July 28, 2019
Fibroblast growth factor 21 (FGF21) is a hormone-like member of FGF family which controls metabolic multiorgan crosstalk enhancing energy expenditure through glucose and lipid metabolism. In […]
July 30, 2019
Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be […]
January 4, 2020
P53 is a crucial tumor suppressor protein that acts as the body’s guardian of the genome. When DNA damage occurs from environmental stresses like radiation or […]
January 6, 2020
Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins […]
January 7, 2020
Telomeres, the caps on our chromosomes, shorten with each cell division. This shortening acts like a cellular clock, and critically short telomeres are linked to premature […]
January 7, 2020
”Senescence is more than merely a cell division clock that regulates the proliferative lifespan of normal cells. “Premature” senescence is an active cytostaticprogram that is triggered […]
January 7, 2020
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age A hallmark of aging is chronic sterile inflammation, which is closely associated with […]
January 8, 2020
Oncogene activation plays a critical role in human health and aging, but it’s a double-edged sword. Oncogenes are genes that, when activated, promote uncontrolled cell growth […]
January 10, 2020
Prevention of premature senescence requires JNK activation. Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal […]