H. pylori infection leads to an increased rate of diabetes
CONCLUSIONS We demonstrated for the first time that H. pylori infection leads to an increased rate of incident diabetes in a prospective cohort study. Our findings implicate a potential role for antibiotic and gastrointestinal treatment in preventing diabetes.
Proton Pump Inhibitors Accelerate Endothelial Senescence
Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity.
Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction.
Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.
Conclusions:Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.
Traditionally, reflux esophagitis was assumed to develop as a caustic, chemical injury inflicted by refluxed acid. Recently, however, studies in rats and humans suggest that reflux esophagitis develops as a cytokine-mediated inflammatory injury, with hypoxia inducible factor (HIF)-2α playing a major role. In response to the reflux of acid and bile, HIF-2α in esophageal epithelial cells becomes stabilized, thereby increasing production of pro-inflammatory cytokines that attract T lymphocytes and other inflammatory cells to damage the esophagus. Recent studies have identified small molecule inhibitors of HIF-2α that demonstrate exquisite isoform selectivity, and clinical trials for treatment of HIF-2α-driven kidney cancers are ongoing. It is conceivable that a HIF-2α-directed therapy might be a novel approach to prevention and treatment of reflux esophagitis.
Chronic Helicobacter pylori infection increases the risk of gastric cancer and induction of hypoxia-induced factor (HIF), which is frequently associated with the development and progression of several types of cancer. We recently showed that H. pylori activation of the PI3K-AKT-mTOR pathway in gastric cells increased HIF-1α expression. Here, we identified the H. pylori virulence factor responsible for HIF-1α induction. A mutant of the H. pylori 84-183 strain was identified with reduced ability to induce HIF-1α. Coomassie blue staining of extracts from these bacteria separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) revealed poor expression of urease subunits that correlated with reduced urease activity. This finding was confirmed in the 26695 strain, where urease mutants were unable to induce HIF-1α expression. Of note, HIF-1α induction was also observed in the presence of the urease inhibitor acetohydroxamic acid at concentrations (of 20 mM) that abrogated urease activity in bacterial culture supernatants, suggesting that enzymatic activity of the urease is not required for HIF-1α induction. Finally, the pre-incubation of the human gastric adenocarcinoma cell line AGS with blocking antibodies against Toll-like receptor-2 (TLR2), but not TLR4, prevented HIF-1α induction. In summary, these results reveal a hitherto unexpected role for the urease protein in HIF-1α induction via TLR2 activation following H. pylori infection of gastric cells.
INGREDIENTS:
Rich Ryan –
Another incredible blend from Interstellar! They research all the most important health issues plaguing humankind and come up with the best possible herbal remedy for each one.
I’ve had intermittent heartburn, gas and diarrhea for years, and thought it was normal. I blamed myself for not eating as well as I should. Little did I know that it was due to a Helicobacter pylori bacterial infection! One that I’d been carrying for many years. This blend is a strong one, but it cleared the infection right out and I haven’t experienced heartburn or diarrhea since.
You don’t need to take this blend all the time, just do a tsp before bed for a couple weeks, then 1/2 tsp for a couple weeks after that.
Then take occasionally (3-7 days a month) for maintenance. One bag will last for probably almost a year.
Superb blend! A+++
Ben Levesque –
I started taking peel blend 3 times a day. Once in the morning, once in the afternoon and once in the evening.
After 3 days I started to see it come down, day 3 it was down to 310, day 5 of was down to 290. a week later I lowered my dosage to once in the morning at that time my blood sugar read 260, it’s been 5+ months now and my sugar is consistently under 200 and back to feeling great again.
I LOVE this product. My skin is so much softer since taking it, and my hands and feet are like baby soft. I have had 2 people tell me that I’m reverse aging. I try and follow a keto diet. In the past when I had fallen off the wagon for a day or two I’d gain 4-5 lbs back. Since taking the peel blend I don’t gain it back. It really is a great product.
One of the biggest challenges we face with cancer exhaustion from both the disease and the treatment for it. This last cycle wiped me out more than any other. I have not been able to regain my energy no matter how much I’ve slept, or rested. This is something I have always been able to overcome by adjusting my blends and fasting, but this time was much different.Under the advice of my daughter (who has taken blends for sometime), , started taking Peel blends and within first week had already noticed a drastic difference in lowering blood sugar levels. Returning 3 months later for doctors visit, after taking Peel blend, she was amazed with my extremely lowered A1C.
Thank you to this product!!!
Shelley McKone –
Helico works right away in killing Helicobater Pylori! I’ve been trying to get rid of this for years. The first side effects were not pleasant as the bacteria put up a fight. BUT after about 3 days I started getting better. I used to feel exhausted every time I ate. This no longer happens. I expect to see better and better health results now that the bacteria is gone. Thank you Gavin for your endless supply of info and support. You are much appreciated!