AUTOPHAGY ACTIVATOR

August 1, 2019

ANTI-ADIPOGENIC (Adipocyte Differentiation Inhibitor)

March 16, 2020

HELICO (Helicobacter Pylori Destroyer)

Name: HELICO (Helicobacter Pylori Destroyer)
SKU: HEL-100
Availability: InStock
Rating: 5.00 (12 reviews)

Rated 5.00 out of 5 based on 12 customer ratings

(12 customer reviews)

$275.00

SKU: HEL-100 Categories: Featured, Uncategorized

100g bag

200:1 Concentration

1 out of 2 people has IT

Heartburn? Indigestion? Irritable bowel syndrome? Gas? Nutrient absorption issues? Ulcers? Stomach problems in general? There’s a high probability you have this resistant little bacteria camping out in your stomach wreaking havoc.

“Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, helically-shaped, microaerophilic bacterium usually found in the stomach.^[6] Its helical shape (from which the genus name, helicobacter, derives) is thought to have evolved in order to penetrate the mucoid lining of the stomach and thereby establish infection.^[7]^[8] The bacterium was first identified in 1982 by Australian doctors Barry Marshall and Robin Warren, who found that it was present in a person with chronic gastritis and gastric ulcers, conditions not previously believed to have a microbial cause.^[9]^[10]^[11] H. pylori has also been linked to the development of duodenal ulcers, polyps, i. e. benign growths, in the small intestine, large intestine, and rectum, and malignancies of the stomach’s secretory glands (termed stomach adenocarcinoma),^[12] of the mucosa-associated lymphoid tissue in the stomach, esophagus, colon, rectum, or tissues around the eye (termed extranodal marginal zone B-cell lymphoma of the cited organ),^[13]^[14]^[15] and of lymphoid tissue in the stomach (termed diffuse large B-cell lymphoma).^[16]

Many investigators have proposed causal associations between H. pylori and a wide range of other diseases (e.g. idiopathic thrombocytopenic purpura, iron deficiency anemia, atherosclerosis, Alzheimer’s disease,^[17] multiple sclerosis, coronary artery disease, periodontitis,^[18] Parkinson’s disease, Guillain–Barré syndrome, rosacea, psoriasis, chronic urticaria, spot baldness, various autoimmune skin diseases, Henoch–Schönlein purpura, low blood levels of vitamin B12, autoimmune neutropenia, the antiphospholipid syndrome, plasma cell dyscrasias, central serous chorioretinitis, open angle glaucoma, blepharitis, diabetes mellitus, the metabolic syndrome, various types of allergies, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, hepatic fibrosis, and liver cancer^[19]). The bacterial infection has also been proposed to have protective effects for its hosts against infections by other pathogens, asthma, obesity,^[17] celiac disease, inflammatory bowel disease,^[18] rhinitis, atopic dermatitis,^[20] gastroesophageal reflux disease,^[21] and esophageal cancer.^[21] However, these deleterious and protective effects have frequently been based on correlative rather than direct relationship studies^[18] and have often been contradicted by other studies that show either the opposite or no effect on the cited disease.^[19] Consequently, many of these relationships are currently regarded as questionable and in need of more definitive studes.^[17] They are not considered further here.

Some studies suggest that H. pylori plays an important role in the natural stomach ecology, e.g. by influencing the type of bacteria that colonize the gastrointestinal tract.^[22]^[19] Other studies suggest that non-pathogenic strains of H. pylori may be beneficial, e.g., by normalizing stomach acid secretion,^[23] and may play a role in regulating appetite, since the bacterium’s presence in the stomach results in a persistent but reversible reduction in the level of ghrelin, an hormone that increases appetite.^[23]

In general, over 50% of the world’s population has H. pylori in their upper gastrointestinal tracts^[5] with this infection (or colonization) being more common in developing countries.^[4] In recent decades, however the prevalence of H. pylori colonization of the gastrointestinal tract has declined in many countries. This is attributed to improved socioeconomic conditions: in the United States of America, for example, the prevalence of H. pylori, as detected by endoscopy conducted on a referral population, fell from 65.8 to 6.8% over a recent 10 year period while over the same time period in some developing countries H. pylori colonization remained very common with prevalence levels as high as 80%.^[24] In all events, H. pylori infection is usually asymptomatic, being associated with overt disease (commonly gastritis or peptic ulcers rather than the relatively very rarely occurring cancers) in less than 20% of cases.^[25].” – WIKI

Inflammation, DNA Damage, Helicobacter pyloriand Gastric Tumorigenesis

Helicobacter pylori (H. pylori) is a Gram negative bacterium that colonizes the stomach of almost half human population. It has evolved to escape immune surveillance, establishes lifelong inflammation, predisposing to genomic instability and DNA damage, notably double strand breaks. The epithelial host cell responds by activation of DNA damage repair (DDR) machinery that seems to be compromised by the infection. It is therefore now accepted that genetic damage is a major mechanism operating in cases of H. pylori induced carcinogenesis. Here, we review the data on the molecular pathways involved in DNA damage and DDR activation during H. pylori infection.

Helicobacter pylori-induced premature senescence

Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases. More recently, it has been shown that H. pylori cytotoxin CagA expression induces cellular senescenceof human gastric nonpolarized epithelial cells that may lead to gastrointestinal disorders and systemic inflammation. Here, we hypothesize that also chronic skin diseases may be promoted by stress-induced premature senescence (SIPS) of skin cells, namely fibroblasts and keratinocytes, stimulated with H. pylori cytotoxins. Future studies involving cell culture models and clinical specimens are needed to verify the involvement of H. pylori in SIPS-based chronic skin diseases.

H. pylori infection leads to an increased rate of diabetes

CONCLUSIONS We demonstrated for the first time that H. pylori infection leads to an increased rate of incident diabetes in a prospective cohort study. Our findings implicate a potential role for antibiotic and gastrointestinal treatment in preventing diabetes.

Proton Pump Inhibitors Accelerate Endothelial Senescence

Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity.

Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction.

Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.

Conclusions:Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.

A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis.

Traditionally, reflux esophagitis was assumed to develop as a caustic, chemical injury inflicted by refluxed acid. Recently, however, studies in rats and humans suggest that reflux esophagitis develops as a cytokine-mediated inflammatory injury, with hypoxia inducible factor (HIF)-2α playing a major role. In response to the reflux of acid and bile, HIF-2α in esophageal epithelial cells becomes stabilized, thereby increasing production of pro-inflammatory cytokines that attract T lymphocytes and other inflammatory cells to damage the esophagus. Recent studies have identified small molecule inhibitors of HIF-2α that demonstrate exquisite isoform selectivity, and clinical trials for treatment of HIF-2α-driven kidney cancers are ongoing. It is conceivable that a HIF-2α-directed therapy might be a novel approach to prevention and treatment of reflux esophagitis.

The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1α in Gastric Cells

Chronic Helicobacter pylori infection increases the risk of gastric cancer and induction of hypoxia-induced factor (HIF), which is frequently associated with the development and progression of several types of cancer. We recently showed that H. pylori activation of the PI3K-AKT-mTOR pathway in gastric cells increased HIF-1α expression. Here, we identified the H. pylori virulence factor responsible for HIF-1α induction. A mutant of the H. pylori 84-183 strain was identified with reduced ability to induce HIF-1α. Coomassie blue staining of extracts from these bacteria separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) revealed poor expression of urease subunits that correlated with reduced urease activity. This finding was confirmed in the 26695 strain, where urease mutants were unable to induce HIF-1α expression. Of note, HIF-1α induction was also observed in the presence of the urease inhibitor acetohydroxamic acid at concentrations (of 20 mM) that abrogated urease activity in bacterial culture supernatants, suggesting that enzymatic activity of the urease is not required for HIF-1α induction. Finally, the pre-incubation of the human gastric adenocarcinoma cell line AGS with blocking antibodies against Toll-like receptor-2 (TLR2), but not TLR4, prevented HIF-1α induction. In summary, these results reveal a hitherto unexpected role for the urease protein in HIF-1α induction via TLR2 activation following H. pylori infection of gastric cells.

INGREDIENTS:

Abrus cantoniensis (Fabaceae)

Impact Of Abrus Cantoniensis Ethanolic Extract On The Growth Inhibition Of Helicobacter Pylori
In Vitro Anti-Helicobacter Pylori Action Of 30 Chinese Herbal Medicines Used To Treat Ulcer Diseases
Progress In Use Of Natural Products And Their Active Components Against Helicobacter Pylori
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review
Chinese conducted the antibacterial action of thirty herbal medicines, which have been frequently used since ancient times for the treatment of gastritis-like disorders (Li et al., 2005). Among those thirty tested Chinese herbs, the ethanol extracts of Saussurea lappa (Asteraceae), Abrus cantoniensis (Fabaceae) and Eugenia caryophyllata (Myrtaceae) had the most strongly bacteriostatic effect (MICs: approximately 40 mg/ml).

Agaricus bisporus extract

Ageratum conyzoides extract

In-vitro antimicrobial activity of Ageratum conyzoides (Linn) on clinical isolates of Helicobacter pylori
Pharmacological ins and outs of medicinal plants against Helicobacter pylori
Ndip et al screened ten medicinal plants from Cameron against 15 clinical isolates by disk diffusion method and determine MIC and minimum bactericidal concentration (MBC) values. All the tested plants showed anti-H.pylori activity with inhibition zone diameters of 0-30 mm. Out of these, Ageratum conyzoides, Scleria striatinux and Lycopodium cernua showed potent anti-H. pylori activity with the lowest MIC and MBC of 0.032 mg/mL and 0.098 mg/mL respectively (Ndip et al., 2007).

Allicin

Angelica sinensis extract

Artemisia annua Extract

Anti-Helicobacter pylori Potential of Artemisinin and Its Derivatives

Bifidobacterium bifidum

Bombax malabaricum DC. Extract

Screening of anti-Helicobacter pylori herbs deriving from Taiwanese folk medicinal plants

Broccoli sprouts (sulforaphane)

Capsaicin

Carthamus tinctorious extract

In vitro Inhibition of Helicobacter pylori by Some Spices and Medicinal Plants Used in Iran

Cassia twig extract

Cinnamomi Ramulus ethanolic extract showed the potent antioxidant activity and cytotoxicity of Helicobacter pylori (H. pylori) and acid-neutralizing capacity.
Comparison of the antibacterial activities according to the extracting methods of Cinnamomum cassia against Helicobacter pylori
These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Cinnamomum cassia.

Celery Seed (novel unnamed component)

Coptis chinensis extract

Cranberry (Vaccinium macrocarpon)

Dateplum persimmon extrat

Decursin

Decursin And Decursinol Angelate Selectively Inhibit Nadh-Fumarate Reductase Of Ascaris Suum
Decursin Inhibits Tumor Growth, Migration, And Invasion In Gastric Cancer By Down-Regulating Cxcr7 Expression
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review
First study of screening medicinal plants against H. pylori was published by Korean researchers who screened several medicinal plants against H. pylori and found extracts of Eugenia caryophyllata (flower), Coptidis japonica (rhizoma), Magnolia officinalis (cortex), Rheum palmatum (rhizoma) and Rhus javanica (galla rhois) had bacteriostatic effect on H. pylori. On further isolation of active constituents, the effects of decursinol angelate and decursin on bacterial inhibition were the most potent with minimum inhibitory concentrations (MICs) values of 6-20 mg/ml (Bae et al., 1998).

EGCG

Eugenia caryophyllata (CLOVES)

In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review.
Chinese conducted the antibacterial action of thirty herbal medicines, which have been frequently used since ancient times for the treatment of gastritis-like disorders (Li et al., 2005). Among those thirty tested Chinese herbs, the ethanol extracts of Saussurea lappa (Asteraceae), Abrus cantoniensis (Fabaceae) and Eugenia caryophyllata (Myrtaceae) had the most strongly bacteriostatic effect (MICs: approximately 40 mg/ml).
Eugenol: a potential phytochemical with multifaceted therapeutic activities

Fructus amomi extract

GALANGIN (Alpinia officinarum extract)

GENIPOSIDE (Fructus Gardeniae)

The Suppressive Effects of Geniposide and Genipin on Helicobacter pylori Infections In Vitro and In Vivo

Ganoderma lucidum extract

Golden cypress Cortex Phellodendri Chinensis) extract

Hawthorn (Crataegus pinnatifida) Extract

Juglans regia extract

Korean Red Ginseng extract

Use of bovine lactoferrin for Helicobacter pylori eradication

L. rhamnosus GG

Lactobacillus reuteri

Lions Mane Mushroom

Luteolin

Lycopodium cernua

In Vitro Anti-Helicobacter Pylori Activity Of Extracts Of Selected Medicinal Plants From North West Cameroon
In Vitro Anti-Helicobacter Pylori Activity Of Lycopodium Cernuum (Linn) Pic. Serm
Preliminary Phytochemical Screening And In Vitro Anti-Helicobacter Pylori Activity Of Extracts Of The Stem Bark Of Bridelia Micrantha (Hochst., Baill., Euphorbiaceae)
Role Of Phosphate Solubilizing Burkholderia Spp. For Successful Colonization And Growth Promotion Of Lycopodium Cernuum L.(Lycopodiaceae) In Lateritic Belt …
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review
Ndip et al screened ten medicinal plants from Cameron against 15 clinical isolates by disk diffusion method and determine MIC and minimum bactericidal concentration (MBC) values. All the tested plants showed anti-H.pylori activity with inhibition zone diameters of 0-30 mm. Out of these, Ageratum conyzoides, Scleria striatinux and Lycopodium cernua showed potent anti-H. pylori activity with the lowest MIC and MBC of 0.032 mg/mL and 0.098 mg/mL respectively (Ndip et al., 2007).

Mangnolia officinalis extract

Anti-Helicobacter pylori activity and inhibition of gastritis by Magnolia officinalis extract

Mastic Gum extract

Oregano

Plumbago zeylanica L. extract

Anti-Helicobacter Pylori Activity Of Plumbago Zeylanica L.
Anti-Helicobacter Pylori And Cytotoxic Activity Of Detoxified Root Of Plumbago Auriculata, Plumbago Indica And Plumbago Zeylanica
High-Performance Liquid Chromatography For Quantification Of Plumbagin, An Anti-Helicobacter Pylori Compound Of Plumbago Zeylanica L.
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review.
Researchers from Taiwan conducted a large scale study and employed fifty medicinal plants against H. pylori. While half of the employed plants showed bactericidal activity, five plants namely Anisomeles indica (L.) O. Kuntze, Bombax malabaricum DC., Paederia scandens (Lour.) Merr., Plumbago zeylanica L., and Alpinia speciosa (J. C. Wendl.) K. Schum demonstrated strong anti-H. pylori activities.

Polygonum cuspidatum extract

Anti-Helicobacter pylori compounds from Polygonum cuspidatum
Anti-Helicobacter pylori activity guided fractionation led to the isolation of five anthraquinones, two stilbenes and one naphthoquinone from the EtOAc fraction of Polygonum cuspidatum, using silica gel column chromatography, Sephadex-LH20, MPLC and recrystallization. The chemical structures were identified to be physcion (1), emodin (2), anthraglycoside B (3), trans-resveratrol (4), anthraglycoside A (5), polydatin (6), 2-methoxy-6-acetyl-7-methyljuglone (7) and citreorosein (8) by UV, ¹H-NMR, ¹³C-NMR and mass spectrometry. Anti-Helicobacter pylori activity including MIC values of each compound was evaluated. All of the isolates exhibited anti-H. pylori activity of which MIC values were lower than that of a positive control, quercetin. Compounds 2 and 7 showed potent growth inhibitory activity. Especially, a naphthoquinone, compound 7 displayed most potent antibacterial activity with MIC₅₀ value of 0.30 µM and MIC₉₀ value of 0.39 µM. Although anti–H. pylori activity of this plant was previously reported, this is the first report on that of compounds isolated from this species. From these findings, P. cuspidatum roots or its isolates may be useful for H. pylori infection and further study is needed to elucidate mechanism of action.

Punica granatum peel extract

Effects of Punica granatum pericarps and Quercus infectoria nutgalls on cell surface hydrophobicity and cell survival of Helicobacter pylori
Punica granatum is more effective to prevent gastric disorders induced by Helicobacter pylori or any other stimulator in humans
Study of In Vitro Inhibition Effect of Pomegranate Rind on H.pylori
In vitro Inhibition of Helicobacter pylori by Some Spices and Medicinal Plants Used in Iran
Helicobacter pylori is the most common cause of gastric infections worldwide. The antibacterial activity of methanol extracts of Satureja hortensis L. (Lamiaceae), Artemisia dracunculus L. (Asteraceae), Carthamus tinctorius L. (Asteraceae), Apium petroselinum L. (Apiaceae), Citrus sinensis L. (Rutaceae) and Punica granatum L. (Punicaceae) were evaluated against H. pylori. Inhibition tests were carried out using the disc diffusion method against 27 clinical isolates of H. pylori for initial screening and then agar dilution method to determine minimum inhibitory concentration (MIC). Among the crude extracts, P. granatum showed the highest inhibition (27.96±0.97mm) and the MICs of its butanol and aqueous fractions were 156 and 195.12 µg/mL, respectively. While its chloroform fraction had no activity against tested H. pylori isolates. All extracts except safflower preserved their anti-Helicobacter pylori activity at 121°C. All the extracts were capable of inhibiting the in in vitro growth of H. pylori and the butanol fraction of P. granatum, showed excellent anti-H. pylori activity

Resveratrol

Rheum officinale extract

Rhizoma coptidis extract

Comparison of Helicobacter pylori urease inhibition by Rhizoma Coptidis, Cortex Phellodendri and Berberine: mechanisms of interaction with the sulfhydryl group

Rottlerin (Mallotus philippinensis Muell. Arg (Euphorbiaceae)

Among the isolated compounds, rottlerin exhibited most potent bactericidal activity with minimum bactericidal concentration (MBC) value of 3.12-6.25 mg/l against several clinical H. pylori isolates including Japanese and Pakistani strains, nine clarithromycin resistant (CR), and seven metronidazole resistant (MR) strains.
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review
We have conducted a study of fifty medicinal plants including twenty-five spices that are commonly prescribed for the treatment of gastrointestinal disorders in Unani medical practice in Pakistan (Zaidi et al., 2009a). MBC values determined were at the concentration range of 7.8 to 500 µg/ml using seven H. pylori clinical isolates and one ATCC reference H. pylori strain (ATCC 43504). It was interesting to note that >50% of herbs at the concentration of 500 µg/ml inhibited the growth of all H. pylori strains. Extracts of Mallotus phillipinesis (Lam) Muell., Curcuma amada Roxb., Psoralea corylifolia L. and Myrisctica fragrans Houtt showed strong anti-H. pylori activity (MBC: 15.6-62.5 µg/ml). The most potent extract (Mallotus phillipinesis (Lam) Muell) was further evaluated for active constituents and found rottlerin to possess strong MBC value range of 3.12-6.25 µg/ml even against geographically distinct Japanese strains and antibiotic resistant strains (Zaidi et al., 2009b).

Saccharomyces boulardii

Saussurea lappa (Asteraceae) Costus Root extract

Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review.
Chinese conducted the antibacterial action of thirty herbal medicines, which have been frequently used since ancient times for the treatment of gastritis-like disorders (Li et al., 2005). Among those thirty tested Chinese herbs, the ethanol extracts of Saussurea lappa (Asteraceae), Abrus cantoniensis (Fabaceae) and Eugenia caryophyllata (Myrtaceae) had the most strongly bacteriostatic effect (MICs: approximately 40 mg/ml).
Anti-microbial activity of Saussurea lappa CB Clarke Roots

Scutellaria baicalensis extract

Smilax glabra rhizome extract

Smoked plum (Fructus Pruni Mume) fruit extract

Tabebuia impetiginosa Martius ex DC dried inner bark (Menadione and plumbagin)

Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori.
The growth-inhibiting activity of Tabebuia impetiginosa Martius ex DC dried inner bark-derived constituents against Helicobacter pylori ATCC 43504 was examined using paper disc diffusion and minimum inhibitory concentration (MIC) bioassays. The activity of the isolated compounds was compared to that of the commercially available anti-Helicobacter pylori agents, amoxicillin, metronidazole, and tetracycline. The biologically active components of Tabebuia impetiginosa dried inner bark (taheebo) were characterized by spectroscopic analysis as 2-(hydroxymethyl)anthraquinone, anthraquinone-2-carboxylic acid, and 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol). With the paper disc diffusion assay 2-(hydroxymethyl)anthraquinone exhibited strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. Anthraquinone-2-carboxylic acid, lapachol and metronidazole were less effective, exhibiting moderate anti-Helicobacter pylori activity at 0.1 mg/disc. Amoxicillin and tetracycline were the most potent compounds tested, displaying very strong activity at 0.005 mg/disc. 2-(Hydroxymethyl)anthraquinone exhibited moderate activity at this dose. Tetracycline still had strong activity at 0.001 mg/disc while amoxicillin had little activity at this dose. In the MIC bioassay, 2-(hydroxymethyl)anthraquinone (2 microg/mL), anthraquinone-2-carboxylic acid (8 microg/mL), and lapachol (4 microg/mL) were more active than metronidazole (32 microg/mL) but less effective than amoxicillin (0.063 microg/mL) and tetracycline (0.5 microg/mL).
The anti-Helicobacter pylori activity of seven 1,4-naphthoquinone derivatives (structurally related to lapachol), 1,4-naphthoquinone, 5,8-dihydroxy-1,4-naphthoquinone (naphthazarin), 2-methyl-1,4-naphthoquinone (menadione), 2-hydroxy-1,4-naphthoquinone (lawsone), 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin), 5-hydroxy-1,4-naphthoquinone (juglone), and 2,3-dichloro-1,4-naphthoquinone (dichlone) was also evaluated using the paper disc assay. Menadione and plumbagin were the most potent compounds tested with the later still exhibiting very strong activity at 0.001 mg/disc. Menadione, juglone and tetracycline had strong activity at this low dose while the latter two compounds and amoxicillin had very strong activity at 0.005 mg/disc.
Lawsone was unusual in that it had very strong activity at 0.1 and 0.05 mg/disc but weak activity at doses of 0.01 mg/disc and lower. Naphthazalin, lapachol and dichlone had similar activities while metronidazole had the lowest activity of all compounds tested. These results may be an indication of at least one of the pharmacological actions of taheebo. The Tabebuia impetiginosa dried inner bark-derived materials, particularly 2-(hydroxymethyl)anthraquinone, merit further study as potential Helicobacter pylori eradicating agents or lead compounds.

tyrosol-elenolic acid dialdehyde (Ty-EDA or Ty-DEA) from Olive oil

In vitro activity of olive oil polyphenols against Helicobacter pylori.
Helicobacter pylori is linked to a majority of peptic ulcers and to some types of gastric cancer, and resistance of the microorganism to antibiotic treatment is now found worldwide. Virgin olive oil is an unrefined vegetable oil that contains a significant amount of phenolic compounds. Under simulated conditions, we have demonstrated that these substances can diffuse from the oil into the gastric juice and be stable for hours in this acidic environment. In vitro, they exerted a strong bactericidal activity against eight strains of H. pylori, three of them resistant to some antibiotics. Among the phenolic compounds, the dialdehydic form of decarboxymethyl ligstroside aglycon showed the strongest bactericidal effect at a concentration as low as 1.3 microg/mL.
Although the experimental conditions are different from other reported works, this bactericidal concentration is much lower than those found for phenolic compounds from tea, wine, and plant extracts. These results open the possibility of considering virgin olive oil a chemopreventive agent for peptic ulcer or gastric cancer, but this bioactivity should be confirmed in vivo in the future.

Wasabi (Wasabia japonica) extract

Improvement Effects of Wasabi (Wasabia japonica) Leaves and Allyl Isothiocyanate on Stomach Lesions of Mongolian Gerbils Infected with Helicobacter pylori
The antimicrobial effects of Wasabia japonica and Armoracia rusticana, J Marine Biology and Aquascape
Leaf extract of Wasabia japonica relieved oxidative stress induced by Helicobacter pylori infection
Infection with Helicobacter pylori (H. pylori) can induce gastric disorders, and though its presence cannot explain disease pathogenesis and does not have associations with other factors, it is well known that H. pylori infection causes stomach inflammation following oxidative stress. We examined the suppressive effects of a leaf extract of Wasabia japonica on H. pylori infection and on stress loading in Mongolian gerbils. Following oral administration of wasabi extract of 50 and 200 mg/kg B.W./d for 10 d, the animals were exposed to restraint stress for 90 and 270 min. As for the results, the level of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) in the stomach and oxidative DNA damage in peripheral erythrocytes at 270 min significantly increased. That elevation was significantly suppressed by the addition of the leaf extract. We concluded that the simultaneous loading of H. pylori infection and physical stress loading might induce oxidative DNA damage additively, while a leaf extract attenuated this DNA damage in the stomach as well as the peripheral erythrocytes.
Pharmacological ins and outs of medicinal plants against Helicobacter pylori: A review
Shin et al from Japan reported anti-H. pylori activity of wasabi (Wasabia japonica) and demonstrated higher bactericidal activity of leaves than root of wasabi (Shin et al., 2004).

Zinc Carnosine

A modified sequential regimen of Helicobacter pylori treatment enforced by Bacillus clausii and Zinc Carnosine complex yields high eradication rates
Introduction: Over the past decade a worldwide trend of decline in the cure rates of Helicobacter pylori is observed. Current eradication rates achieved by the standard triple therapy are below 70%. Sequential therapy had provided a potential alternative that would compensate for the unmet performance of triple therapy. Despite its superiority to triple therapy, the excellent results reported initially were not reproduced by other investigators work. Adding adjuvant agents was also found to improve further the success rate of eradication. Probiotics emerged as a useful adjunct in treatment and prophylaxis of Helicobacter pylori infection. The nutritional supplement Zinc carnosine complex is another adjuvant which is believed to add value to the treatment. Patients and method: an open label randomized observational clinical study designed to compare the efficacy of a modified sequential regimen enforced by two adjuvants the probiotic Bacillus clausii and the nutritional Zinc Carnosine supplement. Patients who fulfilled the inclusion and exclusion criteria were randomized to one of two groups who were given the same components of the regimen of treatment either with clarithromycin (group A, n=131) or levofloxacin replacing it (group B, n=137) and were compared against the current reported response to triple therapy in our area (67.9%). Results: This regimen of eradication had yielded a Per protocol cure rate of 96.4% and an ITT rate of 89.9% for the levofloxacin based therapy. The Per protocol eradication rate for the clarithromycin based treatments was 93.4% and the ITT rate was 90%. The response was not significantly affected by previous exposure to the antibiotics used. Patient satisfaction and compliance were remarkable with most patients having a significant feeling of wellbeing and improvement of their symptoms. Side effects to the components of the regimen were unremarkable. The addition of Bacillus clausii and the nutritional supplement Zinc Carnosine had added great value to the eradication response.

Scientific Studies:

“Helico works right away in killing Helicobater Pylori! I’ve been trying to get rid of this for years. The first side effects were not pleasant as the bacteria put up a fight. BUT after about 3 days I started getting better. I used to feel exhausted every time I ate. This no longer happens. I expect to see better and better health results now that the bacteria is gone. Thank you Gavin for your endless supply of info and support. You are much appreciated!”

⭐️⭐️⭐️⭐️⭐️

—Shelley McKone

Size	25g, 100g

12 reviews for HELICO (Helicobacter Pylori Destroyer)

Rated 5 out of 5
Rich Ryan – March 4, 2020
Another incredible blend from Interstellar! They research all the most important health issues plaguing humankind and come up with the best possible herbal remedy for each one.
I’ve had intermittent heartburn, gas and diarrhea for years, and thought it was normal. I blamed myself for not eating as well as I should. Little did I know that it was due to a Helicobacter pylori bacterial infection! One that I’d been carrying for many years. This blend is a strong one, but it cleared the infection right out and I haven’t experienced heartburn or diarrhea since.
You don’t need to take this blend all the time, just do a tsp before bed for a couple weeks, then 1/2 tsp for a couple weeks after that.
Then take occasionally (3-7 days a month) for maintenance. One bag will last for probably almost a year.
Superb blend! A+++
Rated 5 out of 5
Ben Levesque – March 5, 2020
I started taking peel blend 3 times a day. Once in the morning, once in the afternoon and once in the evening.
After 3 days I started to see it come down, day 3 it was down to 310, day 5 of was down to 290. a week later I lowered my dosage to once in the morning at that time my blood sugar read 260, it’s been 5+ months now and my sugar is consistently under 200 and back to feeling great again.
I LOVE this product. My skin is so much softer since taking it, and my hands and feet are like baby soft. I have had 2 people tell me that I’m reverse aging. I try and follow a keto diet. In the past when I had fallen off the wagon for a day or two I’d gain 4-5 lbs back. Since taking the peel blend I don’t gain it back. It really is a great product.
One of the biggest challenges we face with cancer exhaustion from both the disease and the treatment for it. This last cycle wiped me out more than any other. I have not been able to regain my energy no matter how much I’ve slept, or rested. This is something I have always been able to overcome by adjusting my blends and fasting, but this time was much different.Under the advice of my daughter (who has taken blends for sometime), , started taking Peel blends and within first week had already noticed a drastic difference in lowering blood sugar levels. Returning 3 months later for doctors visit, after taking Peel blend, she was amazed with my extremely lowered A1C.
Thank you to this product!!!
Rated 5 out of 5
Judi Bahr (verified owner) – March 30, 2020
An absolute life changing blend fo me.
Last July I had gallbladder removal surgery and thought all of my gut issues were over. Little did I know ..they were about to get much worse.
About 1 month post op, remedies the surgeon was instructing me to try were not in the least working. Then the Rx’s began.. truthfully, they seemed to make my issues much worse. I was sent to a gastroenterologist, who would do nothing until I went thru more testing. Did every single test he wanted.. nothing out of the ordinary. I’m like really?? Well something was going on…stomach noises so loud, they could be heard across the room, ( sorry TMI) diarrhea was the norm, heartburn so bad I kept antacid tablets on my bedside table. I was probably like a bratty little sister messaging Gavin. Then Helico was a month out from being released. I was determined to try it as soon as I could.
3 weeks ago I took my first dose 1 tsp in fresh grapefruit juice as instructed. It’s grapefruit season here in Arizona, everyone is giving them away.. timing was perfect. Every evening I dutifully squeezed a grapefruit and mixed it with 1 tsp of Helico. Let me tell you, that first week was HELL, and every night I swore I wasn’t going to continue, somehow the next evening, I found myself squeezing another grapefruit all over again. I really needed to give this blend a chance.
7 days took me into my second week… I was still not feeling great. Then day 11 … I had dinner and realized.. no growling gurgling stomach. No RUNNING to the bathroom, and I didnt feel like crap! I approached days 12,& 13 with cautious optimism.
Tonight I will take my first maintenance dose of Helico. This blend is now part of my daily rotation. If you are suffering from gut / gastro issues, heartburn, I cannot say this loud enough
GIVE HELICO A TRY.
See it thru 14 days.. I don’t think you’ll be disappointed.
Rated 5 out of 5
Antonio C – August 16, 2020
It’s true!!! I had the worst stomach problems for the past 10 years always relying on baking soda and ranitidine pills. I loaded on this for 1 week straight, 1 teaspoon before bedtime and my stomach issues are GONE!!!!! I can literally lay down without worry that my stomach acid will back up in my mouth and have a throwing up sensation and leaving my throat burning. Sometimes it would get so bad that I would wake up light headed from such bad reflux I had. My stomach would bulge out in an insane bloat. I’m not a fat guy, but my stomach would bloat crazy and be hard as a rock. 1 week of loading on this fixed a 10 year problem I had. This stuff is INSANE!!!! I know most people swear by the TRINITY but this is my favorite product only because I struggled for so long.
Rated 5 out of 5
Scotty Schmadebeck – August 29, 2020
Helico has changed my life!! I used to have super bad digestive issues such as bloating and constipation.
I immediately felt an improvement in my digestion the day after taking my first dose of helico! My digestion continued to get better with each dose.
Now 3 months later im back to eating a
normal diet and my digestion is 85% healed!!! I absolutely LOVE helico and could not recommend it enough!
Rated 5 out of 5
Joy Mollnar – September 23, 2020
Helico Pylori Destroyer by Interstellar blends is a game changer. I’m currently drinking a cup of coffee after I just ate a huge bowl of mexican soup without ANY indigestion. I would have never DREAMED I could do this two weeks ago. I had a very extreme case of heartburn and digestion problems last month. I could not consume hardly anything without going through tremendous pain and burning in my esophagus. I would lay in bed at night, chest burning. I had to cancel lunch and dinner dates because I could not eat. My regular iced tea and coffee turned into baking soda and water cocktails. I almost threw in the towel after over the counter medicine wouldn’t squash it.
I finally came to Gavin and decided to try the Destroyer blend. It had every single ingredient I had already seen in homeopathic digestion blogs and THEN SOME.
The first day I felt relief. The FIRST freakin’ day! I continued to use every night mixed with half a cup of grapefruit juice before bed. I thought surely my throat will be on fire after this but it wasn’t. It’s almost like the grapefruit juice combined with the blend turned into a bacteria killer in my intestines. I’m back to eating like the foodie I was born to be!
Thank you Gavin for creating such an amazing blend!
Rated 5 out of 5
Andrea Jones (verified owner) – September 25, 2020
My friend got the Gastric Band surgery for weightloss about 4 years ago. She had been experiencing really bad heartburn for the past year. She tried all over the counter medications and nothing worked. I told her about Helico. She was stubborn at first. So when she got to the point where she was tired of experiencing the bad heartburn, she called me and told me to order it for her. So I ordered it for her . Delivery was very good. She took it the first night and the next day immediately felt the difference. No heartburn what so ever. She has been taking it about 2 weeks now and she is very happy to be free of heartburn. I also told her about the Extreme weightloss protocol and she is going to order the blends she needs to get started.
Gavin I really appreciate you and how you get right back with me when I ask a question about anything.
Thank You
Rated 5 out of 5
Joanie Morgan (verified owner) – October 18, 2020
Helicobacter Pylori Destroyer is now one of my top 3 favorite Blends. Helico, Peel and Autophagy are my top 3. So I have always been suffering from digestive issues. I’ve also noticed that since dry fasting, my heartburns have been worst than ever. I’ve now been taking Helico for 2 months. Y’all if you have been suffering from any kind of digestive issue, you need to get this. When you have been suffering from digestive issues for over 30 years and you finally get relief from just taking Helico in just one day and now I’m only taking it once a day. From the first day I took it, I had to see if it really works. I kept some antiacid with me just in case it didn’t work. I went and I had some Korean food. Y’all I love korean food but it always messes my stomach up. As much as I love kimchee, if I eat it, I have diarrhea and gas forever, not to mention the very bad heartburns. That first day, I was surprised that after I ate, I was able to lie down and go to sleep.
I had to wait to really see if this works well. If I ever eat anything spicy, I can forget it. It takes forever for the heartburns to go away and a lot of times it’s accompanied by diarrhea and sharp stomach pain. Let me tell you, it’s not a fun feeling. I have to always carry antiacid with me in my purse, because it’s just been a part of my life for years.
It’s also kind of sad that I know exactly where the antiacid isles are in the grocery stores because I’ve had this bacteria for years. It’s also very weird now that I still have to go there first and not have to purchase antiacids. I AM FREE!!! FINALLY FREE!!! I can eat a bunch of crap and not have to run to the bathroom just like I did for over 30 years of my existence.
My daughter has also been taking Helico without knowing it. I have been sneaking it in her tea in the morning. About a week ago, she came running and asked me if one of my “magic dirt”(blends) cures indigestion and stomach issues. I told her, yes I’ve been dropping some of my “dirt” in her tea every morning. She thanked me and said that she finally noticed that she hasn’t had stomach problems since I’ve been making her tea in the morning. hehehe. Now she’s taking all of the herbs that I have. She asks me every morning to sprinkle some of my magic in her tea.
I can’t tell you enough what Gavin’s blends have been a life saving for myself and my family. Gavin and his team are amazing people. The customer service from Gavin himself and his team is out of this world. He’s always available at all times of the day. If you don’t believe me, then try. Whenever I have a question, I can always count on Gavin to respond right away. The amazing and quick shipping whenever I order anything is out of this world. I will always continue to order more from Gavin because I know his products are the best. You have any issues, just ask Gavin what you need to order to get rid of it. Thank you Gavin for all that you do for everyone. You and your team are God send. God bless you and your business. I pray that it continues to flourish. Mahalo Nui Loa
Rated 5 out of 5
David Velez Quiroz (verified owner) – October 26, 2020
Helico It’s the best , I had been having digestive problems for 2 years, everything I ate hurt my stomach and I constantly had gas and abdominal swelling, it hurt a lot and I was uncomfortable every day.
I stopped eating dairy because I thought I was lactose intolerant, I stopped eating all kinds of things that could irritate my colon and stomach and still the discomfort, bloating and stomach damage would not stop.
I began medical treatments that previously aggravated my stomach and intestinal problem.
I came here one day on someone’s recommendation and wanted to buy Helico to try out if a natural alternative could work for me since nothing had worked for me and I was tired of living day by day with my stomach like this.
In just the first week I had my stomach back in shape, the gas had almost completely disappeared, the abdominal swelling had not returned, I improved so quickly and so satisfactorily that I find it incredible.
I am very grateful because Helico cured my stomach in a week and did what traditional medicine could not do in 2 years, now I feel very good, and my stomach is perfect in 90%, I do not feel uncomfortable, I feel good every day and even I can eat everything that I did not eat before and nothing hurts my stomach, every food feels good and really improve my life, thanks.
Rated 5 out of 5
Max Ryan (verified owner) – January 23, 2021
I began using Interstellar Blends around four years ago. I found them via a referral from my son who suggested I try Trinity. In my late 60’s, but pretty healthy, I noticed various benefits beginning to unfold. My hair thickened; my libido improved; the small amount of post retirement and age related depression I was experiencing lessened; my energy level increased. In short, my age backed up a few years. So, with that as my motivation, I ordered one of the combo packs. All of those products provided noticeable benefits. I have used various supplements for the past 30 or so years and I can tell you that many of them are not worth taking. One must really carefully discern whether or not the supplements they are using are just creating expensive urine or actually improving your health. I have never found anything even close to the obviously positive effects of Interstellar Blends.
I had settled upon using primarily Trinity. Then, my son noticed that I used a huge quantity of stomach acid reducers and suggested I try Helico. I, and much of my family, suffer from painful acid reflux and, in my case, I was consuming about 1/3 of a bottle of well known acid relief chewables every night. Even doing that, I usually would wake up around 2 a.m. and go chew a few more. I tried Helico. It has been beyond belief. I now use only a small number of chewables and have completely stopped my prescription meds. My stomach hasn’t been this comfortable in many years. Gavin, your blends are doing what traditional medicine can’t seem to accomplish. Thank you so much.
Now, I have settled upon Trinity, Seven Sages and Helico. At my age, 72, I might benefit from other blends, but these seem to get me up and running every day and prevent most of the ravages of aging. The amazing effects of these superior quality blends make them certainly worth every penny you pay for them. You are not throwing money away on useless, non-absorbable products that are hardly what they say they are. It is so nice to feel good, but my greatest thanks goes to the Helico blend, Stomach pain is a thing of the past and what a wonderful thing that is. The products deserve a 5+ star review. Thanks!
Rated 5 out of 5
Patrick (verified owner) – April 24, 2021
I have been having stomach problems since I can remember. Everything from gas, diarrhea and a weird stomach pain at random times. After taking Helicobacter Pylori Destroyer for 2 weeks with grapefruit juice, my stomach issues have been completely GONE! If you’re someone struggling with stomach issues in general I recommend you get this blend ASAP! It’s a no-brainer. Cured me after all these years. Feel like a new man. Thanks!
Rated 5 out of 5
Flacko FX – May 11, 2021
Since 2017 I have been sick. My stomach literally felt like it was about to explode, I used to feel pressure on my left side ( Like if there was a ball of air just squishing my organs), I used to have excessive gas and my stomach would literally make loud noises. It was embarrassing at times. I came across Interstellar through Shaun Lee I trust that man knowledge with my life. Thank you Gavin for all your work and dedication in your field. 2021 is when I started the blend I did the stomach reset combo 1 tea spoon mixed in unsweetened kefir 1 tea spoon of each blend. 1 cup in the morning and one at night. Taste is awful but is all worth it. its been 1 moth and fuck I feel like I got a brand new system.