APIGENIN

APIGENIN: The Strongest Apigenin Supplement on the Planet

Adult Neurogenesis | Cognitive Regeneration | NAD+ Elevation | Anti-Excitotoxic Neuroprotection | 200:1 Concentration

 

The Only Apigenin Supplement That Lets You Actually Grow New Brain Cells

Do you want to grow new brain cells? It is called adult neurogenesis, and the most potent botanical compound ever identified for triggering it is apigenin. The Interstellar Blends apigenin supplement is the strongest on the planet, a 200:1 concentrated formula delivering the equivalent of 25 teaspoons of 1:1 extract in a single 1/8 teaspoon serving.

Interstellar APIGENIN is a science-backed herbal supplement designed to rebuild the brain, boost cognition, and reduce anxiety. It helps create new brain cells, removes harmful glutamate, increases NAD+, slows down cell aging, and improves mental clarity by affecting GABA-A and NMDA

It targets brain fog by reducing neuroinflammation, restoring acetylcholine (a neurotransmitter important for memory and learning), balancing NAD+ (nicotinamide adenine dinucleotide, a coenzyme involved in energy metabolism), and protecting neurons. Unlike standard apigenin supplements, it combines flavonoid analogues, biflavonoids, neurotrophin activators, AChE inhibitors, and longevity activators at a 200:1 concentration for full brain support.

The synergy matrix from chamomile, passionflower, celery, parsley, and other botanicals amplifies neurogenesis, memory, learning, and anxiety relief. APIGENIN is the most complete herbal supplement for cognitive regeneration, helping adults grow neurons, restore focus, and enhance brain resilience naturally.

The Science Behind APIGENIN: Seven Neural Regeneration Mechanisms

1. Adult Neurogenesis — Grow New Brain Cells 

APIGENIN stimulates hippocampal neurogenesis by promoting neuronal differentiation from progenitor cells, improving learning and memory. Studies show it enhances spatial memory and strengthens the brain’s learning center. As a natural supplement for memory and neuronal health, it builds actual neurons, unlike typical nootropics that only boost alertness without regenerating neural architecture.

2. SASP Inhibition — Reduce Neuroinflammation 

Senescent cells produce inflammatory SASP (senescence-associated secretory phenotype) factors that drive chronic neuroinflammation and cognitive decline. APIGENIN potently inhibits IL-6, IL-1β, and IL-8, clearing toxic signals and reducing brain fog. This mechanism targets the root cause of cognitive decline, making it a unique plant-based supplement that goes beyond symptom relief to restore neural function.

3. CD38 Inhibition & NAD+ Elevation — Restore Cellular Energy

APIGENIN inhibits CD38, the enzyme that degrades NAD+, restoring this key anti-aging energy currency. Elevated NAD+ supports sirtuin activity, mitochondrial function, DNA repair, and cognitive energy. By naturally increasing NAD+, APIGENIN provides similar advantages to NMN or NR supplements and helps improve brain flexibility, memory, and long-term brain health in a plant-based formula

4. Anti-Excitotoxicity — Protect Neurons from Glutamate Damage 

Excess glutamate causes excitotoxicity and neuronal death via NMDA receptor overstimulation. APIGENIN blocks calcium overload, reduces synaptic excitatory currents, and prevents apoptosis, protecting neurons from stroke, neurodegeneration, and age-related cognitive decline. This mechanism makes it a powerful herbal supplement for brain health, addressing the primary pathway of neurotoxic cell damage.

5. Antidepressant & Anxiolytic Effects — Balance Neurotransmitters 

APIGENIN modulates serotonin, dopamine, and GABA-A pathways to reduce anxiety, stress, and depression symptoms. Combined with passionflower, chrysin, and baicalin, it provides benzodiazepine-level calming without sedation or addiction. Users experience clearer thinking, reduced stress, and enhanced mental performance, making it the most comprehensive plant-based anxiety and memory support supplement.

6. Neurotrophic Support — Boost BDNF & NGF

APIGENIN enhances neurotrophins like BDNF and NGF to build, maintain, and repair neural circuits. The combination of Lion’s mane, bacopa, EGCG, and curcumin promotes dendritic growth, synaptic communication, and hippocampal plasticity. This makes the formula a complete herbal supplement for adult brain health, memory, and cognitive resilience.

7. Testosterone Preservation & Neuroprotection 

Declining testosterone increases Alzheimer’s risk by promoting β-amyloid and tau pathology. APIGENIN prevents age-related testosterone decline via COX-2 inhibition and TXA2 signaling modulation, offering hormonal neuroprotection. Combined with its neurogenesis, SASP inhibition, NAD+ restoration, anti-excitotoxicity, and neurotrophic support, it uniquely protects memory, cognition, and neuronal health in one formula.

80+ Research-Validated Neuroprotective Botanicals

Every compound in APIGENIN is a research-validated plant-based brain health supplement constituent with documented activity for neurogenesis, neuroprotection, cognitive enhancement, or neuroplasticity. This is the most complete natural supplement for neuroplasticity and a supplement for learning and memory enhancement ingredient matrix ever assembled at 200:1 concentration.

 

Apigenin (5,7,4′-Trihydroxyflavone) — Primary Active Compound

Apigenin (5,7,4′-Trihydroxyflavone) is the most studied plant flavonoid for adult neurogenesis; it stimulates the formation of new neurons in the hippocampus, promotes BDNF expression, blocks excitotoxic NMDA calcium overload, inhibits SASP senescence cytokines, raises NAD+ by blocking CD38, and prevents age-related testosterone decline through COX-2 inhibition and StAR protein upregulation.

Chamomile (Matricaria Chamomilla / Chamaemelum Nobile)

Chamomile (Matricaria Chamomilla / Chamaemelum Nobile) is the richest dietary source of apigenin; it contains apigenin-7-glucoside, which crosses the blood-brain barrier, modulates GABA-A receptors for anxiety relief, promotes hippocampal neurogenesis, and provides anti-inflammatory neuroprotection through COX-2 inhibition.

Parsley (Petroselinum Crispum)

Parsley (Petroselinum Crispum) is the second-richest food source of apigenin with luteolin synergy; it supports adult neurogenesis, reduces neuroinflammation via NF-B suppression, provides antioxidant brain protection, and enhances BDNF neurotrophic factor expression in hippocampal tissue.

Celery (Apium Graveolens)

Flavone-rich vegetables provide apigenin and luteolin, activate BDNF and NGF neurotrophic pathways, reduce hippocampal neuroinflammation, inhibit AChE for enhanced acetylcholine, and support healthy cognitive function across aging.

Thyme (Thymus Vulgaris)

Culinary herbs are concentrated in apigenin and rosmarinic acid; they reduce neuroinflammatory COX-2 and NF-κB, enhance BDNF expression, provide robust antioxidant brain protection, and inhibit acetylcholinesterase for improved memory function.

Red Pepper / Capsicum (Capsicum Annuum)

Apigenin and luteolin-containing pepper that activates TRPV1 neuroprotective signalling, enhances cerebral blood flow, reduces neuroinflammatory cytokines, and provides antioxidant protection to hippocampal and cortical neurons during oxidative stress.

Artichoke (Cynara Scolymus)

Exceptional apigenin and luteolin source; inhibits AChE to raise acetylcholine, activates cAMP signalling for memory consolidation, reduces liver toxicity that impairs cognition, and provides strong antioxidant neuronal protection.

Perilla / Shiso (Perilla Frutescens)

A high-apigenin aromatic herb rich in rosmarinic acid reduces neuroinflammatory NF-κB and COX-2, enhances BDNF expression in the hippocampus, crosses the blood-brain barrier, and protects neurons from glutamate excitotoxicity.

Grapefruit Peel (Citrus Paradisi)

The abundant apigenin and naringenin in grapefruit peel (Citrus Paradisi) reduce neuroinflammation, activate AMPK for mitochondrial energy in neurons, enhance cerebral circulation, and provide potent antioxidant protection to brain tissue against oxidative aging.

Oregano (Origanum Vulgare)

Oregano (Origanum Vulgare) is a cooking herb that is high in flavones like apigenin, luteolin, and rosmarinic acid; it effectively blocks

Spearmint (Mentha Spicata)

Apigenin and luteolin-containing mint with documented human clinical evidence for improving working memory, attention, and concentration through antioxidant and anti-inflammatory mechanisms in hippocampal and prefrontal cortical tissue.

Basil (Ocimum Basilicum)

Apigenin-rich culinary herb that inhibits AChE, reduces COX-2 neuroinflammation, provides antioxidant defence against reactive oxygen species in brain tissue, and supports monoamine neurotransmitter balance for mood and cognition.

Passionflower (Passiflora Incarnata)

Apigenin-dominant anxiolytic herb with clinical evidence comparable to benzodiazepines; it binds GABA-A receptors to reduce anxiety without sedation, inhibits NMDA excitotoxicity, and promotes sleep quality and hippocampal neurogenesis.

Coriander / Cilantro (Coriandrum Sativum)

Apigenin and quercetin-containing culinary herb with neuroprotective linalool; reduces neuroinflammatory IL-6 and TNF-α, chelates heavy metals from brain tissue, protects hippocampal neurons, and enhances antioxidant defence systems.

Yarrow (Achillea Millefolium)

A traditional medicinal herb concentrated in apigenin has anti-inflammatory and neuroprotective activities; it inhibits NF-κB, reduces neuroinflammatory cytokines, supports GABA-A receptor modulation, and provides antioxidant protection to neural tissue.

Celery Seed (Apium Graveolens var. dulce seed)

Concentrated apigenin and phthalide source; reduces neuroinflammation, lowers cortisol-driven cognitive impairment, provides antioxidant neuroprotection, and supports healthy cerebrovascular tone for optimal brain blood flow.

Lime Peel (Citrus Aurantifolia)

Apigenin and flavonoid-rich citrus peel that activates Nrf2 antioxidant defence in brain tissue, reduces neuroinflammatory cytokines, enhances cerebral microcirculation, and provides anti-excitotoxic neuroprotection against glutamate overactivation.

Lemon Peel (Citrus Limon)

Apigenin, hesperidin, and eriocitrin source; reduces brain oxidative stress, inhibits AChE activity, crosses the blood-brain barrier, reduces amyloid-β toxicity in neuronal cultures, and protects against age-related cognitive decline.

Spearmint Extract (Rosmarinus Standardised)

Standardised rosmarinic acid and apigenin extract with human clinical evidence showing 15% improvement in working memory, 9% improvement in spatial memory, and significant reduction in age-related cognitive decline through antioxidant mechanisms.

Quercetin (Sophora Japonica)

SASP-inhibiting flavonol that synergises with apigenin to block CD38 NAD+ depletion, inhibits neuroinflammatory NF-κB, activates SIRT1 longevity pathways, promotes BDNF, and protects blood-brain barrier integrity from inflammatory damage.

Luteolin (Peanut Shell / Reseda Luteola)

Structural analogue of apigenin with complementary neuroprotective mechanisms; inhibits microglial neuroinflammation, reduces amyloid-β accumulation, activates CREB memory consolidation pathway, and protects hippocampal neurons from oxidative stress.

Chrysin (Passiflora Caerulea / Pine Bark)

Flavone with high affinity for GABA-A receptors providing anxiolytic effects, inhibits aromatase to maintain testosterone, reduces neuroinflammatory IL-1β, and provides antioxidant neuroprotection to cortical and hippocampal neurons.

Kaempferol (Kaempferia Galanga)

Potent SASP-inhibiting flavonol; activates AMPK and SIRT3 for mitochondrial energy in neurons, promotes adult hippocampal neurogenesis, reduces NF-κB-driven neuroinflammation, and inhibits tau hyperphosphorylation in Alzheimer models.

Apigenin 7-Glucoside (Chamomile-Derived)

Water-soluble apigenin glycoside with enhanced bioavailability; delivers apigenin across the blood-brain barrier more efficiently, provides sustained neurogenesis support, reduces NMDA excitotoxic calcium overload, and exhibits anti-anxiety activity.

Acacetin (Robinia Pseudoacacia / False Acacia)

Apigenin methyl ether with enhanced metabolic stability and bioavailability; inhibits SASP, reduces neuroinflammation, protects neurons from amyloid-β toxicity, activates CREB-BDNF neuroplasticity pathways, and modulates GABA-A receptors.

Naringenin (Citrus Fruits / Tomato Skin)

Citrus flavanone that activates neurotrophin pathways, reduces microglia-driven neuroinflammation, inhibits AChE, crosses the blood-brain barrier, protects hippocampal neurons from oxidative damage, and enhances synaptic plasticity and LTP.

Hesperidin (Citrus Aurantium / Pericarpium Citri)

Citrus flavanone glycoside that reduces neuroinflammatory COX-2 and iNOS, activates Nrf2 antioxidant defence, improves cerebral microcirculation, protects against amyloid-β neurotoxicity, and supports healthy BDNF expression in hippocampus.

Nobiletin (Citrus Peels)

Polymethoxylated flavone from citrus peel that activates ERK-CREB memory signalling, powerfully inhibits microglial neuroinflammation, reduces amyloid-β and tau pathology, and enhances spatial learning and memory in animal models.

Tangeretin (Tangerine Peel)

Polymethoxylated citrus flavone that protects dopaminergic neurons from oxidative stress, inhibits neuroinflammatory NF-κB and cytokine production, reduces amyloid-β aggregation, and provides potent neuroprotective benefits in Parkinson models.

Baicalein (Scutellaria Baicalensis)

Chinese skullcap flavone with potent anti-neuroinflammatory activity; inhibits microglia activation, reduces amyloid-β aggregation, activates AMPK neuroprotective pathways, and promotes adult neurogenesis in the dentate gyrus.

Baicalin (Scutellaria Baicalensis)

Baicalein glycoside with neuroprotective and anxiolytic properties; activates GABA-A receptors for anxiety relief, reduces neuroinflammation, promotes hippocampal neurogenesis, and protects neurons from glutamate-induced excitotoxic cell death.

Wogonin (Scutellaria Baicalensis)

Skullcap flavone that powerfully inhibits neuroinflammatory microglia activation, reduces NLRP3 inflammasome-driven cytokine production in brain, protects neurons from amyloid-β toxicity, and promotes hippocampal BDNF expression.

Scutellarein (Scutellaria Lateriflora)

Hydroxylated apigenin analogue from skullcap with superior GABA-A modulation, potent AChE inhibition for improved memory, strong neuroprotective antioxidant activity, and documented anti-anxiety effects in clinical and animal research.

Vitexin (Hawthorn / Passionflower)

C-glycoside flavone with GABA-A anxiolytic activity, neuroprotective antioxidant effects, BDNF-enhancing neurotrophin support, and anti-excitotoxic protection against glutamate-induced neuronal damage in hippocampal cell cultures.

Isovitexin (Hawthorn Leaves / Passion Flower)

Apigenin C-glucoside with anxiolytic properties comparable to diazepam; reduces glutamate excitotoxicity, inhibits neuroinflammatory cytokines, protects hippocampal neurons from oxidative damage, and promotes calmness without sedation.

Orientin (Vitex Agnus-Castus / Globeflower)

Luteolin C-glucoside with powerful anti-neuroinflammatory activity; inhibits microglial NF-κB activation, reduces brain oxidative stress, provides neuroprotection against ischaemic damage, and supports cerebral blood flow and neurovascular health.

Isoorientin (Bamboo Leaf / Passionflower)

Luteolin C-glucoside that reduces neuroinflammatory IL-6, TNF-α, and iNOS in microglia, protects neurons from oxidative stress-induced apoptosis, inhibits AChE activity, and supports healthy hippocampal function.

Diosmetin (Citrus / Carrot)

Luteolin methyl ether with enhanced blood-brain barrier penetration; inhibits neuroinflammatory COX-2 and NF-κB, reduces amyloid-β cytotoxicity, activates antioxidant Nrf2-HO-1 defence, and supports hippocampal synaptic plasticity.

Linarin (Buddleja / Cirsium)

Acacetin glycoside with documented GABA-A anxiolytic activity and sedative properties; reduces neuroinflammation, protects neurons from excitotoxic glutamate overload, inhibits AChE, and promotes calm, focused mental state.

Genistein (Genista Tinctoria / Soybean)

Isoflavone that activates oestrogen receptor beta in neurons to promote BDNF and neuroprotection, inhibits tyrosine kinase neuroinflammatory signalling, reduces amyloid-β toxicity, and supports cognitive function in menopausal adults.

Biochanin A (Red Clover / Chickpea)

Methylated genistein precursor that inhibits amyloid-β aggregation, reduces microglial neuroinflammation, activates BDNF-TrkB signalling, protects dopaminergic neurons, and provides neuroprotective effects in Alzheimer and Parkinson models.

Formononetin (Red Clover / Astragalus)

Isoflavone with documented BDNF-activating and neuroprotective properties; reduces neuroinflammatory cytokines, protects against ischaemic brain injury, inhibits tau hyperphosphorylation, and supports synaptic plasticity and cognitive performance.

Calycosin (Astragalus Membranaceus)

Astragalus-derived isoflavone that crosses the blood-brain barrier, activates oestrogen receptor-mediated neuroprotection, reduces neuroinflammatory NF-κB, protects against stroke-induced neuronal damage, and promotes post-injury brain regeneration.

Daidzein (Soybean / Kudzu)

Phytoestrogenic isoflavone that activates BDNF and NGF neurotrophic expression, reduces microglia neuroinflammation, inhibits AChE for improved cholinergic function, and provides neuroprotection in Alzheimer and Parkinson disease models.

Puerarin (Kudzu Root / Pueraria Lobata)

Daidzein-8-C-glucoside from kudzu root that improves cerebral blood flow, activates neuroprotective PI3K-Akt signalling, reduces amyloid-β neurotoxicity, inhibits neuroinflammatory NF-κB, and promotes recovery from brain injury.

Rutin (Sophora Japonica / Ruta Graveolens)

Quercetin-3-rutinoside that strengthens blood-brain barrier integrity, reduces neuroinflammatory cytokines, activates SIRT1 longevity pathways, inhibits AChE, protects hippocampal neurons from amyloid-β, and enhances cerebrovascular microcirculation.

Isorhamnetin (Sea Buckthorn / Tamarisk)

Quercetin methyl ether with superior metabolic stability; activates AMPK and Nrf2 neuroprotective pathways, inhibits neuroinflammatory microglia activation, reduces amyloid-β neurotoxicity, and promotes adult hippocampal neurogenesis.

Fisetin (Rhus Succedanea / Strawberry)

Senolytic flavonol that clears senescent cells from brain tissue, activates SIRT1 and CREB memory pathways, promotes BDNF expression, reduces neuroinflammation, and extends cognitive function in ageing animal models.

Myricetin (Black Bayberry / Wax Myrtle)

Flavonol with potent anti-neuroinflammatory and neuroprotective activities; inhibits BACE1 amyloid processing enzyme, reduces tau aggregation, activates Nrf2 antioxidant defence, and enhances long-term potentiation in hippocampal neurons.

Morin (Osage Orange / Morus Alba)

Flavonol from mulberry family with anti-Alzheimer properties; inhibits amyloid-β and tau aggregation, activates SIRT1, reduces NF-κB neuroinflammation, and protects hippocampal neurons from oxidative and excitotoxic damage.

Galangin (Alpinia Officinarum / Propolis)

Flavonol with documented AChE inhibition for enhanced cholinergic cognition, neuroprotective antioxidant activity, anti-neuroinflammatory NF-κB suppression, BDNF promotion, and protective effects against amyloid-β toxicity in neural cells.

Datiscetin (Datisca Cannabina)

Naturally occurring flavonol with neuroprotective antioxidant and anti-inflammatory properties; inhibits NF-κB neuroinflammatory pathways, protects neurons from oxidative stress-induced apoptosis, and supports hippocampal cell viability.

Robinetin (Robinia Pseudoacacia)

Rare 3,7,3′,4′,5′-pentahydroxyflavone with potent antioxidant and anti-neuroinflammatory activity; scavenges reactive oxygen species in neural tissue, inhibits microglial inflammatory cascades, and provides neuroprotection against excitotoxic damage.

Amentoflavone (St. John’s Wort / Ginkgo Biloba)

Biflavonoid that inhibits GABA-A receptor for nootropic stimulation, blocks phosphodiesterase for elevated cAMP, inhibits BACE1 amyloid production enzyme, reduces neuroinflammation, and enhances cognitive performance and alertness.

Hinokiflavone (Hinoki Cypress / Biota Orientalis)

Biflavone with powerful AChE inhibition comparable to pharmacological agents; activates CREB memory consolidation, inhibits neuroinflammatory NF-κB, protects hippocampal neurons from amyloid-β toxicity, and enhances synaptic plasticity.

Ginkgetin (Ginkgo Biloba)

Ginkgo-derived biflavone with potent AChE inhibition, cerebral blood flow enhancement, neuroprotective antioxidant activity, anti-neuroinflammatory NF-κB suppression, and protection of hippocampal neurons from ischaemic and excitotoxic damage.

Isoginkgetin (Ginkgo Biloba)

Ginkgo biflavone with documented anti-neuroinflammatory and neuroprotective activity; inhibits microglial NF-κB activation, reduces neuroinflammatory cytokines, protects hippocampal cells from amyloid-β, and supports synaptic function.

Sciadopitysin (Ginkgo Biloba / Sciadopitys)

Biflavone antioxidant that scavenges reactive oxygen species in neural tissue, inhibits neuroinflammatory NF-κB, protects neurons from excitotoxic glutamate damage, and provides broad cytoprotective support in brain tissue.

Abietatriene Diterpenes (Rosemary / Salvia)

Lipophilic diterpenes from rosemary-type plants with high blood-brain barrier penetration; inhibit AChE and MAO-A/B for elevated acetylcholine and monoamines, reduce neuroinflammatory COX-2, and protect neurons from oxidative damage.

Rosmarinic Acid (Rosemary / Perilla)

Phenolic acid with potent neuroprotective and anti-neuroinflammatory properties; inhibits amyloid-β aggregation, activates Nrf2 antioxidant defence, protects hippocampal neurons, and reduces cortisol-driven cognitive impairment from stress.

Carnosic Acid (Rosemary / Sage)

Lipophilic phenolic diterpene that activates Nrf2-HO-1 antioxidant response in brain tissue, reduces neuroinflammatory NF-κB, inhibits AChE, protects dopaminergic neurons from oxidative damage, and supports NGF-driven neurogenesis.

Carnosol (Rosemary / Sage)

Phenolic diterpene with NRF2 antioxidant activation, AChE inhibition for cholinergic memory support, anti-neuroinflammatory COX-2 suppression, neuroprotection against glutamate excitotoxicity, and support for BDNF neurotrophic factor expression.

Ursolic Acid (Loquat Leaf / Rosemary)

Pentacyclic triterpenoid that activates BDNF and NGF neurotrophic signalling, promotes adult neurogenesis, inhibits neuroinflammatory NF-κB, reduces amyloid-β production, and enhances long-term potentiation in hippocampal neural networks.

Oleanolic Acid (Olive Leaf / Clove)

Triterpenoid that activates AMPK neuroprotective metabolism in neurons, reduces neuroinflammatory NF-κB and NLRP3, protects neurons from oxidative apoptosis, inhibits AChE, and supports healthy cerebrovascular function.

EGCG — Epigallocatechin Gallate (Green Tea)

Most bioactive green tea catechin; inhibits amyloid-β and tau aggregation, activates SIRT1 and AMPK anti-aging neuronal pathways, reduces microglial neuroinflammation, crosses the blood-brain barrier, and promotes hippocampal neurogenesis.

Epicatechin (Green Tea / Dark Cacao)

Flavanol that activates CREB-BDNF memory pathways, enhances cerebral blood flow through nitric oxide production, reduces neuroinflammation, promotes hippocampal neurogenesis, and provides potent antioxidant protection to brain neurons.

Theaflavins (Black Tea)

Condensed catechin dimers from black tea that inhibit AChE, reduce amyloid-β aggregation, activate Nrf2 antioxidant brain defence, reduce neuroinflammatory cytokines, and provide neuroprotection against oxidative and excitotoxic damage.

Pterostilbene (Blueberry / Pterocarpus)

Dimethyl ether of resveratrol with 4x greater bioavailability and blood-brain barrier penetration; activates SIRT1 and CREB memory consolidation, reduces neuroinflammation, and enhances long-term potentiation and spatial memory.

Resveratrol (Polygonum Cuspidatum / Red Grape)

SIRT1-activating stilbene that promotes hippocampal neurogenesis, inhibits amyloid-β and tau pathology, reduces neuroinflammatory NF-κB, activates AMPK longevity pathways, and synergises with apigenin’s NAD+ CD38 inhibition.

Piceatannol (Passion Fruit / Rhubarb)

Hydroxylated resveratrol analogue with potent anti-neuroinflammatory properties; activates SIRT1, inhibits NF-κB microglial activation, reduces brain oxidative stress, and provides neuroprotection against ischaemic and excitotoxic neuronal damage.

Curcumin (Turmeric Root)

Most studied natural neuroprotective compound; inhibits amyloid-β and tau aggregation, reduces neuroinflammatory NF-κB and COX-2, activates BDNF and Nrf2, promotes hippocampal neurogenesis, and reduces cognitive decline with aging.

Piperine (Black Pepper)

Bioavailability-amplifying alkaloid that increases absorption of apigenin and all co-occurring flavonoids by up to 2000%, inhibits MAO-B to elevate dopamine, and provides direct neuroprotective and antidepressant effects.

Lion’s Mane (Hericium Erinaceus)

Premier NGF and BDNF-stimulating mushroom; erinacines and hericenones promote neurite outgrowth and neuronal regeneration, enhance memory and cognition, reduce neuroinflammation, and protect against Alzheimer and Parkinson neurodegenerative progression.

Bacopa Monnieri (Brahmi)

Most clinically validated herbal nootropic; bacoside A and B enhance synaptic signal transmission, promote dendrite proliferation, reduce neuroinflammatory oxidative stress, inhibit AChE, and improve learning and working memory in clinical trials.

Ginkgo Biloba (EGb761 Extract)

Most studied botanical for cognitive support; improves cerebral blood flow, inhibits PAF and AChE, activates BDNF, reduces amyloid-β neurotoxicity, and provides potent antioxidant protection through terpenoid and flavonoid synergy.

Ashwagandha (Withania Somnifera / KSM-66)

Adaptogenic root that reduces cortisol-driven cognitive impairment, activates BDNF and GABA-A pathways for anxiety relief and neurogenesis, promotes dendrite outgrowth through withanolide A, and enhances working memory in clinical trials.

Rhodiola Rosea (Salidroside)

Golden root adaptogen that inhibits MAO-A/B to elevate dopamine and serotonin, activates AMPK neuroprotective metabolism, enhances BDNF expression, reduces neuroinflammation, and improves mental performance under cognitive stress.

Phosphatidylserine (Sunflower Lecithin)

Neuronal membrane phospholipid that improves signal transduction efficiency at synapses, reduces cortisol-induced hippocampal damage, enhances memory and cognitive function in clinical trials, and supports neurotrophic factor receptor activity.

Alpha-GPC (Alpha-Glycerophosphocholine)

Most bioavailable choline precursor; directly raises acetylcholine in the brain, activates BDNF-TrkB signalling, enhances memory and learning, supports neuronal membrane synthesis, and provides neuroprotective benefits in age-related cognitive decline.

Acetyl-L-Carnitine (ALCAR)

Mitochondria-targeting amino acid derivative that enhances neuronal energy production, raises acetylcholine, activates NGF neurotrophic signalling, reduces amyloid-β toxicity, and improves cognitive function in age-related mental decline.

N-Acetyl-L-Tyrosine (NALT)

Bioavailable tyrosine precursor that replenishes dopamine and norepinephrine under cognitive stress, prevents working memory degradation during multitasking and sleep deprivation, and supports sustained mental performance and cognitive flexibility.

Vinpocetine (Vinca Minor / Periwinkle)

Semi-synthetic vinca alkaloid that enhances cerebral blood flow by dilating brain vasculature, inhibits PDE1 to raise cAMP, reduces neuroinflammation, enhances memory consolidation, and protects neurons from ischaemic excitotoxic damage.

Huperzine A (Huperzia Serrata / Toothed Clubmoss)

Most potent natural AChE inhibitor; raises acetylcholine more effectively than pharmaceutical alternatives, protects against NMDA excitotoxicity, reduces amyloid-β accumulation, and enhances memory, learning, and cognitive performance in clinical trials.

Who Should Use APIGENIN?

APIGENIN is the best apigenin supplement and most complete natural supplement for brain health for anyone who demands genuine neural regeneration rather than stimulant-based cognitive enhancement. It is ideal for:

• Adults 35+ with Cognitive Decline: For memory lapses, slower recall, or reduced mental sharpness, seeking the most complete natural brain regeneration supplement.
• Anxiety & Depression Sufferers: For natural anxiety relief and mood support via GABA-A, NMDA, and monoamine pathways without side effects.
• Brain Fog: For mental cloudiness, poor focus, and cognitive fatigue, address root causes naturally.
• Nootropic & Brain Optimizers: For enhanced learning, memory, and mental performance backed by neuroscience, not stimulants.
• Neurological Disease Prevention: For those at risk of Alzheimer’s, Parkinson’s, or cognitive decline, seek full neuronal protection.
• Fasting Practitioners: To amplify neurogenesis and autophagy during intermittent or dry fasting with a potent botanical brain formula.

Dosage and Loading Protocol

APIGENIN is designed with a graduated loading protocol that builds apigenin tissue saturation over time, consistent with its documented 91.8-hour half-life and accumulation kinetics. Start with 1 teaspoon daily for weeks 1–2, then 1/2 teaspoon daily for weeks 3–4, then 1/4 teaspoon daily for weeks 5–6, then 1/8 teaspoon as needed for maintenance. Each 100g container provides approximately 300 servings of 1/8 teaspoon at 200:1 concentration. This graduated approach ensures the slow-absorbing, slow-eliminating apigenin molecules reach their optimal accumulation level for sustained neurogenesis and neuroprotective benefit.

Buy APIGENIN — Grow New Brain Cells with the Most Potent Botanical Neurogenesis Formula Available

Ready to experience the most powerful apigenin supplement ever created? Whether you want to buy apigenin supplement for neurogenesis, anxiety relief, memory improvement, brain fog clearance, or full cognitive regeneration, the Interstellar Blends best apigenin supplement at 200:1 concentration is available at interstellarblends.com and dryfasting.com. With 80+ research-validated neuroprotective botanicals delivering the most complete plant based brain health supplement, supplement for learning and memory enhancement, and natural supplement for neuroplasticity benefits available anywhere, APIGENIN is the answer to the most fundamental question in cognitive health: can you actually grow new brain cells as an adult? The answer is yes.