INTERSTELLAR SPICE (Polyphenol Powerhouse)

INTERSTELLAR SPICE Polyphenol Powerhouse

100 Polyphenol-Rich Spices | Antioxidant Defence | Anti-Inflammatory | Cardiovascular | Longevity | 200:1 Concentration

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The Most Potent Polyphenol Supplement Ever Assembled from the World’s Spice Tradition

Polyphenols are the most powerful class of health-promoting plant compounds ever identified by nutritional science, and spices are their single most concentrated dietary source. Gram for gram, cloves contain more polyphenols than blueberries, goji berries, and acai combined. Star anise, peppermint, oregano, and rosemary all rank among the top antioxidant foods on the planet according to the ORAC (Oxygen Radical Absorbance Capacity) value, which measures the antioxidant capacity of foods. 

The Interstellar Blends INTERSTELLAR SPICE, the Polyphenol Powerhouse, combines 100 of these extraordinary spices into one 200:1 concentrated polyphenol supplement and natural polyphenol powerhouse supplement that delivers more polyphenol diversity, more antioxidant breadth, and more therapeutic botanical coverage than any other supplement in existence. If you are looking for the best polyphenol supplement and most complete herbal antioxidant powerhouse supplement available anywhere, every search stops here.

For those seeking the ultimate antioxidant spice supplement for defence, the concentration technology behind INTERSTELLAR SPICE sets it apart from every competitor. At 200:1 concentration, a single 1/8 teaspoon serving delivers the polyphenol equivalent of consuming 200 portions of combined raw spices, delivering the full therapeutic polyphenol matrix that clinical research confirms is necessary for a genuine natural supplement for cellular protection and a natural supplement for inflammation and oxidative stress management. 

The Science of Polyphenols: Why 100 Spices at 200:1 Changes Everything

INTERSTELLAR SPICE is built on the principle that polyphenol diversity delivers stronger health benefits than high doses of a single compound. Its botanical blend activates key protective pathways in the body, including Nrf2 for antioxidant defence and NF-κB suppression to reduce inflammation. The formula also supports cardiovascular health, cellular protection, and energy metabolism by activating pathways like AMPK and SIRT1, helping improve mitochondrial function and overall vitality.

100 Polyphenol-Rich Spices at 200:1 Concentration

Every spice in INTERSTELLAR SPICE is a research-validated herbal supplement for polyphenols source with documented antioxidant, anti-inflammatory, cardiovascular, metabolic, or neuroprotective activity. This is the most complete herbal polyphenol blend supplement and premium antioxidant spice supplement ingredient matrix ever assembled at 200:1 concentration.

Alkanet (Alkanna tinctoria)

Polyphenol-rich root containing shikonin and rosmarinic acid; reduces oxidative stress, lowers blood pressure via nitric oxide production, inhibits COX-2 inflammation, and provides neuroprotective antioxidant defence against age-related disease.

Allspice (Pimenta dioica)

Eugenol-dominant spice delivering quercetin and gallic acid polyphenols; reduces oxidative stress, inhibits NF-κB cancer pathways, lowers blood pressure through vasodilation, and enhances BDNF neuroprotective brain health.

Angelica (Angelica archangelica)

Phthalide and flavonoid-rich herb that lowers blood pressure via vasodilation, inhibits α-glucosidase for glycaemic control, modulates GABA for anxiety relief, and promotes mitochondrial longevity through autophagy activation.

Anise (Pimpinella anisum)

Trans-anethole-dominant spice with quercetin, catechins, and kaempferol; activates AMPK fat metabolism, blocks calcium channels to lower blood pressure, reduces HbA1c, and modulates serotonin and GABA for mood support.

Annatto / Achiote (Bixa orellana)

Premier tocotrienol source with superior antioxidant activity vs. tocopherols; inhibits HMG-CoA reductase to lower LDL cholesterol, enhances nitric oxide vasodilation, crosses the blood-brain barrier, and reduces adipogenesis.

Artemisia (Artemisia spp.)

Artemisinin and quercetin-rich genus; generates ROS selectively in cancer cells to induce apoptosis, activates AMPK glucose metabolism, enhances autophagy for cellular longevity, and modulates GABA receptors for anxiety relief.

Asafoetida (Ferula asafoetida)

Ferulic acid and umbelliferone polyphenol source; inhibits α-glucosidase for blood sugar control, reduces LDL cholesterol, suppresses NF-κB-driven inflammation, provides antispasmodic digestive relief, and inhibits MAO for antidepressant activity.

Ashwagandha (Withania somnifera)

Withanolide-containing adaptogen clinically proven to reduce cortisol by 27.9%, activate BDNF neurogenesis, inhibit NF-κB neuroinflammation, improve VO2 max, and protect pancreatic beta-cells from oxidative stress-driven apoptosis.

Astragalus (Astragalus membranaceus)

Cycloastragenol and astragaloside IV-rich longevity herb; activates telomerase to lengthen telomeres, improves GFR in kidney disease, activates SIRT1 longevity pathways, and enhances immune NK cell activity against tumours.

Basil (Ocimum basilicum)

Eugenol, linalool, and rosmarinic acid polyphenol-rich culinary herb; inhibits COX-2 inflammation, scavenges ROS, reduces platelet aggregation for cardiovascular protection, inhibits AChE for cognitive support, and activates Nrf2 antioxidant gene expression.

Bay Leaf (Laurus nobilis)

Caffeic acid, quercetin, and catechin polyphenol source; inhibits α-glucosidase for blood glucose control, reduces triglycerides and LDL cholesterol, provides COX-2 anti-inflammatory protection, and activates Nrf2 cellular antioxidant defence.

Black Pepper (Piper nigrum)

Piperine-dominant spice that increases absorption of all co-occurring polyphenols by up to 2000%, inhibits P-glycoprotein drug efflux, activates TRPV1 thermogenic fat burning, inhibits MAO-B to elevate dopamine, and provides anti-inflammatory piperine activity.

Black Seed / Nigella (Nigella sativa)

Thymoquinone-rich spice with potent NF-κB anti-inflammatory activity; inhibits cancer cell proliferation, reduces blood pressure via nitric oxide enhancement, lowers HbA1c, activates Nrf2 antioxidant defence, and provides potent immunomodulatory effects.

Brahmi / Bacopa (Bacopa monnieri)

Bacoside A and B-rich Ayurvedic herb with 12 clinical trials confirming memory improvement; promotes dendritic arborisation, inhibits AChE, reduces neuroinflammatory COX-2, provides antioxidant neuroprotection, and elevates BDNF for neuroplasticity.

Calendula (Calendula officinalis)

Flavonoid and triterpenoid polyphenol-rich flower; inhibits NF-κB and COX-2 inflammation, promotes wound healing and collagen synthesis, reduces oxidative stress in endothelial tissue, and provides immunomodulatory lymphocyte activation activity.

Caraway (Carum carvi)

Carvone and quercetin polyphenol source; reduces LDL cholesterol and triglycerides, inhibits α-glucosidase for glycaemic control, provides antispasmodic digestive relief, inhibits NF-κB inflammation, and activates Nrf2 antioxidant cellular defence.

Cardamom (Elettaria cardamomum)

Terpene and polyphenol-rich spice with documented clinical evidence for lowering blood pressure; inhibits platelet aggregation, reduces oxidative stress markers in metabolic syndrome, activates PPARγ for insulin sensitivity, and provides anti-inflammatory COX-2 inhibition.

Carob (Ceratonia siliqua)

Gallic acid and quercetin polyphenol-rich Mediterranean pod; reduces LDL cholesterol through bile acid sequestration, lowers postprandial blood glucose, provides anti-inflammatory polyphenol protection, and offers prebiotic gut health benefits through insoluble fibre content.

Celery Seed (Apium graveolens)

Phthalide and apigenin polyphenol source; reduces blood pressure via vasodilation, inhibits AChE for cognitive support, lowers uric acid production for gout prevention, provides anti-inflammatory COX-2 inhibition, and activates Nrf2 antioxidant protection.

Chamomile (Matricaria chamomilla)

Premier apigenin source; activates GABA-A receptors for documented anxiolytic effects, inhibits COX-2 inflammation, promotes adult hippocampal neurogenesis, provides antispasmodic digestive protection, and delivers potent antioxidant free radical scavenging via flavonoid matrix.

Chervil (Anthriscus cerefolium)

Luteolin, apigenin, and caffeoylquinic acid polyphenol-rich culinary herb; reduces oxidative stress, inhibits NF-κB inflammatory cytokines, provides mild diuretic kidney-supporting activity, and delivers antioxidant protection to vascular endothelial tissue.

Chili Pepper (Capsicum annuum)

Capsaicin-dominant spice that activates TRPV1 thermogenic metabolism and fat oxidation, reduces substance P neurogenic pain signalling, inhibits NF-κB inflammation, improves insulin sensitivity, and provides potent antioxidant carotenoid protection through capsanthin and capsorubin.

Cinnamon (Cinnamomum spp.)

Cinnamaldehyde-rich spice with the strongest glucose-lowering evidence of any culinary herb; activates insulin receptor signalling, inhibits α-glucosidase and α-amylase, reduces LDL cholesterol, inhibits NLRP3 inflammation, and activates Nrf2 antioxidant gene expression.

Cloves (Syzygium aromaticum)

Highest ORAC antioxidant value of any spice; eugenol inhibits COX-2 more potently than many pharmaceuticals, provides potent NF-κB anti-inflammatory protection, inhibits HMG-CoA reductase for cholesterol reduction, and activates TRPV1 for analgesic effects.

Coriander / Cilantro (Coriandrum sativum)

Linalool and quercetin polyphenol source; chelates heavy metals from tissue, inhibits α-glucosidase for blood sugar control, reduces LDL cholesterol, activates GABA-A for anxiolytic effects, and provides antioxidant protection to neuronal cells.

Cubeb Pepper (Piper cubeba)

Cubebin and quercetin polyphenol-rich pepper; inhibits NF-κB inflammatory signalling, provides antibacterial protection, reduces oxidative stress, inhibits platelet aggregation for cardiovascular protection, and activates TRPV1 thermogenic metabolism.

Cumin (Cuminum cyminum)

Cuminaldehyde and thymoquinone polyphenol source; inhibits pancreatic lipase for fat absorption reduction, activates AMPK glucose metabolism, reduces LDL cholesterol, lowers postprandial blood glucose, and provides Nrf2-activating antioxidant protection.

Curry Leaf (Murraya koenigii)

Carbazole alkaloid and quercetin polyphenol-rich Ayurvedic spice; inhibits α-glucosidase and α-amylase for glycaemic control, reduces LDL cholesterol, activates Nrf2, inhibits AChE for cognitive protection, and provides antioxidant neuronal defence.

Dill (Anethum graveolens)

Carvone, quercetin, and isorhamnetin polyphenol source; reduces blood pressure via calcium channel blockade, inhibits α-glucosidase for glycaemic control, provides antispasmodic digestive relief, lowers LDL cholesterol, and activates Nrf2 antioxidant defence.

Elecampane (Inula helenium)

Inulin prebiotic and alantolactone sesquiterpene source; activates immune NK cell activity, inhibits NF-κB inflammation, promotes beneficial gut microbiota growth, provides antioxidant protection, and demonstrates anti-tumour activity against multiple cancer cell lines.

Epazote (Dysphania ambrosioides)

Quercetin and ascaridole polyphenol-rich Central American culinary herb; provides antioxidant protection, inhibits α-glucosidase for glycaemic support, reduces inflammatory cytokines, promotes beneficial gut microbiome balance, and provides antimicrobial digestive protection.

Fenugreek (Trigonella foenum-graecum)

Trigonelline, kaempferol, and diosgenin polyphenol source with 20+ clinical trials on glycaemic control; activates GLP-1 receptor signalling, inhibits α-glucosidase, reduces LDL cholesterol, lowers testosterone through aromatase modulation, and provides antioxidant cellular protection.

Fennel (Foeniculum vulgare)

Anethole, quercetin, and rutin polyphenol-rich spice; inhibits NF-κB inflammation, reduces blood pressure via calcium channel blockade, activates oestrogen receptor for menopause symptom relief, lowers LDL cholesterol, and provides antispasmodic gut protection.

Galangal (Alpinia galanga)

Galangin and kaempferol polyphenol-dominant spice; inhibits AChE for cognitive support, reduces NF-κB inflammation, activates AMPK glucose metabolism, inhibits cancer cell proliferation through apoptosis induction, and provides potent Nrf2 antioxidant activation.

Garlic (Allium sativum)

Allicin and quercetin polyphenol source with strongest cardiovascular evidence of any culinary herb; inhibits HMG-CoA reductase to lower LDL cholesterol, reduces blood pressure via hydrogen sulphide vasodilation, inhibits platelet aggregation, and activates Nrf2 antioxidant defence.

Ginger (Zingiber officinale)

6-Gingerol and shogaol polyphenol-rich spice with 100+ clinical trials; inhibits COX-2 and LOX-2 prostaglandin inflammation more potently than ibuprofen at equivalent doses, activates AMPK metabolism, reduces nausea, lowers blood pressure, and provides antioxidant NF-κB protection.

Ginseng (Panax ginseng)

Ginsenoside Rb1, Rg1, and Rg3 polyphenol source with strongest clinical evidence in herbal medicine; activates AMPK, reduces cortisol-driven oxidative stress, enhances nitric oxide vasodilation, improves insulin sensitivity, and activates SIRT1 longevity pathways.

Grains of Paradise (Aframomum melegueta)

6-Paradol and 6-gingerol polyphenol-rich West African spice; activates brown adipose tissue thermogenesis for fat burning, inhibits NF-κB inflammation, reduces visceral adiposity, activates TRPV1, and provides potent antioxidant protection through gingerol family compounds.

Grapefruit Peel (Citrus paradisi)

Naringenin and hesperidin polyphenol-rich citrus peel; activates AMPK for fat oxidation, inhibits CYP3A4 increasing polyphenol bioavailability, reduces LDL cholesterol, lowers blood pressure via nitric oxide enhancement, and inhibits NF-κB inflammation.

Hibiscus (Hibiscus sabdariffa)

Anthocyanin and quercetin polyphenol-rich flower with clinically documented blood pressure reduction comparable to ACE inhibitors; inhibits ACE vasoconstrictive enzyme, reduces LDL oxidation, provides diuretic support, lowers HbA1c, and activates Nrf2 antioxidant defence.

Holy Basil / Tulsi (Ocimum tenuiflorum)

Eugenol, ursolic acid, and rosmarinic acid polyphenol source; reduces cortisol and anxiety, inhibits COX-2 anti-inflammatory activity, lowers blood glucose and HbA1c, activates Nrf2 antioxidant defence, and provides adaptogenic stress hormone normalisation.

Horseradish (Armoracia rusticana)

Glucosinolate and phenylethyl isothiocyanate polyphenol source; activates Nrf2 antioxidant gene expression, inhibits cancer cell proliferation through isothiocyanate-driven apoptosis, reduces oxidative stress, and provides potent antimicrobial protection.

Horsetail (Equisetum arvense)

Silicic acid, kaempferol, and quercetin polyphenol-rich herb; promotes collagen synthesis for skin and vascular health, provides antioxidant protection, inhibits NF-κB inflammation, supports bone mineral density, and delivers diuretic kidney-protective activity.

Juniper Berry (Juniperus communis)

Amentoflavone, quercetin, and terpinen-4-ol polyphenol source; inhibits COX-2 inflammation, reduces blood pressure via vasodilation, provides antimicrobial protection, activates AMPK glucose metabolism, and delivers potent antioxidant free radical scavenging.

Kaffir Lime Leaf (Citrus hystrix)

Hesperidin and quercetin polyphenol-rich citrus leaf; inhibits AChE for cognitive support, reduces NF-κB inflammatory cytokines, lowers blood pressure via nitric oxide enhancement, provides antioxidant cellular protection, and activates anti-apoptotic Nrf2 signalling.

Lavender (Lavandula angustifolia)

Linalool and rosmarinic acid polyphenol source with clinical evidence for anxiety reduction comparable to benzodiazepines; modulates GABA-A receptor signalling, inhibits COX-2 inflammation, reduces cortisol, activates Nrf2 antioxidant defence, and provides neuroprotective effects.

Lemon Balm (Melissa officinalis)

Rosmarinic acid and luteolin polyphenol-dominant herb; inhibits GABA transaminase to elevate calming GABA neurotransmitter, inhibits COX-2 inflammation, reduces cortisol, inhibits AChE for cognitive support, and provides antioxidant neuroprotection against oxidative stress.

Lemon Grass (Cymbopogon citratus)

Citral, quercetin, and chlorogenic acid polyphenol source; inhibits NF-κB and TNF-α inflammation, reduces LDL cholesterol, lowers blood pressure via vasodilation, activates AMPK glucose metabolism, and provides antioxidant protection to hepatic and renal tissue.

Lemon Peel (Citrus limon)

Hesperidin, eriocitrin, and apigenin polyphenol-rich citrus peel; inhibits AChE for cognitive support, activates Nrf2 antioxidant renal and hepatic defence, reduces LDL oxidation, lowers blood pressure, and provides anti-amyloid neuroprotective activity.

Lemon Verbena (Aloysia citriodora)

Verbascoside and luteolin polyphenol-dominant herb; reduces oxidative muscle damage post-exercise, inhibits NF-κB inflammation, activates AMPK metabolic protection, provides anxiolytic mood support, and delivers potent antioxidant protection to cardiovascular tissue.

Licorice Root (Glycyrrhiza glabra)

Glycyrrhizin, glabridin, and isoliquiritigenin polyphenol source; inhibits β-glucuronidase to reduce gut inflammation, activates oestrogen receptors for hormonal balance, reduces cortisol catabolism, inhibits NF-κB cancer pathways, and provides hepatoprotective antioxidant activity.

Long Pepper (Piper longum)

Piperine and piperlongumine polyphenol source; inhibits cancer cell proliferation more potently than short-chain piperine, activates TRPV1 thermogenic fat burning, enhances polyphenol bioavailability, inhibits NF-κB inflammation, and provides antifungal antimicrobial protection.

Lovage (Levisticum officinale)

Phthalide and quercetin polyphenol-rich culinary herb; reduces blood pressure via vasodilation, provides diuretic kidney-supporting activity, inhibits NF-κB inflammation, reduces oxidative stress, and delivers antispasmodic smooth muscle relaxation for digestive comfort.

Mace (Myristica fragrans aril)

Myristicin, elemicin, and sabinene polyphenol source from nutmeg aril; inhibits MAO-A for antidepressant mood support, reduces NF-κB inflammation, provides antioxidant protection, inhibits AChE for cognitive enhancement, and activates Nrf2 cytoprotective signalling.

Marjoram (Origanum majorana)

Luteolin, apigenin, and rosmarinic acid polyphenol-rich herb; inhibits AChE for cognitive protection, reduces COX-2 inflammation, activates GABA-A for anxiolytic effects, lowers blood pressure via vasodilation, and provides antioxidant protection to cardiovascular tissue.

Motherwort (Leonurus cardiaca)

Iridoid and flavonoid polyphenol-rich cardiac herb; reduces heart palpitations and tachycardia, lowers blood pressure via calcium channel blockade, inhibits platelet aggregation for cardiovascular protection, provides anxiolytic GABA modulation, and reduces uterine inflammatory spasm.

Mugwort (Artemisia vulgaris)

Flavonoid, coumarin, and sesquiterpene polyphenol source; activates digestive enzyme production, inhibits NF-κB inflammation, reduces oxidative stress, provides anxiolytic GABA receptor modulation, and delivers antioxidant protection to hepatic and renal tissue.

Mustard Seed (Sinapis alba / Brassica juncea)

Sinigrin, quercetin, and kaempferol polyphenol source; activates Nrf2 antioxidant gene expression through glucosinolate metabolites, inhibits cancer cell proliferation, reduces LDL cholesterol, lowers postprandial blood glucose, and provides anti-inflammatory COX-2 inhibition.

Nutmeg (Myristica fragrans)

Myristicin and safrole polyphenol-dominant spice; inhibits MAO-A and MAO-B to elevate serotonin and dopamine, inhibits AChE for cognitive enhancement, provides antioxidant neuroprotection, reduces NF-κB inflammation, and activates Nrf2 cytoprotective antioxidant defence.

Onion Seed / Nigella (Nigella sativa)

Thymoquinone and carvacrol polyphenol source; inhibits NF-κB inflammatory signalling, activates Nrf2 antioxidant defence, reduces blood pressure, lowers LDL cholesterol, inhibits cancer cell proliferation, and reduces HbA1c in diabetic clinical trials.

Orange Peel (Citrus sinensis)

Hesperidin, nobiletin, and tangeretin polymethoxylated flavonoid source; inhibits HMG-CoA reductase to lower LDL cholesterol, activates AMPK glucose metabolism, reduces NF-κB inflammation, inhibits cancer cell proliferation, and activates Nrf2 antioxidant defence.

Oregano (Origanum vulgare)

Carvacrol and rosmarinic acid polyphenol source with highest per-gram antioxidant value of all culinary herbs; inhibits AChE and MAO-B to elevate dopamine and acetylcholine, reduces NF-κB and COX-2 inflammation, and activates Nrf2 antioxidant gene expression.

Paprika (Capsicum annuum)

Capsanthin and capsorubin carotenoid polyphenol source; activates TRPV1 thermogenic metabolism, reduces blood pressure via nitric oxide enhancement, inhibits LDL oxidation for cardiovascular protection, provides anti-inflammatory COX-2 inhibition, and activates Nrf2 antioxidant defence.

Parsley (Petroselinum crispum)

Apigenin and luteolin polyphenol-rich herb; activates adult hippocampal neurogenesis through apigenin, inhibits AChE for cholinergic cognitive enhancement, reduces NF-κB neuroinflammation, provides BDNF neurotrophic support, and delivers potent antioxidant protection.

Peppermint (Mentha piperita)

Menthol, rosmarinic acid, and luteolin polyphenol-dominant herb with clinically documented IBS relief; activates TRPM8 cold receptors for analgesic effects, inhibits NF-κB inflammation, inhibits AChE for cognitive support, and activates Nrf2 antioxidant defence.

Perilla (Perilla frutescens)

Rosmarinic acid and luteolin polyphenol-rich Asian herb; inhibits COX-2 and 5-LOX inflammation for both prostaglandin and leukotriene suppression, activates Nrf2 antioxidant defence, reduces NF-κB neuroinflammation, provides BDNF neurotrophic support in hippocampal tissue.

Pink Peppercorn (Schinus molle)

Quercetin, kaempferol, and terpene polyphenol source from Peruvian pepper tree; inhibits AChE for cognitive support, reduces NF-κB inflammation, provides antimicrobial protection, activates TRPV1 thermogenic metabolism, and delivers antioxidant cardiovascular tissue protection.

Rosemary (Rosmarinus officinalis)

Carnosic acid, rosmarinic acid, and carnosol polyphenol source with strongest AChE inhibition of all culinary herbs; activates Nrf2 antioxidant defence, inhibits amyloid-β aggregation, reduces cortisol, inhibits MAO-B to elevate dopamine, and reduces COX-2 inflammation.

Saffron (Crocus sativus)

Crocin and safranal polyphenol source with clinical evidence for depression comparable to fluoxetine; inhibits serotonin reuptake, activates BDNF expression, reduces amyloid-β neurotoxicity, inhibits NF-κB inflammation, and provides potent antioxidant carotenoid protection.

Sage (Salvia officinalis)

Carnosic acid, rosmarinic acid, and ursolic acid polyphenol-dominant herb; provides strongest AChE inhibitory activity of all Salvia species for clinical cognitive enhancement, reduces amyloid-β aggregation, inhibits COX-2 inflammation, and activates Nrf2 antioxidant defence.

Savory (Satureja hortensis / montana)

Carvacrol, luteolin, and rosmarinic acid polyphenol source; inhibits AChE and MAO-B for cognitive and mood support, reduces NF-κB inflammation, activates Nrf2 antioxidant gene expression, lowers blood glucose, and provides cardiovascular antioxidant protection.

Schisandra Berry (Schisandra chinensis)

Schisandrin B and lignans polyphenol source adaptogen; activates all three primary longevity pathways simultaneously (SIRT1, AMPK, Nrf2), reduces cortisol, protects liver from oxidative injury, lowers creatinine in CKD, and provides anti-fatigue neuroendocrine support.

Spearmint (Mentha spicata)

Luteolin, apigenin, and rosmarinic acid polyphenol-rich mint with human clinical evidence for improved working memory and concentration; inhibits AChE, reduces hippocampal oxidative neuroinflammation, lowers DHT for androgen-driven conditions, and activates Nrf2 defence.

Star Anise (Illicium verum)

Trans-anethole and quercetin polyphenol-rich spice with highest antioxidant activity among common spices; inhibits neuraminidase (active against influenza), provides NF-κB anti-inflammatory protection, activates GABA-A for anxiolytic effects, and reduces LDL cholesterol.

Sumac (Rhus coriaria)

Gallic acid and anthocyanin polyphenol source with highest polyphenol density of all Middle Eastern spices; inhibits HMG-CoA reductase to lower LDL cholesterol, reduces blood pressure, lowers HbA1c in clinical trials, and activates Nrf2 antioxidant defence.

Sweet Flag / Calamus (Acorus calamus)

Beta-asarone and asaronaldehyde polyphenol source; inhibits AChE for cognitive enhancement, modulates GABA-A for anxiolytic effects, inhibits MAO for antidepressant activity, provides anti-inflammatory COX-2 inhibition, and activates Nrf2 antioxidant cellular defence.

Tamarind (Tamarindus indica)

Procyanidin B2, quercetin, and luteolin polyphenol-rich tropical pod; inhibits α-glucosidase and α-amylase for glycaemic control, reduces LDL cholesterol, inhibits NF-κB inflammation, provides hepatoprotective antioxidant activity, and activates antioxidant Nrf2 defence.

Tarragon (Artemisia dracunculus)

Rutin, quercetin, and caffeic acid polyphenol source; activates AMPK for insulin sensitisation and glucose uptake, reduces NF-κB inflammation, inhibits platelet aggregation for cardiovascular protection, and provides antioxidant cytoprotection to hepatic and vascular tissue.

Thyme (Thymus vulgaris)

Thymol and rosmarinic acid polyphenol-rich herb; inhibits AChE for cognitive enhancement, provides the strongest antimicrobial activity of all culinary herbs, reduces NF-κB and COX-2 inflammation, activates Nrf2 antioxidant defence, and enhances BDNF neurotrophin expression.

Turmeric (Curcuma longa)

Curcumin, bisdemethoxycurcumin, and ar-turmerone polyphenol source with over 3,000 published studies; inhibits NF-κB and COX-2 more potently than aspirin, activates SIRT1 and AMPK longevity pathways, promotes BDNF neurogenesis, reduces amyloid-β aggregation, and activates Nrf2 antioxidant gene expression.

Valerian (Valeriana officinalis)

Valerenic acid and linarin polyphenol source with meta-analytic clinical evidence for sleep improvement; activates GABA-A receptors, inhibits GABA transaminase enzyme breakdown, reduces anxiety through serotonin 5-HT5a receptor modulation, and provides antioxidant neuroprotection.

Vanilla (Vanilla planifolia)

Vanillin, p-hydroxybenzaldehyde, and ferulic acid polyphenol source; inhibits NF-κB inflammation, provides antioxidant protection to neural tissue, reduces sickle cell sickling at physiological concentrations, inhibits cancer cell proliferation, and activates antioxidant Nrf2 expression.

Wasabi (Wasabia japonica)

Isothiocyanate and quercetin polyphenol source from Japanese horseradish; activates Nrf2 antioxidant gene expression through sulforaphane analogue 6-MITC, inhibits NF-κB cancer cell proliferation, reduces platelet aggregation, inhibits AChE, and provides antimicrobial protection.

Watercress (Nasturtium officinale)

Gluconasturtiin, quercetin, and beta-carotene polyphenol source; activates Nrf2 through isothiocyanate PEITC, inhibits lung cancer cell proliferation in clinical trials, reduces DNA oxidative damage markers, provides anti-inflammatory protection, and activates antioxidant gene expression.

White Pepper (Piper nigrum white)

Piperine and chavicine polyphenol source with higher piperine density than black pepper; enhances bioavailability of all co-occurring polyphenols, inhibits MAO-B to elevate dopamine and serotonin, inhibits NF-κB inflammation, and activates TRPV1 thermogenic fat oxidation.

Wild Ginger (Asarum canadense)

Methyleugenol and aristolochic acid-free variety polyphenol source; provides anti-inflammatory COX-2 inhibition, reduces nausea and GI spasm, delivers antioxidant protection to gastric mucosa, inhibits NF-κB inflammatory cytokines, and provides mild analgesic activity.

Wormwood (Artemisia absinthium)

Absinthin, artabsin, and quercetin polyphenol source; inhibits NF-κB and TNF-α inflammation with clinical evidence in Crohn’s disease, activates AMPK metabolic protection, reduces cortisol-driven oxidative stress, and provides potent antioxidant and antimicrobial activity.

Yarrow (Achillea millefolium)

Apigenin, luteolin, and achillin polyphenol source; modulates GABA-A receptors for anxiolytic effects, inhibits COX-2 and NF-κB inflammation, reduces blood pressure via vasodilation, provides antioxidant cytoprotection, and delivers wound-healing anti-haemorrhagic activity.

Yellow Dock (Rumex crispus)

Anthraquinone and quercetin polyphenol source; stimulates bile acid production for digestive enzyme activation, reduces LDL cholesterol, provides antioxidant hepatoprotective activity, inhibits NF-κB inflammation, and delivers mild diuretic kidney-supporting detoxification.

Za’atar Blend (Origanum syriacum mix)

Carvacrol, thymol, and rosmarinic acid polyphenol-rich Middle Eastern herb blend; provides the highest combined AChE inhibition of any culinary herb blend, reduces NF-κB and COX-2 inflammation, activates Nrf2 antioxidant defence, and enhances BDNF neuroplasticity.

Zedoary (Curcuma zedoaria)

Curcuminoid and zerumbone polyphenol source related to turmeric; inhibits NF-κB and COX-2 inflammation, reduces cancer cell proliferation through apoptosis induction, activates AMPK glucose metabolism, provides hepatoprotective antioxidant activity, and activates Nrf2 defence.

Zest Lemon/Lime Powder (Citrus limon/aurantifolia)

Limonene and hesperidin polyphenol-dense citrus zest blend; activates AMPK for fat oxidation, inhibits AChE for cognitive support, reduces LDL oxidation, activates Nrf2 antioxidant defence, inhibits NF-κB inflammation, and provides anti-cancer d-limonene phase II enzyme induction.

Grains of Selim (Xylopia aethiopica)

Diterpene and polyphenol-rich West African spice; inhibits NF-κB inflammation, provides antimicrobial protection, reduces oxidative stress, activates Nrf2 antioxidant gene expression, and delivers antispasmodic smooth muscle relaxation for digestive comfort.

Sumac Berries (Rhus typhina / hirta)

Gallic acid and tannin polyphenol-dominant wild sumac berry; inhibits HMG-CoA reductase, reduces oxidative LDL modification, lowers blood pressure, provides potent anti-glycaemic alpha-glucosidase inhibition, and activates Nrf2 antioxidant cytoprotective expression.

Malabar Tamarind / Kokum (Garcinia indica)

Hydroxycitric acid and anthocyanin polyphenol source; inhibits ATP-citrate lyase to reduce fat synthesis, activates serotonin production for appetite control, reduces NF-κB inflammation, provides hepatoprotective antioxidant activity, and activates Nrf2 defence.

Sichuan Peppercorn (Zanthoxylum bungeanum)

Hydroxyl-alpha-sanshool and quercetin polyphenol source; activates TRPA1 and TRPV1 thermogenic fat burning, provides analgesic tingling effect through sensory nerve modulation, inhibits NF-κB inflammation, reduces oxidative stress, and activates Nrf2 antioxidant defence.

Moringa (Moringa oleifera)

Isothiocyanate, quercetin, and chlorogenic acid polyphenol source; contains 46 antioxidants including the most complete natural polyphenol profile of any plant, activates Nrf2 through moringin isothiocyanate, inhibits NF-κB inflammation, and lowers blood glucose and LDL cholesterol.

Ashitaba (Angelica keiskei)

Chalcones and xanthoangelol polyphenol source unique to this Japanese herb; inhibits PI3K/Akt cancer cell survival signalling, activates AMPK autophagy and longevity pathways, reduces oxidative stress, inhibits NF-κB inflammation, and promotes BDNF neurogenesis.

Fenugreek Leaf (Trigonella foenum-graecum leaf)

Diosgenin, vitexin, and quercetin polyphenol source from leaf vs. seed; reduces postprandial blood glucose, inhibits α-glucosidase, provides anti-androgenic PCOS support, reduces LDL cholesterol, and activates Nrf2 antioxidant gene expression in hepatic tissue.

Black Cardamom (Amomum subulatum)

Alpha-terpineol and kaempferol polyphenol source from large Himalayan cardamom; inhibits ACE to reduce blood pressure, provides antimicrobial and antifungal protection, activates AMPK glucose metabolism, reduces NF-κB inflammation, and provides Nrf2 antioxidant activation.

INTERSTELLAR SPICE Benefits: The Full Spectrum of Polyphenol Protection

INTERSTELLAR SPICE is the best polyphenol supplement and most complete natural polyphenol powerhouse supplement for anyone serious about total-body polyphenol coverage. The seven core benefits are:

• Master Antioxidant Activation: Activates Nrf2 pathways to strengthen the body’s natural antioxidant defense systems.
• Anti-Inflammatory Support: Helps reduce key inflammatory signals linked to oxidative stress and chronic inflammation.
• Cardiovascular Protection: Supports healthy cholesterol, blood pressure, circulation, and overall heart health.
• Cellular Protection & Longevity: Promotes cellular repair, mitochondrial health, and long term vitality.
• Energy & Metabolic Support: Helps improve cellular energy production and metabolic efficiency.
• Polyphenol Deficiency Support: Restores diverse plant polyphenols often lacking in modern diets.
• Cognitive & Mood Support: Supports brain health, mental clarity, and balanced mood through natural neuroprotective compounds.

Who Should Use INTERSTELLAR SPICE?

INTERSTELLAR SPICE is the best herbal polyphenol blend supplement and the most complete natural multi-spice supplement for anyone serious about foundational health through polyphenol nutrition.

• Low-Polyphenol Diets: Ideal for individuals whose modern diets lack diverse plant polyphenols.
• Heart Health Supporters: For those seeking natural cardiovascular protection and circulation support.
• Anti-Ageing & Longevity Seekers: Supports cellular health, vitality, and healthy ageing pathways.
• Oxidative Stress & Inflammation: Helps reduce oxidative stress and support balanced inflammatory responses.
• Fasting Practitioners: Provides antioxidant and anti-inflammatory support during fasting periods.
• Daily Antioxidant Users: A comprehensive botanical formula for everyday cellular protection and wellness.

Dosage and Usage

INTERSTELLAR SPICE is available at 200:1 concentration (100g, $275) and 20:1 concentration (100g, $75) to suit different usage needs and budget preferences. At 200:1 concentration, a 1/8 teaspoon daily delivers the polyphenol equivalent of 200 portions of combined raw spices. The 20:1 option is ideal for those who prefer to add INTERSTELLAR SPICE directly to food and beverages as an enhanced culinary spice blend. Mix into warm water, tea, smoothies, or food. The natural spice flavours make INTERSTELLAR SPICE one of the most palatable supplements in the Interstellar Blends range.

Buy INTERSTELLAR SPICEThe World’s Most Complete Polyphenol Supplement

Are you prepared to discover the most potent polyphenol supplement ever created, crafted from 100 of the world’s most beneficial spices? Whether you want to buy a polyphenol supplement for cardiovascular protection, anti-inflammatory defense, cellular longevity, or complete polyphenol deficiency correction, INTERSTELLAR SPICE from Interstellar Blends is available at interstellarblends.com and dryfasting.com. 

As both the best natural polyphenol supplement of 2024 and the most complete high-potency polyphenol supplement available anywhere, this is the answer to the question every polyphenol-aware health seeker asks: how do I get all of nature’s most powerful polyphenols in one place? The answer is INTERSTELLAR SPICE.