MENAQUINONE 4
May 20, 2022CIANIDANOL
June 1, 2022- Overexpression of Atg5 in mice activates autophagy and extends lifespan
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
- Dietary deprivation extends lifespan in Caenorhabditis elegans
- An antidepressant that extends lifespan in adult Caenorhabditis elegans
- rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice
- Increased fidelity of protein synthesis extends lifespan
- Loss of pregnancy‐associated plasma protein A extends lifespan in mice
- The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
- 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
- JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
- Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice
- Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
- D-beta-hydroxybutyrate extends lifespan in C. elegans
- The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
- Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status
- Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
- PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
- Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
- Restriction of amino acids extends lifespan in Drosophila melanogaster
- Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
- Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
- Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan
- Dietary restriction extends lifespan through metabolic regulation of innate immunity
- Glycine supplementation extends lifespan of male and female mice
- Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
- Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans
- Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan
- Roux‐en‐Y gastric bypass enhances energy expenditure and extends lifespan in diet‐induced obese rats
- New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
- The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
- The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila
- Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome
- Deletion of the Mitochondrial Superoxide Dismutase sod-2 extends lifespan in Caenorhabditis elegans
- Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila
- Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model
- The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease
- The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy …
- Royalactin extends lifespan of Caenorhabditis elegans through epidermal growth factor signaling
- Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
- Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism
- Chemical activation of a food deprivation signal extends lifespan
- Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice
- Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and extends lifespan of Caenorhabditis elegans
- Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
- Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
- Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson’s disease model
- Arginase-II deficiency extends lifespan in mice
- Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer’s model
- Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
- Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan
- Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice
- The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice
- Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis
- An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila
- Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila
- Sodium rutin extends lifespan and health span in mice including positive impacts on liver health
- Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer’s disease
- Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster
- Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice
- Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans
- Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis
- Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and extends lifespan in Caenorhabditis elegans
- Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans
- PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
- Phosphatidylcholine extends lifespan via DAF-16 and reduces amyloid-beta-induced toxicity in Caenorhabditis elegans
- Panax notoginseng polysaccharide increases stress resistance and extends lifespan in Caenorhabditis elegans
- Dietary nitrite extends lifespan and prevents age-related locomotor decline in the fruit fly
- L-Theanine extends lifespan of adult Caenorhabditis elegans
- Rebaudioside A enhances resistance to oxidative stress and extends lifespan and healthspan in Caenorhabditis elegans
- Drosophila insulin‐like peptide‐6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin‐like peptide‐2 from the brain
- Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK
- Dietary Restriction extends lifespan in Wild-Derived Populations of Drosophila melanogaster
- The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans
- Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan
- S100A9 extends lifespan in insulin deficiency
- Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans
- The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO
- Vitamin E extends lifespan in the short-lived rotifer Asplanchna brightwelli
- Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR
- Withania somnifera root extract extends lifespan of Caenorhabditis elegans
- Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans
- Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans
- Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome
- Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
- Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans
- Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster
- Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model …
- Purple sweet potato extract extends lifespan by activating autophagy pathway in male drosophila melanogaster
- A novel antioxidant peptide purified from defatted round scad (Decapterus maruadsi) protein hydrolysate extends lifespan in Caenorhabditis elegans
- Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson’s disease through activation of mitophagy
- A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans
- Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans
- Rhodiola rosea extends lifespan and improves stress tolerance in silkworm, Bombyx mori
- Maintenance of protein homeostasis in glia extends lifespan in C. elegans
- N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression
- … red wine consumption increases the expression of longevity-associated genes in controlled human populations and extends lifespan in Drosophila melanogaster
- Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
- Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
- The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation
- Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy
- A reduction in age-enhanced gluconeogenesis extends lifespan
- Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy
- Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species
- An antidiabetic polyherbal phytomedicine confers stress resistance and extends lifespan in Caenorhabditis elegans
- Cyclin‐dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus
- Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans
- Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1
- PBT2 reduces toxicity in a C. elegans model of polyQ aggregation and extends lifespan, reduces striatal atrophy and improves motor performance in the R6/2 mouse …
- The Yang-tonifying herbal medicine cynomorium songaricum extends lifespan and delays aging in drosophila
- 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
- Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum
- Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans
- Genistein from Vigna angularis extends lifespan in Caenorhabditis elegans
- Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans
- MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer’s disease
- … of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans
- Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
- Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice
- Korean red ginseng tonic extends lifespan in D. melanogaster
- Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster
- TORC 1‐mediated sensing of chaperone activity alters glucose metabolism and extends lifespan
- As predicted by hyperfunction theory, rapamycin treatment during development extends lifespan
- Astragalus polysaccharide extends lifespan via mitigating endoplasmic reticulum stress in the silkworm, Bombyx mori
- Echinacoside, a phenylethanoid glycoside from Cistanche deserticola, extends lifespan of Caenorhabditis elegans and protects from Aβ-induced toxicity
- Cocoa improves age-associated health and extends lifespan in C. elegans
- IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lprmice
- Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster
- Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral …
- S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects
- A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP …
- A nutritional supplement containing lactoferrin stimulates the immune system, extends lifespan, and reduces amyloid β peptide toxicity in Caenorhabditis elegans
- Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO
- Sonneradon A extends lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways
- Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of …
- Concentrated fish oil (Lovaza®) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW) F1 mice
- Caloric restriction extends lifespan of mothers at the expense of offspring survival in a predatory mite (Neoseiulus cucumeris)
- Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines
- Bark extract of the amazonian tree Endopleura uchi (Humiriaceae) extends lifespan and enhances stress resistance in Caenorhabditis elegans
- Experimentally reduced insulin/IGF‐1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring
- Rapamycin treatment during development extends lifespan and healthspan
- Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila
- Activation of autophagy attenuates motor deficits and extends lifespan in a C. elegans model of ALS
- Human IGF1 extends lifespan and enhances resistance to Plasmodium falciparum infection in the malaria vector Anopheles stephensi
- Translational control of gene expression by eIF2 modulates proteostasis and extends lifespan
- Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A‐dependent catalytic mechanism
- Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function
- Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice
- Traditional tonifying polyherbal infusion, Jatu-Phala-Tiga, exerts antioxidant activities and extends lifespan of Caenorhabditis elegans
- Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster
- Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)
- Hypoxia extends lifespan of Brachionus manjavacas (Rotifera)
- Intermittent exposure to fluorescent light extends lifespan of human diploid fibroblasts in culture
- Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline
- Ilex paraguariensis extends lifespan and Increases an Ability to Resist Environmental Stresses in Drosophila
- FOXM1 delays senescence and extends lifespan
- Glycerol extends lifespan of Brachionus manjavacas (Rotifera) and protects against stressors
- Inhibition of a eukaryotic initiation factor (eIF2Bδ,/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans
- Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9
- Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice
- Reduced expression of alpha‐1,2‐mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans
- Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans
- Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice
- Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse …
- A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice
- Transition state analogue of MTAP extends lifespan of APCMin/+ mice
- Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex III
- Inhibition of GIP signaling extends lifespan without caloric restriction
- IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
- Mutation of daf‐2 extends lifespan via tissue‐specific effectors that suppress distinct life‐limiting pathologies
- Rejuvenation of the disposable soma: repeated injury extends lifespan in an asexual annelid
- Reduced neuronal expression of ribose‐5‐phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in …
- Astragaloside IV extends lifespan of Caenorhabditis elegans by Improving Age-Related Functional Declines and Triggering Antioxidant Responses
- The collagen-derived compound collagen tripeptide induces collagen expression and extends lifespan via a conserved p38 mitogen-activated protein kinase cascade
- Chinese liquor extract attenuates oxidative damage in HepG2 cells and extends lifespan of Caenorhabditis elegans
- DhHP-6 extends lifespan of Caenorhabditis elegans by enhancing nuclear translocation and transcriptional activity of DAF-16
- A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan
- Gemals, a new drug candidate, extends lifespan and improves electromyographic parameters in a rat model of amyotrophic lateral sclerosis
- Identification of a sustainable two-plant diet that effectively prevents age-related metabolic syndrome and extends lifespan in aged mice
- Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO
- Reevaluation of whether a soma–to–germ-line transformation extends lifespan in Caenorhabditis elegans
- Loss of NDG‐4 extends lifespan and stress resistance in Caenorhabditis elegans
- Autophagy extends lifespan via vacuolar acidification
- Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans
- Oleuropein Enhances Stress Resistance and extends lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in Caenorhabditis elegans
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction
- Jujube (Ziziphus Jujuba Mill.) fruit feeding extends lifespan and increases tolerance to environmental stresses by regulating aging-associated gene expression in …
- A mid-life crisis for aging theory: from yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this …
- Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
- Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans
- PAK1-deficiency/down-regulation reduces brood size, activates HSP16. 2 gene and extends lifespan in Caenorhabditis elegans
- Syntaxin 4 overexpression ameliorates effects of aging and high-fat diet on glucose control and extends lifespan
- Streptococcus thermophilus extends lifespan through activation of DAF-16-mediated antioxidant pathway in Caenorhabditis elegans
- The neuroprotector benzothiazepine CGP37157 extends lifespan in C. elegans worms
- Enhancing mask activity in dopaminergic neurons extends lifespan in flies
- Knockdown expression of eukaryotic initiation factor 5 C-terminal domain containing protein extends lifespan in Drosophila melanogaster
- Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in Caenorhabditis elegans
- S-allylmercapto-N-acetylcysteine protects against oxidative stress and extends lifespan in Caenorhabditis elegans
- Short-term enhancement of motor neuron synaptic exocytosis during early aging extends lifespan in Caenorhabditis elegans
- Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans
- Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila
- A C-terminal truncated mutation of spr-3 gene extends lifespan in Caenorhabditis elegans
- Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans
- Ethanol extends lifespan of the rotifer Brachionus plicatilis
- Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides
- Potassium restriction boosts vacuolar acidity and extends lifespan in yeast
- A steroid hormone that extends the lifespan of Caenorhabditis elegans
- Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage
- 2-SeCD treatment extends lifespan, improves healthspan and enhances resistance to stress in Caenorhabditis elegans
- Rapamycin additively extends lifespan in short-and long-lived lines of the nematode Caenorhabditis remanei
- Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila
- Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
- Enhancing autophagy by redox regulation extends lifespan in Drosophila
- Glucose extends lifespan through enhanced intestinal barrier integrity in Drosophila
- Rapamycin extends maximal lifespan in cancer-prone mice
- Dietary Glycine Supplementation extends lifespan of Genetically Heterogeneous Mice
- Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
- 10-Hydroxy-2-decenoic acid, the major lipid component of royal jelly, extends the lifespan of Caenorhabditis elegans through dietary restriction and target of …
- Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
- Valproic acid extends Caenorhabditis elegans lifespan
- Hyperactivation of the proteasome core particle in Caenorhabditis elegans protects against proteotoxic stress and extends lifespan
- Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion
- Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans
- Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster
- Enhanced proteasome degradation extends Caenorhabditis elegans lifespan and alleviates aggregation-related pathologies
- A genetic model of methionine restriction extends Drosophila health-and lifespan
- Systemic delivery of rAAV6-microdystrophin preserves muscle function and extends lifespan in a murine model of severe muscular dystrophy
- ENA-A actimineral resource A extends lifespan associated with antioxidant mechanism in SMP30 knockout mice
- Overexpression of Fatty-Acid-𝜷-Oxidation-Related Genes extends the lifespan of Drosophila melanogaster
- Transition state analogue of MTAP extends lifespan of APCMin/+ mice
- Crocus sativus L. protects against SDS‑induced intestinal damage and extends lifespan in Drosophila melanogaster
- PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
- Anti-aging effects of Ketanserin; Ketanserin extends lifespan in female drosophila, inhibits cellular senescence and promotes wound healing in-vitro
- LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice
- Lindera obtusiloba extends lifespan of Caenorhabditis elegans
- Correction: PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
- Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
- Fructose extends lifespan and Reduces Intestinal Fat Deposition in Caenorhabditis elegans
- Ras inhibition by trametinib treatment in Drosophila attenuates gut pathology in females and extends lifespan in both sexes
- Author Correction: IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
- Commentary: Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans
- Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans
- eIF2B extends lifespan through inhibition of the integrated stress response
- Valproic ACID extends lifespan of the Zebrafish Model of CLN2 Disease (Late Infantile Neuronal Ceroid Lipofuscinosis)
- Dietary Restriction extends lifespan through Metabolic Regulation of Innate Immunity
- Overexpression of protein carboxyl methyltransferase extends lifespan in Drosophila melanogaster
- Antioxidant extends lifespan
- d-Allulose, a stereoisomer of d-fructose, extends Caenorhabditis elegans lifespan through a dietary restriction mechanism: A new candidate dietary restriction mimetic
- Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer’s disease.
- … of rheumatoid arthritis. Nat. Med. (2005) 11:936-943, and BARBER DF, BARTOLOMÉ A, HERNANDEZ C et al.: PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse …
- INCREASE IN HSP25 extends lifespan AND IMPROVES RESPONSE TO TAU TOXICITY THROUGH A CELL, NON-AUTONOMOUS MECHANISM
- Hepatocyte Transplantation (HTx) extends lifespan, Increases Branched Chain a-Keto Acid Dehydrogenase (BCKDH) Activity, and Improves Neurotransmitter and …
- Systemic Administration of Telomerase RNA Reverses Vascular Senescence and extends lifespan in Progeria Mice
- ZOLEDRONATE extends lifespan AND HEALTHSPAN IN VIVO
- Ophiopogon japonicus herbal tea ameliorates oxidative stress and extends lifespan in caenorhabditis elegans
- Lithium extends lifespan and Slows Brain Aging
- NEURONAL-SPECIFIC PROTEASOME AUGMENTATION VIA extends lifespan AND REDUCES AGE-RELATED NEURODEGENERATION
- Celecoxib extends C. elegans lifespan via inhibition of insulin‐like signaling but not cyclooxygenase‐2 activity
- Downregulation of the tyrosine degradation pathway extends Drosophila lifespan
- Inhibition of lipid peroxidation during the reproductive period extends the lifespan of Caenorhabditis elegans
- REGULATION OF GLUCOSE STORAGE extends lifespan AND PROMOTES HEALTHSPAN
- Prohibitin depletion extends lifespan of a TORC2/SGK-1 mutant through autophagy
- No evidence that wine drinking extends lifespan
- Drinking Chamomile Tea extends lifespan
- Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan
- Royalactin extends lifespan of C. elegans through EGF signaling
- Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
- A small molecule norathyriol extends lifespan in association with mitochondrial function in C. elegans
- Supplementation with elenocysteine extends lifespan and modulates age-related physiological alterations in C. elegans
- Chicoric Acid Promotes Glucose Uptake and extends lifespan
- Enzyme role found for aging gene: two labs independently discover mechanism for how Sir2 extends lifespan.(Hot Papers)
- Metformin extends C. elegans lifespan through lysosomal pathway
- jouvence, a new small nucleolar RNA required in the gut extends lifespan in Drosophila
- Long live the Queen-Royalactin extends lifespan of C. elegans through epidermal growth factor (EGF) signaling
- β‐Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP‐activated protein kinase‐dependent increase in autophagy
- Korean Red Ginseng Tonic extends lifespan in D. melanogaster
- Inhibition of Isw2‐mediated chromatin remodeling by calorie restriction extends lifespan by potentiating stress response
- Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorh…
- Alaskan Lowbush Cranberry extends lifespan in C. elegans
- Tissue-specific downregulation of EDTP suppresses polyglutamine protein aggregates and extends lifespan in Drosophila
- Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously hypertensive rats
- Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy.
- Rapamycin extends murine lifespan but has limited effects on aging
- β‐Hydroxy‐β‐methylbutyrate extends lifespan and attenuates age‐dependent loss of flight ability in Drosophila melanogaster (246.2)
- Corrigendum to “Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans”[Exp. Gerontol. 48 (2013) 191–201]
- Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and extends lifespan via the Heat Shock Response in Caenorhabditis elegans
- Reprogrammed M1 macrophages with inhibited STAT3, STAT6 and/or SMAD3 extends lifespan of mice with experimental carcinoma
- miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7
- … TREATMENT REGIMENS MITIGATE THE IMPACT OF RAPAMYCIN ON GLUCOSE HOMEOSTASIS AND THE IMMUNE SYSTEM, AND extends lifespan
- Dietary restriction extends the lifespan of circadian mutants tim and per
- Moderate hypoxia (10 kPa) extends lifespan with adult but not juvenile exposure in the fruitfly, Drosophila melanogaster
- 629. Intravenous Delivery of a MTMR2-Encoding AAV9 Vector extends lifespan and Improves Muscle Function in Mice with X-Linked Myotubular Myopathy
- 713. IntraCSF Administration of AAV9/MeCP2 extends lifespan of MeCP2-Null Mice While Preventing Toxicity Associated With IV Administration
- Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
- Neoagarotetraose extends the lifespan of Caenorhabditis elegans through AMPK mediated signaling pathways and activation of autophagy
- Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?
- Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species
- Caffeine extends yeast lifespan by targeting TORC1
- A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response
- A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity
- Ferulsinaic acid attenuation of advanced glycation end products extends the lifespan of Caenorhabditis elegans
- Inhibition of GMP synthesis extends yeast replicative lifespan
- CAN1 arginine permease deficiency extends yeast replicative lifespan via translational activation of stress response genes
- HUMAN IGF1 extends MOZZIE lifespan
- Restoration of energy homeostasis by SIRT6 extends healthy lifespan
- Overexpression of malic enzyme in the larval stage extends Drosophila lifespan
- Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway
- rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction
- Neuronal expression of a single‐subunit yeast NADH–ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan
- Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
- Isonicotinamide extends yeast chronological lifespan through a mechanism that diminishes nucleotides
- Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan
- Aiweixin, a Traditional Uyghur Medicinal Formula, extends the lifespan of Caenorhabditis elegans
- SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
- Elevated Proteasome Capacity extends Replicative lifespan in Saccharomyces cerevisiae
- Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity
- Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
- Curcumin Acetylsalicylate extends the lifespan of Caenorhabditis elegans
- gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe
- SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae
- Gengnianchun extends the lifespan of Caenorhabditis elegans via the insulin/IGF-1 signalling pathway
- The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
- Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function
- Reduced expression of C/EBPβ-LIP extends health and lifespan in mice
- Post-reproductive inhibition of the autophagic vesicle nucleation complex extends C. elegans lifespan through the neurons
- Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan
- A novel gene, ecl1+, extends the chronological lifespan in fission yeast
- Telomere elongation in the gut extends zebrafish lifespan
- Low-dose chloroquine treatment extends the lifespan of aged rats
- Glucosamine extends the lifespan of Caenorhabditis elegans via autophagy induction
- Parishin from Gastrodia elata extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway
- Acidic Food pH Increases Palatability and Consumption and extends Drosophila lifespan
- Dairy Propionibacterium extends the mean lifespan of Caenorhabditis elegans via activation of the innate immune system
- D-Allose, a Stereoisomer of D-Glucose, extends the lifespan of Caenorhabditis elegans via Sirtuin and Insulin Signaling D-Allose extends Nematode lifespan via …
- Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
- Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
- Reduced expression of C/EBPb-LIP extends health and lifespan in mice
- Korean mistletoe (Viscum album coloratum) extract extends the lifespan of nematodes and fruit flies
- Mild Muscle Mitochondrial Fusion Distress extends Drosophila lifespan through an Early and Systemic Metabolome Reorganization
- Iron supplementation delays aging and extends cellular lifespan through potentiation of mitochondrial function
- Loss of tumor suppressor STAG2 promotes telomere recombination and extends the replicative lifespan of normal human cells
- Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16
- Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
- Zymolytic Grain Extract (ZGE) Significantly extends the lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans
- A mutation that alters the 255th glutamate to lysine in RSKS-1/S6 kinase reliably extends the lifespan of C. elegans
- Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response
- Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro
- Gentiopicroside, a secoiridoid glycoside from Gentiana rigescens Franch, extends the lifespan of yeast via inducing mitophagy and antioxidative Stress
- Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1 (+/−) mice
- Nordihydroguaiaretic Acid extends the lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters …
- Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster
- Lithocholic Acid extends Yeast Chronological lifespan, Drives the Evolution of Longevity Regulation Mechanisms in Ecosystems and Suppresses Mitochondrial …
- Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double …
- The retrotransposon Ty1 extends chronological lifespan in Saccharomyces paradoxus by influencing cellular responses to stress
