and their microenvironment
- Protein profiling reveals consequences of lifestyle choices on predicted biological AGING
- Cholest erol alimentaire, ami ou ennemi?
- Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
- Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation-induced AGING in mice
- Decline of phosphotransfer and substrate supply metabolic circuits hinders ATP cycling in AGING myocardium
- SKN-1/Nrf, stress responses, and AGING in Caenorhabditis elegans
- Rifampicin reduces advanced glycation end products and activates DAF‐16 to increase lifespan in Caenorhabditis elegans
- Prostaglandins, Leukotrienes and Essential Fatty Acids
- Transcription errors induce proteotoxic stress and shorten cellular lifespan
- Telomerase Activity and Telomere Length in Daphnia
- Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-AGING miRNA expression profile in …
- Walking and psychomotor speed in the elderly: concordance, correlates and prediction of death
- A prospective epigenetic paradigm between cellular senescence and epithelial-mesenchymal transition in organismal development and AGING
- Ageing and the border between health and disease
- Measuring in vivo mitophagy
- Mechanisms and functions of Nrf2 signaling in Drosophila
- Elimination of unfit cells maintains tissue health and prolongs lifespan
- Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients
- AGING Lung, Environmental and Genetic Factors—Race, Ethnicity and Gender
- Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
- Protein aggregates are associated with replicative AGING without compromising protein quality control
- Multisystem physiologic impairments and changes in gait speed of older adults
- Effects of a DVD-delivered exercise intervention on physical function in older adults with multiple sclerosis: A pilot randomized controlled trial
- AGING in Caenorhabditis elegans; the role of Wnt signalling
- Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity
- Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells
- Neural Effects of Cognitive Intervention in Healthy AGING and Dementia
- Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency
- Targeting mitochondrial energy metabolism with TSPO ligands
- Essay: Intervening in the mTOR pathway: a promising anti-ageing therapy for humans?
- The influence of AGING on oocyte quality and the importance of mitochondria
- Involvement of oxysterols in age-related diseases and ageing processes
- Mitochondrial oxidative stress, mitochondrial DNA damage and their role in age-related vascular dysfunction
- Cellular Longevity of Budding Yeast During Replicative and Chronological AGING
- Subjective beliefs, memory and functional health: Change and associations over 12 years in the Australian Longitudinal Study of Ageing
- Biomedical Research
- An evidence-based approach to identify AGING-related genes in Caenorhabditis elegans
- Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise
- Muscle wasting in myotonic dystrophies: a model of premature AGING
- Bioactive silica nanoparticles reverse age-associated bone loss in mice
- ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity
- Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection
- Understanding and reducing disability in older adults following critical illness
- Regenerative biology of tendon: mechanisms for renewal and repair
- Investigating the regulation of stem and progenitor cell mitotic progression by in situ imAGING
- iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis
- DNA damages and premature AGING
- Inflammation and intracellular metabolism: new targets in OA
- Functional and molecular changes of MSCs in AGING
- Systems biology and Systems medicine: The technological tools of the system approaches to complexity
- Circadian rhythmicity as a predictor of weight-loss effectiveness
- Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction
- Identifying Micrornas that Regulate AGING of the Germline Stem Cell Niche
- A critical role of Fas-associated protein with death domain phosphorylation in intracellular reactive oxygen species homeostasis and AGING
- The amazing ubiquitin-proteasome system: structural components and implication in AGING
- Compositional and functional features of the gastrointestinal microbiome and their effects on human health
- Possible role of ABO system in age-related diseases and longevity: a narrative review
- NAD+ metabolism in age-related hearing loss
- Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states
- The GSK-3 family as therapeutic target for myocardial diseases
- Identification of ageing-associated naturally occurring peptides in human urine
- Reversal of hepatocyte senescence after continuous in vivo cell proliferation
- Micronucleus frequency in peripheral blood lymphocytes and frailty status in elderly. A lack of association with clinical features
- Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut
- Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import
- Establishing the microcrustacean Daphnia as a model system for research on AGING
- AntiAGING effects of an intensive mind and body therapeutic program through enhancement of telomerase activity and adult stem cell counts
- The role of mitochondrial DNA in mediating alveolar epithelial cell apoptosis and pulmonary fibrosis
- Interaction between microRNA expression and classical risk factors in the risk of coronary heart disease
- Interfacing mitochondrial biogenesis and elimination to enhance host pathogen defense and longevity
- The fine line between lifespan extension and shortening in response to caloric restriction
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H 2 O 2 accumulation
- Non-coding RNAs in cardiovascular ageing
- Neurodegeneration in accelerated AGING
- Vitellogenin family gene expression does not increase Drosophila lifespan or fecundity
- Proteome analysis in the assessment of ageing
- Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
- GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases
- Aged iPSCs display an uncommon mitochondrial appearance and fail to undergo in vitro neurogenesis
- Inhibition of telomere recombination by inactivation of KEOPS subunit Cgi121 promotes cell longevity
- Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort
- Emerging targets in osteoarthritis therapy
- Modulation of a specific pattern of microRNAs, including miR-29a, miR-30a and miR-34a, in cultured human skin fibroblasts, in response to the application of …
- Acoustic and respiratory measures as a function of age in the male voice
- Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice
- To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss
- Global reorganization of the nuclear landscape in senescent cells
- SIRT1: role in cardiovascular biology
- MicroRNAs as potential targets for progressive pulmonary fibrosis
- Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation
- Fluorescence and bioluminescence imAGING of subcellular Ca2+ in aged hippocampal neurons
- The functional and pathologic relevance of autophagy proteases
- Amelioration of reproduction-associated oxidative stress in a viviparous insect is critical to prevent reproductive senescence
- Mechanisms of development of multimorbidity in the elderly
- Persistent γH2AX: A promising molecular marker of DNA damage and AGING
- AGING without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex
- Protective role of melatonin in mitochondrial dysfunction and related disorders
- Farnesol-like endogenous sesquiterpenoids in vertebrates: the probable but overlooked functional “inbrome” anti-AGING counterpart of juvenile hormone of …
- The crossroads between cancer stem cells and AGING
- Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and AGING
- Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis
- Suppression of Cellular Senescence by Cordycepin in Replicative Aged Human Dermal Fibroblasts
- AGING of cell communication: loss of receptor function
- Liver sinusoidal endothelial cells in hepatic fibrosis
- Distinct metabolomic signatures are associated with longevity in humans
- Pyridine nucleotides in regulation of cell death and survival by redox and non-redox reactions
- Telomere shortening: a diagnostic tool and therapeutic target for cardiovascular disease?
- Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
- Mining the modular structure of protein interaction networks
- Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis
- DNA Damage and Checkpoint Responses in Adult Stem Cells
- Caloric restriction mimetics: towards a molecular definition
- Muscle weakness during AGING: a deficiency state involving declining angiogenesis
- Chronic Asthma and Leukocyte Telomere Length
- Trehalose accumulation triggers autophagy during plant desiccation
- The retrotransposon Ty1 extends chronological lifespan in Saccharomyces paradoxus by influencing cellular responses to stress
- Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis
- Targeting mitochondria with small molecules: the preparation of MitoB and MitoP as exomarkers of mitochondrial hydrogen peroxide
- Is amyloid-β an innocent bystander and marker in Alzheimer’s disease? Is the liability of multivalent cation homeostasis and its influence on amyloid-β function the real …
- The age related markers lipofuscin and apoptosis show different genetic architecture by QTL mapping in short-lived Nothobranchius fish
- The aggregation and inheritance of damaged proteins determines cell fate during mitosis
- The role of telomeres and vitamin D in cellular AGING and age-related diseases
- ShaPINg cell fate upon DNA damage: role of Pin1 isomerase in DNA damage-induced cell death and repair
- Whole-genome fingerprint of the DNA methylome during human B cell differentiation
- Association between Longitudinally Assessed Dietary Composition and Blood Telomere Length among Young Adult Filipinos
- Evidence-based medicine in older patients: how can we do better
- Chromothripsis and Epigenetics, Important Mechanisms for Transgenerational Inheritance of Environmental History, Congenital Malformations and …
- Quality control of oxidatively damaged mitochondrial proteins is mediated by p97 and the proteasome
- HIV infection worsens age-associated defects in antibody responses to influenza vaccine
- The effect of genomic instability on responsiveness to angiotensin II type 1 receptor stimulation and blockade
- Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition
- Mitochondria, muscle health, and exercise with advancing age
- The effect of coenzyme Q10 on age-related changes of the distal colon mucosa of male albino rats: a histological and immunohistochemical study
- Understanding leukemic hematopoiesis as a complex adaptive system
- Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade
- Molecular mechanisms of dietary restriction in AGING—insights from Caenorhabditis elegans research
- Accumulation Of Subcortical Iron As A Modifier Of Volumetric And Cognitive Decline In Healthy AGING: Two Longitudinal Studies
- Nutritional approaches for healthy AGING of the brain and the prevention of neurodegenerative diseases
- Repair of endogenous DNA base lesions modulate lifespan in mice
- The role of extracellular vesicles: an epigenetic view of the cancer microenvironment
- Pathogenesis and Susceptibility to Injury
- Proteostasis in pediatric pulmonary pathology
- Multifocal epithelial tumors and field cancerization: stroma as a primary determinant
- Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss …
- Amelioration of Reproduction-Associated Oxidative Stress in a Viviparous Insect Is
- Clinicopathological and prognostic significance of interleukin-8 expression and its relationship to KRAS mutation in lung adenocarcinoma
- PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis
- Resveratrol: a focus on several neurodegenerative diseases
- Evidence-based medicine: blepharoplasty
- MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection
- Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury
- Analysis of lifespan-promoting effect of garlic extract by an integrated metabolo-proteomics approach
- Food preferences of elderly people of Mohodi Ga Manthata village in Limpopo Province, South Africa.
- The role of microRNAs in mitochondria: small players acting wide
- The senescence-associated secretory phenotype promotes benign prostatic hyperplasia
- Targeting Mitochondria for Healthy Brain AGING
- Alterations in gene array patterns in dendritic cells from aged humans
- Autophagy and apoptosis in liver injury
- Xianghong Yan1, Catherine Serre2, Laurine Bergeron2, Ludivine Mur2, Valère Busuttil2
- Sox4 links tumor suppression to accelerated AGING in mice by modulating stem cell activation
- Protein Biogenesis Machinery is a Driver of Replicative 4 AGING in Yeast 5
- CINcere Modelling: What Have Mouse
- IGF-1 colocalizes with muscle satellite cells following acute exercise in humans
- Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation
- Mitochondrial respiration controls lysosomal function during inflammatory T cell responses
- mTOR, AMPK, and Sirt1: key players in metabolic stress management
- Emerging regulators of the inflammatory process in osteoarthritis
- Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
- The insulin-like growth factor system in the long-lived naked mole-rat
- Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner
- Chitinase but N-acetyl-β-D-glucosaminidase production correlates to the biomass decline in Penicillium and Aspergillus species
- RTEL1: functions of a disease-associated helicase
- Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells
- A co-translational ubiquitination pathway for quality control of newly synthesized proteins
- Integrative analysis of age-related changes in the transcriptome of Caenorhabditis elegans
- Joint inhibition of TOR and JNK pathways interacts to extend the lifespan of Brachionus manjavacas (Rotifera)
- Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer’s disease.
- Higher Alu methylation levels in catch-up growth in twenty-year-old offsprings
- Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing
- Spartan deficiency causes genomic instability and progeroid phenotypes
- The MRE11 complex and ATM activate distinct signaling responses to defend against DNA viruses versus DNA breaks
- Epigenetics in liver disease
- Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populations
- AGING, disease, and longevity in mice
- Cross-sectional relations of arterial stiffness, pressure pulsatility, wave reflection, and arterial calcification
- Uncoupling reproduction from metabolism extends chronological lifespan in yeast
- Strengthening the role of convergence science in medicine
- Autophagy and cellular senescence in lung diseases
- Healthy AGING: Focus on the elderly people living at home with cardiovascular disease
- Mitochondrial Priming and Anti-Apoptotic Dependencies in AGING and Diseased Bone Marrow
- c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells
- Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium
- Inside and out: the activities of senescence in cancer
- Genetic Regulation of Health Beneficial Phytonutrients in Fresh Produce
- Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells
- Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease
- Skeletal muscle degeneration and regeneration in mice and flies
- Self-consumption: the interplay of autophagy and apoptosis
- Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism
- MicroRNAs expression profiles in cardiovascular diseases
- Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro
- Idiopathic Pulmonary Fibrosis: Clinical Behavior, Pathogenic Mechanisms and Therapeutic Approach
- Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease
- Senescence-Associated Secretory Phenotype (SASP) involvement in the development of cancer, AGING and age related diseases
- Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease
- General introduction: The PKB/FOXO switch in ageing and cancer
- Vascular and glial alterations during AGING in wild-type mice and along Alzheimer’s disease progression in APP/PS1 mice
- Protein clearance mechanisms and their demise in age-related neurodegenerative diseases
- Dissection of the cord blood stromal component reveals predictive parameters for culture outcome
- Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence
- Chitinase but N-acetyl-ß-D-glucosaminidase production correlates to the biomass decline in Penicillium and Aspergillus species
- Assembly of Slx4 signaling complexes behind DNA replication forks
- NK cells are activated in amnestic mild cognitive impairment but not in mild Alzheimer’s disease patients
- Homology modeling, Molecular Dynamic Simulation and in silico screening of Activator for the Intensification of human sirtuin type 1 (SIRT1) by novel 1, 3, 4 …
- The Impact of Immunosenescence on Pulmonary
- NF-κB activation impairs somatic cell reprogramming in ageing
- Protective effects of melatonin and mitochondria-targeted antioxidants against oxidative stress: a review
- Nutrition in Older Adults Topic 36
- Quantification of cellular viability by automated microscopy and flow cytometry
- Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells
- Why is Qi-invigorating therapy in Chinese medicine suitable for mitochondrial diseases? A bioenergetic perspective
- Autophagy in the hypothalamus: role of Neuropeptide Y and impact on Synaptic Plasticity
- Multitasking Roles for Poly (ADP-ribosyl) ation in AGING and Longevity
- 20S proteasome activation promotes life span extension and resistance to proteotoxicity in
- Of mice, pigs and humans: an analysis of mitochondrial phospholipids from mammals with very different maximal lifespans
- An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegans
- Quantitative proteomics of synaptic and nonsynaptic mitochondria: insights for synaptic mitochondrial vulnerability
- Role of macrophage migration inhibitory factor in age-related lung disease
- Regulation of autophagy by cytosolic acetyl-coenzyme A
- Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction.
- Autophagic activity as an indicator for selecting good quality embryos
- The renin–angiotensin system and its involvement in vascular disease
- Disturbed flow promotes endothelial senescence via a p53-dependent pathway
- Haptoglobin increases with age in rat hippocampus and modulates Apolipoprotein E mediated cholesterol trafficking in neuroblastoma cell lines
- Clinical advances in geriatric psychiatry: a focus on prevention of mood and cognitive disorders
- Long-term quiescent fibroblast cells transit into senescence
- Loss of MT 1‐MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
- Activins: more than reproductive hormones
- The impact of age and sex in DLBCL: systems biology analyses identify distinct molecular changes and signaling networks
- Weaning triggers a maturation step of pancreatic β cells
- Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
- Word count: 6352 (without Refs) References: 127
- The disruption of proteostasis in neurodegenerative disorders
- Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts
- Rebels with a cause: molecular features and physiological consequences of yeast prions
- Excess costs of comorbidities in chronic obstructive pulmonary disease: a systematic review
- A resourceful genome: updating the functional repertoire and evolutionary role of animal mitochondrial DNAs
- Replicating through telomeres: a means to an end.
- O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity
- The Influence of the Insulin-Like Gene Family and Diet-Drug Interactions on Caenorhabditis elegans Physiology: A Dissertation
- Variation in transcriptome size: are we getting the message?
- Non-canonical Wnt4 prevents skeletal AGING and inflammation by inhibiting NF-κB
- The systemic milieu as a mediator of dietary influence on stem cell function during ageing
- Drug synergy drives conserved pathways to increase fission yeast lifespan
- Recent developments in cardiovascular stem cells
- American association for cancer research—AACR congress 2014
- An endocrine genetic signal between blood cells and vascular smooth muscle cells: role of microRNA-223 in smooth muscle function and atherogenesis
- Hematopoietic Stem and Progenitor Cell Function in Rheumatoid Arthritis
- Sequential logic of polarity determination during the haploid-to-diploid transition in Saccharomyces cerevisiae
- Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein
- Combinatorial strategies for the induction of immunogenic cell death
- Studying the Role of Sirtuin-1 Gene in the Maintenance of Mouse Intestinal Epithelium
- The interplay between mitochondrial protein and iron homeostasis and its possible role in ageing
- Post-mitotic protein production causes cell size to increase with replicative age in Saccharomyces cerevisiae
- Pharmacotherapy in the ageing patient: The impact of age per se (A review)
- Quantification of oxygen consumption in retina ex vivo demonstrates limited reserve capacity of photoreceptor mitochondria
- Evolutionary genetic bases of longevity and senescence
- Vitamin E supplementation delays cellular senescence in vitro
- Cell-Autonomous Progeroid Changes in Conditional Mouse Models for
- AGING and balance-A quantitative study of four different balance tasks and the Berg Balance scale on a highly functional elderly sample
- Genetic and epigenomic analyses of Drosophila phenotypes
- Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
- Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae
- Ubiquitin-mediated regulation of cell death, inflammation, and defense of homeostasis
- Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis
- Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence
- Investigation into the relationships between molecular chaperones, mitochondrial antioxidant enzymes, and endothermic vertebrate longevity
- Ablation of insulin-producing cells prevents obesity but not premature mortality caused by a high-sugar diet in Drosophila
- Rehabilitation concerns in geriatric trauma
- Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans
- Lithocholic Acid and Macromitophagy Regulate the Dynamics of Lipid Metabolism and Storage to Modulate Chronological AGING in Saccharomyces cerevisiae
- Approaches to in vitro tissue regeneration with application for human disease modeling and drug development
- Mitochondrial DNA rearrangements during human AGING: a study on liver, muscle and adipose tissue
- Nutrition Around the Clock and Inflammation: The Right Food at the Right Time Makes the Difference
- Aerobic Thermogenesis in mtDNA Mutator Mice: Fibroblast Growth Factor 21 at the Nexus of Mitochondrial Stress and Metabolic Adaptation
- Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols
- A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity
- Chronic Lymphocytic Leukemia (CLL)
- Association between diabetes, obesity, AGING, and cancer: review of recent literature
- Acute myeloid leukemia in the elderly patient: new strategies
- Evaluation of traditional medicines for neurodegenerative diseases using Drosophila models
- Isolation and characterization of human endothelial colony forming cells (ECFCs) and effect of oxidative stress on their differentiation
- Regenerative Cells in the Ageing Lung
- Single-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in Arabidopsis
- DNA and chromosomal damage as a hallmark of the induced genomic instability in barley
- Understanding and Reducing Disability in Older Adults Following Critical Illness
- Effects of insulin gene dosage on murine obesity and lifespan
- Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) protects against ceramide-induced cellular toxicity in rat brain astrocytes and neurons by activation of …
- p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload
- Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders
- Research Journal of Pharmaceutical, Biological and Chemical Sciences
- Comparative meta-analysis of transcriptomics data during cellular senescence and in vivo tissue ageing
- Exploring the role of dopamine in stress response and AGING in Drosophila melanogaster – implications for neurodegenerative diseases
- Age-regulated function of autophagy in the mouse inner ear
- Preventing clonal evolutionary processes in cancer: Insights from mathematical models
- Autophagy in colorectal cancer: An important switch from physiology to pathology
- Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance
- Haemocytes control stem cell activity in the Drosophila intestine
- Stress responses during ageing: molecular pathways regulating protein homeostasis
- Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain
- Chromatin plasticity in response to DNA damage: The shape of things to come
- Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway
- Metal-induced oxidative stress in human fibroblasts: A role in cellular ageing
- Epigenetics, inflammation, and AGING
- Identifying aneuploidy-tolerating genes
- The hair follicle stem cell niche: the bulge and its environment
- Chronological AGING of the Yeast Saccharomyces Cerevisiae Is Linked to a Differentiation Program Converting Quiescent Cells into Non-Quiescent Cells
- Telomerase as a “stemness” enzyme
- The P2X7 receptor in AMD
- Mismatch repair-deficient crypt foci in Lynch syndrome–molecular alterations and association with clinical parameters
- Danika M. Khong, Jarrod A. Dudakov,* Maree V. Hammett, Marc I. Jurblum, Sacha ML Khong, Gabrielle L. Goldberg, Tomoo Ueno, Lisa Spyroglou, Lauren F …
- Metabolic engineering of Saccharomyces cerevisiae for the production of triacetic acid lactone
- Trial Watch: Radioimmunotherapy for oncological indications
- The disruption of proteostasis in neurodegenerative diseases
- Astrocytes require insulin-like growth factor I to protect neurons
- Investigating Genome Instability and Retrotransposition during Replicative AGING in Saccharomyces cerevisiae
- Normal Cell-Type Epigenetics and Breast Cancer Classification: A Case Study of Cell Mixture–Adjusted Analysis of DNA Methylation Data from Tumors …
- Emergent patterns of cellular phenotypes in health and disease
- Coffee induces autophagy in vivo
- Role of microglia in myelin turnover
- The Effect of Pim Kinases Upon Mitochondrial Dynamics and Metabolism
- THE ROLE OF STING IN CANCER
- Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation
- Modelling of ischemic stroke: focus on co-morbidities and therapeutic intervention
- Protein synthesis as an integral quality control mechanism during ageing
- Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy
- Hutchison-Gilford Progeria Syndrome–A new treatment strategy and the role of prelamin A in oncogenesis
- Hannah Withers, Research Assistant, Rehabilitation Studies Unit, Sydney Medical School Northern, The University of Sydney. Dr Kathryn Higgins, Research …
- Uncovering phenotypes with supercells: applications to single-cell sequencing
- Mechanism of liponecrosis, a distinct mode of programmed cell death
- Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue
- Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis
- Proteomics and Phosphoproteomics of Brain:(1) Analyses of the PINK1 Knockout Model of Parkinson Disease;(2) Insights Into the Progression of Alzheimer Disease; …
- Pim1 kinase functional effect depends upon intracellular localization in human cardiac progenitor cells
- From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive
- Pharmacological diversity among drugs that inhibit bone resorption
- Functional effect of Pim1 depends upon intracellular localization in human cardiac progenitor cells
- Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) …
- Among metabolic factors, significance of fasting and postprandial increases in acyl and desacyl ghrelin and the acyl/desacyl ratio in obstructive sleep apnea before …
- Functional and cellular changes after royalactin treatment in C. elegans
- Diet-induced plasticity in the adult Drosphilia melanogaster midgut
- The role of macrophage migration inhibitory factor in osteoarthritis
- Autophagy in Drosophila: from historical studies to current knowledge
- Guidelines for biomarkers of healthy ageing
- A comparison of differing modalities of exercise on the acute satellite cell responses in older adults
- Long-range and temporal aspects of the genetics of gene expression
- Regulation of the Ran GTPase System and Nucleocytoplasmic Transport
- Computational approaches to understanding the role of fibroblast-myocyte interactions in cardiac arrhythmogenesis
- Sphingolipids and mitochondrial function, lessons learned from yeast
- Rocío de Iriarte Rodríguez, Sara Pulido, Lourdes Rodríguez-de la Rosa, Marta 4
- Mechanistic pathways linking mitochondrial oxidative stress and white matter degeneration in the AGING mammalian female brain
- Epigenetic regulation of alternative splicing in cancer
- TIMPs in Mammary Stem Cell Homeostasis and Breast Cancer Progression
- Lithocholic Acid Extends Yeast Chronological Lifespan, Drives the Evolution of Longevity Regulation Mechanisms in Ecosystems and Suppresses Mitochondrial …
- Progressive lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence of mouse embryonic fibroblasts
- The role of the stress response gene Gadd45b in senescence
- Control of Autophagy in Parkinson’s Disease
- Biological Basis of Ageing, Age-related Diseases and Interventions
- DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans
- The role of brain and muscle ARNTL 1 (BMAL1) in bone homeostasis
- Principles of studying a cell-a non-boastful paper for all molecular biologists
- Aneuploidy causes proteotoxic stress in Saccharomyces cerevisiae
- Transcriptional network regulated by Caenorhabditis elegans transcription factors CEH-23 and CEP-1 modulates lifespan through AMPK signalings when …
- Asymmetric Division of Damaged Proteins in Proliferating Cells
- Proteolysis mediated by cysteine cathepsins and legumain—recent advances and cell biological challenges
- Interventions for age-related diseases: shifting the
- Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays
- High-throughput Screening of Age-related Changes in Caenorhabditis elegans
- Bazal Hymenoptera (Insecta) Familyalarında Mitokondri Genomunun Evrimi: Hymenoptera Filogenisinin Yeniden Yapılandırılması
- Predicting the pro-longevity or anti-longevity effect of model organism genes with new hierarchical feature selection methods
- Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity
- Quasi-steady-state analysis based on structural modules and timed Petri net predict system’s dynamics: the life cycle of the insulin receptor
- The molecular and epigenetic regulation of osteoblast and osteoclast differentiation and the implications in osteoporosis
- Regulation of Autophagy by Acetyl Coenzime A: From the Mechanisms to a Revised Definition of Caloric Restriction Mimetics
- Repair of bipyrimidine photoproducts at telomeres of ultraviolet light irradiated mammalian cells
- The effects of novel anti-inflammatory nutritional and pharmaceutical supplementation during resistance training on muscle and bone in older adults
- 1 Yeast as a Model for Systems Biology Studies on Complex Diseases
- Investigation of age-related protein changes in the human lens by quasi-elastic light scattering
- Metabolic and Redox Effects of Intermittent Fasting
- TABE OF CONTENTS
- Clinical manifestations of Chikungunya virus infection in HIV infected individuals: a case-control study during the Dominican Republic’s 2014 outbreak
- Body composition, bone health and vitamin D status of African adults in the North West Province
- Specific neutralizing antibody detection against chikungunya virus in HIV-positive and HIV-negative individuals, Dominican Republic 2014
- Telomere Extension Using Modified Tert mRNA to Lengthen Healthspan
- Gene Therapy and Cell Fusion Enhances Stem Cell Mediated Cardiac Repair
- Identification of novel chromatin and nuclear factors regulating oncogene-induced senescence
- Pharmacology: The Pharmacodynamics of Nutrients and Nutrient Interactions in Biological Functions
- Salla Savela
- Influence of sex chromosome complement and hormones on heterochromatin silencing in mice
- Virtue and empirical psychology
- Crosstalk between ceramide and cell signalling pathways controlling chronological lifespan in yeast
- Patent application title: NAD BIOSYNTHESIS AND PRECURSORS FOR THE TREATMENT AND PREVENTION OF CANCER AND PROLIFERATION …
- DETERMINATION OF PRION PROTEIN (PrP) AND CHANGES IN FERTILITY HORMONES WITH SLEEP DEPRIVATION IN ALBINO RATS
- Regulation of Regenerative Responses by Factors in the Extracellular Matrix during Axolotl (Ambystoma mexicanum) Limb Regeneration
- Role of autophagy in neurodegeneration and new for its study
- Stimulus-dependent glucocorticoid receptor signalling in early-life stressed mice
- DIET AND OTHER LIFESTYLE FACTORS IN ADULTHOOD AND INCIDENCE OF CHRONIC DISEASES AND MORTALITY: A PASSIVE-CASE FINDING COHORT …
- Metabolic Engineering of Saccharomyces cerevisiae for the High-Level Synthesis of Polyketides
- Characterization of mitochondrial genomes in bivalve species with doubly uniparental inheritance of mitochondria
- Functionalizing the mitochondrial proteome-mitochondrial metabolism, protein quality control and beyond
- Olive oil and the hallmarks of AGING
- Evidence for the hallmarks of human AGING in replicatively AGING yeast
- Effects of sex, strain, and energy intake on hallmarks of AGING in mice
- Molecular and biological hallmarks of ageing
- Long-term neuroglial cocultures as a brain AGING model: hallmarks of senescence, microRNA expression profiles, and comparison with in vivo models
- In vivo amelioration of age-associated hallmarks by partial reprogramming
- Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
- Lung fibroblasts, AGING, and idiopathic pulmonary fibrosis
- The hallmarks of cancer from a redox perspective
- The AGING population: demographics and the biology of AGING
- AGING and pulmonary fibrosis
- The role of hydrogen sulfide in AGING and age-related pathologies
- The AGING epigenome
- WNT signaling in lung AGING and disease
- AGING and vision
- Air pollution stress and the AGING phenotype: the telomere connection
- Andrographolide recovers cognitive impairment in a natural model of Alzheimer’s disease (Octodon degus)
- AGING metabolism: evitable or inevitable?
- iPSCs-based anti-AGING therapies: Recent discoveries and future challenges
- Biology of healthy AGING and longevity
- Cardiovascular disease and AGING
- Mitochondrial health in AGING and age-related metabolic disease
- Attenuated anticorrelation between the default and dorsal attention networks with AGING: evidence from task and rest
- Anti-AGING strategies based on cellular reprogramming
- Various mechanistic pathways representing the AGING process are altered in COPD
- The metabolic impact on histone acetylation and transcription in ageing
- Metabolic control of longevity
- Stem cells and AGING
- Two phases of AGING separated by the Smurf transition as a public path to death
- Is chronic obstructive pulmonary disease an accelerated AGING disease?
- Mechanisms of action of curcumin on AGING: nutritional and pharmacological applications
- Nothobranchius furzeri: a model for AGING research and more
- Staying young at heart: autophagy and adaptation to cardiac AGING
- AGING amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion
- Mitochondrial dysfunction meets senescence
- Induction of nuclear enlargement and senescence by sirtuin inhibitors in glioblastoma cells
- The biology of AGING: citizen scientists and their pets as a bridge between research on model organisms and human subjects
- Mammalian target of rapamycin: a target for (lung) diseases and AGING
- Commentary: XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity
- Proteome-wide changes in protein turnover rates in C. elegans models of longevity and age-related disease
- Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal AGING
- AGING enables Ca 2+ overload and apoptosis induced by amyloid-β oligomers in rat hippocampal neurons: neuroprotection by non-steroidal anti-inflammatory drugs …
- Specific premature epigenetic AGING of cartilage in osteoarthritis
- AMPK function in AGING process
- THE TRUE EFFECTS OF EXERCISE ON HUMAN AGING.
- Disease drivers of AGING
- Age-related DNA methylation changes in normal and osteoarthritis cartilage
- Are aberrant phase transitions a driver of cellular AGING?
- Chaperones and metabolism in Saccharomyces cerevisiae: molecular docking of Hsp90 with Snf1 and Tor1
- The impact of senescence on the zebrafish’s neuroregenerative capacities
- AGING of the immune system: focus on inflammation and vaccination
- Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes-and gender-specific hallmarks
- The role of AGING in Alzheimer’s disease
- The synergistic GIT2-RXFP3 system in the brain and its importance in age-related disorders
- Long noncoding RNAs in diseases of AGING
- Pharmaceutical rejuvenation of age-associated decline in spatial memory
- Early injury of the neonatal lung contributes to premature lung AGING: a hypothesis
- The mitochondrial basis of AGING
- Highly charged proteins: the Achilles’ heel of AGING proteomes
- InflammAGING increases susceptibility to cigarette smoke-induced COPD
- Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: roles of PERK/eIF2α signaling pathway
- Is AGING as inevitable as death and taxes?
- Hdac3 deficiency increases marrow adiposity and induces lipid storage and glucocorticoid metabolism in osteochondroprogenitor cells
- Reprogramming of energy metabolism as a driver of AGING
- Unraveling the links between cancer and AGING
- Functional properties of human stem cell-derived neurons in health and disease
- Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts
- Anti-AGING Effect of Siraitia grosuenorii by Enhancement of Hematopoietic Stem Cell Function
- Microglia: senescence impairs clearance of myelin debris
- Renal AGING and Transplantation
- Relative leukocyte telomere length, hematological parameters and anemia-data from the Berlin AGING Study II (BASE-II)
- Telomere attrition: a window into common mental disorders and cellular AGING
- Molecular mechanisms of biological AGING in intervertebral discs
- Metabolic Control of Longevity
- Mitochondrial Uncoupling Protein Ucp2 Regulates AGING-Related Experimental Lung Fibrosis
- Bursts of reprogramming: a path to extend lifespan?
- Longitudinal RNA-Seq analysis of vertebrate AGING identifies mitochondrial complex I as a small-molecule-sensitive modifier of lifespan
- Moving geroscience into uncharted waters
- Osteoporosis and mechanisms of skeletal AGING
- Comparative biology of AGING: insights from long-lived rodent species
- Ageing and the pathogenesis of osteoarthritis
- Biomarkers of skin AGING
- Osteoarthritis year in review 2015: biology
- Ursolic acid regulates AGING process through enhancing of metabolic sensor proteins level
- Genome integrity in AGING: human syndromes, mouse models, and therapeutic options
- AGING in COPD and idiopathic pulmonary fibrosis
- AGING: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes
- Epigenetics and AGING
- The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian AGING and longevity control
- Do DNA double-strand breaks drive AGING?
- The role of immunosenescence in the development of age-related diseases
- Epigenetic Responses to Diet in AGING
- Genetic control of circadian rhythms and AGING
- Evidence of tau hyperphosphorylation and dystrophic microglia in the common marmoset
- Fat-specific Dicer deficiency accelerates AGING and mitigates several effects of dietary restriction in mice
- Molecular basis of nutrition and AGING: a volume in the molecular nutrition series
- Microbes without borders: Decompartmentalization of the AGING gut
- Toward a better understanding of the complexity of cancer drug resistance
- Effects of AGING on slow-wave sleep dynamics and human spatial navigational memory consolidation
- A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of AGING (BLSA)
- Deciphering hallmark processes of AGING from interaction networks
- AGING increases the susceptibility of hepatic inflammation, liver fibrosis and AGING in response to high-fat diet in mice
- role of stem cells in skeletal muscle development, regeneration, repair, AGING, and disease
- Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
- Effects of AGING on the male reproductive system
- Ageing, neurodegeneration and brain rejuvenation
- Functional networks of AGING markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity
- Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model
- Evolutionary ecology of AGING: time to reconcile field and laboratory research
- Oxidative stress promotes peroxiredoxin hyperoxidation and attenuates pro-survival signaling in AGING chondrocytes
- Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate
- Breast cancer beyond the age of mutation
- The role of osteocytes in age-related bone loss
- An update on the pathophysiology of osteoarthritis
- Journal of Ageing Science
- Energetic interventions for healthspan and resiliency with AGING
- Behavioural Science Section/The Berlin AGING Study II–An Overview
- Parkinson’s disease and AGING
- Nutrition and lifestyle in healthy AGING: the telomerase challenge
- What might retrotransposons teach us about AGING?
- Dietary protein, metabolism, and AGING
- Connecting the dots: from DNA damage and repair to AGING
- The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span
- Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans
- Molecular and cellular basis of AGING
- Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with AGING fRAilTy via intravenoUS delivery (CRATUS) study: a …
- Double strand breaks may be a missing link between entropy and AGING
- Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in AGING and age‐related disorders
- Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans
- Signaling networks determining life span
- Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic
- The essential mechanisms of AGING: what have we learnt in ten years?
- Hair follicle AGING is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
- The chromatin landscape of cellular senescence
- Understanding age-related diseases: report of the 2015 Ageing Summit
- Nutrients and ageing: what can we learn about ageing interactions from animal biology?
- DNA-methylation changes in replicative senescence and AGING: two sides of the same coin?
- Effects of ageing in physical fitness
- Amyloid β protein aggravates neuronal senescence and cognitive deficits in 5XFAD mouse model of Alzheimer’s disease
- Long live FOXO: unraveling the role of FOXO proteins in AGING and longevity
- Nutritional strategies to optimise cognitive function in the AGING brain
- The effect of AGING on brain barriers and the consequences for Alzheimer’s disease development
- Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature AGING
- Developmental drift and the role of wnt signaling in AGING
- iPSCs: on the road to reprogramming AGING
- Targeted therapy for idiopathic pulmonary fibrosis: where to now?
- Role of sirtuins in maintenance of genomic stability: relevance to cancer and healthy AGING
- LncRNA mediated regulation of AGING pathways in Drosophila melanogaster during dietary restriction
- Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2
- A system wide view of replicative AGING in budding yeast
- Timing of expression of the core clock gene Bmal1 influences its effects on AGING and survival
- Epigenetic modifications upon senescence of mesenchymal stem cells
- A mitochondrial perspective of chronic obstructive pulmonary disease pathogenesis
- Mitochondrial ROS produced via reverse electron transport extend animal lifespan
- The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions
- Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie‐restricted mice
- Hutchinson–Gilford progeria syndrome as a model for vascular AGING
- Rejuvenation on the Road to Pluripotency
- Nutrients, foods, dietary patterns and telomere length: Update of epidemiological studies and randomized trials
- Commentary: life course epidemiology embraces geroscience
- Pathology of mouse models of accelerated AGING
- Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases
- Life span extension by targeting a link between metabolism and histone acetylation in Drosophila
- Pervasive effects of AGING on gene expression in wild wolves
- SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
- The effect of AGING on mitochondrial complex I and the extent of oxidative stress in the rat brain cortex
- Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1
- Response to hyperoxia is associated with similar ho-1 gene expression level in lungs of AGING CBA mice of both sexes
- Cistanches Herba: a neuropharmacology review
- The role of capillaries in the lesser ailments of old age and in Alzheimer’s disease and vascular dementia: The potential of pro-therapeutic angiogenesis
- Discovery of plant extracts that greatly delay yeast chronological AGING and have different effects on longevity-defining cellular processes
- Modifiable factors influencing telomere length and AGING
- NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
- Environmental enrichment modified epigenetic mechanisms in SAMP8 mouse hippocampus by reducing oxidative stress and inflammAGING and achieving …
- Telomeres in AGING and disease: lessons from zebrafish
- Frailty in pulmonary and critical care medicine
- Fendrr Is An Epigenetic Regulator Of Cellular Senescence In Pulmonary Fibroblasts
- FROM REPLICATIVE SENESCENCE TO MICRORNA BASED DIAGNOSTICS OF AGE-ASSOCIATED DISEASES
- Geroscience approaches to increase healthspan and slow AGING
- Role of lncRNAs in cellular AGING
- Molecular insights into the premature AGING disease progeria
- Short telomeres in key tissues initiate local and systemic AGING in zebrafish
- GDF11 administration does not extend lifespan in a mouse model of premature AGING
- Time-dependent dysregulation of autophagy: Implications in AGING and mitochondrial homeostasis in the kidney proximal tubule
- MitoAge: a database for comparative analysis of mitochondrial DNA, with a special focus on animal longevity
- Crosstalk of clock gene expression and autophagy in AGING
- “InflammAGING” as a druggable target: a senescence-associated secretory phenotype—centered view of type 2 diabetes
- Selected Theories of Ageing
- Double Strand Breaks May Be a Missing Link between
- Vitamin C alleviates AGING defects in a stem cell model for Werner syndrome
- Pharmacological strategies to retard cardiovascular AGING
- Cellular senescence and lung function during AGING. Yin and Yang
- mberHappily (n) ever after: AGING in the context of oxidative stress, proteostasis loss and cellular senescence
- Ultraviolet radiation-induced skin AGING: the role of DNA damage and oxidative stress in epidermal stem cell damage mediated skin AGING
- Influence of AGING on proliferation, pluripotency, immunogenic profiles from bone marrow mesenchymal stem cells
- Role of mitochondrial complex IV in age-dependent obesity
- The role of vitamin K in chronic AGING diseases: inflammation, cardiovascular disease, and osteoarthritis
- Characterization of mammary epithelial stem/progenitor cells and their changes with AGING in common marmosets
- High-Throughput Analysis of Age-Dependent Protein Changes in Layer II/III of the Human Orbitofrontal Cortex
- Epigenetic mechanisms of longevity and AGING
- Normal AGING and dementia
- Systematic analysis of the gerontome reveals links between AGING and age-related diseases
- AGING and serum MCP-1 are associated with gut microbiome composition in a murine model
- Early-life stress and reproductive cost: A two-hit developmental model of accelerated AGING?
- The neuronal kinesin UNC-104/KIF1A is a key regulator of synaptic AGING and insulin signaling-regulated memory
- Bcl11a deficiency leads to hematopoietic stem cell defects with an AGING-like phenotype
- Reciprocal changes in phosphoenolpyruvate carboxykinase and pyruvate kinase with age are a determinant of AGING in Caenorhabditis elegans
- Quantitative podocyte parameters predict human native kidney and allograft half-lives
- Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease
- Identifying a New Driver of AGING in C. elegans
- Deteriorating Infrastructure in the Aged Muscle Stem Cell Niche
- Cardiorenal fibrosis and dysfunction in AGING: imbalance in mediators and regulators of collagen
- HIV and AGING
- Vitamin C, antioxidant status, and cardiovascular AGING
- Protein damage, radiation sensitivity and AGING
- A systematic investigation into AGING related genes in brain and their relationship with alzheimer’s disease
- Mitophagy plays a central role in mitochondrial ageing
- Mode-specific physical activity and leukocyte telomere length among US adults: implications of running on cellular AGING
- Oxidative stress, cellular senescence and ageing
- Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis
- A hidden epithelial barrier in the brain with a central role in regulating brain homeostasis. Implications for AGING
- Cellular Senescence: Spotlight on the Mitochondria
- Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans
- Effect of hyperglycemia on the number of CD117+ progenitor cells and their differentiation toward endothelial progenitor cells in young and old ages
- Biochemical basis of sestrin physiological activities
- Early life origins of adult health and AGING
- Regenerative decline of stem cells in sarcopenia
- Epigenetic targets in cancer and AGING: dietary and therapeutic interventions
- Reversal of phenotypes of cellular senescence by pan-mTOR inhibition
- Roles of renin-angiotensin system and Wnt pathway in AGING-related phenotypes
- Tethering telomerase to telomeres increases genome instability and promotes chronological AGING in yeast
- UPS activation in the battle against AGING and aggregation-related diseases: an extended review
- Pathways for salvage and protection of the heart under stress: novel routes for cardiac rejuvenation
- 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates AGING and Alzheimer’s Disease Progression in Caenorhabditis elegans and Neuronal Cultures
- Global gene profiling of AGING lungs in Atp8b1 mutant mice
- Biomarkers of Replicative Senescence Revisited
- Discover the network mechanisms underlying the connections between AGING and age-related diseases
- A synopsis on AGING—Theories, mechanisms and future prospects
- Deficient activity of the nuclease MRE11A induces T cell AGING and promotes arthritogenic effector functions in patients with rheumatoid arthritis
- Yeast longevity promoted by reversing AGING-associated decline in heavy isotope content
- Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans: A case–control study
- Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
- Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)
- Caenorhabditis elegans as a toolkit for studying mammalian AGING pathways
- ROS, cell senescence, and novel molecular mechanisms in AGING and age-related diseases
- Cellular senescence and vascular disease: novel routes to better understanding and therapy
- Water-Transfer Slows AGING in Saccharomyces cerevisiae
- Evidence that hematopoietic stem cell function is preserved during AGING in long-lived S6K1 mutant mice
- Redox mechanisms in age-related lung fibrosis
- Telomere protein RAP1 levels are affected by cellular AGING and oxidative stress
- Age-Related Senescence of Rat Bone Marrow-Derived Mesenchymal Stem Cells
- Therapeutic manipulation of ageing: repurposing old dogs and discovering new tricks
- Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model
- Dissecting the contribution of vascular alterations and AGING to Alzheimer’s disease
- Child poverty and the promise of human capacity: childhood as a foundation for healthy AGING
- The AGING brain: movement speed and spatial control
- Cellular senescence and tumor promotion: is AGING the key?
- Sirt 6 as a novel target for neuroinflammation and brain AGING
- Ultra-weak photon emission of hands in AGING prediction
- Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury
- The evolution of epigenetics: from prokaryotes to humans and its biological consequences
- Introduction to the Theme “Cancer Pharmacology”
- The role of autophagy, mitophagy and lysosomal functions in modulating bioenergetics and survival in the context of redox and proteotoxic damage …
- Leukocyte telomere length and mortality risk in patients with type 2 diabetes
- Classification for longevity potential: the use of novel biomarkers
- Effects of dietary restriction on adipose mass and biomarkers of healthy AGING in human
- Metabolism and the UPRmt
- Keeping the senescence secretome under control: molecular reins on the senescence-associated secretory phenotype
- Neuroendocrinology of AGING
- Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts
- Genomic stability during cellular reprogramming: mission impossible?
- Derailed proteostasis as a determinant of cardiac AGING
- The impact of AGING on cancer progression and treatment
- Two conserved histone demethylases regulate mitochondrial stress-induced longevity
- Modifiers of Neural Stem Cells and AGING: Pulling the Trigger of a Neurogenic Decline
- Gene expression signatures of human cell and tissue longevity
- Mitochondria and oxidative stress in heart AGING
- DNA damage: a main determinant of vascular AGING
- Unraveling Stochastic AGING Processes in Mouse Liver: Dissecting Biological from Chronological Age
- On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae)
- MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism
- Cancer stem cells: basic concepts and therapeutic implications
- The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans
- What we know about the pathogenesis of idiopathic pulmonary fibrosis
- Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
- DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age
- Beyond diabetes: does obesity-induced oxidative stress drive the AGING process?
- Coenzyme Q biosynthesis and its role in the respiratory chain structure
- The impact of low-protein high-carbohydrate diets on AGING and lifespan
- Profiling IgG N-glycans as potential biomarker of chronological and biological ages: A community-based study in a Han Chinese population
- Epigenetic significance of chromatin organization during cellular AGING and organismal lifespan
- In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state
- Mitochondrial form, function and signalling in AGING
- Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with AGING in male and female mice
- Absence of non-histone protein complexes at natural chromosomal pause sites results in reduced replication pausing in AGING yeast cells
- Age intrinsic loss of telomere protection via TRF1 reduction in endothelial cells
- Diastolic dysfunction and cardiac troponin I decrease in AGING hearts
- Nrf2 signaling and redox homeostasis in the AGING heart: a potential target to prevent cardiovascular diseases?
- Molecular and Genetic Investigation of AGING: The Role of Mitochondrial Metabolism Genes on Life Span Determination
- In search of lost time: age and the promise of induced pluripotent stem cell models of the brain
- The Effects of Rapamycin on the Unfolded Protein Response in Relation to Healthy AGING
- Increased levels of hyper-stable protein aggregates in plasma of older adults
- Exercise: a “new drug” for elderly patients with chronic heart failure
- QUALITY-OF-LIFE OUTCOMES OF AGING ADULTS WITH AUTISM AND THEIR FAMILIES
- Systemic DNA damage responses in AGING and diseases
- Glycomics and glycoproteomics focused on AGING and age-related diseases—Glycans as a potential biomarker for physiological alterations
- Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila
- Protective effect of seleno-β-lactoglobulin (Se-β-lg) against oxidative stress in D-galactose-induced AGING mice
- Early-life intelligence predicts midlife biological age
- AGING and the HPA axis: Stress and resilience in older adults
- The role of stem cell AGING in acute myeloid leukemia.
- Forkhead-box A1 induces cell senescence in endometrial cancer by regulating p16INK4a
- SESSION 300 (SYMPOSIUM)
- Age-dependent changes in the activation and regulation of microglia
- Finding Ponce de Leon’s pill: challenges in screening for anti-AGING molecules
- Mechanisms and consequences of cancer genome instability: lessons from genome sequencing studies
- Regulation of Stem Cells in Their Niche
- Orchestrating the network of molecular pathways affecting AGING: role of nonselective autophagy and mitophagy
- Understanding vascular diseases: lessons from premature AGING syndromes
- Uncoupling protein 2 protects mice from AGING
- Long-term dietary alpha-linolenic acid supplement alleviates cognitive impairment correlate with activating hippocampal CREB signaling in natural AGING rats
- Long noncoding RNAs in AGING and age-related diseases
- Six plant extracts delay yeast chronological AGING through different signaling pathways
- Osteoarthritis in the Elderly
- Epigenetic regulations of hematopoietic stem cells ageing and the regulation of traditional Chinese medicine
- Living long and well: prospects for a personalized approach to the medicine of ageing
- Mitochondria and senescence: new actors for an old play
- Citation metadata
- Hematopoiesis during development, AGING, and disease
- Chromothripsis and epigenomics complete causality criteria for cannabis-and addiction-connected carcinogenicity, congenital toxicity and heritable genotoxicity
- Method specific calibration corrects for DNA extraction method effects on relative telomere length measurements by quantitative PCR
- The anti-AGING effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain
- Animal models of frailty: current applications in clinical research
- Generating late-onset human iPSC-based disease models by inducing neuronal age-related phenotypes through telomerase manipulation
- Extracellular vesicles in chronic obstructive pulmonary disease
- Audition and language comprehension in adult AGING: Stability in the face of change
- Extracellular vesicles as new players in cellular senescence
- Towards a multidimensional healthy ageing phenotype
- Protective effect of ginsenoside Rg1 on hematopoietic stem/progenitor cells through attenuating oxidative stress and the Wnt/β-catenin signaling pathway in a mouse …
- Poly (ADP-Ribose) Polymerases in AGING–Friend or Foe?
- Accelerated accumulation of multimorbidity after bilateral oophorectomy: a population-based cohort study
- Ageing and the telomere connection: An intimate relationship with inflammation
- Metabolomics of Mammalian and Cellular Models of AGING
- Sirtuins, healthspan, and longevity in mammals
- Species-specific lifespans: Can it be a lottery based on the mode of mitochondrial DNA replication?
- A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia
- Amniotic epithelial cells: a new tool to combat AGING and age-related diseases?
- Nuclear DNA damage signalling to mitochondria in ageing
- The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
- Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy
- Genome-wide DNA methylation changes during AGING
- Understanding and predicting protein misfolding and aggregation: Insights from proteomics
- Reorganization of chromosome architecture in replicative cellular senescence
- Notable decrease in transcriptome conservation during mammalian AGING
- The short-lived African turquoise killifish: an emerging experimental model for ageing
- Human neural stem cell AGING is counteracted by α-glycerylphosphorylethanolamine
- The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
- Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health?
- Strategies and challenges in clinical trials targeting human AGING
- From paediatrics to geriatrics: a life course perspective on the MRC National Survey of Health and Development
- Phycocyanin moderates AGING and proteotoxicity in Caenorhabditis elegans
- Chaperone mediated autophagy in AGING: starve to prosper
- Cell-nonautonomous mechanisms underlying cellular and organismal AGING
- Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan
- The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor
- Caloric restriction: beneficial effects on brain AGING and Alzheimer’s disease
- XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence
- Habituation in the tail withdrawal reflex circuit is impaired during AGING in Aplysia californica
- Optical monitoring of retinal respiration in real time: 670 nm light increases the redox state of mitochondria
- Ageing as an important risk factor for cancer
- Animal and human models to understand ageing
- Stem Cell Therapies for Cardiac Regeneration: Current Burden—Future Directions
- Effects of AGING and short-term dietary restriction on neurogenesis and cellular senescence in the zebrafish (Danio Reio) brain
- Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice
- Supplementation with Lactobacillus plantarum WCFS1 prevents decline of mucus barrier in colon of accelerated AGING Ercc1−/Δ7 mice
- Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an α‑Klotho–Deficient Model
- Longevity of animals under reactive oxygen species stress and disease susceptibility due to global warming
- Interaction of age at diagnosis with transcriptional profiling in papillary thyroid cancer
- Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation
- The utility of preoperative frailty assessment
- Identification of potential key lncRNAs and genes associated with AGING based on microarray data of adipocytes from mice
- Variation of global DNA methylation levels with age and in autistic children
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
- Predicting disease onset in clinically healthy people
- Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels
- A shape shifting organelle: unusual mitochondrial phenotype determined with three-dimensional electron microscopy reconstruction
- Nutrigenomics and Nutrigenetics: The Basis of Molecular Nutrition
- EPIGENETIC FACTORS IN CARDIOVASCULAR DISEASE. AGEING STUDIES. REVIEW
- Alzheimer’s as a systems-level disease involving the interplay of multiple cellular networks
- Changes in frailty predict changes in cognition in older men: the Honolulu-Asia AGING Study
- Interventions for human frailty: physical activity as a model
- Diet-induced phenotypic plasticity during AGING
- Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
- Stress-induced (Premature) senescence
- Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants
- Therapy of endocrine disease: improvement of cardiovascular risk factors after adrenalectomy in patients with adrenal tumors and subclinical Cushing’s …
- Stem cells: a renaissance in human biology research
- Review of recent studies and research analysis for anti-oxidant and anti-AGING materials
- HIV and ageing: improving quantity and quality of life
- NADPH oxidases: key modulators in AGING and age-related cardiovascular diseases?
- An Accumulation of Senescent Cells May Contribute to Chronic Inflammation of the Mammalian Liver
- A diphenyl diselenide-supplemented diet and swimming exercise promote neuroprotection, reduced cell apoptosis and glial cell activation in the hypothalamus of old …
- The protective role of protein L-isoaspartyl (D-aspartate) O-methyltransferase for maintenance of mitochondrial morphology in A549 cell
- Behaviour and cognitive changes correlated with hippocampal neuroinflammAGING and neuronal markers in female SAMP8, a model of accelerated senescence
- Cell fusion proteins can rejuvenate adult dendritic trees
- AMPK as a pro-longevity target
- Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated AGING, or one?
- A frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes
- Simplified assay for epigenetic age estimation in whole blood of adults
- Grundy, Richard G.(2015) Expression alterations define unique molecular characteristics of spinal ependymomas. Oncotarget, 6 (23). pp. 19780-19791. ISSN …
- Secondary progression in multiple sclerosis: neuronal exhaustion or distinct pathology?
- Endothelial cell senescence and inflammAGING: microRNAs as biomarkers and innovative therapeutic tools
- Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage
- Mitochondria quality control and muscle mass maintenance
- Measuring biological age via metabonomics: the metabolic age score
- A short leucocyte telomere length is associated with development of insulin resistance
- Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: prospective cohort study
- Change in epigenome-wide DNA methylation over 9 years and subsequent mortality: results from the InCHIANTI Study
- The proteasome and oxidative stress in Alzheimer’s disease
- Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes
- Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
- Ageing: consequences of excessive free radicals and inflammation
- Genomic Instability and AGING: Causes and Consequences
- Systematic and cell type-specific telomere length changes in subsets of lymphocytes
- Common SIRT1 variants modify the effect of abdominal adipose tissue on AGING-related lung function decline
- Regulation of mitochondrial dynamics and bioenergetics: implications of circadian clock and neurosteroids in health and diseases
- Mitochondrial reactive oxygen species: do they extend or shorten animal lifespan?
- Evaluation of candidate reference genes for RT-qPCR studies in three metabolism related tissues of mice after caloric restriction
- Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology
- From DNA damage to functional changes of the trabecular meshwork in AGING and glaucoma
- 39 ROS and Epigenetics
- Effect of Maternal Age on Offspring Social Behaviour in Drosophila Melanogaster
- TNFA gene variants related to the inflammatory status and its association with cellular AGING: from the CORDIOPREV study
- A genetic interaction between rap 1 and telomerase reveals an unanticipated role for rap 1 in telomere maintenance
- Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians
- Periodic acid-Schiff granules in the brain of aged mice: From amyloid aggregates to degenerative structures containing neo-epitopes
- Shared biologic pathways between Alzheimer disease and major depression: a systematic review of MicroRNA expression studies
- Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
- Inside out: the role of nucleocytoplasmic transport in ALS and FTLD
- Gerontology versus geriatrics: different ways of understanding ageing and old age
- Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
- Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant
- Discovery of Plant Extracts That Delay Yeast Chronological AGING through Different Signaling Pathways
- Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila
- When science meets cluttered writing: adjectives and adverbs in academia revisited
- Effects of aerobic training on markers of autophagy in the elderly
- Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli
- Replication-independent histone variant H3. 3 controls animal lifespan through the regulation of pro-longevity transcriptional programs
- Associations between long-term serum platinum and neurotoxicity and ototoxicity, endocrine gonadal function, and cardiovascular disease in testicular cancer …
- Genetic Manipulation of Glycogen Allocation Affects Replicative Lifespan in E. coli
- Temporal development of autonomic dysfunction in heart failure: effects of age in an ovine rapid-pacing model
- Revista de
- Shortened telomere length in patients with depression: a meta-analytic study
- Heterochronic parabiosis studies of the AGING immune system
- A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis
- Diabetes and AGING
- The aged lymphoid tissue environment fails to support naïve T cell homeostasis
- Mechanosensory neuron AGING: differential trajectories with lifespan-extending Alaskan berry and fungal treatments in Caenorhabditis elegans
- Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance
- Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats
- Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling
- Reliability of the 6-minute walk test and cardiac autonomic markers in active and sedentary older women
- TGF-β and NF-κB signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response
- Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird
- Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy …
- MAP3K19 is a novel regulator of TGF-β signaling that impacts bleomycin-induced lung injury and pulmonary fibrosis
- Periodic acid-Schiff granules in the brain of aged mice: from amyloid aggregates to degenerative structures containing neo-epitopes
- Enhancer Remodeling During Early Mammalian Embryogenesis: Lessons for Somatic Reprogramming, Rejuvenation, and AGING
- Lysosomal cathepsins and their regulation in AGING and neurodegeneration
- Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2
- Epigenetic and Pten Regulation of Longevity Pathways Related to Idiopathic Pulmonary Fibrosis and Organismal AGING
- Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice
- Mammalian target of rapamycin (mTOR), AGING, neuroscience, and their association with AGING-related diseases
- Pleiotropic effects of tocotrienols and quercetin on cellular senescence: introducing the perspective of senolytic effects of phytochemicals
- Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival
- Emotions and family interactions in childhood: Associations with leukocyte telomere length
- Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
- Proteostasis alterations in myeloproliferative neoplasms: Oncogenic relevance and therapeutic opportunities
- Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR
- Validation and comparison of instruments to identify frail patientes in primary care settings: study protocol
- Roles of apoptosis and cellular senescence in cancer and AGING
- Interruption of progerin–lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype
- Glutathione maintenance mitigates age-related susceptibility to redox cycling agents
- Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease
- Stem Cell AGING Research Literatures
- Key role of DAMP in inflammation, cancer, and tissue repair
- Influence of ageing on tendon homeostasis
- Nutrition in the Elderly: General Aspects
- Maintenance of the adult Drosophila intestine: all roads lead to homeostasis
- Phenomenon of ageing–a process or a state
- Epigenetic perturbations in AGING stem cells
- Treatment of facial photodamage and rhytides using a novel 1,565 nm non‐ablative fractional erbium‐doped fiber laser
- Identification of longevity and cancer resistance mechanisms in long-lived rodent species
- Reflections on the role of senescence during development and AGING
- DNA damage response in hematopoietic stem cell ageing
- Role of telomerase in the cardiovascular system
- p53 and the carcinogenicity of chronic inflammation
- Genetics and idiopathic interstitial pneumonias
- Targeting Senescent Cells to Improve Human Health
- Effects of age and working memory capacity on speech recognition performance in noise among listeners with normal hearing
- Prostate cancer: is it a battle lost to age?
- The association of serum cathepsin B concentration with age-related cardiovascular-renal subclinical state in a healthy Chinese population
- Histone modifications in ageing and lifespan regulation
- Mammalian telomeres and their partnership with lamins
- Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
- Sirt6 links genome stability and tumor suppression pathways to longevity maintenance
- Cardioprotection and lifespan extension by the natural polyamine spermidine
- Ageing in the musculoskeletal system: cellular function and dysfunction throughout life
- Hypermethylation of FOXP3 Promoter and Premature AGING of the Immune System in Female Patients with Panic Disorder?
- Improving mitochondrial function protects bumblebees from neonicotinoid pesticides
- Hitting the high notes: Healthy AGING in professional orchestral musicians
- Practical Laboratory Medicine
- Mechanisms of lung fibrosis resolution
- Menopause: genome stability as new paradigm
- Integrated multiregional analysis proposing a new model of colorectal cancer evolution
- The pathophysiology of defective proteostasis in the hypothalamus—from obesity to ageing
- High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice
- Understanding long-term outcomes following sepsis: implications and challenges
- Chromatin Signaling in AGING and Cellular Senescence
- rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts
- Age-dependent modulation of fasting and long-term dietary restriction on acetylcholinesterase in non-neuronal tissues of mice
- Connecting the functions of the proteasome and mitochondria in the lung
- LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR
- Protective effects of α-tocopherol, γ-tocopherol and oleic acid, three compounds of olive oils, and no effect of trolox, on 7-ketocholesterol-induced …
- Hyperglycemic stress and carbon stress in diabetic glucotoxicity
- Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function
- Translational control in nutrient response and AGING
- Physical activity and Alzheimer disease: a protective association
- TEMPOL increases NAD+ and improves redox imbalance in obese mice
- Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome
- HSF1 regulation in AGING and its role in longevity
- Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance
- Effects of low-dose ibuprofen supplementation and resistance training on bone and muscle in postmenopausal women: a randomized controlled trial
- Vitamin C improves the health span of animal models of werner syndrome
- Telomere shortening in middle-aged men with sleep-disordered breathing
- DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY
- The redundancy of the mammalian heterochromatic compartment
- Exploring the homeostatic and sensory roles of the immune system
- Influence of DNA extraction methods on relative telomere length measurements and its impact on epidemiological studies
- MMP-25 metalloprotease regulates innate immune response through NF-κB signaling
- Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan
- Creation of databases of ageing-related drugs and statistical analysis and applied machine learning for the prioritization of potential lifespan-extension drugs
- The germline/soma dichotomy: implications for AGING and degenerative disease
- Physiological and pathological AGING affects chromatin dynamics, structure and function at the nuclear edge
- Barrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes
- Circulating microRNAs during human AGING and longevity
- Unabridged analysis of human histone H3 by differential top-down mass spectrometry reveals hypermethylated proteoforms from MMSET/NSD2 …
- Mitochondrial health, the epigenome and healthspan
- Stage dependent nutritional regulation of transgenerational longevity
- Critical role of lysosomes in the dysfunction of human Cardiac Stem Cells obtained from failing hearts
- Systemic immune markers characterizing early stages of rheumatoid arthritis
- Mir-184 affects lifespan via regulating the Activin pathway in Drosophila
- Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert’s Syndrome
- Calculating the rate of senescence from mortality data: an analysis of data from the ERA-EDTA Registry
- Biological rationale for regular physical exercise as an effective intervention for the prevention and treatment of depressive disorders
- HIV and AGING: parallels and synergistic mechanisms leading to premature disease and functional decline
- Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
- Optimization of reference genes for normalization of reverse transcription quantitative real-time polymerase chain reaction results in senescence study of …
- GIT2 acts as a systems-level coordinator of neurometabolic activity and pathophysiological AGING
- Changes in mitochondrial fitness of fibroblasts due to oxidative stress
- AGING, AGING Process and Roles of Genes in AGING
- Relative contributions of arterial stiffness and hypertension to cardiovascular disease: the Framingham Heart Study
- Candidate genes of idiopathic pulmonary fibrosis: current evidence and research
- Weight loss upregulates the small GTPase DIRAS3 in human white adipose progenitor cells, which negatively regulates adipogenesis and activates …
- A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
- Polyketide-based anti-AGING therapeutic development via synthetic enzymology
- Cellular Memory of Adverse Intrauterine Nutrition Associated with Altered Cell Function and Epigenetic Dysregulation
- Metabolic control of methylation and acetylation
- Neuromodulatory potential of aqueous extracts of cumin, cinnamon: evidence from rotenone model in drosophila: implications to Parkinson’s disease
- SCC ONTARIO EDUCATION DAY
- BubR1 in cancer, AGING and development
- The health benefits of exercise and physical activity
- Autophagy maintains stemness by preventing senescence
- Long noncoding RNAs in HPV-induced oncogenesis
- AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
- Discarded human thymus is a novel source of stable and long‐lived therapeutic regulatory T cells
- Changes in Drosophila mitochondrial proteins following chaperone-mediated lifespan extension confirm a role of Hsp22 in mitochondrial UPR and reveal a …
- SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks
- Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3′ ends in Drosophila
- Dianna T. Kenny and
- The transcriptional repressor Sum1p counteracts Sir2p in regulation of the actin cytoskeleton, mitochondrial quality control and replicative lifespan in …
- Screening for frailty in Canada’s health care system: a time for action
- Estradiol-induced transcriptional regulation of long non-coding RNA, HOTAIR
- NF-κB signaling as a driver of ageing
- Novel LMNA mutations cause an aggressive atypical neonatal progeria without progerin accumulation
- Investigate the role of Nrip1 in metabolic AGING and longevity in mouse model
- BTK modulates p53 activity to enhance apoptotic and senescent responses
- Systematic review of the association between chronic social stress and telomere length: A life course perspective
- Genes Related to Fatty Acid β-Oxidation Play a Role in the Functional Decline of the Drosophila Brain with Age
- Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability
- Older age is associated with more MRI-detected inflammation in hand and foot joints
- Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome
- The impact of the eye in dementia: the eye and its role in diagnosis and follow-up
- AUTEN-67 (autophagy enhancer-67) hampers the progression of neurodegenerative symptoms in a Drosophila model of Huntington’s disease
- Socio-demographic and Health Aspects Associated with the Quality of Life in the Elderly of the Family Health Strategy. An Analytical Study.
- Loss of Nat4 and its associated histone H4 N‐terminal acetylation mediates calorie restriction‐induced longevity
- Mitochondria-targeting ceria nanoparticles as antioxidants for Alzheimer’s disease
- SIRT 7 promotes genome integrity and modulates non‐homologous end joining DNA repair
- TNF‐α inhibits FoxO1 by upregulating miR‐705 to aggravate oxidative damage in bone marrow‐derived mesenchymal stem cells during osteoporosis
- Senescence associated heterochromatic foci: SAHF
- Profiling IgG N-glycans as potential biomarker of chronological and biological ages
- EQ-5D-5L in the general German population: comparison and evaluation of three yearly cross-section surveys
- Lysosomal cathepsins and their regulation in AGING and
- Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance
- Characterisation of Novel Markers and Effectors of Senescence and their Role in Cancer and Ageing
- Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response
- Current advances in the functional studies of fatty acids and fatty acid-derived lipids in C. elegans
- Targeting mitochondrial phenotypes for non-communicable diseases
- Sumoylation in cellular senescence and AGING
- Nontranscriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis
- Differential proteomic analysis of human placenta-derived mesenchymal stem cells cultured on normal tissue culture surface and hyaluronan-coated surface
- Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity
- Polyphenol-related epigenetic modifications in osteoarthritis: current therapeutic perspectives
- Altered Expression of Cellular Markers in Molecular Brain AGING
- Application of Bioinformatics Methodologies in the Fields of Skin Biology and Dermatology
- Impaired epidermal to dendritic T cell signaling slows wound repair in aged skin
- Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo
- Optimizing pharmacological lifespan extension: Testing chemical compounds for additive effects on longevity
- Phylloquinone and menaquinone-4 tissue distribution at different life stages in male and female Sprague–Dawley rats fed different VK levels since weaning or …
- Reversing stem cell AGING: Implications for vascular regeneration
- Sedentary time, cardiorespiratory fitness, and cardiovascular risk factor clustering in older adults–the Generation 100 study
- Expression profiling and functional prediction of long noncoding RNAs in nasopharyngeal nonkeratinizing carcinoma
- Uncovering the mechanisms of Caenorhabditis elegans ageing from global quantification of the underlying landscape
- Nutritional issues in geriatric care: nutrition and HIV
- Interactions between Innate Immune Signaling, Gut Microbiota, and Tissue Regeneration in the Control of Homeostasis in the AGING Fly Intestine
- Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma
- On the interplay between chronic pain and age with regard to neurocognitive integrity: Two interacting conditions?
- Proteostatic Mechanisms and Degree of Transcriptional Change with Age in Different Neural Stem Cell Populations
- Bone Reports
- Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing
- Regulation and Role of Mirna and Target Genes in Cell Cycle during Oxidative Stress-Induced Premature Senescence in Mesenchymal Stem Cell
- THAI DERMATOLOGIST SURVEY OF SKIN AGING ASSESSMENT
- Mechanisms of mitophagy: putting the powerhouse into the doghouse
- IGF-1 levels are inversely associated with metabolic syndrome in obstructive sleep apnea
- Histone H3 and TORC1 prevent organelle dysfunction and cell death by promoting nuclear retention of HMGB proteins
- Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence
- Current evidence for developmental, structural, and functional brain defects following prenatal radiation exposure
- Aneuploidy impairs protein folding and genome integrity in human cells
- Analysis of Deleted in Breast Cancer 1 (DBC1} as a Novel Molecular Target of Resveratrol and Its Metabolites
- Physiological responding to stress in middle-aged males enriched for longevity: a social stress study
- Decoding the regulatory landscape of ageing in musculoskeletal engineered tissues using genome-wide DNA methylation and RNASeq
- Exosomes in the Preservation of Cellular Homeostasis
- Identification of novel lipid signalling mechanisms
- Application of bioactive quercetin in oncotherapy: from nutrition to nanomedicine
- Studies on the regulation of genome maintenance factors by non-covalent interaction with poly (ADP-ribose) with a focus on RECQL helicases
- Non-thermal atmospheric pressure plasma efficiently promotes the proliferation of adipose tissue-derived stem cells by activating NO-response pathways
- Moonlight-like proteins of the cell wall protect sessile cells of Candida from oxidative stress
- 1, 4-Dihydropyridines active on the SIRT1/AMPK pathway ameliorate skin repair and mitochondrial function and exhibit inhibition of proliferation in cancer cells
- Cross talk of proteostasis and mitostasis in cellular homeodynamics, ageing, and disease
- Tomato aqueous extract modulates the inflammatory profile of immune cells and endothelial cells
- Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice
- Modulation of gluconeogenesis and lipid production in an engineered oleaginous Saccharomyces cerevisiae transformant
- Structure and function of the mitochondrial ribosome
- Telomere dysfunction drives pulmonary fibrosis and offers new therapeutic strategies
- The safety of treatment options for elderly people with acute myeloid leukemia
- Studying the effects of Ubisol-Q10 in animal models of Alzheimer’s and Parkinson’s disease
- Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis
- A Modest Proposal: Differentiating Daughters are Sacrificed during Starvation to Protect Stem Cells in the Drosophila Testis.
- Chemopreventive and therapeutic effects of edible berries: A focus on colon cancer prevention and treatment
- Studies on Molecular Basis for FOXO1-DNA Damage Responses
- Comprehension and effort for vocoded speech varying in syntactic complexity
- Epigenomics-based identification of major cell identity regulators within heterogeneous cell populations
- Disparities in Environmental Exposures and Health in Thailand: Molecular Effects of Chronic Cadmium Exposure and Trends in Childhood Leukemia
- The impact of oxidative stress induced RNA granules on cellular senescence
- Agonist-stimulated phosphatidylinositol-3, 4, 5-trisphosphate generation by scaffolded phosphoinositide kinases
- A Novel Mechanism of Spermatogonia Death in Drosophila that Contributes to Tissue Homeostatis During Starvation.
- Evidence supporting the utility of blood cell respiratory capacity as a systemic marker of mitochondrial health and biological age
- Prevention of chronic conditions and cancer
- WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE
- Rational Autologous Cell Sources For Therapy of Heart Failure–Vehicles and Targets For Gene and RNA Therapies
- HIV-1 gp120 mediated neuronal deregulation: Unraveling the molecular mechanisms involved
- The Influence of Antithymocyte Globulin on CD4+ T Cells from Patients with Rheumatoid Arthritis
- Fibrocytes, y-Herpesvirus and Periostin Augment Bleomycin-induced Lung Fibrosis.
- Autophagy and inflammation in the pathogenesis of idiopathic dilated cardiomyopathy
- The ageing muscle: Macrophage kinetics and local inflammation in response to resistance training
- Does Androgen Deprivation Therapy Impact Subjective Cognitive Function in Men with Non-metastatic Prostate Cancer?
- The orphan drug 4-phenyl butyrate protects the heart against Atrial Fibrillation by blocking ER stress-induced autophagy
- Modeling CNS Development and
- “It’s not how old we are; it’s how we are old”: A salutogenic approach to how older Australian women experience ageing and respond to life stressors
- Redox Status and Proteostasis in Ageing and Disease
- The Molecular Mechanisms of MAP4K3-mediated Autophagy Induction
- Identification of Pathogenic Determinants and Mechanisms of C9ORF72 linked ALS/FTD
- Dysfunctional phenotype of T cells and their contribution to impaired B cell function during HIV-1 infection
- NAD LIMITATION AND ITS IMPACT ON C. GLABRATA SURVIVAL AND VIRULENCE
- Health-related quality of life outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction (HOOP-PCI study)
- Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening
- IIM secretary e-mail: fisiologia@ unich. it D’Alfonso Antonella Info: www. co ra mi im. it
- Annales Universitatis Paedagogicae Cracoviensis. 215. Studia ad Didacticam Biologiae Pertinentia 6
- Establishment an in vitro primary mouse hepatocyte model to investigate the modes of action of carcinogens carcinogens study∗
- A transthyretin-related gene
- Obstructive sleep apnea and hallmarks of AGING
- MicroRNAs and the metabolic hallmarks of AGING
- The biology of AGING and cancer: a brief overview of shared and divergent molecular hallmarks
- Molecular and physiological manifestations and measurement of AGING in humans
- Mechanisms of lung AGING
- Mitotic dysfunction associated with AGING hallmarks
- Autophagy in stem cell AGING
- The mitochondrial basis of AGING and age-related disorders
- The intersection of AGING biology and the pathobiology of lung diseases: a joint NHLBI/NIA workshop
- Direct reprogramming rather than iPSC-based reprogramming maintains AGING hallmarks in human motor neurons
- Translational geroscience: A new paradigm for 21st century medicine
- Recent advances in understanding Werner syndrome
- Molecular and phenotypic biomarkers of AGING
- Mechanisms linking AGING, diseases and biological age estimation
- Protein posttranslational modifications: roles in AGING and age-related disease
- Transcriptional signatures of AGING
- The role of AGING in the development of osteoarthritis
- Fueling inflamm-AGING through mitochondrial dysfunction: mechanisms and molecular targets
- IPF lung fibroblasts have a senescent phenotype
- Circadian Rhythms and Their Impact on AGING
- Cancer and AGING-the inflammatory connection
- Anti-AGING action of PPARs: Potential therapeutic targets
- Role of mitochondrial metabolism in the control of early lineage progression and AGING phenotypes in adult hippocampal neurogenesis
- Epigenetics and oxidative stress in AGING
- Aspartic acid racemization on AGING
- The system capacity view of AGING and longevity
- Resilient protein co-expression network in male orbitofrontal cortex layer 2/3 during human AGING
- SPACEFLIGHT MIMICKS RAPID BONE AGING
- Rejuvenation by partial reprogramming of the epigenome
- AGING and Chronic Respiratory Diseases: Novel Mechanisms
- Small Nucleoli and Reduced Ribosomal Biogenesis are Hallmarks of Longevity
- Reproduction Onset Regulates a Collapse in a Broad Spectrum of AGING Hallmarks
- Biphasic modeling of mitochondrial metabolism dysregulation during AGING
- The potential role of intracellular heat shock protein 70 deficiency in AGING and pulmonary fibrosis
- Cell and tissue biology paves a path to breast cancer prevention
- Hormones of Hypothalamus in AGING
- Senescence in COPD and its comorbidities
- Molecular connections of AGING and cancer
- Fleeting factors, turning back time
- DNA-PK promotes the mitochondrial, metabolic, and physical decline that occurs during AGING
- Mutation and catastrophe in the AGING genome
- Mesenchymal stem cells for frailty?
- A PATH FORWARD TO PREVENTING BREAST CANCER
- Insulin-like growth factor 1: at the crossroads of brain development and AGING
- How can AGING be thought of as anything other than a disease
- Chronic Kidney Disease and Idiopathic Pulmonary Fibrosis: Thinking Outside the Box in Disease Management and Prognostication.
- Osteomacs and bone regeneration
- Geroscience and the trans-NIH geroscience interest group, GSIG
- Collagen VI null mice as a model for early onset muscle decline in AGING
- Dr. rer. nat. Michael Seimetz
- Involvement of Klotho downregulation in radiation-induced senescence of renal epithelial cells
- Stem cell transplantation for frailty
- Environmental chemicals and AGING
- Polyglutamine-expanded huntingtin exacerbates age-related disruption of nuclear integrity and nucleocytoplasmic transport
- NAD+ in AGING: molecular mechanisms and translational implications
- Metabolic regulation of angiogenesis in diabetes and AGING
- The impacts of cellular senescence in elderly pneumonia and in age-related lung diseases that increase the risk of respiratory infections
- Advanced glycation and AGING
- Modulation of telomere protection by the PI3K/AKT pathway
- UNDERSTANDING THE MECHANISM OF GENOMIC INSTABILITY DURING REPLICATIVE AGING IN BUDDING YEAST
- Endoplasmic reticulum proteostasis impairment in AGING
- AGING metabolism: intervention strategies
- Telomere shortening, inflammatory cytokines, and anti-cytomegalovirus antibody follow distinct age-associated trajectories in humans
- Biology of premature ageing in survivors of cancer
- Pharynx mitochondrial [Ca2+] dynamics in live C. elegans worms during AGING
- 2nd interventions in AGING conference
- Biological predictors of AGING and potential of FTIR to study age-related diseases and AGING metabolic fingerprint
- POSTTRANSLATIONAL MODULATION OF MACROMOLECULES DURING AGING
- Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease
- Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity
- Biomarkers of AGING: from cellular senescence to age-associated diseases
- Modelling age-associated diseases using transgenic progerin expression
- Happily (n) ever after: AGING in the context of oxidative stress, proteostasis loss and cellular senescence
- Xenohormesis in early life: New avenues of research to explore anti-AGING strategies through the maternal diet
- T (ell) TALE signs of AGING
- Biomarkers of AGING associated with past treatments in breast cancer survivors
- Genome instability and AGING: Cause or effect?
- Aged stem cells reprogram their daily rhythmic functions to adapt to stress
- Physiology of ageing of the musculoskeletal system
- AGING: somatic mutations, epigenetic drift and gene dosage imbalance
- The decay of redox-stress response capacity is a substantive characteristic of AGING: revising the redox theory of AGING
- The age-and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in …
- AGING and caloric restriction research: a biological perspective with translational potential
- Will you still need me (Ca2+, TnT, and DHPR), will you still cleave me (calpain), when I’m 64?
- Run regular, age slower, be neuroplastic
- Regeneration of the AGING lung: a mini-review
- Single-cell analysis of human pancreas reveals transcriptional signatures of AGING and somatic mutation patterns
- Mitochondria in the spotlight of AGING and idiopathic pulmonary fibrosis
- Epigenetic drift is a determinant of mammalian lifespan
- The AGING population with HIV infection
- Intercellular competition and the inevitability of multicellular AGING
- Beneficial effects of antioxidative lactic acid bacteria
- Geroprotectors: a unified concept and screening approaches
- Calorie restriction breaks an epigenetic barrier to longevity
- Alterations of the translation apparatus during AGING and stress response
- Huntington’s disease: nuclear gatekeepers under attack
- Red blood cell distribution width: genetic evidence for AGING pathways in 116,666 volunteers
- Long live partial reprogramming
- Regulation of stem cell AGING by metabolism and epigenetics
- DNA Damage-related Vascular Dysfunction: Pathways and Interventions
- The Atg8 family of proteins—modulating shape and functionality of autophagic membranes
- Genome-wide transcriptomics of AGING in the rotifer Brachionus manjavacas, an emerging model system
- Astrocyte elevated gene-1 (AEG-1) and the A (E) Ging HIV/AIDS-HAND
- Human T cell immunosenescence and inflammation in AGING
- The biology of AGING and cancer: frailty, inflammation, and immunity
- Study on the Role of SIRT2 in Stem Cell AGING and Chronic Inflammation
- A tissue engineered model of AGING: interdependence and cooperative effects in failing tissues
- Insights into mortality patterns and causes of death through a process point of view model
- Redox theory of AGING: implications for health and disease
- InflammAGING and the lung
- A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs
- Pulmonary Diseases, a Matter of Time
- Maintained memory in AGING is associated with young epigenetic age
- Effects of diet on telomere length: systematic review and meta-analysis
- Cognitive decline in neuronal AGING and Alzheimer’s disease: role of NMDA receptors and associated proteins
- Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature AGING
- DNA methylation-based age prediction from various tissues and body fluids
- Dissecting the molecular mechanisms that impair stress granule formation in AGING cells
- Geropsychology: Mindfulness, stereotypes, and cognition in the AGING population.
- Novel strategies for anti-AGING drug discovery
- Integrins in senescence and AGING
- Epigenetics of AGING and Longevity: Translational Epigenetics vol 4
- The chromatin accessibility signature of AGING in human blood leukocytes stem from CD8+ T cells.
- Analysis of senescence-related differentiation potentials and gene expression profiles in human dental pulp stem cells
- AGING: molecular pathways and implications on the cardiovascular system
- Inflammatory cytokines and comorbidity development in breast cancer survivors versus noncancer controls: evidence for accelerated AGING?
- Lung diseases of the elderly: cellular mechanisms
- The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies
- Licence to kill senescent cells in idiopathic pulmonary fibrosis?
- Mitochondrial sirtuins and molecular mechanisms of AGING
- The longitudinal study of AGING in human young adults: knowledge gaps and research agenda
- Splicing regulatory factors, ageing and age-related disease
- Metabolic adventures in AGING research
- Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity-associated AGING and diabetes
- Septic shock and the AGING process: a molecular comparison
- POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions
- Circadian dysregulation and melatonin rhythm suppression in the context of AGING
- Critical functions of the lysosome in cancer biology
- Immune and inflammatory responses to DNA damage in cancer and AGING
- Gerodontology: effects of ageing on the oral mucosa
- Oncological challenges for an ageing population living with HIV
- Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
- Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption
- AGING, metabolism, and cancer development: from Peto’s paradox to the Warburg effect
- Interplay of Hemolymph (HL) miRNA in The Regulation of AGING
- The potential of iPSCs for the treatment of premature AGING disorders
- Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
- Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells
- New Challenges—2017
- Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the AGING brain
- AGING in Rothmund-Thomson syndrome and related RECQL4 genetic disorders
- AGING, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks
- Circadian reprogramming in the liver identifies metabolic pathways of AGING
- DAF-16/FOXO transcription factor in AGING and longevity
- Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species
- SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy
- What modulates animal longevity? Fast and slow AGING in bivalves as a model for the study of lifespan
- Healthy human AGING: intrinsic and environmental factors
- Good Ol’fat: links between lipid signaling and longevity
- Independent impacts of AGING on mitochondrial DNA quantity and quality in humans
- The NAD+/PARP1/SIRT1 axis in AGING
- Physiological links of circadian clock and biological clock of AGING
- Mitochondria and epigenetics–crosstalk in homeostasis and stress
- Functional relevance of miRNAs in premature ageing
- MiRNA deregulation in cardiac AGING and associated disorders
- Effects of testosterone administration on liver structure and function in AGING rats
- Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
- The Biology of AGING and Cancer
- Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
- Frailty and anesthesia
- Increased Arf/p53 activity in stem cells, AGING and cancer
- Complex interplay between AGING and cancer: role of TGF-β signaling
- Current perspective in the discovery of anti-AGING agents from natural products
- Probiotic bacteria for healthier AGING: immunomodulation and metabolism of phytoestrogens
- Theories and Mechanisms of AGING
- The possible role of epigenetics in the memory impairment elicited by circadian rhythm disruption
- Multigenerational silencing dynamics control cell AGING
- Recognizing degenerative AGING as a treatable medical condition: methodology and policy
- Embryonic stem cells: a novel paradigm to study proteostasis?
- Mitochondrial ALDH2 deficiency promotes fibrosis and reactive oxygen species formation in the myocardium of aged mice
- Geroprotectors: A Unified Concept and Screening Approaches
- Circadian Clocks and mTOR Signaling
- Human immunodeficiency virus and AGING in the era of effective antiretroviral therapy
- Investigating the role of the CCT chaperonin in stem cell identity and AGING
- Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury
- Communication and the Normal AGING Process
- Carbonyl toxification hypothesis of biological AGING
- Current insights to regulation and role of telomerase in human diseases
- Health benefits of late-onset metformin treatment every other week in mice
- How can I protect my telomeres and slow AGING?
- Physiological AGING: links among adipose tissue dysfunction, diabetes, and frailty
- Single cell transcriptome analysis of human pancreas reveals transcriptional signatures of AGING and somatic mutation patterns
- Visualization of AGING-associated chromatin alterations with an engineered TALE system
- Exploring animal models that resemble idiopathic pulmonary fibrosis
- Internal normalization of nascent RNA sequencing experiments to identify age-related changes of the mouse liver transcriptome
- Alternative splicing in AGING and age-related diseases
- Metabolic and genetic markers of biological age
- AGING, metabolism and stem cells: Spotlight on muscle stem cells
- Translating measures of biological AGING to test effectiveness of geroprotective interventions: what can we learn from research on telomeres?
- miRNAs in stem cell AGING and age-related disease
- Clearance of senescent cells: an immunotherapeutic approach
- Genetics of AGING and longevity
- Transcriptomic profiles of AGING in naïve and memory CD4+ cells from mice
- Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
- Epigenomics of human CD8 T cell differentiation and AGING
- Note: Page numbers followed by f and t indicate figures and tables
- Anti-ageing therapies in Alzheimer’s disease
- Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders
- GOLDEN anniversary of the acute respiratory distress syndrome: still much work to do!
- Note: Page numbers followed by f and t indicate figures and tables respectivelyA
- Functional relevance of miRNAs in premature ageing
- Vitamins associated with brain AGING, mild cognitive impairment, and Alzheimer disease: Biomarkers, epidemiological and experimental evidence, plausible …
- Rapamycin treatment attenuates age-associated periodontitis in mice
- Caloric restriction improves health and survival of rhesus monkeys
- The role of matrix metalloproteinases in AGING: Tissue remodeling and beyond
- The changing face of AGING: highly sulfated glycosaminoglycans induce amyloid formation in a lattice corneal dystrophy model protein
- Endoplasmic reticulum proteostasis impairment in AGING
- TGH: Trans-Generational Hormesis and the Inheritance of AGING Resistance
- Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report
- Detection of senescent cells by extracellular markers using a flow cytometry-based approach
- Protective effects of alpha phenyl-tert-butyl nitrone and ascorbic acid in human adipose derived mesenchymal stem cells from differently aged donors
- Endoplasmic reticulum proteostasis impairment in AGING
- Towards a global initiative for fibrosis treatment (GIFT)
- Age-related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development
- Generation of a Human Induced Pluripotent Stem Cell Based Model of Progerin Induced AGING
- Biological and Social Theories of AGING
- The citrus flavanone naringenin protects myocardial cells against age-associated damage
- Chronicle of a Neuronal Death Foretold: Preventing AGING by Keeping MGRN1 at the Nucleus
- Biomechanical strain exacerbates inflammation on a progeria‐on‐a‐chip model
- Retinal, NPY-and 5 ht-inputs to the aged suprachiasmatic nucleus in common marmosets (Callithrix jacchus)
- The AGING cardiovascular system: understanding it at the cellular and clinical levels
- The Role Of Intracellular Heat Shock Protein 70 Deficiency In Idiopathic Pulmonary Fibrosis
- Keeping up with the Red Queen: the pace of AGING as an adaptation
- Sarcopenia: causes and treatments
- Chronic inflammation in immune AGING: role of pattern recognition receptor crosstalk with the telomere complex?
- Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives
- The Endocrinology of AGING: a key to longevity “Great Expectations”
- Blue light-induced oxidative stress in live skin
- Nucleolar expansion and elevated protein translation in premature AGING
- Cytokine-induced senescence for cancer surveillance
- Chemical screening identifies ATM as a target for alleviating senescence
- The role of epigenetics in renal ageing
- The potential role of senescence as a modulator of platelets and tumorigenesis
- Age-related changes in plasma extracellular vesicle characteristics and internalization by leukocytes
- Red Blood Cell Distribution Width: genetic evidence for AGING pathways in 116,666 volunteers
- Telomere-driven diseases and telomere-targeting therapies
- SELECTED THEORIES OF AGEING
- 2 Understanding AGING
- HIV-associated cellular senescence: a contributor to accelerated AGING
- Unveiling the role of senescence-induced cellular plasticity
- NAD and the AGING process: Role in life, death and everything in between
- Studying the geroprotective effects of inhibitors suppressing AGING-associated signaling cascades in model organisms
- A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans
- Eco-AGING: stem cells and microbes are controlled by AGING antagonist FoxO
- Increased genome instability is not accompanied by sensitivity to DNA damAGING agents in aged yeast cells
- Using comparative biology to understand how AGING affects mitochondrial metabolism
- New approach to generating insights for AGING research based on literature mining and knowledge integration
- The clinical potential of senolytic drugs
- AGING Schwann cells: mechanisms, implications, future directions
- Microglia priming with AGING and stress
- Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline
- Role of circulating factors in cardiac AGING
- Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells
- The origin of life at the origin of ageing?
- Physical exercise as an effective antiAGING intervention
- Mitochondrial dysfunction in pulmonary fibrosis
- Bloom’s syndrome: Why not premature AGING?: A comparison of the BLM and WRN helicases
- Molecular chaperone accumulation in cancer and decrease in Alzheimer’s disease: the potential roles of HSF1
- Inflammation and premature AGING in advanced chronic kidney disease
- Hepatic S6K1 partially regulates lifespan of mice with mitochondrial complex I deficiency
- Three‐year changes in physical activity and decline in physical performance over 9 years of follow‐up in older adults: the invecchiare in Chianti study
- Energy metabolism and ageing in the mouse: a mini-review
- Regulation of TERRA on telomeric and mitochondrial functions in IPF pathogenesis
- Ginsenoside Rg3 prevents oxidative stress-induced astrocytic senescence and ameliorates senescence paracrine effects on glioblastoma
- Methylation of the ribosomal RNA gene promoter is associated with AGING and age‐related decline
- 18 Manipulating AGING to Treat
- MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice
- Are there any biomarkers of AGING? Biomarkers of the brain
- Ageing and ocular surface immunity
- Arginase-II deficiency extends lifespan in mice
- Changes of protein turnover in AGING Caenorhabditis elegans
- Cellular senescence, immunosenescence and HIV
- ANGPTL2―A New Causal Player in Accelerating Heart Disease Development in the AGING―
- Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet
- Coupling Protein Catabolism to Lifespan and Reproduction in Caenorhabditis elegans
- Improving mitochondrial function significantly reduces metabolic, visual, motor and cognitive decline in aged Drosophila melanogaster
- Does eating less make you live longer and better? An update on calorie restriction
- Conserved and species-specific molecular denominators in mammalian skeletal muscle AGING
- Masters athletes: Exemplars of successful AGING?
- Proteostatic and metabolic control of stemness
- Life stress, glucocorticoid signaling, and the AGING epigenome: implications for AGING-related diseases
- Interaction between epigenetic and metabolism in AGING stem cells
- Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle
- Impact of yoga and meditation on cellular AGING in apparently healthy individuals: a prospective, open-label single-arm exploratory study
- Age-associated DNA methylation changes in naive CD4+ T cells suggest an evolving autoimmune epigenotype in AGING T cells
- Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically AGING …
- Molecular signatures of longevity: insights from cross-species comparative studies
- D108 CELL FATE DECISIONS: SENESCENCE, REPAIR, AND REGENERATION: Mitochondrial Uncoupling Protein-2 Mediates Fibroblast Senescence In Age …
- Hexokinases link DJ-1 to the PINK1/parkin pathway
- The UPRER: sensor and coordinator of organismal homeostasis
- Mitochondrial Uncoupling Protein-2 Mediates Fibroblast Senescence In Age-Related Lung Fibrosis
- Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age
- Interleukin-7 and immunosenescence
- Integrin beta 3 regulates cellular senescence by activating the TGF-β pathway
- Common methods of biological age estimation
- Absence of correlation between chimeric RNA and AGING
- A null mutation in SERPINE1 protects against biological AGING in humans
- Restoring pharmacologic preconditioning in the AGING heart: role of mitophagy/autophagy
- Cognitive functions and neurotropic factors associated with AGING: A review
- Mitogen-activated protein kinases, Fus3 and Kss1, regulate chronological lifespan in yeast
- Emerging candidate treatment strategies for Hutchinson-Gilford progeria syndrome
- Protective effects of short-term dietary restriction in surgical stress and chemotherapy
- Commentary: The ageing as a therapeutic target for Alzheimer’s disease
- The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
- Mitophagy in neurodegeneration and AGING
- Modulation of the senescence-associated inflammatory phenotype in human fibroblasts by olive phenols
- Lifelong dietary intervention does not affect hematopoietic stem cell function
- Nutrient sensing pathways as therapeutic targets for healthy ageing
- Multi-protection of DL0410 in ameliorating cognitive defects in D-galactose induced AGING mice
- Neurobiology of sleep and microbiomics in AGING
- Mitochondria deliver a gut check to intestinal stem cells
- 6-bromo-indirubin-3′-oxime (6BIO), a Glycogen synthase kinase-3β inhibitor, activates cytoprotective cellular modules and suppresses cellular senescence …
- TERT promoter mutations in telomere biology
- Mechanisms underlying the essential role of mitochondrial membrane lipids in yeast chronological AGING
- Targeting chromatin AGING-The epigenetic impact of longevity-associated interventions
- FOXO transcriptional factors and long-term living
- Quantitative and systems pharmacology 3. Network-based identification of new targets for natural products enables potential uses in AGING-associated …
- Dietary protein, AGING and nutritional geometry
- The companion dog as a unique translational model for AGING
- Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and AGING
- The effects of AGING on platelet bioenergetics
- 3-year changes in physical activity and physical performance decline over 9 years of follow-up in older adults: The InCHIANTI study
- Role of pattern recognition receptors of the neurovascular unit in inflamm-AGING
- Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and AGING
- Back and forth in time: Directing age in iPSC-derived lineages
- The epigenetic landscape of age-related diseases: the geroscience perspective
- Rhodiola rosea L.: an herb with anti-stress, anti-AGING, and immunostimulating properties for cancer chemoprevention
- Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila
- Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro
- Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans
- Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the AGING brain
- The effect of polyphenols on protein degradation pathways: implications for neuroprotection
- Ochratoxin A induced premature senescence in human renal proximal tubular cells
- Transcriptional profiling reveals protective mechanisms in brains of long-lived mice
- Integrating frailty research into the medical specialties—report from a U13 conference
- AGING asymmetry: systematic survey of changes in age-related biomarkers in the annual fish Nothobranchius guentheri
- Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation
- Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity
- Glutaminolysis: a hallmark of cancer metabolism
- Knockout of vasohibin-1 gene in mice results in healthy longevity with reduced expression of insulin receptor, insulin receptor substrate 1, and insulin receptor …
- Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment
- Report: NIA workshop on measures of physiologic resiliencies in human AGING
- Muscle stem cells: a model system for adult stem cell biology
- What have we learned on AGING from omics studies?
- Baicalein Exerts Beneficial Effects in d-Galactose-Induced AGING Rats Through Attenuation of Inflammation and Metabolic Dysfunction
- Transcriptomic network analysis of brain AGING and alzheimers disease
- Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout
- Validation of minimally-invasive sample collection methods for measurement of telomere length
- Deletion of mitochondrial inorganic pyrophosphatase gene extends life span in haploid yeast (Saccharomyces cerevisiae)
- Rejuvenation of cardiac tissue developed from reprogrammed aged somatic cells
- Role of estrogen and other sex hormones in brain AGING. Neuroprotection and DNA repair
- AGING and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats
- The association between post-traumatic stress disorder and shorter telomere length: a systematic review and meta-analysis
- The role of cancer-associated fibroblasts and fibrosis in liver cancer
- AGING: Fewer Obstacles to DNA Replication?
- SIRT1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms
- Membrane damage by betulinic acid provides insights into cellular AGING
- Mitochondrial AGING: is there a mitochondrial clock?
- Sedentary behavior, physical activity and cardiorespiratory fitness on leukocyte telomere length
- Age-Related Dysfunction in Lung Barrier Function in Health and Disease: Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related …
- AGING and amyloid β oligomers enhance TLR4 expression, LPS-induced Ca 2+ responses, and neuron cell death in cultured rat hippocampal neurons
- Long noncoding RNAs and RNA-binding proteins in oxidative stress, cellular senescence, and age-related diseases
- Implantation of cryopreserved human placental fragments restores prooxidant-antioxidant balance in experimental animals of late ontogeny
- Bone microRNAs and ageing
- Novel insights into systemic autoimmune rheumatic diseases using shared molecular signatures and an integrative analysis
- From one syndrome to many: incorporating geriatric consultation into HIV care
- HDAC6 suppresses age-dependent ectopic fat accumulation by maintaining the proteostasis of PLIN2 in Drosophila
- Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular AGING to cell cycle regulation, maintenance of a quiescent state, entry …
- Comparative analysis of oxidative stress during AGING of Kluyveromyces marxianus in synthetic and whey media
- Extracellular RNA in AGING
- Uncoupling of metabolic health from longevity through genetic alteration of adipose tissue lipid-binding proteins
- Inflammation and cognition in older adults: evidence from Taiwan
- Oogenesis, vitellogenin-mediated ovarian degeneration and immune response in the annual fish Nothobranchius guentheri
- Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological AGING
- AGING and immortality in unicellular species
- Clock mediates liver senescence by controlling ER stress
- Mesenchymal stem cell-based cartilage regeneration approach and cell senescence: can we manipulate cell AGING and function?
- Techniques used for determination of Biological Age.
- Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice
- Intranasal cerebrolysin attenuates learning and memory impairments in D-galactose-induced senescence in mice
- Epigenetic AGING signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment
- Small heat shock proteins in ageing and age-related diseases
- Circulating markers of ageing and allostatic load: a slow train coming
- Ras signaling in AGING and metabolic regulation
- Mitochondrial dynamics: coupling mitochondrial fitness with healthy AGING
- Synergistic effect of rapamycin and metformin against age-dependent oxidative stress in rat erythrocytes
- SASP regulation by noncoding RNA
- Mitochondria in cell senescence: is mitophagy the weakest link?
- Comparison of intermittent fasting versus caloric restriction in obese subjects: A two year follow-up
- Telomere length in elite athletes
- Glucose transporter 1–dependent glycolysis is increased during AGING-related lung fibrosis, and phloretin inhibits lung fibrosis
- Antagonistic pleiotropy and mutation accumulation influence human senescence and disease
- Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular AGING
- Development and diabetes on the fly
- Reactive oxygen species as signaling molecules in the development of lung fibrosis
- Tocotrienol-Rich Fraction Supplementation Improves the Quality of Oocytes and Maintains Telomere Length in Ovaries from AGING Mice
- Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions
- Autophagy is pro-senescence when seen in close-up, but anti-senescence in long-shot
- Cellular regulation of amyloid formation in AGING and disease
- Regulation of stem cell AGING by SIRT1–Linking metabolic signaling to epigenetic modifications
- Endogenous stem cells in homeostasis and AGING
- Mental retirement and health selection: Analyses from the US Health and Retirement Study
- Can we rejuvenate? Implications of biological AGING research
- Time-dependent genetic effects on gene expression implicate AGING processes
- Saccharomyces cerevisiae as a Model to Confirm the Ability of FTIR to Evaluate the Presence of Protein Aggregates
- Promising links between meditation and reduced (brain) AGING: an attempt to bridge some gaps between the alleged fountain of youth and the youth of the …
- The association between Alu hypomethylation and severity of type 2 diabetes mellitus
- Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing
- Lymphangioleiomyomatosis: a monogenic model of malignancy
- FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres
- Drug-induced premature senescence model in human dental follicle stem cells
- Tat-mediated induction of miRs-34a &-138 promotes astrocytic activation via downregulation of SIRT1: implications for AGING in HAND
- Sleep apnea: a geriatric syndrome
- Polyunsaturated fatty acids ameliorate AGING via redox-telomere-antioncogene axis
- Purification and antioxidant activity of phycocyanin from Synechococcus sp. R42DM isolated from industrially polluted site
- P49/STRAP, a serum response factor binding protein (SRFBP1), is involved in the redistribution of cytoskeletal f-actin proteins during glucose deprivation
- Anti-AGING effect of riboflavin via endogenous antioxidant in fruit fly Drosophila melanogaster
- AGING modifies daily variation of antioxidant enzymes and oxidative status in the hippocampus
- Emerging molecular pathways governing dietary regulation of neural stem cells during AGING
- Current Perspective in the Discovery of Anti-AGING Agents from Natural Products
- The concept of ageing in evolutionary algorithms: discussion and inspirations for human ageing
- Mitochondrial gene polymorphism is associated with gut microbial communities in mice
- Biomarkers of chronic inflammation in disease development and prevention: challenges and opportunities
- Basic biology of oxidative stress and the cardiovascular system: part 1 of a 3-part series
- Investigating the Relationship Between DNA Damage and Hormesis in Saccharomyces cerevisiae Chronological AGING
- Apoptosis in the AGING liver
- Age-related changes in locomotor performance reveal a similar pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo …
- AGING as an epigenetic phenomenon
- The chromatin accessibility signature of human immune AGING stems from CD8+ T cells
- Immunoproteasomes control the homeostasis of medullary thymic epithelial cells by alleviating proteotoxic stress
- Proteomics and metabolomics in ageing research: from biomarkers to systems biology
- From rapalogs to anti-AGING formula
- Autophagy and microglia: novel partners in neurodegeneration and AGING
- Predicting age using neuroimAGING: innovative brain ageing biomarkers
- Nucleotide diversity inflation as a genome-wide response to experimental lifespan extension in Drosophila melanogaster
- Osteoarthritis: toward a comprehensive understanding of pathological mechanism
- Biomarkers of AGING: From Cellular Senescence to Age-Associated Diseases
- Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma
- Mitochondrial function and mitophagy in the elderly: effects of exercise
- Changing mutational and adaptive landscapes and the genesis of cancer
- Cryopreserved Placental Explants Increase Lifespan of Male Mice and Change Survival Features of Female Mice
- Gene therapy with the TRF 1 telomere gene rescues decreased TRF 1 levels with AGING and prolongs mouse health span
- Landscape of genome-wide age-related DNA methylation in breast tissue
- The fountain of youth by targeting senescent cells?
- Isolation and identification of senescent renal tubular epithelial cells using immunomagnetic beads based on DcR2
- AGING and the Krüppel-like factors
- Nucleosome remodelling, DNA repair and transcriptional regulation build negative feedback loops in cancer and cellular ageing
- Impact of age, caloric restriction, and influenza infection on mouse gut microbiome: an exploratory study of the role of age-related microbiome changes on …
- Peroxiredoxins in Redox Signaling and AGING
- Endocrinology of cancer and age: Early and late developmental stages
- Paradoxical AGING in HIV: immune senescence of B Cells is most prominent in young age
- Significance of miR-146a quantification in human blood plasma for the diagnosis of colorectal cancer
- Biological and clinical implications of telomere dysfunction in myeloid malignancies
- Mitochondrial stress restores the heat shock response and prevents proteostasis collapse during AGING
- Effects of resveratrol and other polyphenols on the most common brain age-related diseases
- Interstitial lung abnormalities and AGING
- Longevity is impacted by growth hormone action during early postnatal period
- Interleukin-6 affects AGING-related changes of the pparα-PGC-1α axis in the myocardium
- Cellular senescence is associated with human retinal microaneurysm formation during AGING
- Inflammatory long pentraxin 3 is associated with leukocyte telomere length in night-shift workers
- Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
- SuperAgers: do octogenarians with exceptional memory hold the key to healthy AGING?
- Old age causes de novo intracortical bone remodeling and porosity in mice
- Senescence-inflammatory regulation of reparative cellular reprogramming in AGING and cancer
- β-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares
- Sofie Degerman1, Maria Josefsson2, Annelie Nordin Adolfsson3, Sigrid Wennstedt1, Mattias Landfors1
- Topoisomerase IIβ and its role in different biological contexts
- Enhanced molecular AGING in late-life depression: the senescent-associated secretory phenotype
- Changing direction: From therapeutic telomerase inhibition to activation?
- NAD+ deficits in age-related diseases and cancer
- Metabolic roles of poly (ADP-ribose) polymerases
- Licorice extract attenuates brain AGING of d-galactose induced rats through inhibition of oxidative stress and attenuation of neuronal apoptosis
- High plasticity of new granule cells in the AGING hippocampus
- Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats
- Mitochondrial-targeted catalase: extended longevity and the roles in various disease models
- Evaluation of respiratory function in physically active elderly males in comparison to males having sedentary lifestyle
- Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
- The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age
- Dysfunction of the MDM2/p53 axis is linked to premature AGING
- Geriatric syndromes: new frontiers in HIV and sarcopenia
- P16 INK4a deletion ameliorated renal tubulointerstitial injury in a stress-induced premature senescence model of Bmi-1 deficiency
- Role of kallistatin treatment in AGING and cancer by modulating miR-34a and miR-21 expression
- Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE
- Nutrients in energy and one-carbon metabolism: learning from metformin users
- Exercise and bone health across the lifespan
- Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice
- TOR‐mediated regulation of metabolism in AGING
- Drug discovery strategies in the field of tumor energy metabolism: Limitations by metabolic flexibility and metabolic resistance to chemotherapy
- Critically short telomeres and toxicity of chemotherapy in early breast cancer
- Age-dependent obesity and mitochondrial dysfunction
- Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts
- Remodeling of the extracellular matrix in COPD. a process of accelerated lung ageing?
- Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs. Antioxidants and Redox Signaling, 29 (9), 864-879 …
- Molecular chaperones in neurodegenerative diseases: a short review
- Molecular mechanisms determining lifespan in short-and long-lived species
- Nutrition in early life and age-associated diseases
- Getting old through the blood: Circulating molecules in AGING and senescence of cardiovascular regenerative cells
- Regulation of metabolic health and AGING by nutrient-sensitive signaling pathways
- Clock-enhancing small molecules and potential applications in chronic diseases and AGING
- Effects of physical activity on the cerebral networks
- Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs
- Erratum to “Impact of yoga and meditation on cellular AGING in apparently healthy individuals: a prospective, open-label single-arm exploratory study”
- Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophy
- High sensitivity of human adipose stem cells to differentiate into myofibroblasts in the presence of C. aspersa egg extract
- Modern biotechnological approaches to lifespan extension of animals and humans
- Social isolation in the elderly; Physical Activity to the Rescue
- Cancer—incidence, prevalence and mortality in the oldest-old. A comprehensive review
- A reduction in DNA damage in neural tissue and peripheral blood of old mice treated with caffeine
- MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions
- Biosystems Study of the Molecular Networks Underlying Hippocampal AGING Progression and Anti-AGING Treatment in Mice
- Allogeneic mesenchymal stem cells ameliorate AGING frailty: a phase II randomized, double-blind, placebo-controlled clinical trial
- Biophysical and biomolecular determination of cellular age in humans
- Interventions to support healthy eating in later life
- Greater cortical thickness in elderly female yoga practitioners—a cross-sectional study
- Potential therapeutic effects of lipoic acid on memory deficits related to AGING and neurodegeneration
- Neuroprotective functions for the histone deacetylase SIRT6
- King’s Research Portal
- Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4
- How endothelial cells adapt their metabolism to form vessels in tumors
- miRNA-34b is directly involved in the AGING of macrophages
- Mitochondrial metabolism-mediated regulation of adult neurogenesis
- IRE1 signaling exacerbates Alzheimer’s disease pathogenesis
- Pachymic acid promotes induction of autophagy related to IGF-1 signaling pathway in WI-38 cells
- BAG2 interferes with CHIP-mediated ubiquitination of HSP72
- Autophagy in the presynaptic compartment in health and disease
- Pro-and antioxidant functions of the peroxisome-mitochondria connection and its impact on AGING and disease
- NutrimiRAGING: micromanAGING nutrient sensing pathways through nutrition to promote healthy AGING
- Cellular senescence in age-related macular degeneration: can autophagy and DNA damage response play a role?
- D-galactose-induced brain ageing model: a systematic review and meta-analysis on cognitive outcomes and oxidative stress indices
- Lung cancer in patients with idiopathic pulmonary fibrosis
- Disentangling the effect of dietary restriction on mitochondrial function using recombinant inbred mice
- Genome and epigenome editing in mechanistic studies of human AGING and AGING-related disease
- miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1
- Allogeneic human mesenchymal stem cell infusions for AGING frailty
- Parabiosis and AGING Researches
- Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time
- Unmasking transcriptional heterogeneity in senescent cells
- Human induced pluripotent stem cells illuminate pathways and novel treatment targets for age-related macular degeneration
- Assessment of the AGING of the brown adipose tissue by 18F-FDG PET/CT imAGING in the progeria mouse model LmnaG609G/G609G
- Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes
- Psychological Stress and Cellular AGING
- Herba Cistanches: anti-AGING
- Mechanisms of three-dimensional transcriptional regulation in cell senescence
- Yeast models of Parkinson’s disease-associated molecular pathologies
- Vitamin E supplementation reduces cellular loss in the brain of a premature AGING mouse model
- Calorie restriction effects on circadian rhythms in gene expression are sex dependent
- Calorie restriction in rodents: caveats to consider
- Cytochrome P450-2E1 is involved in AGING-related kidney damage in mice through increased nitroxidative stress
- Modulatory effects of Decalepis hamiltonii extract and its compounds on the antioxidant status of the AGING rat brain
- Pleiotropic responses to methionine restriction
- Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO
- CAN1 arginine permease deficiency extends yeast replicative lifespan via translational activation of stress response genes
- The genetics of human longevity: an intricacy of genes, environment, culture and microbiome
- Autophagy maintains the metabolism and function of young and old stem cells
- GPR56 as a Potential Regulator of Human Normal and Leukemic Stem Cells
- 2, 3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound
- Multiple roles for the MLL/COMPASS family in the epigenetic regulation of gene expression and in cancer
- Cryptomphalus aspersa mollusc egg extract promotes regenerative effects in human dermal papilla stem cells
- Effects of rapamycin on life span and on expression of TOR and S6K in Brachionus calyciflorus (Rotifera)
- DIZZINESS AND ITS ASSOCIATED FACTORS IN GERIATRIC POPULATION IMPACTING FUNCTIONAL AND PSYCHOLOGICAL STATUS
- Sirtuins and DNA damage repair: SIRT7 comes to play
- AGING and Vasoreactivity
- AGING and Dieting: an overview of dietary interventions and their role in lifespan and health span
- Nampt expression decreases age-related senescence in rat bone marrow mesenchymal stem cells by targeting Sirt1
- Epithelial autophagy and longevity of Hydra oligactis, a new model for AGING research
- On somatic constraints in the evolution of multicellularity
- Novel Metabolites that Modulate AGING and AGING-related Symptoms
- Cancer-related cognitive impairment in older adults
- Caloric restriction protects livers from ischemia/reperfusion damage by preventing Ca2+-induced mitochondrial permeability transition
- Age and gender alter synaptic proteins in zebrafish (Danio Rerio) models of normal and delayed AGING
- Physical activity and the effect of multimorbidity on all-cause mortality in older adults
- Multi-tissue DNA methylation age predictor in mouse
- Mitochondria, Cybrids, AGING, and Alzheimer’s disease
- The relationship of survivorship and body mass modeled by metabolic and vitality theories
- Epigenetic treatment of neurodegenerative ophthalmic disorders: an eye toward the future
- Oxidative status predicts quality in human mesenchymal stem cells
- A life-long approach to physical activity for brain health
- Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation
- Cancer epigenetics
- Mechanisms of oncogene-induced genomic instability
- Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort
- The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan
- Hormetic induction of antioxidant defenses for promotion of healthy AGING
- Age-associated molecular changes are deleterious and may modulate life span through diet
- AGING-associated dysbiosis increases susceptibility to enteric viral infection in Drosophila
- Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
- A progressive reduction in autophagic capacity contributes to induction of replicative senescence in Hs68 cells
- AGING results in a decline in cellular energy metabolism in the trophocytes and oenocytes of worker honeybees (Apis mellifera)
- Dictyostelium discoideum: A Model System to Study Autophagy Mediated Life Extension
- Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response
- Lung remodeling in AGING surfactant protein D deficient mice
- Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7
- What do we mean by older adult and physical activity? Reviewing the use of these terms in recent research
- From Sarcopenia to Frailty: the pathophysiological basis and potential target molecules of intervention
- Proteostatic and metabolic control of stemness
- Human health and AGING over an infinite time horizon
- Non-coding RNA molecules connect calorie restriction and lifespan
- Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans
- Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
- Formal models of biological systems
- A review of supervised machine learning applied to ageing research
- Distribution pattern following systemic mesenchymal stem cell injection depends on the age of the recipient and neuronal health
- Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults
- Assessing Health Span in Caenorhabditis elegans: Lessons From Short-Lived Mutants
- Dietary restriction and AMPK increase lifespan via mitochondrial network and peroxisome remodeling
- 3β-Hydroxy-urs-12-en-28-oic Acid Modulates Dietary Restriction Mediated Longevity and Ameliorates Toxic Protein Aggregation in C. elegans
- Successful and maladaptive T cell AGING
- Sleep variability among older adults with insomnia: associations with sleep quality and cardiometabolic disease risk
- Frailty in older adults
- Omics approaches for identifying physiological adaptations to genome instability in AGING
- Proteostasis of huntingtin in health and disease
- Pathogenesis of COPD 4–Cell Death, Senescence, and Autophagy: Is There a Possibility of Developing New Drugs from the Standpoint of This Pathogenetic …
- Estimating influenza vaccine effectiveness: evolution of methods to better understand effects of confounding in older adults
- Characterization and Modeling of Metabolic Stress Responses in Cellular AGING
- Vascular smooth muscle cells and arterial stiffening: relevance in development, AGING, and disease
- An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo
- Sex-specific lifespan and its evolution in nematodes
- Olive Oil polyphenols can be Useful to Prevent AGING-Associated Neurodegeneration
- Telomere-driven diseases and telomere-targeting therapies
- Parity history determines a systemic inflammatory response to spread of ovarian cancer in naturally aged mice
- Caloric Restriction, Sirtuins, and Ageing
- Analyzing tumor metabolism in vivo
- Anesthetic isoflurane induces DNA damage through oxidative stress and p53 pathway
- From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”
- Signaling and immune regulation in melanoma development and responses to therapy
- Anticancer effects of the microbiome and its products
- Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer’s disease
- Noncoding RNA in cancer
- Sarcopenic obesity, weight loss, and mortality: the English Longitudinal Study of Ageing
- The emerging role of Wnt signaling dysregulation in the understanding and modification of age-associated diseases
- Metabolic and Genetic Markers of Biological Age. Front. Genet. 8: 64. doi: 10.3389/fgene. 2017.00064 Metabolic and Genetic Markers of Biological Age S …
- Overcoming immune dysregulation with immunoengineered nanobiomaterials
- Proteostasis in cardiac health and disease
- Long-term calorie restriction in humans is not associated with indices of delayed immunologic AGING: a descriptive study
- Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte AGING
- Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers
- Non-Thermal Atmospheric Pressure Plasma Enhances Proliferation of Adipose Tissue-Derived Stem Cells via Nitric Oxide-Response Pathways
- Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy
- Expression profiling of mRNAs and long non-coding RNAs in aged mouse olfactory bulb
- Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
- Antioxidant defence, oxidative stress and oxidative damage in saliva, plasma and erythrocytes of dementia patients. Can salivary AGE be a marker of dementia?
- NMR studies reveal that protein dynamics critically mediate aggregation of the well-folded and very soluble E. coli S1 ribosomal protein
- Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity
- Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase
- Secrets from immortal worms: what can we learn about biological ageing from the planarian model system?
- Influence of resistance training in quality of life, body composition, and physical performance of community-dwelling elderly women
- Tissue-, sex-, and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin-like growth factor 2 imprinting control region
- Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans
- The role of mitochondria in the myocardium of senescent Meriones unguiculates
- The role of Nrf2 in cardiovascular function and disease
- The ubiquitin ligase CHIP integrates proteostasis and AGING by regulation of insulin receptor turnover
- Blood to Blood: A New Therapeutic Opportunity for Age-Related Diseases
- Nicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice
- Changes in the lethality of frailty over 30 years: evidence from two cohorts of 70-year-olds in Gothenburg Sweden
- LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis
- Age, gender and UV-exposition related effects on gene expression in in vivo aged short term cultivated human dermal fibroblasts
- Unfolded protein response of the endoplasmic reticulum in tumor progression and immunogenicity
- Sex matters: The effects of biological sex on adipose tissue biology and energy metabolism
- Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
- Jaws and Dental Panoramic Radiographic Findings in the Elderly in Kerman, Iran
- Evolutionary perspectives on ageing
- Determinants and regulation of protein turnover in yeast
- Perceived consequences of ageing with late effects of polio and strategies for manAGING daily life: a qualitative study
- SIRT6 overexpression improves various aspects of mouse healthspan
- Standardized Kaempferia parviflora extract inhibits intrinsic AGING process in human dermal fibroblasts and hairless mice by inhibiting cellular senescence …
- Cofactors as metabolic sensors driving cell adaptation in physiology and disease
- Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
- α-Synuclein pathology and mitochondrial dysfunction
- Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
- Plasticity of Antioxidant Defense Pathways in Response to AGING and Cadmium in Glutathione-Deficient Mice
- Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?
- High volume exercise training in older athletes influences inflammatory and redox responses to acute exercise
- The role of the nuclear envelope protein man1 in mesenchymal stem cell differentiation
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- Hypolipidimic Effects of Dried Tomato Pomace Powder on AGING Female Rats
- The fusogen AFF-1 can rejuvenate the regenerative potential of adult dendritic trees by self-fusion
- Myelinodegeneration and Its Influence on Pain: AGING, Diets, and Genetic Dysregulation
- Progressive changes in non-coding RNA profile in leucocytes with age
- Ubiquitin accumulation on disease associated protein aggregates is correlated with nuclear ubiquitin depletion, histone de-ubiquitination and impaired DNA …
- Comparison of cortisol and inflammatory response between aged and middle-aged patients undergoing total hip arthroplasty: a prospective observational …
- Long non-coding RNA: Functional agent for disease traits
- Risk factors for postoperative complications in elderly after colorectal cancer resection
- The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent
- Hepatostat: Liver regeneration and normal liver tissue maintenance
- Mitochondrial Longevity Pathways
- CONTRIBUTION OF VARIOUS FACTORS IN THE INVERSE RELATIONSHIP OF ALZHEIMER’S DISEASE AND CANCER
- The role of autophagy in AGING: molecular mechanisms
- AAMC. See Association of American Medical Colleges (AAMC) Ablation thermal MR–guided
- Stem Cell Applications in Rejuvenation
- The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic …
- Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles
- The relationship between reproductive and biochemical ageing at the time of the menopausal transition
- TORC1 inhibition as an immunotherapy to reduce infections in the elderly
- microRNA in cardiovascular AGING and age-related cardiovascular diseases
- Nervous system ageing
- The ageing brain: effects on DNA repair and DNA methylation in mice
- Nutrition and Healthy AGING
- Evaluating aged mice in three touchscreen tests that differ in visual demands: Impaired cognitive function and impaired visual abilities
- Characterization of epigenetic and transcriptional changes in AGING and Alzheimer’s disease
- Proliferation cycle causes age dependent mitochondrial deficiencies and contributes to the AGING of stem cells
- Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing
- Idiopathic pulmonary fibrosis
- Supply and demand of energy in the oocyte and the role of mitochondria
- Current advances and limitations in modeling ALS/FTD in a dish using induced pluripotent stem cells
- How to get the most bang for your buck: the evolution and physiology of nutrition-dependent resource allocation strategies
- The AGING immune system and nutritional interventions
- Proteostasis and AGING in Saccharomyces cerevisiae-The role of a Peroxiredoxin
- Cellular Senescence and Stem Cell Niche
- Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity
- Membrane Lipid Replacement for chronic illnesses, AGING and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore …
- Adequate Protein in Nutrition: Arguments for More or Less?
- Chemical modification of bacterial cellulose for use in regenerative medicine
- AGING and autophagy in hematopoietic stem cells
- Shining the light on senescence associated LncRNAs
- Caloric restriction extends yeast chronological life span by optimizing the Snf1 (AMPK) signaling pathway
- In vivo Mitophagy Monitoring in Caenorhabditis elegans to Determine Mitochondrial Homeostasis
- Life history traits of an extended longevity phenotype of Drosophila melanogaster
- Regulation and Consequences of Retrotransposition During Quiescence in Budding Yeast
- Lack of association between pbmc telomere length and endurance exercise
- Perspective: neuroregenerative nutrition
- Preparation of plasma membrane vesicles from bone marrow mesenchymal stem cells for potential cytoplasm replacement therapy
- Longevity, AGING and DNA damage: investigation of the role of 53BP1 in the maintenance of genomic stability
- Overcoming on-target resistance to tyrosine kinase inhibitors in lung cancer
- Caloric-restriction induced alterations in CG and non-CG methylation attenuate age-associated changes in the old brain
- Polymorphonuclear neutrophil functions are differentially altered in amnestic mild cognitive impairment and mild alzheimer’s disease patients
- Caloric-restriction mitigates age-associated alteration in CG and non-CG methylation in the old brain
- The role of p16INK4a pathway in human epidermal stem cell self-renewal, AGING and cancer
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone …
- Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment
- Augmenting brain metabolism to increase macro-and chaperone-mediated autophagy for decreasing neuronal proteotoxicity and AGING
- Differing expression of cytokines and tumor markers in combined pulmonary fibrosis and emphysema compared to emphysema and pulmonary fibrosis
- Differential decrease in soluble and DNA-bound telomerase in senescent human fibroblasts
- Exploring a role for regulatory miRNAs in wound healing during ageing: involvement of miR-200c in wound repair
- YuZhenLinusPaulingInstitGeneExpressionLiver. pdf
- Doubling the human lifespan
- Effectiveness of nutritional and exercise interventions to improve body composition and muscle strength or function in sarcopenic obese older adults: A systematic …
- Unraveling the link between the Mdm2-p53 axis and AGING
- Doubling the human lifespan: An interdisciplinary approach to longevity extension
- DNA damage in protective and adverse inflammatory responses: Friend of foe?
- Studies on the delaying effect of caloric restriction on the carcinogenic process.
- Mitochondrial Base Excision Repair
- A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling
- Translational Research in Acute Lung Injury and Pulmonary Fibrosis: Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung …
- Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells
- Resveratrol attenuates copper-induced senescence by improving cellular proteostasis
- Gender differences in functional disability and self-care among seniors in Bangladesh
- Lamins and metabolism
- The role of the immune system in metabolic health and disease
- Promotive effect of Polygonum multiflorum radix ethanol extract on melanogenesis
- Isolation and prolonged expansion of oral mesenchymal stem cells under clinical-grade, GMP-compliant conditions differentially affects “stemness” properties
- Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis
- Autophagy, its mechanisms and regulation: implications in neurodegenerative diseases
- Assessing Mitochondrial Selective Autophagy in the Nematode Caenorhabditis elegans
- Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin‐1 production
- Circadian Control of Mitochondrial Dynamics and Its Implication in AGING
- Neurodegeneration enhances the development of arthritis
- The use of urinary proteomics in the assessment of suitability of mouse models for ageing
- Inhibitors of DNA methylation support TGF-β1-induced IL11 expression in gingival fibroblasts
- Role of dietary pattern and obesity on telomere homeostasis
- The Role of p16 in Controlling Mammary Epithelial Cell Senescence and Brca1-Deficient Tumorigenesis
- Basic science and pathogenesis of ageing with HIV: potential mechanisms and biomarkers
- Phenomic and Metabolomic Analysis of Chronological AGING in Saccharomyces cerevisiae
- GSK3beta at the intersection of growth, metabolism and longevity
- The co-expression pattern of p63 and HDAC1: a potential way to disclose stem cells in interfollicular epidermis
- Implications of DNA methylation in Parkinson’s disease
- Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B
- Physiological and pathological functions of mitochondrial proteases
- Cytosolic proteostasis through importing of misfolded proteins into mitochondria
- Investigating the Role of Glycogen Accumulation in Neurodegeneration and Brain AGING
- RAP80 binds p32 to preserve the functional integrity of mitochondria
- Prospective Epigenetic Paradigms and Models for Cellular Senescence and Epithelial–Mesenchymal Transition in Organismal Development and AGING
- Is Senescence Important in Hepatic Diseases?
- Parity history determines a systemic inflammatory response to spread of ovarian cancer in naturally aged mice
- Food supplementation with rice bran enzymatic extract prevents vascular apoptosis and atherogenesis in ApoE−/− mice
- The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical
- Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity
- Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens
- Quantitative proteomics analysis of Caenorhabditis elegans upon germ cell loss
- Rescuing Age-related Proteolysis Deficits with Methylene Blue
- Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease
- Autophagy in the vertebrate inner ear
- Doubling healthy lifespan using drug synergy
- Parkinson’s disease: from pathogenesis to pharmacogenomics
- Metabolic effects of fasting on human and mouse blood in vivo
- Mild hypothermia attenuates the anesthetic isoflurane-induced cytotoxicity
- A homeostatic shift facilitates endoplasmic reticulum proteostasis through transcriptional integration of proteostatic stress response pathways
- The Tryptophan Metabolite Kynurenic Acid is a Neuromodulator Mediating Learning, Brain AGING, and Neurodegeneration
- In vitro studies to evaluate the effect of varying culture conditions and IPL fluencies on tenocyte activities
- Molecular Mechanisms Regulating the Interactions of Senescent Cells with the Immune System
- Lung homeostasis: influence of age, microbes, and the immune system
- Mouse models of central nervous system ageing
- Why we age–a new evolutionary view
- Identification of bladder cancer prognostic biomarkers using an ageing gene-related competitive endogenous RNA network
- Longevity Promotion: Multidisciplinary Perspectives
- Doubling healthy lifespan using drug synergy
- The Effect of Age on Social Behaviour In Drosophila Melanogaster and the Progeny of Aged Parents
- PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
- Nup100 regulates Saccharomyces cerevisiae replicative life span by mediating the nuclear export of specific tRNAs
- Health and Ageing in Older Adults: A gender-specific and life-course perspective
- Development of an LC-MS/MS method for the analysis of Saccharomyces cerevisiae lipidome to determine the mechanism through which plant extract 21 delays …
- Neuromodulation as a cognitive enhancement strategy in healthy older adults: promises and pitfalls
- Brain rules for AGING well: 10 principles for staying vital, happy, and sharp
- Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction
- Circulating levels of soluble Receptor for Advanced Glycation End-products (sRAGE) decrease with AGING and may predict age-related cardiac remodeling
- Treatment of skin AGING and photoAGING with innovative oral dosage forms of nonhydrolized carnosine and carcinine
- Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?
- Oleic acid and hydroxytyrosol inhibit cholesterol and fatty acid synthesis in C6 glioma cells
- Caloric restriction promotes structural and metabolic changes in the skin
- AGING and the Plasma Metabolome: Relation to Physiological Function
- Systematic analysis of mitochondrial-auntophagy activity in yeast chronological-life span genetic factors= Análisis sistemático de la autofagia mitocondrial en …
- Studies investigating the distinct effects of estradiol deficiency and AGING on the redox system of skeletal muscle as it relates to strength and power
- Developing Circadian Therapeutics Against Age-Related Metabolic Decline
- ZRF 1 is a novel S6 kinase substrate that drives the senescence programme
- The indirubin derivative 6-bromoindirubin-3′-oxime activates proteostatic modules, reprograms cellular bioenergetic pathways, and exerts antiAGING effects
- Nicotinamide ameliorates disease phenotypes in a human iPSC model of age-related macular degeneration
- Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic …
- Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation
- Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions
- Analysis of phenotype reversibility in Hutchinson-Gilford progeria syndrome in mice
- A circulating microRNA signature predicts age-based development of lymphoma
- Interrelations between mitochondrial DNA copy number and inflammation in older adults
- Species comparison of liver proteomes reveals enhanced lipid metabolism, reduced mitochondrial respiration and enhanced expression of detoxifying …
- Jihad AM Alzyoud, Ilyas M. Khan &
- A novel method to quantify base substitution mutations at the 10− 6 per bp level in DNA samples
- Normalisation against Circadian and Age-Related Disturbances Enables Robust Detection of Gene Expression Changes in Liver of Aged Mice
- Bioactive growth hormone in older men and women: It’s relationship to immune markers and healthspan
- Subtle Changes in Clonal Dynamics Underlie the Age-Related Decline in Neurogenesis
- Charting the dynamic methylome across the human lifespan
- A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance
- Alterations in Autophagy and Senescence in the Pathologically Aged Uraemic Heart
- Circadian rhythms and proteostasis in AGING
- Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity
- An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
- YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
- THE ENACTMENT OF ADVANCED STYLE
- Subclinical atherosclerosis, cardiac and kidney function, heart failure, and dementia in the very elderly
- A class of reactive acyl-CoA species reveals the non-enzymatic origins of protein acylation
- Approaches for extending human healthspan: from antioxidants to healthspan pharmacology
- Longitudinal Studies of Caenorhabditis Elegans AGING and Behavior Using a Microfabricated Multi-Well Device
- Boosting ATM Activity Promotes Longevity in Nematodes and Mice
- Regulation and Repair of Neural Stem Cells and the Neurogenic Niche
- Aspirin inhibits LPS-induced macrophage activation via the NF-κB pathway
- Endpoint or kinetic measurement of hydrogen sulfide production capacity in tissue extracts
- The Role of microRNAs in Drosophila Circadian Rhythms and AGING and Genome-wide Identification of Activity-regulated Genes
- Physiological Changes of Senescent Endothelial cells and their Contribution to AGING Phenotype
- Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long‐term intermittent hypoxia
- Protein carbonylation: Principles, analysis, and biological implications
- Substrate selection and its impact on mitochondrial respiration and redox
- Genetic variation in glia–neuron signalling modulates ageing rate
- The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance
- MicroRNA perturbation of the MRN complex buffers DNA damage response from VEGF signaling
- Postmenopausal osteoporosis in rheumatoid arthritis: the estrogen deficiency-immune mechanisms link
- Hormones in clock regulation during ageing
- Extending lifespan through autophagy stimulation: A future perspective
- The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite
- Mutational analysis of fructose-1, 6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress
- Reduced cancer mortality at high altitude: The role of glucose, lipids, iron and physical activity
- HIV/AIDS: oxidative stress and dietary antioxidants
- Human SLE bone marrow mesenchymal stem cells (BMSCs) have a senescence-associated secretory phenotype (SASP) mediated by a MAVS-IFNβ …
- Alterations in Energy Metabolism and Neurodegeneration as a Consequence of DNA Damage
- Similarities and interactions between the ageing process and high chronic intake of added sugars
- Genetic and lifestyle influences on memory, brain structure, and dementia
- The crosstalk between the gut microbiota and mitochondria during exercise
- ANALYSIS OF NEURONAL DIFFERENTIATION IN GENETIC FORMS OF PARKINSON’S DISEASE REVEALS A NEURODEVELOPMENTAL CONTRIBUTION
- Diet-Dependent Balance Between Autophagy and Proliferation Regulates Follicle Stem Cell Lifetime
- Synthetic mRNA devices that detect endogenous proteins and distinguish mammalian cells
- Docking studies and biological evaluation of a potential β-secretase inhibitor of 3-hydroxyhericenone F from Hericium erinaceus
- PARTIAL INHIBITION OF MITOCHONDRIAL COMPLEX I ACTIVATES STRESS RESPONSE PATHWAYS INDUCING A PROTECTION AGAINST OXIDATIVE STRESS
- Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7 …
- Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
- Exosomes regulate microglia activation during inflammation and AGING
- Nutrition and Inflammation: are centenarians calorie-restricted like individuals?
- The role of autophagy in AGING-related Osteoarthritis
- The role of autophagy in AGING-related osteoarthritis
- Role of Histone Methyltransferase SET-4 in Developmental Plasticity and Longevity
- REGULATION OF LIFE SPAN BY THE GUT MICROBIOTA IN THE SHORT-LIVED AFRICAN 1 TURQUOISE KILLIFISH 2
- TP53 Modulates Oxidative Stress in Gata1+ Erythroid Cells
- Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy
- Connexin-dependent intercellular stress signaling in tissue homeostasis and tumor development
- A biochemical assessment of Ochratoxin A stress responses in vitro, with resveratrol as a possible therapeutic intervention.
- LINE-1 repression attenuates degeneration in adult dopaminergic neurons
- The Lucky Years: How to Thrive in the Brave New World of Health
- Validation of Rat Mesentery Culture Model for Time-Lapse Drug Evaluation and Cell Lineage Studies
- Natural genetic variation in C. elegans reveals genomic loci controlling metabolite levels
- Identification of Neuropeptide Y receptors in human articular cartilage: influence of gender and osteoarthritis
- Curriculum Vitae-Pinchas Cohen
- Role of Extracellular Matrix Crosslinking Enzyme Tissue Transglutaminase in Trabecular Meshwork Homeostasis and Regulating Intraocular Pressure
- Alterations in the molecular properties of neural stem cells from aged brains and brain tumors
- The Role of Parkin in Maintaining Proteasome Activity Following Acute Neurotoxic Insult
- Nonparametric Methods for Functional Genomics and Applications to Immune AGING
- Molecular regulation of hair follicle stem and progenitor cell homeostasis
- Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity
- Physical Exercise as an Effective AntiAGING Intervention
- A genetic tool to track protein aggregates and control prion inheritance
- Physical exercise and DNA injury: good or evil?
- Dairy protein, exercise and inflammatory markers in older adults
- Outcome of Emergency Gastrointestinal Procedures in the Elderly
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- The Role of Sigma-1 Receptors in an Alzheimer’s Disease Mouse Model
- A non-genetic meiotic repair program inferred from spore survival values in fission yeast wild isolates: a clue for an epigenetic ratchet-like model of ageing?
- Idiopathic Pulmonary Fibrosis
- Overview of autophagy
- Brand positioning in the pharmaceutical industry: content analysis applied to antiAGING drugs
- Physical and functional interactions of the tumor suppressor protein p53 with poly (ADP-ribose) polymerase-1 and its enzymatic product poly (ADP-ribose)
- The Role of Nucleoid Exclusion in the Intracellular Spatial Organization of Escherichia coli
- The relationship between moderate physical activities and sleep quality and quantity among persons with dementia
- 4D analysis of facial ageing using dynamic features
- Inhibition of soluble adenylyl cyclase (SAC) causes a robust increase in glycolysis in cultured astrocytes
- Mechanisms by which nuclear A-type lamins are downregulated in neuroblastoma.
- Optical control of muscarinic acetylcholine receptors using photoswitchable bitopic ligands
- Multimodality ImAGING of Cardiovascular Dysfunction: risk factors, diagnostics and treatment options
- Augmented cerebral mitochondrial function and hippocampal ketone body metabolism in Db/db mice
- Compartmentalised signalling-metabolism coupling in brain cells-putative drug targets for neurological diseases?
- Molecular characterization of the hypoxia-induced mitochondrial activity regulator Ndufa4l2
- MTU01-02
- Macrophages in M1/M2 states and exposed to amyloid-beta: a RNA-seq analysis in human cells
- Biomechanical analyses of ventricular and vascular function in disease models
- Telomerase regulation by non-coding RNAs
- Understanding the Chondrogenic Potential of Articular Chondrocytes
- The Effects of Diet, Body Composition and Exercise on The Serum Metabolome in Health and Disease
- Advancements in forensic DNA-based identification
- Delineating Transcriptional and Epigenetic Regulations in Normal and Ageing Spermatogonial Stem Cells
- DVR-Kongress
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- Abstracts from The 35th Annual National Neurotrauma Symposium July 7–12, 2017 Snowbird, Utah
- The Relationship Between Amount of Physical Activity and Postural Balance in Rural Community Dwelling Adults Age 65 Years and Older
- Darwin: A hardware-acceleration framework for genomic sequence alignment
- Preoperative Evaluation
- Prediction and prevention of suicidality among patients with depressive disorders: comorbidity as a risk factor
- Personalized approach in the treatment of tinnitus and insomnia: combining repetitive transcranial magnetic stimulation and cognitive behavioral therapy
- Evolution of the non-coding genome
- Nephrin-marker for early detection of hypertensive nephropathy
- Degradation of skin elastin in ageing and disease-an ex vivo quantitative proteomic approach
- Predicting cardiovascular risk in diabetic patients: arewe all on the same side?
- Homocysteine: risk factor for coronary artery disease in patients with type 2 diabetes mellitus
- EPMA world congress: traditional forum in predictive, preventive and personalised medicine for multi-professional consideration and consolidation
- PKA phosphorylation of ATAXIN1 in Purkinje cells modulates early onset of ataxia
- A genetic platform for the study of protein perturbation and prion-based inheritance
- The role of selective autophagy on tau clearance
- Mouse models to disentangle the hallmarks of human AGING
- Chronic obstructive pulmonary disease and the hallmarks of AGING
- Hallmarks of cellular senescence
- Hallmarks of brain AGING: adaptive and pathological modification by metabolic states
- Gene expression hallmarks of cellular ageing
- Time and the metrics of AGING
- Therapeutic potential of boosting NAD+ in AGING and age-related diseases
- EVALUATING BIOLOGICAL HALLMARKS OF AGING IN A CLINICAL TRIAL ON AGING: OBSTACLES BETWEEN BENCH AND BEDSIDE
- AGING and the immune system: An overview
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- On the relationship between AGING & cancer
- AGING epigenetics: changes and challenges
- Effect of resveratrol and pterostilbene on AGING and longevity
- Effects of exercise and AGING on skeletal muscle
- Of microbes and minds: a narrative review on the second brain AGING
- as a model for AGING research
- Sex and AGING
- Translational Medicine of AGING
- Molecular basis and emerging strategies for anti-AGING interventions
- AGING hallmarks: the benefits of physical exercise
- Keynote lecture: strategies for optimal cardiovascular AGING
- Genomic instabilities, cellular senescence, and AGING: in vitro, in vivo and AGING-like human syndromes
- Resveratrol and/or exercise training counteract AGING-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function
- AGING, inflammation and the environment
- Metabolic control of AGING in C. elegans
- Potential mechanisms of age acceleration caused by estrogen deprivation: do endocrine therapies carry the same risks?
- Lung cellular senescence is independent of AGING in a mouse model of COPD/emphysema
- Biomedical Research in AGING
- EVIDENCE THAT EPIGENETIC ALTERATIONS DRIVE MAMMALIAN AGING
- Population Epigenomics and AGING
- Circulating mitochondrial DNA at the crossroads of mitochondrial dysfunction and inflammation during AGING and muscle wasting disorders
- The spectrum of fundamental basic science discoveries contributing to organismal AGING
- Modifying progression of AGING and reducing the risk of neurodegenerative diseases by probiotics and synbiotics
- Pathways of cellular proteostasis in AGING and disease
- Oral health in geroscience: animal models and the AGING oral cavity
- Geroscience
- AGING in the cardiovascular system: lessons from Hutchinson-Gilford progeria syndrome
- The tame trial: a prototype for geroscience-guided therapeutics
- Senolytic drugs in respiratory medicine: is it an appropriate therapeutic approach?
- Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study
- Novel anti-AGING gene NM_026333 contributes to proton-induced AGING via NCX1-pathway
- Targeting AGING for disease modification in osteoarthritis
- Sarcopenia and AGING
- Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype
- Inhibition of mTOR Signalling: A Potential Anti-AGING Drug Strategy
- Introduction to Cardiovascular AGING Compendium: “AGING as the Quintessential Complex Phenotype”
- Targeting senescence to delay progression of multiple sclerosis
- Therapeutic manipulation of cancer cell metabolism with the mitochondrial metabolism inhibitor Cpi-613 in addition to chemotherapy abrogates the adverse …
- At the crossroads between neurodegeneration and cancer: a review of overlapping biology and its implications
- Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint …
- New phytochemicals as potential human anti-AGING compounds: Reality, promise, and challenges
- mTOR as regulator of lifespan, AGING, and cellular senescence: a mini-review
- The dysfunctional MDM2–p53 axis in adipocytes contributes to AGING-related metabolic complications by induction of lipodystrophy
- AGING and proteins: what does proteostasis have to do with age?
- Sir-2.1 mediated attenuation of α-synuclein expression by Alaskan bog blueberry polyphenols in a transgenic model of Caenorhabditis elegans
- Horizons in the evolution of AGING
- Fibrosis: lessons from OMICS analyses of the human lung
- A review on anti-AGING properties of probiotics
- Senescence and AGING: Causes, consequences, and therapeutic avenues
- The Basics of Biogerontology
- Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an AGING populace
- The paths of mortality: how understanding the biology of AGING can help explain systems behavior of single cells
- A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
- An international perspective on chronic multimorbidity: approaching the elephant in the room
- A distinct pattern of circulating amino acids characterizes older persons with physical frailty and sarcopenia: results from the BIOSPHERE study
- Elixir of life: thwarting AGING with regenerative reprogramming
- A call to action in hematologic disorders: A report from the ASH scientific workshop on hematology and AGING
- A network-based meta-analysis for characterizing the genetic landscape of human AGING
- Development of clinical trials to extend healthy lifespan
- Angiogenesis: focusing on the effects of exercise in AGING and cancer
- Lithium treatment and mechanisms of AGING
- The geometric framework: An approach for studying the impact of nutrition on healthy AGING
- Insulin signaling regulates oocyte quality maintenance with age via cathepsin B activity
- Cross-organelle communication at the core of longevity
- AGING across the tree of life: The importance of a comparative perspective for the use of animal models in AGING
- Histone modification changes during AGING: cause or consequence?—What we have learned about epigenetic regulation of AGING from model organisms
- A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of AGING yeast
- The yeast replicative AGING model
- Ayurveda and the science of AGING
- A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence
- G protein-coupled receptor systems as crucial regulators of DNA damage response processes
- Unveiling epigenetic regulation in cancer, AGING, and rejuvenation with in vivo reprogramming technology
- AGING With HIV and Oxidative Stress
- Towards a biological geriatric assessment
- Relevance of the p53–MDM2 axis to AGING
- Molecular and cellular mechanisms of AGING and age-related disorders
- Histone modifications in AGING: the underlying mechanisms and implications
- Role of endogenous glucocorticoids in cancer in the elderly
- Connecting chaperone-mediated autophagy dysfunction to cellular senescence
- Enhanced expression of thioredoxin‐interacting‐protein regulates oxidative DNA damage and AGING
- Interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells
- The impact of AGING on mechanisms of mammalian epimorphic regeneration
- The mitochondria in lung fibrosis: friend or foe?
- The African turquoise killifish Nothobranchius furzeri as a model for AGING research
- New mechanisms driving muscle stem cell regenerative decline with AGING
- AGING, inflammation and cancer
- Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer’s disease
- Immunosenescence and lymphomagenesis
- Age reprogramming and epigenetic rejuvenation
- Neuropathology and cognitive performance in self-reported cognitively healthy centenarians
- AGING related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury
- Caloric restriction research: new perspectives on the biology of AGING
- Hacking AGING: a strategy to use big data from medical studies to extend human life
- Pioglitazone attenuates AGING-related disorders in aged apolipoprotein E deficient mice
- Animal Models of Pathological AGING
- Nucleolar function in lifespan regulation
- Age is relative—Impact of donor age on induced pluripotent stem cell-derived cell functionality
- Transcriptome network analysis reveals AGING-related mitochondrial and proteasomal dysfunction and immune activation in human thyroid
- The nematode Caenorhabditis elegans as a model for AGING research
- Epigenetic regulation of skin cells in natural AGING and premature AGING diseases
- Longevity Escape Velocity Medicine: A New Medical Specialty for Longevity?
- The integration of inflammAGING in age-related diseases
- Opportunities for organoids as new models of AGING
- AGING in a relativistic biological space-time
- Fifteen years of progress in understanding frailty and health in AGING
- Caloric restriction and cellular senescence
- Can an infection hypothesis explain the beta amyloid hypothesis of Alzheimer’s disease?
- Molecular mechanisms regulating lifespan and environmental stress responses
- Glycomic and proteomic changes in AGING brain nigrostriatal pathway
- Caenorhabditis elegans as a model organism for AGING: relevance, limitations and future
- Effects of resveratrol and other polyphenols on Sirt1: relevance to brain function during AGING
- Towards success against senescence?
- Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, provoke propagated neuronal death
- Biological processes modulating longevity across primates: a phylogenetic genome-phenome analysis
- The quest for osteoporosis mechanisms and rational therapies: how far we’ve come, how much further we need to go
- Theories and mechanisms of AGING
- Environmental enrichment improves cognitive deficits, AD hallmarks and epigenetic alterations presented in 5xFAD mouse model
- Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis
- Recent insights into the cellular and molecular determinants of AGING
- Sex differences in AGING: genomic instability
- Euchromatic histone methyltransferases regulate peripheral heterochromatin tethering via histone and non-histone protein methylations
- When nature’s robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human AGING disease pathologies
- DICER1: A key player in rheumatoid arthritis, at the crossroads of cellular stress, innate immunity, and chronic inflammation in AGING
- Forward and reverse genetics approaches to uncover metabolic AGING pathways in Caenorhabditis elegans
- AGING of hematopoietic stem cells
- Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update
- A distinct pattern of circulating amino acids characterizes older persons with physical frailty and Sarcopenia: Preliminary results from the BIOSPHERE Study
- Machine learning on human muscle transcriptomic data for biomarker discovery and tissue-specific drug target identification
- Fuchs endothelial corneal dystrophy through the prism of oxidative stress
- VU Research Portal
- Brain AGING: Hsp90 and neurodegenerative diseases
- Higher gene expression stability during AGING in long-lived giant mole-rats than in short-lived rats
- Biological Determinants of Men’s Health and AGING
- The role of mitochondrial ROS in the AGING brain
- Telomere homeostasis: interplay with magnesium
- Human Muscle Stem Cells and the Effect of AGING
- Immune-inflammatory responses in the elderly: an update
- Mitochondrial quality control mechanisms as molecular targets in cardiac ageing
- Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease
- Mitochondria, its DNA and telomeres in ageing and human population
- A futile battle? Protein quality control and the stress of AGING
- Invertebrates as model organisms for research on AGING biology
- Facing up to the global challenges of ageing
- Walnut consumption for two years and leukocyte telomere attrition in Mediterranean elders: results of a randomized controlled trial
- Barshop Symposium on AGING 2017 Abstracts
- Olive oil and skin anti-AGING.
- The Effect of AGING-Like Stressors on AGING Related Candidate Genes in Mice
- Computational approaches for the systematic analysis of AGING-associated molecular alterations
- Autophagy and proteostasis in the control of synapse AGING and disease
- The reality of getting old
- Hydra, a model system for deciphering the mechanisms of AGING and resistance to AGING
- Recent advances in the systems biology of AGING
- Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults
- Heart-breaking telomeres
- Intracellular and intercellular signalling mechanisms following DNA damage are modulated by PINK1
- The guardian of the genome revisited: p53 downregulates genes required for telomere maintenance, DNA repair, and centromere structure
- Lineage plasticity in cancer progression and treatment
- Restoring effects of natural anti-oxidant quercetin on cellular senescent human dermal fibroblasts
- AGING and drug discovery
- Intestinal snakeskin limits microbial dysbiosis during AGING and promotes longevity
- Asthma in the elderly and late‐onset adult asthma
- PIWI-piRNA pathway: Setting the pace of AGING by reducing DNA damage
- Understanding epigenetics in the neurodegeneration of Alzheimer’s disease: SAMP8 mouse model
- Human neurons to model AGING: a dish best served old
- Epigenetic erosion in adult stem cells: drivers and passengers of AGING
- An analysis of AGING-related genes derived from the genotype-tissue expression project (GTEx)
- Oxidative stress and AGING: learning from yeast lessons
- Stem cells and anti-AGING genes: double-edged sword—do the same job of life extension
- AGING and neurodegeneration are associated with increased mutations in single human neurons
- miRACA: A database for miRNAs associated with cancers and age related disorders (ARD)
- Physical activity: Evidence for the Anti-ageing effects in elderly
- Accelerated AGING in schizophrenia and related disorders: Future research
- Age-and sex-dependent changes in levels of circulating brain-enriched microRNAs during normal AGING
- Telomeres, nutrition, and longevity: can we really navigate our AGING?
- Novel role of the SIRT4-OPA1 axis in mitochondrial quality control
- Pharmaceutical intervention of AGING
- Protease Silencing to Explore the Molecular Mechanisms of Cancer and AGING
- The role of Na/K-ATPase signaling in oxidative stress related to AGING: implications in obesity and cardiovascular disease
- A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer’s disease
- AGING: Antagonistic pleiotropy supported by gut eating
- non-coding RNAs: entwining metabolism and AGING
- Autophagy in cardiovascular AGING
- Sirtuins and accelerated AGING in scleroderma
- The synergy of AGING and LPS exposure in a mouse model of Parkinson’s disease
- Some metabolites act as second messengers in yeast chronological AGING
- CDK4, a new metabolic sensor that antagonizes AMPK
- A polymorphism in the tumor suppressor p53 affects AGING and longevity in mouse models
- Healthy AGING and Epigenetic Drugs for Diabetes and Obesity: A Novel Perspective
- Somatic mutations in neurons during AGING and neurodegeneration
- Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of AGING in …
- Physical activity and nutrition: two promising strategies for telomere maintenance?
- Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of AGING?
- General Introduction AGING of Hematopoietic Stem cells
- Epigenetics and AGING research: Between adult malleability and early life programming
- Hsp90 inhibitors as senolytic drugs to extend healthy AGING
- Age-related dataset on the mechanical properties and collagen fibril structure of tendons from a murine model
- Neuropathology and cognitive performance in centenarians
- Biomarkers of cellular senescence and skin AGING
- Single-cell chromatin modification profiling reveals increased epigenetic variations with AGING
- In vivo X-nuclear MRS imAGING methods for quantitative assessment of neuroenergetic biomarkers in studying brain function and AGING
- Tetrahydroxystilbene glucoside delayed senile symptoms in old mice via regulation of the AMPK/SIRT1/PGC-1α signaling cascade
- Epigenetic regulation of cell fate reprogramming in AGING and disease: A predictive computational model
- Impact of age on disease progression and microenvironment in oral cancer
- The role of advanced glycation end products in AGING and metabolic diseases: bridging association and causality
- Behead and live long or the tale of cathepsin L
- Myotonic Dystrophy—A Progeroid Disease?
- Novel targets for delaying AGING: the importance of the liver and advances in drug delivery
- Identifying ubiquitinated proteins and aggregates
- DISCOVERY OF A NOVEL CIRCULATING PEPTIDOME IN HUMAN SERUM THAT CORRELATES WITH AGING
- Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism
- The epigenetic regulation of telomere maintenance in AGING
- Designing drug trials for frailty: ICFSR Task Force 2018
- With great age comes great metastatic ability: ovarian cancer and the appeal of the AGING peritoneal microenvironment
- Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological AGING: do they measure the same thing?
- Higher transcriptome stability during AGING in long-lived giant mole-rats compared to short-lived rats
- Apelin/APJ system: A novel promising target for anti-AGING intervention
- A cell-intrinsic interferon-like response links replication stress to cellular AGING caused by progerin
- AMP-activated protein kinase regulation of the NLRP3 inflammasome during AGING
- Spermidine in health and disease
- ATF6 safeguards organelle homeostasis and cellular AGING in human mesenchymal stem cells
- A time to fast
- Human AGING and disease: lessons from age-related macular degeneration
- Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in AGING male mice
- Single-cell transcriptomics of the aged mouse brain reveals convergent, divergent and unique AGING signatures
- Glucocorticoid‐mediated modulation of morphological changes associated with AGING in microglia
- Premature physiologic AGING as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer
- Gut microbiome and AGING: Physiological and mechanistic insights
- AGING kidney and AGING-related disease
- The RNA world of human ageing
- Lung tissue gene-expression signature for the ageing lung in COPD
- Targeting the BECN1-BCL2 autophagy regulatory complex to promote longevity
- 11β-HSD1 inhibition by RL-118 promotes autophagy and correlates with reduced oxidative stress and inflammation, enhancing cognitive performance in SAMP8 …
- Mechanisms and Treatment of Blood-brain Barrier Dysfunction and Related Pathology During AGING
- Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in …
- Telomere length as a biomarker of accelerated AGING: is it influenced by dietary intake?
- Resveratrol and SIRT1 activators for the treatment of AGING and age-related diseases
- Cardiovascular AGING: the unveiled enigma from bench to bedside
- Eric B. Emmons, Youngcho Kim, and
- Adrenergic nerve degeneration in bone marrow drives AGING of the hematopoietic stem cell niche
- Response to Le Bourg
- Comparative metabolomics of AGING in a long-lived bat: insights into the physiology of extreme longevity
- Retrospective Three-dimensional facial soft tissue analysis in skeletal Class I malocclusions with premolar extractions
- Effect of polysaccharides from a Korean ginseng berry on the immunosenescence of aged mice
- Possible role of ginsenoside Rb1 in skin wound healing via regulating senescent skin dermal fibroblast
- Glycogen regulates cellular proliferation in the context of AGING, tumorigenesis, and hepatic regeneration
- Fat and bone: PGC-1α regulates mesenchymal cell fate during AGING and osteoporosis
- The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature AGING
- The relationship between dietary macronutrients and hepatic telomere length in AGING mice
- Evaluation of oxidative stress in cardiomyocytes during the AGING process in rats treated with resveratrol
- Role of Forkhead Box O (FOXO) transcription factor in AGING and diseases
- The molecular intersection between senescence and major depression in the elderly
- Comparative study of serum lipid profiles in nepalese cancer patients attending a tertiary care hospital
- Toward Using Fluorescent Nanodiamonds To Study Chronological AGING in Saccharomyces cerevisiae
- Gene expression signature of the ageing lung: breathing new life into COPD
- AGING of the bone
- Modulation of the process of AGING in human organism: recent advances in biomarkers for diagnosis and treatment
- Secretome analysis of in vitro aged human mesenchymal stem cells reveals IGFBP7 as a putative factor for promoting osteogenesis
- Abnormal epigenetic regulation of immune system during AGING
- Influence of cell distribution and diabetes status on the association between mitochondrial DNA copy number and AGING phenotypes in the In CHIANTI study
- A new AGING measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study
- Immunosenescence of natural killer cells, inflammation, and Alzheimer’s disease
- An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome
- Bone marrow neutrophil AGING in sickle cell disease mice is associated with impaired osteoblast functions
- Drosophila as a model for ageing
- Elastin molecular AGING promotes MDA‐MB‐231 breast cancer cell invasiveness
- Nutrition and ageing
- Oxidative stress in mesenchymal stem cell senescence: regulation by coding and noncoding RNAs
- Resilience to AGING in the regeneration‐capable flatworm Macrostomum lignano
- Three-year changes in physical activity and subsequent loss of ability to walk 400-m in older adults: The InCHIANTI study
- Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases
- The AGING mitochondria
- AGING and chromatoid body assembly: Are these two physiological events linked?
- Analysis of DNA modifications in AGING research
- Periodontology for Geriatric Patients
- A call for a neuroscience approach to cancer-related cognitive impairment
- Keeping it tight: The relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila
- AGING-related increase in store-operated Ca2+ influx in human ventricular fibroblasts
- DNA damage and oxidative stress in long-lived aquatic organisms
- Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases
- Signaling pathways regulating hematopoietic stem cell and progenitor AGING
- Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation
- Beyond ROS clearance: Peroxiredoxins in stress signaling and AGING
- Blank spots on the map: some current questions on nuclear organization and genome architecture
- Comparing the effects of low-protein and high-carbohydrate diets and caloric restriction on brain AGING in mice
- MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction
- The role of pulmonary and systemic immunosenescence in acute lung injury
- Comprehensive geriatric assessment: an updated perspective
- Urinary 8-hydroxydeoxyguanosine is a better biomarker of AGING in non-smokers
- Muscle stem cells and AGING
- Mitochondrial and reactive oxygen species signaling coordinate stem cell fate decisions and life long maintenance
- Immune senescence, epigenetics and autoimmunity
- DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936
- Chronic Obstructive Pulmonary Disease (COPD) as a disease of early AGING: Evidence from the EpiChron Cohort
- Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated AGING
- The fountain of youth: it’s all in our veins
- Update on mitochondria and muscle AGING: all wrong roads lead to sarcopenia
- Long-term effects of dietary protein and branched-chain amino acids on metabolism and inflammation in mice
- ER proteostasis control of neuronal physiology and synaptic function
- Inorganic nitrate alleviates the senescence-related decline inliver function
- BUBR1 insufficiency is correlated with eNOS reduction experimentally in vitro and in vivo, and in gastric cancer tissue
- SNCA overexpression disturbs hippocampal gene expression trajectories in midlife
- Back to the future: epigenetic clock plasticity towards healthy AGING
- Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production
- Endothelial cell metabolism in atherosclerosis
- AGING affects the in vivo regenerative potential of human mesoangioblasts
- Loss of ovarian hormones and accelerated somatic and mental AGING
- IGFBP-3 plays an important role in senescence as an AGING marker
- Fighting the Cause of Alzheimer’s and GNE Myopathy
- Emerging omics approaches in AGING research
- Targeting mitochondria to counteract age-related cellular dysfunction
- Immune cells and inflammation in AKI to CKD progression
- Autophagy induction: A promising antiAGING strategy
- The effect of different levels of dietary restriction on glucose homeostasis and metabolic memory
- Chromatin architectural changes during cellular senescence and AGING
- Oxidative stress and the epigenetics of cell senescence: Insights from progeroid syndromes
- Experimental models of human skin AGING
- Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain AGING of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR …
- Rapid and transient oxygen consumption increase following acute HDAC/KDAC inhibition in Drosophila tissue
- Cellular reprogramming: A new way to understand AGING mechanisms
- Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
- To Find and Destroy: Identification and Elimination of Senescent Cells
- The temporal sequence of improved mitochondrial function on the dynamics of respiration, mobility, and cognition in aged Drosophila
- Effects of resveratrol on the renin-angiotensin system in the AGING kidney
- Exosomes as mediators of the systemic adaptations to endurance exercise
- Regeneration of injured tissue: stem cell dynamics at interplay with mTORC1
- Repression of human and mouse brain inflammAGING transcriptome by broad gene-body histone hyperacetylation
- Role of Autophagy in AGING of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine
- Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
- Extracellular vesicles, ageing, and therapeutic interventions
- Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
- Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of …
- Epigenetic biomarkers for biological age
- Chronic exposure to triadimenol at environmentally relevant concentration adversely affects AGING biomarkers in Caenorhabditis elegans associated with insulin/IGF-1 …
- Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in AGING C57BL/6J mice
- Aerobic exercise‑stimulated Klotho upregulation extends life span by attenuating the excess production of reactive oxygen species in the brain and kidney
- The impact of the microbiome on immunosenescence
- Longevity, metabolic disease, and community health
- Macrophages in the AGING liver and age-related liver disease
- Metformin directly targets the H3K27me3 demethylase KDM6A/UTX
- Role of the inflammation-autophagy-senescence integrative network in osteoarthritis
- Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function
- p53 isoforms regulate premature AGING in human cells
- Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence
- Role of sphingolipids in senescence: implication in AGING and age-related diseases
- Change in the rate of biological AGING in response to caloric restriction: CALERIE Biobank analysis
- Deep sequencing of the mitochondrial genome reveals common heteroplasmic sites in NADH dehydrogenase genes
- Stem cells in dermatology and anti-AGING care of the skin
- Sex-specific associations between telomere length and candidate miRNA expression in placenta
- Royal jelly delays motor functional impairment during AGING in genetically heterogeneous male mice
- Cover Page Article Discoveries
- Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease
- Mitochondrial Paths to Sarcopenia–A Refined Short Review
- EVALUATION OF THE EFFECTS OF FTO AND ENVIRONMENT ON BODY MASS INDEX (BMI) IN A MULTI-ETHNIC COHORT OF OLDER ADULTS
- Association Between Androgen Deprivation Therapy for Prostate Cancer and Alzheimer’s Disease
- Metformin in Idiopathic Pulmonary Fibrosis” Seeking the Holy-Grail through Drug-Repositioning”
- Elevated serum IL-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults
- Blood Telomere Length changes after DRV/R+ either RAL or TDF/FTC as first line ART
- AGING in the brain: new roles of epigenetics in cognitive decline
- Enhancing lysosomal activation restores neural stem cell function during AGING
- Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis
- Cellular metabolism and oxidative stress as a possible determinant for longevity in small breed and large breed dogs
- Identification of key pathways and metabolic fingerprints of longevity in C. elegans
- AGING and AGING-associated diseases: a microRNA-based endocrine regulation hypothesis
- Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation
- Mechanisms of vascular AGING
- Age differences in age perceptions and developmental transitions
- Caloric restriction study design limitations in rodent and nonhuman primate studies
- Chaperone-Mediated Autophagy
- Role of Prion protein in premature senescence of human fibroblasts
- The Na/K-ATPase oxidant amplification loop regulates AGING
- Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature AGING
- Modeling AGING and Age-Associated Pathology in Zebrafish
- Chromatin changes trigger laminin genes dysregulation in AGING kidneys
- Activating the anaphase promoting complex to enhance genomic stability and prolong lifespan
- Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis
- Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases
- Alu siRNA to increase Alu element methylation and prevent DNA damage
- Rank-related contrasts in longevity arise from extra-group excursions not delayed senescence in a cooperative mammal
- Vascular senescence in cardiovascular and metabolic diseases
- Glutathione as a marker for human disease
- Exercise Medicine
- The Place of Geroprotective Agents in Life Quality and Longevity of Companion Animals
- AGING and the Brain
- Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans
- Testing a model of successful AGING in a cohort of masters swimmers
- Nrf2: Molecular and epigenetic regulation during AGING
- Idiopathic pulmonary fibrosis: AGING, mitochondrial dysfunction, and cellular bioenergetics
- Blood Markers in Healthy-Aged Nonagenarians: A Combination of High Telomere Length and Low Amyloidβ Are Strongly Associated With Healthy AGING in …
- Emerging roles for sphingolipids in cellular AGING
- The Miniature-chemostat AGING Device: A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of replicatively AGING …
- Molecular mechanisms and cellular pathways implicated in Machado-Joseph disease pathogenesis
- Absolute quantitative lipidomics reveals lipidome-wide alterations in AGING brain
- Substrate topography modulates cell AGING on a progeria cell model
- All about the core: a therapeutic strategy to prevent protein accumulation with proteasome core particle stimulators
- DEVELOPMENT OF A NOVEL METABOLIC GLYCO-SENSING APPROACH WITH ANTI-AGING POTENTIAL
- Osteogenesis and AGING: lessons from mesenchymal stem cells
- Whole-transcriptome changes in gene expression accompany AGING of sensory neurons in Aplysia californica
- Zebrafish AGING models and possible interventions
- Translational geroscience: From invertebrate models to companion animal and human interventions
- Isogenic organisms age at different rates due to critical-slowing-down of damage removal
- Early senescence and leukocyte telomere shortening in schizophrenia: a role for cytomegalovirus infection?
- Human ageing genomic resources: new and updated databases
- Increased epigenetic age in normal breast tissue from luminal breast cancer patients
- Fisetin as a caloric restriction mimetic protects rat brain against AGING induced oxidative stress, apoptosis and neurodegeneration
- Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
- AGING of complex systems
- Human AGING and cancer: role of miRNA in tumor microenvironment
- Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and AGING
- Epigenetic age in male combat-exposed war veterans: associations with posttraumatic stress disorder status
- The Lysosome, Elixir of Neural Stem Cell Youth
- Impaired immune surveillance accelerates accumulation of senescent cells and AGING
- 3′ UTR lengthening as a novel mechanism in regulating cellular senescence
- AGING-induced biological changes and cardiovascular diseases
- Major trauma and acceleration of the ageing process
- The role of autophagy in the regulation of yeast life span
- The mitochondrial contribution to animal performance, adaptation, and life-history variation
- Proteasomal function is impaired in human osteoarthritic chondrocytes and promotes decreased SOX9 and aggrecan levels
- Effects of Novel AGING-Delaying Plant Extracts on the Lipid Composition of the Yeast Saccharomyces Cerevisiae
- Cross-species comparison of proteome turnover kinetics
- The ageing brain in sleep apnoea: paradoxical resilience, survival of the fittest, or simply comparing apples and oranges?
- Somatic mutant clones colonize the human esophagus with age
- Cellular senescence: a view throughout organismal life
- What do experimental models teach us about comorbidities in stroke?
- TORC1 inhibition enhances immune function and reduces infections in the elderly
- Implementation of environmental enrichment after middle age promotes healthy AGING
- Effects of Acarbose on Age-Related Declines in Motor and Cardiac Function
- An overview of the role of lipofuscin in age-related neurodegeneration
- Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX 9 and Aggrecan
- AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer
- Role of dietary fat and supplementation in modulating neurodegenerative pathology in two animal model systems
- Oxysterol signatures distinguish age-related macular degeneration from physiologic AGING
- Is there a link between AGING and microbiome diversity in exceptional mammalian longevity?
- Kynurenic acid accumulation underlies learning and memory impairment associated with AGING
- Polyamine catabolism and oxidative damage
- Two Different Methods of Quantification of Oxidized Nicotinamide Adenine Dinucleotide (NAD+) and Reduced Nicotinamide Adenine Dinucleotide (NADH) …
- Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort
- Age structure landscapes emerge from the equilibrium between AGING and rejuvenation in bacterial populations
- Articular cartilage AGING-potential regenerative capacities of cell manipulation and stem cell therapy
- Targeting of NAT10 enhances healthspan in a mouse model of human accelerated AGING syndrome
- Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
- Evolution favours AGING in populations with assortative mating and in sexually dimorphic populations
- Lactobacillus paracasei PS23 delays progression of age-related cognitive decline in senescence accelerated mouse prone 8 (SAMP8) mice
- Tissue engineering and regenerative medicine: a translational research for antiAGING strategy
- The causal relationship between epigenetic abnormality and cancer development: in vivo reprogramming and its future application
- Implementing a method for studying longitudinal DNA methylation variability in association with age
- Dwarf mice and AGING
- Regulation of reproduction and longevity by nutrient-sensing pathways
- Growth Hormones and AGING 26
- Ghrelin signaling in immunometabolism and inflamm-AGING
- Senescent cells and osteoarthritis: a painful connection
- Sex-dependent differences in liver and gut metabolomic profiles with acarbose and calorie restriction in C57BL/6 mice
- Long-lived rodents reveal signatures of positive selection in genes associated with lifespan
- Machine learning based classification of cells into chronological stages using single-cell transcriptomics
- Anti-senescence compounds: a potential nutraceutical approach to healthy AGING
- Impaired DNA demethylation of C/EBP sites causes premature AGING
- The interplay between immunity and AGING in Drosophila
- Sex and the AGING Immune System
- Resistance training prevents muscle loss induced by caloric restriction in obese elderly individuals: a systematic review and meta-analysis
- The association between obstructive sleep apnea and shortened telomere length: a systematic review and meta-analysis
- Epigenetic influences on AGING: a longitudinal genome-wide methylation study in old Swedish twins
- Cancer chemoprevention via activation of proteostatic modules
- ALDH2 activity reduces mitochondrial oxygen reserve capacity in endothelial cells and induces senescence properties
- Inflammation and Trajectory of Renal Function in Community‐Dwelling Older Adults
- Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease
- AGING Process Immunity and Its Relation with Periodontal Disease in Genetic Aspect
- Sexual activity affects the redox profile along the AGING process in male rats
- Stem cell transcription factor FoxO controls microbiome resilience in Hydra
- Diet quality and telomere length in older Australian men and women
- Microenvironment-cell nucleus relationship in the context of oxidative stress
- Epigenetic mechanisms impacting AGING: a focus on histone levels and telomeres
- Brain age predicts mortality
- Whey protein concentrate wpc-80 improves antioxidant defense systems in the salivary glands of 14-month wistar rats
- Mitochondria-associated membranes in AGING and senescence: structure, function, and dynamics
- TGF-β induces corneal endothelial senescence via increase of mitochondrial reactive oxygen species in chronic corneal allograft failure
- Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila …
- Decelerated DNA methylation age predicts poor prognosis of breast cancer
- Metformin alleviates human cellular AGING by upregulating the endoplasmic reticulum glutathione peroxidase 7
- The systems biology of single-cell AGING
- Leukocyte telomere length and chronic conditions in older women of northeast brazil: a cross-sectional study
- Epigenetic modifications in cardiovascular AGING and diseases
- DNA methyltransferases, DNA methylation, and age-associated cognitive function
- Nutriepigenetics and cardiovascular disease
- Long non-coding RNAs in neuronal AGING
- Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics
- Epigenetic effects of metformin: from molecular mechanisms to clinical implications
- Vive la radioresistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and …
- Understanding lamin proteins and their roles in AGING and cardiovascular diseases
- The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma
- Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in AGING posterior touch receptor neurons
- AGING-related changes of EEG synchronization during a visual working memory task
- Upregulation of lncRNA-ATB by transforming growth factor β1 (TGF-β1) promotes migration and invasion of papillary thyroid carcinoma cells
- The clearance effect of tetrahedral DNA nanostructures on senescent human dermal fibroblasts
- GREM1 Improves the Regenerative Potential of AGING Cardiac Progenitor Cells
- Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis
- Age-associated bimodal transcriptional drift reduces intergenic disparities in transcription
- Inhibition by microbial metabolites of Chinese dark tea of age-related neurodegenerative disorders in senescence-accelerated mouse prone 8 (SAMP8) mice
- Quantifying resilience of humans and other animals
- Genomic instability and DNA replication defects in progeroid syndromes
- Strategies targeting cellular senescence
- Impaired cohesion and homologous recombination during replicative AGING in budding yeast
- Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge
- Effects of long-term treatment with a blend of highly purified olive secoiridoids on cognition and brain ATP levels in aged NMRI mice
- Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su (z) 2) negatively regulate longevity in Drosophila melanogaster
- The relationship of mammal survivorship and body mass modeled by metabolic and vitality theories
- Cellular senescence as a therapeutic target to improve renal transplantation outcome
- Autophagy and the cell biology of age-related disease
- Stem cells: AGING and transcriptional fingerprints
- Does physical activity age wild animals?
- Species comparison of liver proteomes reveals links to naked mole-rat longevity and human AGING
- Extracellular RNA profiles with human age
- NLRP3 inflammasome activation in inflammAGING
- Physiological and Pathological Vascular AGING
- Deficient mitochondrial biogenesis in IL-2 activated NK cells correlates with impaired PGC1-α upregulation in elderly humans
- What is the ethics of ageing?
- Sex differences in the response to dietary restriction in rodents
- Protective mechanism of adipose-derived stem cells in remodelling of the skin stem cell niche during photoAGING
- AGING-associated Changes in the DNA Methylome and Characteristics of the Epigenetic Clock
- Differential stem cell AGING kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome
- DNA methylation–based measures of biological AGING
- Telomere maintenance during anterior regeneration and AGING in the freshwater annelid Aeolosoma viride
- Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart
- Telomere Length as Cardiovascular AGING Biomarker: JACC Review Topic of the Week
- Rapamycin prevents the intervertebral disc degeneration via inhibiting differentiation and senescence of annulus fibrosus cells
- Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1
- Identity noise and adipogenic traits characterize dermal fibroblast AGING
- The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis
- Breaking the ceiling of human maximal life span
- AGING-related compensated hypogonadism: Role of metabolomic analysis in physiopathological and therapeutic evaluation
- The role of DNA‐PK in AGING and energy metabolism
- Myeloid-derived suppressor cells at the intersection of inflammAGING and bone fragility
- Structural similarity-based prediction of the potential active ingredients and mechanism of action of traditional Chinese medicine formulations used to anti …
- Novel insights into the anti-AGING role of mitophagy
- Usefulness of telomere length in DNA from human teeth for age estimation
- Genomics: new light on Alzheimer’s disease research
- Increased expression of long noncoding RNA HMMR-AS1 in epithelial ovarian cancer: an independent prognostic factor
- Pyruvate protects against cellular senescence through the control of mitochondrial and lysosomal function in dermal fibroblasts
- Mitochondrial oxidative stress and cardiac ageing
- Protein synthesis and quality control in AGING
- Assessment of the AGING of the Brown Adipose Tissue by 18F-FDG PET/CT ImAGING in the Progeria Mouse Model Lmna−/−
- Mice with reduced expression of the telomere‐associated protein Ft1 develop p53‐sensitive progeroid traits
- Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing
- Spermidine ameliorates the neuronal AGING by improving the mitochondrial function in vitro
- An osteopenic/osteoporotic phenotype delays alveolar bone repair
- Application of biological age assessment of Chinese population in potential anti-ageing technology
- Geriatric Rehabilitation 20
- Mitochondrial metabolism and the age-associated cardiovascular diseases
- The AGING lung: tissue telomere shortening in health and disease
- SUMOylation, AGING and autophagy in neurodegeneration
- GRK5–A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders
- Impact of long-term RF-EMF on oxidative stress and neuroinflammation in AGING brains of C57BL/6 mice
- Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk
- Mitoproteomics: Tackling mitochondrial dysfunction in human disease
- Leukocyte telomere length in patients with bipolar disorder: an updated meta-analysis and subgroup analysis by mood status
- Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan
- Clonal hematopoiesis and evolution to hematopoietic malignancies
- Ultrastructural and molecular analysis of ribose-induced glycated reconstructed human skin
- Recent advances: decoding Alzheimer’s disease with stem cells
- Epigenetics and cardiovascular regenerative medicine in the elderly
- Mitochondria, oxidative stress and the kynurenine system, with a focus on ageing and neuroprotection
- Mesenchymal stem cell therapy for AGING frailty
- JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the Drosophila testis
- Age and age-related diseases: role of inflammation triggers and cytokines
- Opposing action of hedgehog and insulin signaling balances proliferation and autophagy to determine follicle stem cell lifespan
- Parallels in immunometabolic adipose tissue dysfunction with ageing and obesity
- The therapeutic potential of metformin in neurodegenerative diseases
- Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila
- Autophagy maintains stem cells and intestinal homeostasis in Drosophila
- Evaluating intrinsic and non-intrinsic cancer risk factors
- Metformin is a direct SIRT1-activating compound: computational modeling and experimental validation
- Integrating geriatric principles into critical care medicine: the time is now
- The AGING heart
- MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling
- Osthole delays Tert-butyl hydroperoxide-induced premature senescence in neural stem cells
- Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1
- The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageing
- N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during AGING
- Harnessing protease activity to improve cancer care
- Physical activity and CVD in older adults: an expert’s perspective
- Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and AGING
- Decipher reliable biomarkers of brain AGING by integrating literature-based evidence with interactome data
- Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women
- LncRNA PlncRNA-1 overexpression inhibits the growth of breast cancer by upregulating TGF-β1 and downregulating PHGDH
- Physical activity and the development of visible age-related signs in the general population: a prospective cohort study
- Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response
- The telomerase complex directly controls hematopoietic stem cell differentiation and senescence in an induced pluripotent stem cell model of telomeropathy
- Long-term dietary macronutrients and hepatic gene expression in AGING mice
- High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings
- Low serum tryptophan levels as an indicator of global cognitive performance in nondemented women over 50 years of age
- In vivo somatic cell reprogramming for tissue regeneration: The emerging role of the local microenvironment
- Impact of stress on aged immune system compartments: Overview from fundamental to clinical data
- Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescence
- Dynamical analysis of cellular ageing by modeling of gene regulatory network based attractor landscape
- Repurposing proteostasis-modifying drugs to prevent or treat age-related dementia: a systematic review
- Measures of biologic age in a community sample predict mortality and age-related disease: the Framingham Offspring Study
- Free Radicals, Oxidants and Antioxidant Systems in Physiology and Disease
- Operation of the permeability transition pore in rat heart mitochondria in AGING
- Brain AGING in HIV-1 Infection
- New insight in the molecular mechanisms of neurodegenerative disease
- Emerging Connections: Synaptic Autophagy in Brain AGING and Disease
- The Smurf transition: new insights on ageing from end-of-life studies in animal models
- Inhibitory effect of vitamin C on intrinsic AGING in human dermal fibroblasts and hairless mice
- Association of Prevotella enterotype with polysomnographic data in obstructive sleep apnea/hypopnea syndrome patients
- The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae
- Knockout of tissue transglutaminase ameliorates TGFβ2-induced ocular hypertension: A novel therapeutic target for glaucoma?
- Natural variations in yeast AGING reveal genetic and environmental factors
- The Kruppel-like Factors in AGING and AGING Associated Pathology
- Characterization of senescence of human adipose-derived stem cells after long-term expansion
- Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
- Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial …
- Sestrins are Gatekeepers in the Way from Stress to AGING and Disease
- The Aplication of Topical Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium (Wjmsc-Cm) Inhibit the Increase in Expression of Matrix Metalloproteinase-1 …
- Sodium butyrate improves memory and modulates the activity of histone deacetylases in aged rats after the administration of d-galactose
- Factors Affecting the Occurrence of Complications in the Early Stages After Dental Implant Placement: A Retrospective Cohort Study
- Physiological basis for sex-specific differences in longevity
- ATP Synthase, a Target for Dementia and AGING?
- Inosine improves cognitive function and decreases AGING-induced oxidative stress and neuroinflammation in aged female rats
- Lung cancer in chronic obstructive pulmonary disease patients: importance of cellular senescence
- The effects of mind-body exercise on cognitive performance in elderly: a systematic review and meta-analysis
- Cutaneous infections in the mature patient
- Widespread accumulation of ribosome-associated isolated 3′ UTRs in neuronal cell populations of the AGING brain
- High-dimensional phenotyping identifies age-emergent cells in human mammary epithelia
- Accelerated AGING induced by deficiency of Zmpste24 protects old mice to develop bleomycin-induced pulmonary fibrosis
- The absence of tau prevents AGING-associated cognitive impairment by blocking mitochondrial permeability transition pore opening
- The insulin/IGF-1, the sirtuin and the mTOR pathway. How alterations of these pathways could affect age-related diseases and lifespan.
- Tissue iron is negatively correlated with TERC or TERT mRNA expression: a heterochronic parabiosis study in mice
- AGING attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles (‘vehicular smog’)
- Anti-AGING and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans
- Molecular basis of mitotic decline during human AGING
- A virus-acquired host cytokine controls systemic AGING by antagonizing apoptosis
- Proteoforms: methods of analysis and clinical prospects
- Assistive ai for coping with memory loss
- Bmal1-deficient mouse fibroblast cells do not provide premature cellular senescence in vitro
- Age-Related Variations in Gene Expression Patterns of Renal Cell Carcinoma: Biological and Translational Implications
- Ageing, cellular senescence and neurodegenerative disease
- The good, the bad, and the ugly of ROS: new insights on AGING and AGING-related diseases from eukaryotic and prokaryotic model organisms
- Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes
- PPARs and metabolic disorders associated with challenged adipose tissue plasticity
- Levels of histidine-rich glycoprotein in human blood predict accelerated AGING
- AGING, telomere integrity, and antioxidant food
- Lifelong calorie restriction affects indicators of colonic health in AGING C57Bl/6J mice
- Immune Modulation and Its Role in AntiAGING
- Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system
- Computational methods for developing novel antiAGING interventions
- Drug synergy slows AGING and improves healthspan through IGF and SREBP lipid signaling
- Antiretroviral Drug Mediated Astrocyte Senescence as a Contributor to HIV-1-Associated Neurocognitive Disorders
- The emerging role of lncRNAs in the regulation of cancer stem cells
- Leukocyte Telomere Length and Cognitive Function in Older Adults
- Understanding mechanisms to promote successful AGING in persons living with HIV
- Current Approaches of Anti-inflammatory-Dependent AntiAGING Strategies
- Dietary patterns and whole plant foods in AGING and disease
- TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac AGING
- Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration
- Autophagy as a promoter of longevity: insights from model organisms
- Disruption of adipokinetic hormone mediated energy homeostasis has subtle effects on physiology, behavior and lipid status during AGING in Drosophila
- From Neurons to Transcription Factors: the Biological Regulation of AGING
- Maximal strength training increases muscle force generating capacity and the anaerobic ATP synthesis flux without altering the cost of contraction in elderly
- Impaired autophagic activity and ATG4B deficiency are associated with increased endoplasmic reticulum stress-induced lung injury.
- Role of glial immunity in lifespan determination: a Drosophila perspective
- An Analysis of the effects of Mocs1 upregulation on lifespan in Drosophila melanogaster
- Gene expression analysis reveals novel gene signatures between young and old adults in human prefrontal cortex
- Hyperphosphatemia promotes senescence of myoblasts by impairing autophagy through ilk overexpression, a possible mechanism involved in sarcopenia
- Multinutrient Approach to Slow Down Brain AGING and Related Neurodegenerative Disorders
- Study of age-related changes in compensatory processes in the model of neurodegeneration of the nigrostriatal system in rats
- AGING is an adaptation that selects in animals against disruption of homeostasis
- Role of NLRP3-inflammasone in functional decline in physiological AGING. Implications for cardio-metabolic events.
- Linking cellular proteostasis to yeast longevity
- Cannabinoid 1 receptor signaling on GABAergic neurons influences astrocytes in the ageing brain
- Oncogene-induced senescence: a double edged sword in cancer
- Trend-analysis of dental hard-tissue conditions as function of tooth age
- Genetic Ablation of p16INK4a Does Not Protect against Cellular Senescence in Mouse Models of Chronic Obstructive Pulmonary Disease/Emphysema
- Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by AGING
- Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells
- Theories of Individual Ageing
- Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
- Boosting ATM activity alleviates AGING and extends lifespan in a mouse model of progeria
- Fernblock prevents dermal cell damage induced by visible and infrared a radiation
- Alternative formats
- European-wide studies on pro-inflammatory risk factors in early life and molecular markers of AGING
- Timing of neuronal plasticity in development and AGING
- PGC-1α protects RPE cells of the AGING retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality control …
- Epigenetic mechanisms regulating adaptive responses to targeted kinase inhibitors in cancer
- Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
- Left Ventricular Diastolic Dysfunction in Hutchinson-Gilford Progeria Syndrome
- Mitochondrial metabolism and AGING in yeast
- Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death
- LncRNA HOTAIR improves diabetic cardiomyopathy by increasing viability of cardiomyocytes through activation of the PI3K/Akt pathway
- Srebp-1c-dependent metabolic remodeling of white adipose tissue by caloric restriction
- MicroRNAs-103/107 regulate autophagy in the epidermis
- Potentials of cellular reprogramming as a novel strategy for neuroregeneration
- Cancer-free AGING: insights from Spalax ehrenbergi superspecies
- Healthy ageing and the science of longevity in dogs. Part I: is grey the new gold?
- Fertility, IVF and reproductive genetics
- Quantitative phosphoproteomics reveals GTBP-1 regulating C. elegans lifespan at different environmental temperatures
- Experimental models for AGING and their potential for novel drug discovery
- Mitochondrial Dysfunction Underlies the Proinflammatory Phenotype of Multipotent Mesenchymal Stromal Cells from Atherosclerotic Individuals
- Telomeric epigenetic response mediated by Gadd45a regulates stem cell AGING and lifespan
- Impact of habitual physical activity and type of exercise on physical performance across ages in community-living people
- Horizon meeting on cardiovascular physiology: Dedicated to Dr. Mike Sharratt
- The role of the protein SNEVhPrp19/hPso4 in function and morphology of human dermal fibroblasts and human epidermal keratinocytes
- Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis
- Premature brain AGING in humans exposed to maternal nutrient restriction during early gestation
- Mitohormesis, an antiAGING paradigm
- Centenarians as a model to discover genetic and epigenetic signatures of healthy ageing
- The inflammatory potential of the diet at midlife is associated with later healthy AGING in French adults
- Protein quality control in the endoplasmic reticulum and cancer
- Epigenetic Mechanisms in Osteoporosis
- Telomere maintenance mechanisms in cancer
- Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells
- The emerging roles for telomerase in the central nervous system
- Presynaptic neurodegeneration: CSP-α/DNAJC5 at the synaptic vesicle cycle and beyond
- The effect of aerobic training with Citrus aurantium L. on Sirtuin 1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha gene expression …
- From apparent to real age: gender, age, ethnic, makeup, and expression bias analysis in real age estimation
- The Role of Noncoding RNAs in Genome Stability and AGING
- Zinc-induced metallothionein in centenarian offspring from a large European population: the MARK-AGE project
- Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly
- Regulation of age-related decline by transcription factors and their crosstalk with the epigenome
- ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications
- Physical activity attenuates the impact of poor physical, mental, and social health on total and cardiovascular mortality in older adults: a population-based prospective …
- Altered expression of mitochondrial NAD+ carriers influences yeast chronological lifespan by modulating cytosolic and mitochondrial metabolism
- Therapeutics of Stem Cell Treatment in Anti-AGING and Rejuvenation
- TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage–induced activation of NF-κB
- Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity
- Leucine supplementation does not attenuate skeletal muscle loss during leg immobilization in healthy, young men
- T cell epigenetic remodeling and accelerated epigenetic AGING are linked to long-term immune alterations in childhood cancer survivors
- Catecholamine-induced senescence of endothelial cells and bone marrow cells promotes cardiac dysfunction in mice
- The emerging role of follistatin under stresses and its implications in diseases
- Mitophagy in cardiomyocytes and in platelets: a major mechanism of cardioprotection against ischemia/reperfusion injury
- Chronic inflammation and sarcopenia: A regenerative cell therapy perspective
- Applying parametric models to survival data: tradeoffs between statistical significance, biological plausibility, and common sense
- Glucose intake hampers PKA-regulated HSP90 chaperone activity
- Integrative analysis of global gene expression identifies opposite patterns of reactive astrogliosis in aged human prefrontal cortex
- Leucine Exerts Lifespan Extension and Improvement in Three Types of Stress Resistance (Thermotolerance, Anti-Oxidation and Anti-UV Irradiation) in C …
- Age associated decrease of sialin in salivary glands
- An aged human heart tissue model showing age-related molecular and functional deterioration resembling the native heart
- Loss of stemness, EMT, and supernumerary tooth formation in Cebpb−/− Runx2+/− murine incisors
- Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study
- Molecular differences between human small intestine and colon stem and progenitor cells
- Epigenetic modifications of the α-synuclein gene and relative protein content are affected by ageing and physical exercise in blood from healthy subjects
- Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans
- Elevated and correlated expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in human abdominal adipose tissue play a role in adiposity and insulin …
- Nicotinamide adenine dinucleotide (NAD+) and cell AGING
- LncRNA ZEB1-AS1 expression in cancer prognosis: Review and meta-analysis
- Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases
- Anthropometric and dietary factors as predictors of DNA damage in obese women
- Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice
- Asthma over the age of 65: all’s well that ends well
- Ferrosenescence: the iron age of neurodegeneration?
- Effect of a 12-month exercise intervention on leukocyte telomere length: Results from the ALPHA Trial
- Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells
- Putting a strain on diversity
- Notch2 signaling maintains NSC quiescence in the murine ventricular-subventricular zone
- Depletion of Ubiquilin induces an augmentation in soluble ubiquitinated Drosophila TDP-43 to drive neurotoxicity in the fly
- Tuberculosis in the elderly: Why inflammation matters
- Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster
- Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts
- Medicine in Older Patients: Evidence Based?
- Epigenetic drift of H3K27me3 in AGING links glycolysis to healthy longevity in Drosophila
- Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma
- U1 snRNP alteration and neuronal cell cycle reentry in Alzheimer disease
- Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats
- The NAD+ precursor nicotinamide riboside rescues mitochondrial defects and neuronal loss in iPSC and fly models of Parkinson’s disease
- Long non-coding RNAs involved in metastasis of gastric cancer
- ICAM-1 deficiency in the bone marrow niche impairs quiescence and repopulation of hematopoietic stem cells
- Efficacy and durability of hyaluronic acid fillers for malar enhancement: A prospective, randomized, split-face clinical controlled trial
- Intergenerational transfers and the older population
- miR-200a modulates the expression of the DNA repair protein OGG1 playing a role in AGING of primary human keratinocytes
- How do chaperones protect a cell’s proteins from oxidative damage?
- Biological embedding of psychosocial stress over the life course
- DNA methylation patterns separate senescence from transformation potential and indicate cancer risk
- Glutathione as a Marker for Human Disease
- The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on …
- Age-associated functional morphology of thyroid and its impact on the expression of vimentin, cytokeratins and VEGF. The role of nigella in refinement
- The interplay between immunity and AGING in Drosophila
- Identification and expression of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in zebrafish Danio rerio: Implication for age …
- Janusz Ligęza
- Why the UK needs a social policy on ageing
- Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK …
- Better Nutritional Status Is Positively Associated with mRNA Expression of SIRT1 in Community-Dwelling Older Adults in the Toledo Study for Healthy AGING
- Colonoscopy in the very elderly
- Advances and current challenges associated with the use of human induced pluripotent stem cells in modeling neurodegenerative disease
- The emerging roles of microRNAs in stem cell AGING
- Metabolite sensing and signaling in cell metabolism
- Microglia polarization, gene-environment interactions and Wnt/β-catenin signaling: emerging roles of glia-neuron and glia-stem/neuroprogenitor crosstalk for …
- Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism
- Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition
- Does physical activity age wild animals?
- DNA damage, metabolism and AGING in pro-inflammatory T cells: Rheumatoid arthritis as a model system
- Endoplasmic reticulum stress in the pathogenesis of fibrotic disease
- Mitochondrial tethers and their impact on lifespan in budding yeast
- Taurine supplementation induces long-term beneficial effects on glucose homeostasis in ob/ob mice
- Mitochondrial quality control mechanisms and the PHB (Prohibitin) complex
- Antioxidant and oxidative stress: a mutual interplay in age-related diseases
- Investigating the role of Sirtuins in cell reprogramming
- Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti
- Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2
- Short-duration swimming exercise after myocardial infarction attenuates cardiac dysfunction and regulates mitochondrial quality control in aged mice
- Nicotinamide improves aspects of healthspan, but not lifespan, in mice
- Inhibition of oxidative stress in cholinergic projection neurons fully rescues AGING-associated olfactory circuit degeneration in Drosophila
- Properties of the epigenetic clock and age acceleration
- The Circadian Clock and the AGING Process
- Involvement of MicroRNAs in the AGING-related decline of CD28 expression by human T cells
- Mechanisms of vascular AGING: What can we learn from Hutchinson-Gilford progeria syndrome?
- Weighing in on mTOR complex 2 signaling: the expanding role in cell metabolism
- Correlates and aetiological factors associated with hedonic well-being among an ageing population of US men and women: secondary data analysis of a …
- InflammAGING: a new immune–metabolic viewpoint for age-related diseases
- Molecular mechanisms of intervertebral disc degeneration
- Temporal integrative analysis of mRNA and microRNAs expression profiles and epigenetic alterations in female SAMP8, a model of age-related cognitive …
- Circadian Mechanisms of Calorie Restriction in Delaying AGING
- Aged kidney: can we protect it? Autophagy, mitochondria and mechanisms of ischemic preconditioning
- Assessing the Effect of Epigenetic Dysregulation on Oncogenesis and Immunocompetence in a Mouse Model
- Intermittent Fasting-Dietary Restriction as a Geroprotector
- Age-Related Changes in the Expression of an Enhancer Reporter in the Mouse Brain
- Relation of long-term patterns in caregiving activity and depressive symptoms to telomere length in older women
- AGING of Human Mesenchymal Stem Cells
- Autophagy gene overexpression in Saccharomyces cerevisiae perturbs subcellular organellar function and accumulates ROS to accelerate cell death with relevance …
- Telomere length and its association with hippocampal gray matter volume in antipsychotic-naïve/free schizophrenia patients
- The role of free radicals in autophagy regulation: implications for ageing
- Effect of polyphenols from coffee and grape on gene expression in myoblasts
- Senescent cell clearance by the immune system: Emerging therapeutic opportunities
- Major Lifestyles and Phenotypes in AGING and Disease
- Parity-dependent hemosiderin and lipofuscin accumulation in the reproductively aged mouse ovary
- AGING pathology in sprague dawley rats: background lesions and comparative study between wild type and transgenic rats with neuronal overexpression of human …
- mTORC inhibitors as broad-spectrum therapeutics for age-related diseases
- Neurocognitive disorders and dehydration in older patients: clinical experience supports the hydromolecular hypothesis of dementia
- Genotype and sex differences in longevity in transgenic mouse models of Alzheimer’s disease
- Committed as a violent sexual predator in his 10th decade: A case study
- Gonadal steroids
- Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic AGING
- Polyamine metabolism and gene methylation in conjunction with one-carbon metabolism
- Effects of physiological overexpression of SIRT6 in metabolism and cancer
- Clinical outcomes and prognostic factors in patients directly transferred to the intensive care unit from long-term care beds in institutions and hospitals: a …
- Identification of Molecular Determinants of Cellular Senescence in Cancer and AGING
- Molecular habituation’as a potential mechanism of gradual homeostatic loss with age
- Non-senescent Hydra tolerates severe disturbances in the nuclear lamina
- Holothuria scabra extracts possess anti-oxidant activity and promote stress resistance and lifespan extension in Caenorhabditis elegans
- Age-related gene expression profiles of immature human oocytes
- AGING Immunity: Monocyte Derived Dendritic Cell’s Metabolic Shift Associated with Human AGING
- Sirtuins in mitochondrial stress: Indispensable helpers behind the scenes
- LONELINESS AND DEPRESSION AMONG INSTITUTIONALIZED AND NON-INSTITUTIONALIZED ELDERS COMPARATIVE STUDY
- Genetic and Pharmacological Regulation of Epigenetic AGING
- The rate of telomere loss is related to maximum lifespan in birds
- SIN-3 as a key determinant of lifespan and its sex dependent differential role on healthspan in Caenorhabditis elegans
- The cost of intraoperative adverse events in abdominal and pelvic surgery: A systematic review
- β-Arrestin based receptor signaling paradigms: potential therapeutic targets for complex age-related disorders
- Heme oxygenase-1 deficiency affects bone marrow niche and triggers premature exhaustion of hematopoietic stem cells
- Updates on old and weary haematopoiesis
- Yeast replicative AGING leads to permanent cell cycle arrest in G1 effectuated by the start repressor Whi5
- Yoga Meditation Lifestyle Intervention: Impact on Male Reproductive Health
- La suplementación con té verde promueve la elongación de los telómeros de leucocitos en mujeres obesas
- Transcriptional repression of high-mobility group box 2 by p21 in radiation-induced senescence
- Age-dependent changes in transcription factor FOXO targeting in Drosophila melanogaster
- Insights from large-scale cancer genome sequencing
- CSA and CSB play a role in the response to DNA breaks
- Is overall mortality the right composite endpoint in clinical trials of acute respiratory distress syndrome?
- TRF1 as a major contributor for telomeres’ shortening in the context of obesity
- Organoruthenium (II) complexes ameliorates oxidative stress and impedes the age associated deterioration in Caenorhabditis elegans through JNK-1/DAF-16 …
- Relative bioavailability of Silybin A and Silybin B from 2 multiconstituent dietary supplement formulations containing milk thistle extract: A single-dose study
- Association of DNA methylation-based biological age with health risk factors and overall and cause-specific mortality
- Healthy at 100: Genetic factors and phenotypes associated with healthy AGING and longevity
- Insulin Signaling-independent Activation of DAF-16 Shapes the Transcriptome during Normal AGING
- A framework for uncovering the roles of calories and macronutrients in health and AGING
- Manipulation of mitochondrial function by polyphenols for new treatment strategies
- An oral combination of vitamins A, C, E, and Mg++ improves auditory thresholds in age-related hearing loss
- Altered monocyte phenotypes but not impaired peripheral T cell immunity may explain susceptibility of the elderly to develop tuberculosis
- Dominance rank-associated gene expression is widespread, sex-specific, and a precursor to high social status in wild male baboons
- p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice
- Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS)
- Endothelial cell senescence in the pathogenesis of endothelial dysfunction
- Identification of 170 new long noncoding RNAs in Schistosoma mansoni
- Roles of non-coding RNAs in transcriptional regulation
- Changes of immunoglobulin G glycosylation with age
- Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research
- Explaining cancer: Finding order in disorder
- Effects of boron-containing compounds on cardiovascular disease risk factors–a review
- Cocaine use may induce telomere shortening in individuals with HIV infection
- Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro
- Zmynd17 controls muscle mitochondrial quality and whole‐body metabolism
- Role of autophagy in proteostasis: friend and foe in cardiac diseases
- Polymeric microsphere-facilitated site-specific delivery of quercetin prevents senescence of pancreatic islets in vivo and improves transplantation outcomes in mouse …
- Loss of CD31 receptor in CD4+ and CD8+ T-cell subsets in children with primary hypertension is associated with hypertension severity and hypertensive target organ …
- Interaction of neuropeptide F and diet levels effects carbonyl levels in grasshoppers
- Ub and down: ubiquitin exercise for the elderly
- Swimming exercise and transient food deprivation in Caenorhabditis elegans promote mitochondrial maintenance and protect against chemical-induced …
- Reduced expression of C/EBPβ-LIP extends health and lifespan in mice
- Metabolomics: State-of-the-Art Technologies and Applications on Drosophila melanogaster
- Long Non-Coding RNAs in Neuronal AGING.
- Healthy ageing: the natural consequences of good nutrition—a conference report
- Female Reproductive AGING: From consequences to Mechanisms, Markers, and Treatments
- The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span
- Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford progeria syndrome (HGPS) revealed an impaired melanogenesis …
- Non-developmental dimensions of adult regeneration in Hydra
- Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer’s …
- Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells
- Role of Nutraceuticals in Modulation of Gut-Brain Axis in Elderly Persons
- Idiopathic pulmonary fibrosis: pathogenesis and management
- Plasticity of lifelong calorie‐restricted C57 BL/6J mice in adapting to a medium‐fat diet intervention at old age
- A population neuroscience approach to the study of cerebral small vessel disease in midlife and late life: an invited review
- Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice
- The role of melatonin, a multitasking molecule, in retarding the processes of ageing
- Shelterin differentially respond to oxidative stress induced by TiO2-NPs and regulate telomere length in human hepatocytes and hepatocarcinoma cells in vitro
- The effects of graded levels of calorie restriction: X. Transcriptomic responses of epididymal adipose tissue
- Cellular regulation of amyloid formation in AGING and disease
- Gender and sex differences in adipose tissue
- The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental …
- Targeting oxidatively induced DNA damage response in cancer: opportunities for novel cancer therapies
- Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals
- Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?
- Metabolic determinants of longevity: dietary supplementation and mitochondria
- Increased senescent CD8+ T cells in the peripheral blood mononuclear cells of Behçet’s disease patients
- Physiological roles of the DNA demethylation-associated proteins Gadd45a and Ing1
- Studies on the Mechanisms of DNA Damage Repair in Human Neurons
- Parity dependent hemosiderin and lipofuscin accumulation in the reproductively aged mouse ovary
- Extension of life span in laboratory mice
- IAPP/amylin and β-cell failure: implication of the risk factors of type 2 diabetes
- Metabotypes with elevated protein and lipid catabolism and inflammation precede clinical mastitis in prepartal transition dairy cows
- Increasing neural stem cell division asymmetry and quiescence are predicted to contribute to the age-related decline in neurogenesis
- Higher spermidine intake is linked to lower mortality: a prospective population-based study
- Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation
- MYBL2 supports DNA double strand break repair in hematopoietic stem cells
- Evolutionarily adapted hormesis-inducing stressors can be a practical solution to mitigate harmful effects of chronic exposure to low dose chemical mixtures
- Harnessing lysosomal pH through PLGA nanoemulsion as a treatment of lysosomal-related neurodegenerative diseases
- Estimates of the heritability of human longevity are substantially inflated due to assortative mating
- Environmental conditions shape the temporal pattern of investment in reproduction and survival
- Ubisol-Q 10 (a nanomicellar water-soluble formulation of CoQ 10) treatment inhibits Alzheimer-type behavioral and pathological symptoms in a double transgenic …
- Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration, and invasion in human hepatoma carcinoma by up-regulating ROCK1
- The consequences of mutator-driven mutagenesis and analysis of lifespan extending compounds using outgrowth analysis and replicative lifespan in Saccharomyces …
- Role of Human Endogenous Retrovirus type K (HERV-K) in immunosenescence: RNA-seq based transcriptomic analysis
- The physiology of homeoprotein transduction
- Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture
- DNA damage induced by human CD40 ligand mutant promotes senescence and induces demethylation of GATA4 in lung cancer
- Age-related response to an acute innate immune challenge in mice: proteomics reveals a telomere maintenance-related cost
- Impact of a shift work-like lighting schedule on the functioning of the circadian system in the short-lived fish Nothobranchius furzeri
- Suboptimal extracellular pH values alter DNA damage response to induced double‐strand breaks
- The combination of NAD+-dependent deacetylase gene deletion and the interruption of gluconeogenesis causes increased glucose metabolism in budding …
- Temporal dynamics of microbiota before and after host death
- Treatment outcomes of tuberculosis at Asella Teaching Hospital, Ethiopia: ten years’ retrospective aggregated data
- Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate
- Nutrition and inflammation: are centenarians similar to individuals on calorie-restricted diets?
- Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue
- Hypothalamic mitochondrial dysfunction as a target in obesity and metabolic disease
- Using CRISPR/dCas9 to Dissect the Role of Ribosomal DNA in Cellular Growth and AGING in Saccharomyces cerevisiae
- Modeling neuropsychiatric and neurodegenerative diseases with induced pluripotent stem cells
- Biphasic regulation of spindle assembly checkpoint by low and high concentrations of resveratrol leads to the opposite effect on chromosomal instability
- The proteome of neurofilament-containing protein aggregates in blood
- Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
- Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study
- Rejuvenation of the aged neuromuscular junction by exercise
- Role of miRNA in the regulatory mechanisms of estrogens in cardiovascular ageing
- Identifying the critical gaps in research on sex differences in metabolism across the life span
- Intervertebral Disc Inflammation: The Effect Of Il-1ra Deficiency On Development, AGING And Injury Of The Murine Caudal Intervertebral Disc
- Telomerase Activator 65 (TA-65) Favorably Affects Parameters of Metabolic Syndrome-A Pilot Study
- The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer
- Integrative approaches to cognitive decline.
- Pseudomonas aeruginosa induces cellular senescence in lung tissue at the early stage of two-hit septic mice
- Retracted: Ananas sativa increases longevity through oxidative stress resistance in Drosophila melanogaster
- RETRACTION: ANANAS SATIVA INCREASES LONGEVITY THROUGH OXIDATIVE STRESS RESISTANCE IN DROSOPHILA MELANOGASTER
- AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11
- Genetic code expansion in animals
- Senescence of multicellular individuals: imbalance of epigenetic and non-epigenetic information in histone modifications
- Upregulation of dNTP levels after telomerase inactivation influences telomerase-independent telomere maintenance pathway choice in Saccharomyces cerevisiae
- Epigenetic modulation of vascular diseases: assessing the evidence and exploring the opportunities
- Metabolic changes in primary, secondary, and lipid metabolism in tobacco leaf in response to topping
- A new approach to treating neurodegenerative otologic disorders
- Physical activity attenuates total and cardiovascular mortality associated with physical disability: a national cohort of older adults
- Hallmarks of AGING: an autophagic perspective
- Hallmarks of AGING in the liver
- Hallmarks of senescence and AGING
- Redox regulation by NRF2 in AGING and disease
- From molecular promise to preclinical results: HDAC inhibitors in the race for healthy AGING drugs
- Proteostasis and Energetics as Proteome Hallmarks of AGING and Influenza Challenge in Pulmonary Disease
- The hallmarks of ferroptosis
- The AGING lung and idiopathic pulmonary fibrosis
- Obesity may accelerate the AGING process
- The epigenetics of AGING in invertebrates
- Harnessing cellular AGING in human stem cell models of amyotrophic lateral sclerosis
- Autophagic control of skin AGING
- EPIGENETIC PROFILES OF BIOLOGICAL AGING HALLMARKS
- Time for the systems-level integration of AGING: resilience enhancing strategies to prevent Alzheimer’s disease
- A defined human AGING phenome
- Incomplete healing as a cause of AGING: the role of mitochondria and the cell danger response
- Epigenetic biomarkers of AGING
- An overview of the molecular and cellular biomarkers of AGING
- Models and studies of AGING: Executive summary of a report from the U13 conference series
- Epigenetic clock: just a convenient marker or an active driver of AGING?
- Senotherapeutics: emerging strategy for healthy AGING and age-related disease
- Accelerated lung AGING and chronic obstructive pulmonary disease
- Mitochondria and AGING—The role of exercise as a countermeasure
- Mitochondrial dysfunction and AGING: Insights from the analysis of extracellular vesicles
- Telomere shortening as a hallmark of stem cell senescence
- Exposure to environmental pollutants and their association with biomarkers of AGING: A multipollutant approach
- Proteostasis collapse, a hallmark of AGING, hinders the chaperone-Start network and arrests cells in G1
- Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural AGING?
- In silico clinical trials for anti-AGING therapies
- In search of an AGING antidote
- An atlas of the AGING lung mapped by single cell transcriptomics and deep tissue proteomics
- The genetics of AGING: a vertebrate perspective
- Approaches towards longevity: reprogramming, senolysis, and improved mitotic competence as anti-AGING therapies
- DNA METHYLATION: CAUSE OR CONSEQUENCE OF AGING?
- SYSTEMS-LEVEL MODELING OF BIOLOGICAL AND MOLECULAR AGING CHANGES OVER TIME
- Developments in molecular epidemiology of AGING
- Special Issue “Anti-AGING Properties of Natural Compounds”
- Molecular Mechanisms Underlying Cardiometabolic Disease in AGING
- Mechanisms and Late-Life Intervention of AGING
- Molecular mechanisms underlying cardiometabolic disease in AGING
- DNA break-induced epigenetic drift as a cause of mammalian AGING
- Chaperone-mediated autophagy is a cytoprotective response of photoreceptors during AGING and retinal diseases.
- Partial Reprogramming: A Shortcut to Rejuvenation
- www. AGING-us. com AGING 2019, Vol. 11, Advance
- Interplay between nutrient-sensing molecules during AGING and longevity
- MicroRNAs and the genetic nexus of brain AGING, neuroinflammation, neurodegeneration, and brain trauma
- Senescence in the lung: is this getting old?
- Role of HMSG2 mediated FAO deficiency in IPF pathogenesis
- ESPO/BIOLOGICAL SCIENCES SECTION SYMPOSIUM: EMERGING INSIGHTS IN INTERACTIONS AND NETWORKS IN THE BIOLOGY OF AGING DEVELOPING C …
- Comparative analysis of epigenetic AGING clocks from CpG characteristics to functional associations
- DEVELOPMENT OF EPIGENETIC MEASURES FOR GEROSCIENCE CLINICAL TRIALS
- Re:“Decreased Levels of Anti-AGING Klotho in Obstructive Sleep Apnea” by Pákó et al.(Rejuvenation Res 2019 [Epub ahead of print]; DOI: 10.1089/rej. 2019.2183)
- Preclinical research of Dihydromyricetin for brain AGING and neurodegenerative diseases
- Interleukin-37 improves AGING-associated declines in adaptive immunity leading to enhanced suppression of Ph+ leukemia
- Juel Rasmussen Group
- Time for a new strategy in the war on Alzheimer’s disease
- KDM3A and KDM4C regulate mesenchymal stromal cell senescence and bone AGING via condensin-mediated heterochromatin reorganization
- Response to Rizza and Filomenia re:“Regulation of S-Nitrosylation in AGING and Senescence”
- Role of hypothalamus in AGING and its underlying cellular mechanisms
- The role of DNA repair in cellular AGING process
- Cortical network dynamics are coupled with cognitive AGING in rats
- Implications of AGING in plastic surgery
- Environmental factors in successful AGING: the potential impact of air pollution
- AGING by pollutants: Introducing the AGING dose (AD) 50
- Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in AGING-related disorders
- Hydralazine Improves Mitochondrial Function via SIRT1/SIRT5 Activation and Protects against Glucose Toxicity
- Mitophagy and oxidation status of mitochondria in Idiopathic Pulmonary Fibrosis (IPF) macrophages: a study in bronchoalveolar lavage fluid (BALF)
- Transient non-integrative nuclear reprogramming promotes multifaceted reversal of AGING in human cells
- OPCs on a Diet: A Youthful Serving of Remyelination
- Epigenome-wide association study of leukocyte telomere length
- Late Breaking Abstract-WNT/ß-catenin signaling induces cellular senescence in lung alveolar epithelial cells
- Decelerating ageing and biological clocks by autophagy
- Genomic and Epigenomic Potential With Age: Genome, Epigenome, and the Epigenetic Clock
- Metformin restores CNS remyelination capacity by rejuvenating aged stem cells
- Telomere abnormalities in the pathobiology of idiopathic pulmonary fibrosis
- Measuring AGING and identifying AGING phenotypes in cancer survivors
- From powerhouse to perpetrator—mitochondria in health and disease
- Modulating AGING and AGING-related Symptoms Using Endogenous Small Molecules
- G protein-coupled receptor systems and their role in cellular senescence
- Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence
- PANORAMIC VIEW OF ANTI-AGING PROBLEMS: FROM A CELL TO THE PERSONAL PRODUCT
- Accumulation of damaged mitochondria in alveolar macrophages with reduced OXPHOS related gene expression in IPF
- The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
- Towards a unified mechanistic theory of AGING
- A multi-institutional comparison of younger and older adults with sickle cell disease
- Ageing as a risk factor for neurodegenerative disease
- GRSF1 is an age-related regulator of senescence
- Rapamycin and Alzheimer’s disease: time for a clinical trial?
- SA-β-galactosidase-based screening assay for the identification of senotherapeutic drugs
- Studying Werner syndrome to elucidate mechanisms and therapeutics of human AGING and age-related diseases
- Inflamm-AGING of hematopoietic stem cells
- Mechanisms of cellular rejuvenation
- Healthy AGING: a bibliometric analysis of the literature
- Chronic stress exposure and daily stress appraisals relate to biological AGING marker p16INK4a
- Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites
- Mitochondrial dysfunction and cell senescence: deciphering a complex relationship
- Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
- Plausible links between metabolic networks, stem cells, and longevity
- The role of pathological AGING in cardiac and pulmonary fibrosis
- ER stress links AGING to sporadic ALS
- Maximizing longevity and healthspan: multiple approaches all converging on autophagy
- Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic …
- KMT 1 family methyltransferases regulate heterochromatin–nuclear periphery tethering via histone and non‐histone protein methylation
- Independent and combined effects of telomere shortening and mtDNA4977 deletion on long-term outcomes of patients with coronary artery disease
- Hypoxia and AGING
- It is Time to Embrace 21st-Century Medicine
- Potential role of E4orf1 protein in AGING-associated impairment in glycemic control
- Fenofibrate, a peroxisome proliferator-activated receptor alpha, is a novel molecule with senolytic and autophagy activity for cartilage degeneration and osteoarthritis
- Single-cell transcriptomic profiling of the AGING mouse brain
- Breast cancer treatment and its effects on AGING
- Astrocyte senescence: evidence and significance
- Genomics of AGING and Longevity
- STING SNP R293Q is associated with a decreased risk of AGING-related diseases
- Mitochondrial dysfunction in AGING and cancer
- Embrace the fat when getting old
- Psychological wellbeing and healthy AGING: focus on telomeres
- Drugs that target AGING: how do we discover them?
- The role of lipids in AGING-related metabolic changes
- Biomarkers of DNA damage in COPD patients undergoing pulmonary rehabilitation: Integrating clinical parameters with genomic profiling
- mTOR as a central regulator of lifespan and AGING
- Epigenetic mechanisms in cognitive impairment linked to AGING and Alzheimer’s disease
- Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis
- Brain organoids: a next step for humanized Alzheimer’s disease models?
- Lipid assemblies at the crossroads of AGING, proteostasis, and neurodegeneration
- Response kinetics reveal novel features of ageing in murine T cells
- EXISTING STRATEGIES FOR ELECTRONIC DATA COLLECTION BY ELDER ABUSE MULTI-DISCIPLINARY TEAMS
- The impact of caloric restriction on the epigenetic signatures of AGING
- Re:“Regulation of S-Nitrosylation in AGING and Senescence” by Larrick and Mendelsohn (Rejuvenation Res 2019; 22: 171–174)
- What can yeast tell us about AGING modulation by bioactive substances in functional food
- NAD+ Metabolism in AGING and Cancer
- LeverAGING budding yeast Saccharomyces cerevisiae for discovering AGING modulation substances for functional food
- Hereditary syndromes with signs of premature AGING
- Human Telomerase M-RNA Rescues Cellular Functions, Gene Regulation, and Chromatin Structure in Progeria Ipsc-Derived Endothelial Cells
- Genetic pathways of AGING and their relevance in the dog as a natural model of human AGING
- Noncoding RNA: AGING well with Norad
- Geroscience and the challenges of AGING societies
- Transcriptional heterogeneity of fibroblasts is a hallmark of the AGING heart
- Toward a unified theory of AGING and regeneration
- What Is the Exposome and How It Can Help Research on Air Pollution
- Are we ill because we age?
- The epigenetics of stem cell AGING comes of age
- Age and poverty status alter the coding and noncoding transcriptome
- Senolytics and senostatics: a two-pronged approach to target cellular senescence for delaying AGING and age-related diseases
- Are we nearing the extinction of Gerentology?
- MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage
- Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice
- Murine single-cell RNA-seq reveals cell-identity-and tissue-specific trajectories of AGING
- Targeting senescent cells: Approaches, opportunities, challenges
- Circular RNA involvement in AGING: an emerging player with great potential
- The function of lncRNAs in AGING-related diseases and 3D genome
- Characterization of senescence biomarkers in rheumatoid arthritis: relevance to disease progression
- New Insights into Chronological Mobility of Retrotransposons In Vivo
- To the freezers! Stored biospecimens from human randomized trials are an important new direction for studies of biological AGING
- Comparability of biological AGING measures in the National Health and Nutrition Examination Study, 1999–2002
- Neuronal O-GlcNAcylation improves cognitive function in the aged mouse brain
- Exosomes, cancer’s little army
- Latest advances in AGING research and drug discovery
- Pulmonary diseases and ageing
- Introductory Chapter: DNA Repair in Human Cells-A Daily Challenge
- A novel pyrazolopyrimidine ligand of human PGK1 and stress sensor DJ1 modulates the shelterin complex and telomere length regulation
- NADPH oxidases and AGING models of lung fibrosis
- Quest for Bioactive Compounds in Our Diet with Anti-Ageing and Anti-Aggregation Properties
- Circulating miRNAs in Successful and Unsuccessful AGING. A mini-review
- Epigenetics of AGING and Cancer: A Comprehensive Look
- Dissecting AGING and senescence—current concepts and open lessons
- Alternate day fasting improves physiological and molecular markers of AGING in healthy, non-obese humans
- The consequences of ageing, progeroid syndromes and cellular senescence on mechanotransduction and the nucleus
- Epigenetic AGING clocks in ecology and evolution
- Current state of saliva biomarkers for AGING and Alzheimer’s disease
- Partial reprogramming as a therapeutic approach for heart disease: A state‐of‐the‐art review
- Telomere and its role in the AGING pathways: telomere shortening, cell senescence and mitochondria dysfunction
- Deconstructing age reprogramming
- TGF-β signaling in cellular senescence and AGING-related pathology
- Cellular senescence in bone
- On the fly: recent progress on autophagy and AGING in Drosophila
- Elevating acetyl-CoA levels reduces aspects of brain AGING
- Emerging insights into the metabolic alterations in AGING using metabolomics
- Socio-Economic Position Under the Microscope: Getting ‘Under the Skin’and into the Cells
- Future cell and gene therapy for osteoarthritis (OA): potential for using mammalian protein production platforms, irradiated and transfected protein packAGING …
- Nutrient sensing and redox balance: GCN2 as a new integrator in AGING
- AGING, lifestyle and dementia
- Lipotoxicity, AGING, and muscle contractility: does fiber type matter?
- Plasma-based strategies for therapeutic modulation of brain AGING
- Epigenomic drivers of immune dysfunction in AGING
- Tamoxifen induction of Cre recombinase does not cause long-lasting or sexually divergent responses in the CNS epigenome or transcriptome: implications for the …
- Mice with hyper-long telomeres show less metabolic AGING and longer lifespans
- PHYTOCHEMICALS AS PROSPECTIVE HUMAN ANTI-AGING COMPOUNDS
- Of AGING mice and men: gait speed decline is a translatable trait, with species-specific underlying properties
- Population Epigenetics and AGING
- Epigenetics and AGING
- Recombinant buckwheat trypsin inhibitor improves the protein and mitochondria homeostasis in Caenorhabditis elegans model of AGING and age-related disease
- Invertebrate and vertebrate models in AGING research.
- Sex differences in the AGING human heart: decreased sirtuins, pro-inflammatory shift and reduced anti-oxidative defense
- SIRT2 functions in AGING, autophagy, and apoptosis in post-maturation bovine oocytes
- The effect of exclusive olive oil consumption on successful AGING: a combined analysis of the ATTICA and MEDIS epidemiological studies
- Cell senescence in lupus
- KMT1/Suv39 methyltransferase family regulates peripheral heterochromatin tethering via histone and non-histone protein methylations
- NAD+ in brain AGING and neurodegenerative disorders
- Epigenetic clock analysis of blood samples from Japanese schizophrenia patients
- A triple drug combination targeting components of the nutrient-sensing network maximizes longevity
- Autophagy as a beacon and sentry for AGING stem cells
- DESIGNING TECHNOLOGY TO SUPPORT HEALTHCARE FOR AGING ADULTS
- The Cambridge handbook of successful AGING
- Is Nature our Best Assurance of Healthy Ageing? Lessons from age-resilient animal species
- Epigenetic clock and relative telomere length represent largely different aspects of AGING in the Berlin AGING Study II (BASE-II)
- Nutrigenomics as a tool to study the impact of diet on AGING and age-related diseases: the Drosophila approach
- Intracellular heat shock protein 70 deficiency in pulmonary fibrosis
- Cognitive and Brain AGING: Interventions to Promote Well-Being in Old Age
- Cognitive AGING is not created equally: Differentiating unique cognitive phenotypes in “normal” adults
- What AGING with HIV means in the year 2019
- Proteasome activation to combat proteotoxicity
- Mutat Res Gen Tox En
- Chronic obstructive pulmonary disease as a main factor of premature AGING
- Breast cancer risk in a rapidly AGING population: advances and approaches to study the AGING tissue microenvironment
- Identification of key genes and transcription factors in AGING mesenchymal stem cells by DNA microarray data
- AGING and the immune system: the impact of immunosenescence on viral infection, immunity and vaccine immunogenicity
- Lactobacillus Strains Alleviated AGING Symptoms and AGING-Induced Metabolic Disorders in Aged Rats
- Acceleration of β cell AGING determines diabetes and senolysis improves disease outcomes
- The microbiome and AGING
- Emerging senolytic agents derived from natural products
- Remodeling of bone marrow hematopoietic stem cell niches promotes myeloid cell expansion during premature or physiological AGING
- Allogeneic mesenchymal stem cell therapy: a regenerative medicine approach to geroscience
- Mitochondrial dysfunction in the AGING retina
- Molecular mechanisms of AGING: the role of oxidative stress and epigenetic modifications
- Cellular senescence as a mechanism and target in chronic lung diseases
- Oxidative stress: eustress and distress in redox homeostasis
- COPD as a Disease of Immunosenescence
- Dynamic DNA methylation during AGING: A “prophet” of age-related outcomes
- Epigenetic changes during AGING and their reprogramming potential
- Topical rapamycin reduces markers of senescence and AGING in human skin: an exploratory, prospective, randomized trial
- Effects of AGING and diet on cardioprotection and cardiometabolic risk markers
- Characterizing the Induction of Senescence by Tau and Beta-Amyloid in Rat Astrocytes
- Classical monocytes from older adults maintain capacity for metabolic compensation during glucose deprivation and lipopolysaccharide stimulation
- Age-related alterations affecting the chondrogenic differentiation of synovial fluid mesenchymal stromal cells in an equine model
- Roles of Telomeres and Telomerase in AGING
- The Origins of Ageing
- The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degeneration
- Role of nicotinamide in genomic stability and skin cancer chemoprevention
- Negative conditioning of mitochondrial dysfunction in age-related neurodegenerative diseases
- Programmed (Adaptive) AGING Theories
- Sargassum fusiforme fucoidan SP2 extends the lifespan of Drosophila melanogaster by upregulating the Nrf2-mediated antioxidant signaling pathway
- Nucleolar and ribosomal dysfunction—a common pathomechanism in childhood progerias?
- Plant-rich dietary patterns, plant foods and nutrients, and telomere length
- Relationships between ion channels, mitochondrial functions and inflammation in human AGING
- Basic and translational AGING research in China: present and future
- Multidimensional Proteomics Identifies Declines in Protein Homeostasis and Mitochondria as Early Signals for Normal AGING and Age-associated Disease in …
- Impaired proteostasis during skeletal muscle AGING
- Pairwise combinations of chemical compounds that delay yeast chronological AGING through different signaling pathways display synergistic effects on the …
- Blood autophagy defect causes accelerated non-hematopoietic organ AGING
- Turning back time with emerging rejuvenation strategies
- Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance
- How to measure population AGING? The answer is less than obvious: a review
- Rapamycin modulates tissue AGING and lifespan independently of the gut microbiota in Drosophila
- DNA damage repair and DNA methylation in the kidney
- Impact of AGING on bone, marrow and their interactions
- Age-related gene and miRNA expression changes in airways of healthy individuals
- AGING triggers H3K27 trimethylation hoarding in the chromatin of Nothobranchius furzeri skeletal muscle
- microRNAs in the functional defects of skin AGING
- Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults
- IMPACT OF WELLBEING ON QUALITY OF LIFE OF AGING POPULATION IN PAKISTAN: EVIDENCE FROM KARACHI.
- Functional genomics of dietary restriction and longevity in yeast
- The murine transcriptome reveals global AGING nodes with organ-specific phase and amplitude
- Association of 10-Year C-reactive protein trajectories with markers of healthy AGING: Findings from the English Longitudinal Study of AGING
- DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during AGING
- Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species
- Yeast at the forefront of research on ageing and age-related diseases
- Toward understanding genomic instability, mitochondrial dysfunction and AGING
